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Found 32 hits Enz. Inhib. hit(s) with Target = 'Trans-sialidase' AND taxid = 5693   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trans-sialidase


(Trypanosoma cruzi)
BDBM84698
PNG
(Quinolinone derivative, 9)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(\C(=C/c2ccc(O)c(O)c2)C(=O)c2ccccc12)c1ccc(O)c(O)c1
Show InChI InChI=1S/C29H23NO7S/c1-17-6-10-20(11-7-17)38(36,37)30-23-5-3-2-4-21(23)29(35)22(14-18-8-12-24(31)26(33)15-18)28(30)19-9-13-25(32)27(34)16-19/h2-16,28,31-34H,1H3/b22-14+
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400 -37.7 600n/an/an/an/a7.635



University of British Columbia



Assay Description
Inhibition assay using trans-sialidase, a membrane-associated protein.


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50174833
PNG
(CHEMBL199442 | N-(3-(3-(3,4-dihydroxyphenyl)acrylo...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C22H19NO5S/c1-15-5-9-19(10-6-15)29(27,28)23-18-4-2-3-17(14-18)20(24)11-7-16-8-12-21(25)22(26)13-16/h2-14,23,25-26H,1H3/b11-7+
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3.70E+3 -32.0 2.50E+3n/an/an/an/a7.635



University of British Columbia



Assay Description
Inhibition assay using trans-sialidase, a membrane-associated protein.


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50174837
PNG
(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C22H19NO5S/c1-15-2-10-19(11-3-15)29(27,28)23-18-8-6-17(7-9-18)20(24)12-4-16-5-13-21(25)22(26)14-16/h2-14,23,25-26H,1H3/b12-4+
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4.60E+3 -31.5 900n/an/an/an/a7.635



University of British Columbia



Assay Description
Inhibition assay using trans-sialidase, a membrane-associated protein.


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50118216
PNG
((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Show SMILES Cc1ncc(COP(O)(O)=O)c(C=O)c1O
Show InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
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PubMed
7.30E+6n/an/an/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM4706
PNG
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O
Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1
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PubMed
1.23E+7n/an/an/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Trans-sialidase


(Trypanosoma cruzi)
BDBM84697
PNG
(Quinolinone derivative, 8)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(\C(=C/c2ccc(O)cc2)C(=O)c2ccccc12)c1ccc(O)cc1
Show InChI InChI=1S/C29H23NO5S/c1-19-6-16-24(17-7-19)36(34,35)30-27-5-3-2-4-25(27)29(33)26(18-20-8-12-22(31)13-9-20)28(30)21-10-14-23(32)15-11-21/h2-18,28,31-32H,1H3/b26-18+
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n/an/a 3.00E+4n/an/an/an/a7.635



University of British Columbia



Assay Description
Inhibition assay using trans-sialidase, a membrane-associated protein.


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50174834
PNG
(CHEMBL382280 | N-(3-(3-(4-hydroxyphenyl)acryloyl)p...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)C(=O)\C=C\c1ccc(O)cc1
Show InChI InChI=1S/C22H19NO4S/c1-16-5-12-21(13-6-16)28(26,27)23-19-4-2-3-18(15-19)22(25)14-9-17-7-10-20(24)11-8-17/h2-15,23-24H,1H3/b14-9+
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n/an/a 3.70E+4n/an/an/an/a7.635



University of British Columbia



Assay Description
Inhibition assay using trans-sialidase, a membrane-associated protein.


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50174835
PNG
(4'-(4-toluenesulfonamido)-4-hydroxychalcone | 4'-(...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1
Show InChI InChI=1S/C22H19NO4S/c1-16-2-13-21(14-3-16)28(26,27)23-19-9-7-18(8-10-19)22(25)15-6-17-4-11-20(24)12-5-17/h2-15,23-24H,1H3/b15-6+
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n/an/a 7.30E+4n/an/an/an/a7.635



University of British Columbia



Assay Description
Inhibition assay using trans-sialidase, a membrane-associated protein.


