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Compile Data Set for Download or QSAR

Found 1099 hits Enz. Inhib. hit(s) with Target = 'Trace amine-associated receptor 1 (TAAR1)' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119143
PNG
(US8673950, 10)
Show SMILES Cc1cc(Nc2ccc(CC[C@H]3COC(N)=N3)cc2)ccc1OC(F)(F)F
Show InChI InChI=1S/C19H20F3N3O2/c1-12-10-15(8-9-17(12)27-19(20,21)22)24-14-5-2-13(3-6-14)4-7-16-11-26-18(23)25-16/h2-3,5-6,8-10,16,24H,4,7,11H2,1H3,(H2,23,25)/t16-/m0/s1
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US Patent
0.100n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109401
PNG
(US8604061, 115)
Show SMILES Cc1cccc(CC[C@H]2COC(N)=N2)c1
Show InChI InChI=1S/C12H16N2O/c1-9-3-2-4-10(7-9)5-6-11-8-15-12(13)14-11/h2-4,7,11H,5-6,8H2,1H3,(H2,13,14)/t11-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122323
PNG
(US8729113, 35)
Show SMILES NC1=N[C@@H](CCOc2cccc(Br)c2)CO1
Show InChI InChI=1S/C11H13BrN2O2/c12-8-2-1-3-10(6-8)15-5-4-9-7-16-11(13)14-9/h1-3,6,9H,4-5,7H2,(H2,13,14)/t9-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122301
PNG
(US8729113, 8)
Show SMILES NC1=N[C@@H](CCOc2ccc(F)c(Cl)c2)CO1
Show InChI InChI=1S/C11H12ClFN2O2/c12-9-5-8(1-2-10(9)13)16-4-3-7-6-17-11(14)15-7/h1-2,5,7H,3-4,6H2,(H2,14,15)/t7-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119191
PNG
(US8673950, 58)
Show SMILES CCC(CC)c1cnc(Nc2ccc(CC[C@H]3COC(N)=N3)cc2)nc1
Show InChI InChI=1S/C20H27N5O/c1-3-15(4-2)16-11-22-20(23-12-16)25-17-8-5-14(6-9-17)7-10-18-13-26-19(21)24-18/h5-6,8-9,11-12,15,18H,3-4,7,10,13H2,1-2H3,(H2,21,24)(H,22,23,25)/t18-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119152
PNG
(US8673950, 19)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ccc(Cl)c(Cl)c3)cc2)CO1
Show InChI InChI=1S/C17H17Cl2N3O/c18-15-8-7-13(9-16(15)19)21-12-4-1-11(2-5-12)3-6-14-10-23-17(20)22-14/h1-2,4-5,7-9,14,21H,3,6,10H2,(H2,20,22)/t14-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119144
PNG
(US8673950, 11)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ccc(cn3)C(F)(F)F)cc2)CO1
Show InChI InChI=1S/C17H17F3N4O/c18-17(19,20)12-4-8-15(22-9-12)23-13-5-1-11(2-6-13)3-7-14-10-25-16(21)24-14/h1-2,4-6,8-9,14H,3,7,10H2,(H2,21,24)(H,22,23)/t14-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119141
PNG
(US8673950, 8)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ccc(cc3)C(F)(F)F)cc2)CO1
Show InChI InChI=1S/C18H18F3N3O/c19-18(20,21)13-4-9-15(10-5-13)23-14-6-1-12(2-7-14)3-8-16-11-25-17(22)24-16/h1-2,4-7,9-10,16,23H,3,8,11H2,(H2,22,24)/t16-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119139
PNG
(US8673950, 6)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ccc(Cl)cc3)cc2)CO1
Show InChI InChI=1S/C17H18ClN3O/c18-13-4-9-15(10-5-13)20-14-6-1-12(2-7-14)3-8-16-11-22-17(19)21-16/h1-2,4-7,9-10,16,20H,3,8,11H2,(H2,19,21)/t16-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109462
PNG
(US8604061, 201)
Show SMILES NC1=N[C@H](CO1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C9H8Cl2N2O/c10-6-1-5(2-7(11)3-6)8-4-14-9(12)13-8/h1-3,8H,4H2,(H2,12,13)/t8-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109373
PNG
(US8604061, 48)
Show SMILES NC1=N[C@@H](Cc2cccc3ccccc23)CO1
Show InChI InChI=1S/C14H14N2O/c15-14-16-12(9-17-14)8-11-6-3-5-10-4-1-2-7-13(10)11/h1-7,12H,8-9H2,(H2,15,16)/t12-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119187
PNG
(US8673950, 54)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ncc(cn3)C3CC3)cc2)CO1
Show InChI InChI=1S/C18H21N5O/c19-17-22-16(11-24-17)8-3-12-1-6-15(7-2-12)23-18-20-9-14(10-21-18)13-4-5-13/h1-2,6-7,9-10,13,16H,3-5,8,11H2,(H2,19,22)(H,20,21,23)/t16-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109564
PNG
(US8604061, 354)
Show SMILES NC1=N[C@@H](COc2ccccc2F)CO1
Show InChI InChI=1S/C10H11FN2O2/c11-8-3-1-2-4-9(8)14-5-7-6-15-10(12)13-7/h1-4,7H,5-6H2,(H2,12,13)/t7-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122333
PNG
(US8729113, 57)
Show SMILES NC1=N[C@@H](CCOc2ccc(Cl)c(Cl)c2)CO1
Show InChI InChI=1S/C11H12Cl2N2O2/c12-9-2-1-8(5-10(9)13)16-4-3-7-6-17-11(14)15-7/h1-2,5,7H,3-4,6H2,(H2,14,15)/t7-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM190607
PNG
(US9181230, 13)
Show SMILES Fc1ccc(-c2cc(n[nH]2)-c2ccc(cc2)[C@H]2CNCCO2)c(F)c1
Show InChI InChI=1/C19H17F2N3O/c20-14-5-6-15(16(21)9-14)18-10-17(23-24-18)12-1-3-13(4-2-12)19-11-22-7-8-25-19/h1-6,9-10,19,22H,7-8,11H2,(H,23,24)/t19-/s2
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


