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Compile Data Set for Download or QSAR

Found 424 hits Enz. Inhib. hit(s) with Target = 'Transcription Factor STAT1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50382460
PNG
(CHEMBL2023985)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(cc1)-c1ccc(CN(C(=O)CN(C)S(=O)(=O)c2ccc(C)cc2)c2ccc(C(O)=O)c(O)c2)cc1
Show InChI InChI=1S/C38H34N2O8S/c1-25-7-18-33(19-8-25)49(46,47)39(2)24-36(42)40(32-17-20-34(37(43)44)35(41)22-32)23-26-9-11-27(12-10-26)28-13-15-29(16-14-28)30-5-4-6-31(21-30)38(45)48-3/h4-22,41H,23-24H2,1-3H3,(H,43,44)
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PubMed
3.20E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50353444
PNG
(CHEMBL1829870)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C35H36N2O6S/c1-36(44(42,43)31-19-16-29(17-20-31)27-10-6-3-7-11-27)24-34(39)37(30-18-21-32(35(40)41)33(38)22-30)23-25-12-14-28(15-13-25)26-8-4-2-5-9-26/h3,6-7,10-22,26,38H,2,4-5,8-9,23-24H2,1H3,(H,40,41)
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PubMed
8.80E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50382459
PNG
(CHEMBL2023986)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)-c1ccc(cc1)-c1ccc(cc1)C(N)=O)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C37H33N3O7S/c1-24-3-18-32(19-4-24)48(46,47)39(2)23-35(42)40(31-17-20-33(37(44)45)34(41)21-31)22-25-5-7-26(8-6-25)27-9-11-28(12-10-27)29-13-15-30(16-14-29)36(38)43/h3-21,41H,22-23H2,1-2H3,(H2,38,43)(H,44,45)
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9.50E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50353445
PNG
(CHEMBL1829862)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C32H38N2O6S/c1-21-16-22(2)31(23(3)17-21)41(39,40)33(4)20-30(36)34(27-14-15-28(32(37)38)29(35)18-27)19-24-10-12-26(13-11-24)25-8-6-5-7-9-25/h10-18,25,35H,5-9,19-20H2,1-4H3,(H,37,38)
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9.70E+3n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50353435
PNG
(CHEMBL1829874)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H31ClN2O6S/c1-31(39(37,38)25-14-11-23(30)12-15-25)19-28(34)32(24-13-16-26(29(35)36)27(33)17-24)18-20-7-9-22(10-8-20)21-5-3-2-4-6-21/h7-17,21,33H,2-6,18-19H2,1H3,(H,35,36)
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2.20E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50382463
PNG
(CHEMBL2023989)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C34H40N2O8S/c1-23-10-17-28(18-11-23)45(42,43)36(33(41)44-34(2,3)4)22-31(38)35(27-16-19-29(32(39)40)30(37)20-27)21-24-12-14-26(15-13-24)25-8-6-5-7-9-25/h10-20,25,37H,5-9,21-22H2,1-4H3,(H,39,40)
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>2.50E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50382461
PNG
(CHEMBL2023987)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCN(CC1)S(=O)(=O)c1ccc(cc1)C#N)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C36H36N4O8S2/c1-25-3-12-31(13-4-25)49(45,46)38(2)24-35(42)40(30-11-16-33(36(43)44)34(41)21-30)23-27-5-9-28(10-6-27)29-17-19-39(20-18-29)50(47,48)32-14-7-26(22-37)8-15-32/h3-16,21,29,41H,17-20,23-24H2,1-2H3,(H,43,44)
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>2.50E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50353441
PNG
(CHEMBL1829786)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C30H34N2O6S/c1-21-8-15-26(16-9-21)39(37,38)31(2)20-29(34)32(25-14-17-27(30(35)36)28(33)18-25)19-22-10-12-24(13-11-22)23-6-4-3-5-7-23/h8-18,23,33H,3-7,19-20H2,1-2H3,(H,35,36)
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>2.50E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50382464
PNG