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266507
PNG
(3-(benzo[d]thiazol-2-yl)-4-(2,5-dimethylphenyl)but...)
Show SMILES Cc1ccc(C)c(\C=C(/CC([O-])=O)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C19H17NO2S/c1-12-7-8-13(2)14(9-12)10-15(11-18(21)22)19-20-16-5-3-4-6-17(16)23-19/h3-10H,11H2,1-2H3,(H,21,22)/p-1/b15-10+
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n/an/a 1.20E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266479
PNG
(3-(benzo[d]thiazol-2-yl)-4-(3-fluorophenyl)but-3-e...)
Show SMILES [O-]C(=O)C\C(=C/c1cccc(F)c1)c1nc2ccccc2s1
Show InChI InChI=1S/C17H12FNO2S/c18-13-5-3-4-11(9-13)8-12(10-16(20)21)17-19-14-6-1-2-7-15(14)22-17/h1-9H,10H2,(H,20,21)/p-1/b12-8+
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n/an/a 1.20E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266386
PNG
(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Show SMILES CC(C)Oc1ccccc1\C=C(/CC([O-])=O)c1nc2ccccc2s1
Show InChI InChI=1S/C20H19NO3S/c1-13(2)24-17-9-5-3-7-14(17)11-15(12-19(22)23)20-21-16-8-4-6-10-18(16)25-20/h3-11,13H,12H2,1-2H3,(H,22,23)/p-1/b15-11+
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n/an/a 1.50E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266509
PNG
(3-(benzo[d]thiazol-2-yl)-4-(3-(trifluoromethyl)phe...)
Show SMILES [O-]C(=O)C\C(=C/c1cccc(c1)C(F)(F)F)c1nc2ccccc2s1
Show InChI InChI=1S/C18H12F3NO2S/c19-18(20,21)13-5-3-4-11(9-13)8-12(10-16(23)24)17-22-14-6-1-2-7-15(14)25-17/h1-9H,10H2,(H,23,24)/p-1/b12-8+
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n/an/a 1.50E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266506
PNG
(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Show SMILES CCOc1ccccc1\C=C(/CC([O-])=O)c1nc2ccccc2s1
Show InChI InChI=1S/C19H17NO3S/c1-2-23-16-9-5-3-7-13(16)11-14(12-18(21)22)19-20-15-8-4-6-10-17(15)24-19/h3-11H,2,12H2,1H3,(H,21,22)/p-1/b14-11+
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n/an/a 1.60E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266478
PNG
(3-(benzo[d]thiazol-2-yl)-4-(3,4-dimethoxyphenyl)bu...)
Show SMILES COc1ccc(\C=C(/CC([O-])=O)c2nc3ccccc3s2)cc1OC
Show InChI InChI=1S/C19H17NO4S/c1-23-15-8-7-12(10-16(15)24-2)9-13(11-18(21)22)19-20-14-5-3-4-6-17(14)25-19/h3-10H,11H2,1-2H3,(H,21,22)/p-1/b13-9+
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n/an/a 1.80E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266444
PNG
(2-(4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-ylca...)
Show SMILES CCCOC(=O)c1c(C)c(C)sc1NC(=O)C1CCCCC1C([O-])=O
Show InChI InChI=1S/C18H25NO5S/c1-4-9-24-18(23)14-10(2)11(3)25-16(14)19-15(20)12-7-5-6-8-13(12)17(21)22/h12-13H,4-9H2,1-3H3,(H,19,20)(H,21,22)/p-1
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n/an/a 2.10E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266334
PNG
(2-(2-acetyl-5-tert-butylthiophen-3-ylcarbamoyl)ben...)
Show SMILES CC(=O)c1sc(cc1NC(=O)c1ccccc1C([O-])=O)C(C)(C)C
Show InChI InChI=1S/C18H19NO4S/c1-10(20)15-13(9-14(24-15)18(2,3)4)19-16(21)11-7-5-6-8-12(11)17(22)23/h5-9H,1-4H3,(H,19,21)(H,22,23)/p-1
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n/an/a 2.70E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266335
PNG
((5-(2-(benzo[d][1,3]dioxol-5-ylamino)-2-oxoethylth...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)[N-]c1nnc(SCC(=O)Nc2ccc3OCOc3c2)s1
Show InChI InChI=1S/C18H16N4O5S3/c1-11-2-5-13(6-3-11)30(24,25)22-17-20-21-18(29-17)28-9-16(23)19-12-4-7-14-15(8-12)27-10-26-14/h2-8H,9-10H2,1H3,(H2,19,20,22,23)/p-1
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n/an/a 2.80E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266386
PNG
(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Show SMILES CC(C)Oc1ccccc1\C=C(/CC([O-])=O)c1nc2ccccc2s1
Show InChI InChI=1S/C20H19NO3S/c1-13(2)24-17-9-5-3-7-14(17)11-15(12-19(22)23)20-21-16-8-4-6-10-18(16)25-20/h3-11,13H,12H2,1-2H3,(H,22,23)/p-1/b15-11+
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n/an/a 2.90E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266510
PNG
(2-(2-acetylthiophen-3-ylcarbamoyl)benzoate | cid_2...)
Show SMILES CC(=O)c1sccc1NC(=O)c1ccccc1C([O-])=O
Show InChI InChI=1S/C14H11NO4S/c1-8(16)12-11(6-7-20-12)15-13(17)9-4-2-3-5-10(9)14(18)19/h2-7H,1H3,(H,15,17)(H,18,19)/p-1
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n/an/a 2.90E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266477
PNG
(3-(benzo[d]thiazol-2-yl)-4-(3-methoxyphenyl)but-3-...)
Show SMILES COc1cccc(\C=C(/CC([O-])=O)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C18H15NO3S/c1-22-14-6-4-5-12(10-14)9-13(11-17(20)21)18-19-15-7-2-3-8-16(15)23-18/h2-10H,11H2,1H3,(H,20,21)/p-1/b13-9+
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n/an/a 3.10E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266506
PNG
(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Show SMILES CCOc1ccccc1\C=C(/CC([O-])=O)c1nc2ccccc2s1
Show InChI InChI=1S/C19H17NO3S/c1-2-23-16-9-5-3-7-13(16)11-14(12-18(21)22)19-20-15-8-4-6-10-17(15)24-19/h3-11H,2,12H2,1H3,(H,21,22)/p-1/b14-11+
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n/an/a 4.20E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM4733
PNG
(5-Acetylamino-6-aminopyridine-2-carboxylic acid | ...)
Show SMILES CC(=O)Nc1ccc(nc1N)C(O)=O
Show InChI InChI=1S/C8H9N3O3/c1-4(12)10-5-2-3-6(8(13)14)11-7(5)9/h2-3H,1H3,(H2,9,11)(H,10,12)(H,13,14)
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n/an/a 4.40E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266508
PNG
(3-(benzo[d]thiazol-2-yl)-4-(3-hydroxyphenyl)but-3-...)
Show SMILES Oc1cccc(\C=C(/CC([O-])=O)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C17H13NO3S/c19-13-5-3-4-11(9-13)8-12(10-16(20)21)17-18-14-6-1-2-7-15(14)22-17/h1-9,19H,10H2,(H,20,21)/p-1/b12-8+
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n/an/a 5.20E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assay