US Patent US9181230 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM167453
PNG
(US9073911, 2)
Show SMILES Clc1cccc(c1)-c1cc(n[nH]1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1/C20H19ClN4O2/c21-15-3-1-2-14(10-15)17-11-18(25-24-17)20(26)23-16-6-4-13(5-7-16)19-12-22-8-9-27-19/h1-7,10-11,19,22H,8-9,12H2,(H,23,26)(H,24,25)/t19-/s2
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0.300n/an/an/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...


US Patent US9073911 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119156
PNG
(US8673950, 23)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3cc(ccn3)C(F)(F)F)cc2)CO1
Show InChI InChI=1S/C17H17F3N4O/c18-17(19,20)12-7-8-22-15(9-12)23-13-4-1-11(2-5-13)3-6-14-10-25-16(21)24-14/h1-2,4-5,7-9,14H,3,6,10H2,(H2,21,24)(H,22,23)/t14-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122298
PNG
(US8729113, 5)
Show SMILES NC1=N[C@@H](CCOc2cccc(Cl)c2)CO1
Show InChI InChI=1S/C11H13ClN2O2/c12-8-2-1-3-10(6-8)15-5-4-9-7-16-11(13)14-9/h1-3,6,9H,4-5,7H2,(H2,13,14)/t9-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109408
PNG
(US8604061, 127)
Show SMILES NC1=N[C@@H](CCc2ccc(Cl)c(Cl)c2)CO1
Show InChI InChI=1S/C11H12Cl2N2O/c12-9-4-2-7(5-10(9)13)1-3-8-6-16-11(14)15-8/h2,4-5,8H,1,3,6H2,(H2,14,15)/t8-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119193
PNG
(US8673950, 60)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ncc(cn3)C3CCC3)cc2)CO1
Show InChI InChI=1S/C19H23N5O/c20-18-23-17(12-25-18)9-6-13-4-7-16(8-5-13)24-19-21-10-15(11-22-19)14-2-1-3-14/h4-5,7-8,10-11,14,17H,1-3,6,9,12H2,(H2,20,23)(H,21,22,24)/t17-/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM60837
PNG
(US9181230, 9)
Show SMILES Clc1cccc(c1)-c1cc(n[nH]1)-c1ccc(cc1)C1CNCCO1
Show InChI InChI=1/C19H18ClN3O/c20-16-3-1-2-15(10-16)18-11-17(22-23-18)13-4-6-14(7-5-13)19-12-21-8-9-24-19/h1-7,10-11,19,21H,8-9,12H2,(H,22,23)
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