(CHEMBL2024086)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N(CC(=O)N(Cc1ccccc1)c1ccc(C(O)=O)c(O)c1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H30N2O8S/c1-19-10-13-22(14-11-19)39(36,37)30(27(35)38-28(2,3)4)18-25(32)29(17-20-8-6-5-7-9-20)21-12-15-23(26(33)34)24(31)16-21/h5-16,31H,17-18H2,1-4H3,(H,33,34)
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>2.50E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50382462
PNG
(CHEMBL2023988)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCN(CC1)c1ccc(cc1)C(N)=O)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C36H38N4O7S/c1-24-3-14-31(15-4-24)48(46,47)38(2)23-34(42)40(30-13-16-32(36(44)45)33(41)21-30)22-25-5-7-26(8-6-25)27-17-19-39(20-18-27)29-11-9-28(10-12-29)35(37)43/h3-16,21,27,41H,17-20,22-23H2,1-2H3,(H2,37,43)(H,44,45)
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2.78E+4n/an/an/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43505
PNG
(4-[4-(4-keto-2-thioxo-1H-quinazolin-3-yl)benzoyl]p...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-n1c(=S)[nH]c2ccccc2c1=O
Show InChI InChI=1S/C22H22N4O4S/c1-2-30-22(29)25-13-11-24(12-14-25)19(27)15-7-9-16(10-8-15)26-20(28)17-5-3-4-6-18(17)23-21(26)31/h3-10H,2,11-14H2,1H3,(H,23,31)
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n/an/a 3.47E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43529
PNG
(2-(4-methylphenyl)-5-pyridin-4-yl-4H-benzo[i][1,3,...)
Show SMILES Cc1ccc(cc1)C1=NNC(c2ccncc2)=c2ccc3ccccc3c2=N1
Show InChI InChI=1S/C24H18N4/c1-16-6-8-19(9-7-16)24-26-23-20-5-3-2-4-17(20)10-11-21(23)22(27-28-24)18-12-14-25-15-13-18/h2-15,27H,1H3
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n/an/a 3.52E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43519
PNG
(3-[[4-(2-fluorophenyl)-1,3-thiazol-2-yl]methyl]-2-...)
Show SMILES CN1CCN(Cc2nc3ccccc3c(=O)n2Cc2nc(cs2)-c2ccccc2F)CC1
Show InChI InChI=1S/C24H24FN5OS/c1-28-10-12-29(13-11-28)14-22-26-20-9-5-3-7-18(20)24(31)30(22)15-23-27-21(16-32-23)17-6-2-4-8-19(17)25/h2-9,16H,10-15H2,1H3
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n/an/a 4.24E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43527
PNG
(2-[(7-hydroxy-2-keto-chromen-4-yl)methylthio]-1H-q...)
Show SMILES Oc1ccc2c(CSc3nc4ccccc4c(=O)[nH]3)cc(=O)oc2c1
Show InChI InChI=1S/C18H12N2O4S/c21-11-5-6-12-10(7-16(22)24-15(12)8-11)9-25-18-19-14-4-2-1-3-13(14)17(23)20-18/h1-8,21H,9H2,(H,19,20,23)
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n/an/a 4.36E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43517
PNG
(Isonicotinic acid N'-(1,3-diethyl-4,6-dioxo-2-...)
Show SMILES CCN1C(=S)N(CC)C(=O)C(=CNNC(=O)c2ccncc2)C1=O
Show InChI InChI=1S/C15H17N5O3S/c1-3-19-13(22)11(14(23)20(4-2)15(19)24)9-17-18-12(21)10-5-7-16-8-6-10/h5-9,17H,3-4H2,1-2H3,(H,18,21)
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n/an/a 4.42E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43512
PNG
(3-(3,4-dimethylphenyl)-4-keto-phthalazine-1-carbox...)
Show SMILES Cc1ccc(cc1C)-n1nc(C(O)=O)c2ccccc2c1=O
Show InChI InChI=1S/C17H14N2O3/c1-10-7-8-12(9-11(10)2)19-16(20)14-6-4-3-5-13(14)15(18-19)17(21)22/h3-9H,1-2H3,(H,21,22)
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n/an/a 5.20E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50440967
PNG
(CHEMBL2431993)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C37H37F3N2O6S/c1-25-11-18-31(19-12-25)49(47,48)41(23-29-9-5-6-10-33(29)37(38,39)40)24-35(44)42(30-17-20-32(36(45)46)34(43)21-30)22-26-13-15-28(16-14-26)27-7-3-2-4-8-27/h5-6,9-21,27,43H,2-4,7-8,22-24H2,1H3,(H,45,46)
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n/an/a 5.80E+3n/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Binding affinity to Stat1 (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after 30 mins by fluorescenc...