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266705
PNG
(4-acetamido-3-(hydroxymethyl)benzoate)
Show SMILES CC(=O)Nc1ccc(cc1CO)C([O-])=O
Show InChI InChI=1S/C10H11NO4/c1-6(13)11-9-3-2-7(10(14)15)4-8(9)5-12/h2-4,12H,5H2,1H3,(H,11,13)(H,14,15)/p-1
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n/an/a 5.40E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50377984
PNG
(Cephulac Syrup | Cholac | Chronulac | Constilac | ...)
Show SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12-/m1/s1
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n/an/a 5.70E+5n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266707
PNG
((3S,4S,5R)-4-acetamido-3,5-dihydroxycyclohex-1-eny...)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)CC(=C[C@@H]1O)P([O-])(=O)CCO[C@@H]1[C@@H](O)C(O)O[C@H](CO)[C@@H]1O
Show InChI InChI=1S/C16H28NO11P/c1-7(19)17-12-9(20)4-8(5-10(12)21)29(25,26)3-2-27-15-13(22)11(6-18)28-16(24)14(15)23/h4,9-16,18,20-24H,2-3,5-6H2,1H3,(H,17,19)(H,25,26)/p-1/t9-,10-,11+,12-,13-,14+,15-,16?/m0/s1
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n/an/a 1.50E+6n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
Trans-sialidase


(Trypanosoma cruzi)
BDBM50266703
PNG
(ethyl (3S,4R,5R)-4-acetamido-3-hydroxy-5-(2-hydrox...)
Show SMILES CCOP([O-])(=O)C1=C[C@H](O)[C@@H](NC(C)=O)[C@@H](C1)OCCO
Show InChI InChI=1S/C12H22NO7P/c1-3-20-21(17,18)9-6-10(16)12(13-8(2)15)11(7-9)19-5-4-14/h6,10-12,14,16H,3-5,7H2,1-2H3,(H,13,15)(H,17,18)/p-1/t10-,11+,12+/m0/s1
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n/an/a 5.00E+6n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi trans-Sialidase


Citation and Details
More data for this
Ligand-Target Pair
trans-Sialidase (TS)