US Patent US9181230 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122318
PNG
(US8729113, 30)
Show SMILES NC1=N[C@@H](CCC2(CC2)c2ccc(Cl)cc2)CO1
Show InChI InChI=1S/C14H17ClN2O/c15-11-3-1-10(2-4-11)14(7-8-14)6-5-12-9-18-13(16)17-12/h1-4,12H,5-9H2,(H2,16,17)/t12-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109528
PNG
(US8604061, 298)
Show SMILES NC1=N[C@H](CO1)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C9H8Cl2N2O/c10-5-1-2-7(11)6(3-5)8-4-14-9(12)13-8/h1-3,8H,4H2,(H2,12,13)/t8-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109580
PNG
(US8604061, 296)
Show SMILES NC1=N[C@H](CO1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C9H8Cl2N2O/c10-5-1-2-6(7(11)3-5)8-4-14-9(12)13-8/h1-3,8H,4H2,(H2,12,13)/t8-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109390
PNG
(US8604061, 103)
Show SMILES NC1=N[C@H](CO1)c1ccc2ccccc2c1
Show InChI InChI=1S/C13H12N2O/c14-13-15-12(8-16-13)11-6-5-9-3-1-2-4-10(9)7-11/h1-7,12H,8H2,(H2,14,15)/t12-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109446
PNG
(US8604061, 178)
Show SMILES NC1=N[C@H](CO1)c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C9H8ClFN2O/c10-6-1-5(2-7(11)3-6)8-4-14-9(12)13-8/h1-3,8H,4H2,(H2,12,13)/t8-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM190621
PNG
(US9181230, 27)
Show SMILES Fc1ccc(cc1)-c1cn(nn1)-c1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1/C18H17FN4O/c19-15-5-1-13(2-6-15)17-12-23(22-21-17)16-7-3-14(4-8-16)18-11-20-9-10-24-18/h1-8,12,18,20H,9-11H2/t18-/s2
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


US Patent US9181230 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM190602
PNG
(US9181230, 8)
Show SMILES Clc1ccc(cc1)-c1cc(n[nH]1)-c1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1/C19H18ClN3O/c20-16-7-5-14(6-8-16)18-11-17(22-23-18)13-1-3-15(4-2-13)19-12-21-9-10-24-19/h1-8,11,19,21H,9-10,12H2,(H,22,23)/t19-/s2
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


US Patent US9181230 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122380
PNG
(US8729113, 136)
Show SMILES NC1=N[C@@H](CCOc2cccc(c2)C(=O)OCc2ccccc2)CO1
Show InChI InChI=1S/C19H20N2O4/c20-19-21-16(13-25-19)9-10-23-17-8-4-7-15(11-17)18(22)24-12-14-5-2-1-3-6-14/h1-8,11,16H,9-10,12-13H2,(H2,20,21)/t16-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122319
PNG
(US8729113, 31)
Show SMILES NC1=N[C@@H](CCC2(CC2)c2ccccc2)CO1
Show InChI InChI=1S/C14H18N2O/c15-13-16-12(10-17-13)6-7-14(8-9-14)11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,16)/t12-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122385
PNG
(US8729113, 144)
Show SMILES NC1=N[C@@H](CCC2(CC2)c2ccc(Br)cc2)CO1
Show InChI InChI=1S/C14H17BrN2O/c15-11-3-1-10(2-4-11)14(7-8-14)6-5-12-9-18-13(16)17-12/h1-4,12H,5-9H2,(H2,16,17)/t12-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM129410
PNG
(US8802673, 52)
Show SMILES Clc1cccc2ccc(Nc3ccc(cc3)[C@H]3CNCCO3)nc12
Show InChI InChI=1S/C19H18ClN3O/c20-16-3-1-2-14-6-9-18(23-19(14)16)22-15-7-4-13(5-8-15)17-12-21-10-11-24-17/h1-9,17,21H,10-12H2,(H,22,23)/t17-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ina...