Citation and Details
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 1-alpha/beta


(Homo sapiens (human))
BDBM196138
PNG
(US9211296, Table 7, Compd: 9)
Show SMILES CC1=CC(C)(C)N=C(Nc2nc(C)c3cc(C)cc(C)c3n2)N1
Show InChI InChI=1S/C18H23N5/c1-10-7-11(2)15-14(8-10)13(4)20-16(21-15)22-17-19-12(3)9-18(5,6)23-17/h7-9H,1-6H3,(H2,19,20,21,22,23)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Pittsburgh Chemical Diversity Center

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis


Bioorg Med Chem Lett 24: 5081-5 (2014)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43507
PNG
(4-(4-{[4-(2-methoxyphenyl)-6-(trifluoromethyl)-2-p...)
Show SMILES COc1ccccc1-c1cc(nc(n1)S(=O)(=O)CCCC(=O)N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N3O5S/c1-30-16-6-3-2-5-14(16)15-13-17(20(21,22)23)25-19(24-15)32(28,29)12-4-7-18(27)26-8-10-31-11-9-26/h2-3,5-6,13H,4,7-12H2,1H3
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n/an/a>6.19E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43511
PNG
(2-[[(5-methyl-2-phenyl-3-pyrazolyl)amino]methylide...)
Show SMILES CCOC(=O)C(C=Nc1cc(C)nn1-c1ccccc1)C(=O)OCC
Show InChI InChI=1S/C18H21N3O4/c1-4-24-17(22)15(18(23)25-5-2)12-19-16-11-13(3)20-21(16)14-9-7-6-8-10-14/h6-12,15H,4-5H2,1-3H3
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n/an/a 6.37E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM36973
PNG
(1-[[5-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-...)
Show SMILES Cc1ccc(cc1)-c1csc2ncnc(Sc3nnc(CN4CCCCCC4=O)o3)c12
Show InChI InChI=1S/C22H21N5O2S2/c1-14-6-8-15(9-7-14)16-12-30-20-19(16)21(24-13-23-20)31-22-26-25-17(29-22)11-27-10-4-2-3-5-18(27)28/h6-9,12-13H,2-5,10-11H2,1H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43521
PNG
(MLS000394345 | N-(4-fluorophenyl)-2-[4-(4-methylph...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(C(=O)Nc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C25H26FN3O3S/c1-19-7-13-23(14-8-19)33(31,32)29-17-15-28(16-18-29)24(20-5-3-2-4-6-20)25(30)27-22-11-9-21(26)10-12-22/h2-14,24H,15-18H2,1H3,(H,27,30)
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n/an/a 7.87E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM39665
PNG
((2E)-2-[(3-methyl-2-thienyl)methylene]tetralin-1-o...)
Show SMILES Cc1ccsc1\C=C1/CCc2ccccc2C1=O
Show InChI InChI=1S/C16H14OS/c1-11-8-9-18-15(11)10-13-7-6-12-4-2-3-5-14(12)16(13)17/h2-5,8-10H,6-7H2,1H3/b13-10+
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n/an/a 7.89E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43510
PNG
(3-[oxo(1-pyrrolidinyl)methyl]-5-(phenylmethyl)-6-b...)
Show SMILES O=C(N1CCCC1)c1ccc2Sc3ccccc3C(=O)N(Cc3ccccc3)c2c1
Show InChI InChI=1S/C25H22N2O2S/c28-24(26-14-6-7-15-26)19-12-13-23-21(16-19)27(17-18-8-2-1-3-9-18)25(29)20-10-4-5-11-22(20)30-23/h1-5,8-13,16H,6-7,14-15,17H2
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n/an/a 8.43E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43508
PNG
(MLS000526191 | N-[1-(4-Methyl-6-oxo-6H-pyrimidin-1...)
Show SMILES Cc1cc(=O)n(cn1)C(NC(=O)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C20H17N3O3/c1-14-12-17(24)23(13-21-14)19(18(25)15-8-4-2-5-9-15)22-20(26)16-10-6-3-7-11-16/h2-13,19H,1H3,(H,22,26)
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n/an/a 9.25E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43526
PNG
(2-[2-(2,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-1H-...)
Show SMILES Oc1ccc(C(=O)CSc2nc3ccccc3c(=O)[nH]2)c(O)c1
Show InChI InChI=1S/C16H12N2O4S/c19-9-5-6-11(13(20)7-9)14(21)8-23-16-17-12-4-2-1-3-10(12)15(22)18-16/h1-7,19-20H,8H2,(H,17,18,22)
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n/an/a 9.39E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43520
PNG
(2-[(4-methyl-1-piperazinyl)methyl]-3-[[4-(2-naphth...)
Show SMILES CN1CCN(Cc2nc3ccccc3c(=O)n2Cc2nc(cs2)-c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C28H27N5OS/c1-31-12-14-32(15-13-31)17-26-29-24-9-5-4-8-23(24)28(34)33(26)18-27-30-25(19-35-27)22-11-10-20-6-2-3-7-21(20)16-22/h2-11,16,19H,12-15,17-18H2,1H3
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n/an/a 9.58E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM46374
PNG
(1-(1-acetyl-2,3-dihydroindol-5-yl)-4-hydroxy-3-pyr...)
Show SMILES COC(=O)c1nn(cc1O)-c1ccc2N(CCc2c1)C(C)=O
Show InChI InChI=1S/C15H15N3O4/c1-9(19)17-6-5-10-7-11(3-4-12(10)17)18-8-13(20)14(16-18)15(21)22-2/h3-4,7-8,20H,5-6H2,1-2H3
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n/an/a 9.87E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM31063
PNG
(2-(methylsulfonyl)-4-phenyl-6-(trifluoromethyl)pyr...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C12H9F3N2O2S/c1-20(18,19)11-16-9(8-5-3-2-4-6-8)7-10(17-11)12(13,14)15/h2-7H,1H3
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n/an/a 9.97E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50396176
PNG
(CHEMBL207155)
Show SMILES c1cc2nc1cc1ccc([nH]1)c(-c1ccccc1)c1ccc(cc3ccc(n3)c2-c2ccccc2)[nH]1
Show InChI InChI=1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33-34H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Southern California