(Trypanosoma cruzi)
BDBM217357
PNG
(NeuSGal | methyl-S-(5-acetamide-3,5-dideoxy-D-glyc...)
Show SMILES COC1OC(CO)C(O)C(SC2(CC(O)C(NC(C)=O)C(O2)[C@H](O)[C@H](O)CO)C([O-])=O)C1O
Show InChI InChI=1/C18H31NO13S/c1-6(22)19-10-7(23)3-18(17(28)29,32-14(10)11(25)8(24)4-20)33-15-12(26)9(5-21)31-16(30-2)13(15)27/h7-16,20-21,23-27H,3-5H2,1-2H3,(H,19,22)(H,28,29)/p-1/t7?,8-,9?,10?,11-,12?,13?,14?,15?,16?,18?/s2
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n/an/an/a 4.56E+5n/an/an/an/an/a



Universidade Federal do Rio de Janeiro



Assay Description
Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...


J Biol Chem 289: 423-36 (2014)

More data for this
Ligand-Target Pair
trans-Sialidase (TS Y342H)


(Trypanosoma cruzi)
BDBM217358
PNG
(α2,3'-sialyllactose | 3-SL)
Show SMILES CC(=O)NC1C(O)CC(OC2C(O)C(CO)OC(OC3C(CO)OC(O)C(O)C3O)C2O)(OC1[C@H](O)[C@H](O)CO)C(O)=O
Show InChI InChI=1/C23H39NO19/c1-6(28)24-11-7(29)2-23(22(37)38,42-18(11)12(31)8(30)3-25)43-19-13(32)9(4-26)40-21(16(19)35)41-17-10(5-27)39-20(36)15(34)14(17)33/h7-21,25-27,29-36H,2-5H2,1H3,(H,24,28)(H,37,38)/t7?,8-,9?,10?,11?,12-,13?,14?,15?,16?,17?,18?,19?,20?,21?,23?/s2
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n/an/an/a 2.34E+5n/an/an/an/an/a



Universidade Federal do Rio de Janeiro



Assay Description
Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...


J Biol Chem 289: 423-36 (2014)

More data for this
Ligand-Target Pair
trans-Sialidase (TS D247A)


(Trypanosoma cruzi)
BDBM217358
PNG
(α2,3'-sialyllactose | 3-SL)
Show SMILES CC(=O)NC1C(O)CC(OC2C(O)C(CO)OC(OC3C(CO)OC(O)C(O)C3O)C2O)(OC1[C@H](O)[C@H](O)CO)C(O)=O
Show InChI InChI=1/C23H39NO19/c1-6(28)24-11-7(29)2-23(22(37)38,42-18(11)12(31)8(30)3-25)43-19-13(32)9(4-26)40-21(16(19)35)41-17-10(5-27)39-20(36)15(34)14(17)33/h7-21,25-27,29-36H,2-5H2,1H3,(H,24,28)(H,37,38)/t7?,8-,9?,10?,11?,12-,13?,14?,15?,16?,17?,18?,19?,20?,21?,23?/s2
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n/an/an/a 1.07E+5n/an/an/an/an/a



Universidade Federal do Rio de Janeiro



Assay Description
Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...


J Biol Chem 289: 423-36 (2014)

More data for this
Ligand-Target Pair
trans-Sialidase (TS)


(Trypanosoma cruzi)
BDBM50048093
PNG
(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
Show SMILES CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1/C13H24O11/c1-21-12-10(20)8(18)11(5(3-15)23-12)24-13-9(19)7(17)6(16)4(2-14)22-13/h4-20H,2-3H2,1H3/t4-,5-,6+,7+,8-,9-,10-,11-,12-,13+/s2
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n/an/an/a 1.50E+4n/an/an/an/an/a



Universidade Federal do Rio de Janeiro



Assay Description
Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...


J Biol Chem 289: 423-36 (2014)

More data for this
Ligand-Target Pair
trans-Sialidase (TS Y342H)


(Trypanosoma cruzi)
BDBM50048093
PNG
(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
Show SMILES CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1/C13H24O11/c1-21-12-10(20)8(18)11(5(3-15)23-12)24-13-9(19)7(17)6(16)4(2-14)22-13/h4-20H,2-3H2,1H3/t4-,5-,6+,7+,8-,9-,10-,11-,12-,13+/s2
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n/an/an/a 5.20E+4n/an/an/an/an/a



Universidade Federal do Rio de Janeiro



Assay Description
Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...


J Biol Chem 289: 423-36 (2014)

More data for this
Ligand-Target Pair