US Patent US8802673 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM129420
PNG
(US8802673, 62)
Show SMILES Cc1cc(Nc2ccc(cc2)[C@H]2CNCCO2)ncc1Br
Show InChI InChI=1S/C16H18BrN3O/c1-11-8-16(19-9-14(11)17)20-13-4-2-12(3-5-13)15-10-18-6-7-21-15/h2-5,8-9,15,18H,6-7,10H2,1H3,(H,19,20)/t15-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ina...


US Patent US8802673 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM129366
PNG
(US8802673, 8)
Show SMILES Clc1ccc(Nc2ccc(cc2)C2CNCCO2)cc1
Show InChI InChI=1S/C16H17ClN2O/c17-13-3-7-15(8-4-13)19-14-5-1-12(2-6-14)16-11-18-9-10-20-16/h1-8,16,18-19H,9-11H2
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ina...


US Patent US8802673 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM158299
PNG
(US9029370, 93)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc([C@@H]2CNCCO2)c(Cl)c1
Show InChI InChI=1/C21H19ClF2N4O3/c22-18-9-14(1-6-17(18)19-11-25-7-8-30-19)27-20(29)13-10-26-28(12-13)15-2-4-16(5-3-15)31-21(23)24/h1-6,9-10,12,19,21,25H,7-8,11H2,(H,27,29)/t19-/s2
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Membrane Preparation and Radioligand Binding. HEK-293 cells stably expressing mouse TAA 1 were maintained at 37 C and 5% C02 in DMEM high glucose med...


US Patent US9029370 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM60838
PNG
(US9181230, 12)
Show SMILES N#Cc1cccc(c1)-c1cc(n[nH]1)-c1ccc(cc1)C1CNCCO1
Show InChI InChI=1/C20H18N4O/c21-12-14-2-1-3-17(10-14)19-11-18(23-24-19)15-4-6-16(7-5-15)20-13-22-8-9-25-20/h1-7,10-11,20,22H,8-9,13H2,(H,23,24)
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


US Patent US9181230 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM167491
PNG
(US9073911, 40)
Show SMILES FC(F)Oc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1/C21H20F2N4O3/c22-21(23)30-16-3-1-2-14(10-16)17-11-18(27-26-17)20(28)25-15-6-4-13(5-7-15)19-12-24-8-9-29-19/h1-7,10-11,19,21,24H,8-9,12H2,(H,25,28)(H,26,27)/t19-/s2
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0.5n/an/an/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...


US Patent US9073911 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM167461
PNG
(US9073911, 10)
Show SMILES Clc1ccccc1-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1/C20H19ClN4O2/c21-16-4-2-1-3-15(16)17-11-18(25-24-17)20(26)23-14-7-5-13(6-8-14)19-12-22-9-10-27-19/h1-8,11,19,22H,9-10,12H2,(H,23,26)(H,24,25)/t19-/s2
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0.5n/an/an/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...


US Patent US9073911 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM167463
PNG
(US9073911, 12)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1/C20H19ClN4O2/c21-15-5-1-13(2-6-15)17-11-18(25-24-17)20(26)23-16-7-3-14(4-8-16)19-12-22-9-10-27-19/h1-8,11,19,22H,9-10,12H2,(H,23,26)(H,24,25)/t19-/s2
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0.5n/an/an/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...


US Patent US9073911 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109356
PNG
(US8604061, 14)
Show SMILES NC1=NC(CO1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C9H8Cl2N2O/c10-6-2-1-5(3-7(6)11)8-4-14-9(12)13-8/h1-3,8H,4H2,(H2,12,13)
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119148
PNG
(US8673950, 15)
Show SMILES NC1=N[C@@H](CCc2ccc(Nc3ccc(Cl)cn3)cc2)CO1
Show InChI InChI=1S/C16H17ClN4O/c17-12-4-8-15(19-9-12)20-13-5-1-11(2-6-13)3-7-14-10-22-16(18)21-14/h1-2,4-6,8-9,14H,3,7,10H2,(H2,18,21)(H,19,20)/t14-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM119190
PNG
(US8673950, 57)
Show SMILES CC(C)(C)c1cnc(Nc2ccc(CC[C@H]3COC(N)=N3)cc2)nc1
Show InChI InChI=1S/C19H25N5O/c1-19(2,3)14-10-21-18(22-11-14)24-15-7-4-13(5-8-15)6-9-16-12-25-17(20)23-16/h4-5,7-8,10-11,16H,6,9,12H2,1-3H3,(H2,20,23)(H,21,22,24)/t16-/m0/s1
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...


US Patent US8673950 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM122296
PNG
(US8729113, 3)
Show SMILES NC1=N[C@@H](CCOc2ccc(Cl)cc2)CO1
Show InChI InChI=1S/C11H13ClN2O2/c12-8-1-3-10(4-2-8)15-6-5-9-7-16-11(13)14-9/h1-4,9H,5-7H2,(H2,13,14)/t9-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Binding assay was performed at 4 C. in a final volume of 1 ml, and with an incubation time of 30 min. The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-...


US Patent US8729113 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM129522
PNG
(US8802673, 164)
Show SMILES C1CO[C@@H](CN1)c1ccc(Nc2ccn(n2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H20N4O/c1-2-4-17(5-3-1)23-12-10-19(22-23)21-16-8-6-15(7-9-16)18-14-20-11-13-24-18/h1-10,12,18,20H,11,13-14H2,(H,21,22)/t18-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ina...


US Patent US8802673 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM158296
PNG
(US9029370, 90)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc([C@H]2CNCCO2)c(F)c1
Show InChI InChI=1/C21H19F3N4O3/c22-18-9-14(1-6-17(18)19-11-25-7-8-30-19)27-20(29)13-10-26-28(12-13)15-2-4-16(5-3-15)31-21(23)24/h1-6,9-10,12,19,21,25H,7-8,11H2,(H,27,29)/t19-/s2
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0.600n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Membrane Preparation and Radioligand Binding. HEK-293 cells stably expressing mouse TAA 1 were maintained at 37 C and 5% C02 in DMEM high glucose med...


US Patent US9029370 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM190620
PNG
(US9181230, 26)
Show SMILES Fc1ccc(cc1)-n1cc(cn1)-c1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1/C19H18FN3O/c20-17-5-7-18(8-6-17)23-13-16(11-22-23)14-1-3-15(4-2-14)19-12-21-9-10-24-19/h1-8,11,13,19,21H,9-10,12H2/t19-/s2
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US Patent
0.600n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


US Patent US9181230 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM129441
PNG
(US8802673, 83)
Show SMILES Cc1cc(Nc2ccc(cc2)[C@H]2CNCCO2)ncc1Cl
Show InChI InChI=1S/C16H18ClN3O/c1-11-8-16(19-9-14(11)17)20-13-4-2-12(3-5-13)15-10-18-6-7-21-15/h2-5,8-9,15,18H,6-7,10H2,1H3,(H,19,20)/t15-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ina...


US Patent US8802673 (2014)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM167466
PNG
(US9073911, 15)
Show SMILES Clc1cccc(c1)-c1cc([nH]n1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1/C20H19ClN4O2/c21-15-3-1-2-14(10-15)17-11-18(25-24-17)20(26)23-16-6-4-13(5-7-16)19-12-22-8-9-27-19/h1-7,10-11,19,22H,8-9,12H2,(H,23,26)(H,24,25)/t19-/s2
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0.600n/an/an/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The TAAR1 radioligand 3[H](S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration ...


US Patent US9073911 (2015)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109388
PNG
(US8604061, 91)
Show SMILES NC1=N[C@H](CO1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C9H8Cl2N2O/c10-6-2-1-5(3-7(6)11)8-4-14-9(12)13-8/h1-3,8H,4H2,(H2,12,13)/t8-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM109504
PNG
(US8604061, 256)
Show SMILES NC1=N[C@@H](CCc2ccc(Cl)cc2)CO1
Show InChI InChI=1S/C11H13ClN2O/c12-9-4-1-8(2-5-9)3-6-10-7-15-11(13)14-10/h1-2,4-5,10H,3,6-7H2,(H2,13,14)/t10-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Radioligand binding assay using TAAR1.


US Patent US8604061 (2013)

More data for this
Ligand-Target Pair
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