Curated by ChEMBL


Assay Description
Inhibition of STAT1 SH2 domain assessed as inhibition of STAT1 SH2-phosphotyrosine interaction by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43506
PNG
(3-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulf...)
Show SMILES CCOC(=O)CCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C16H15F3N2O4S/c1-2-25-14(22)8-9-26(23,24)15-20-12(11-6-4-3-5-7-11)10-13(21-15)16(17,18)19/h3-7,10H,2,8-9H2,1H3
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n/an/a 1.02E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43541
PNG
(2-[(4-methyl-1-piperazinyl)methyl]-3-[[4-(3-nitrop...)
Show SMILES CN1CCN(Cc2nc3ccccc3c(=O)n2Cc2nc(cs2)-c2cccc(c2)[N+]([O-])=O)CC1
Show InChI InChI=1S/C24H24N6O3S/c1-27-9-11-28(12-10-27)14-22-25-20-8-3-2-7-19(20)24(31)29(22)15-23-26-21(16-34-23)17-5-4-6-18(13-17)30(32)33/h2-8,13,16H,9-12,14-15H2,1H3
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n/an/a 1.05E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43534
PNG
(MLS000692834 | N-[[(Z)-2-bromanyl-3-phenyl-prop-2-...)
Show SMILES Cc1c([nH][nH]c1=O)C(=O)NN=CC(Br)=Cc1ccccc1
Show InChI InChI=1S/C14H13BrN4O2/c1-9-12(17-19-13(9)20)14(21)18-16-8-11(15)7-10-5-3-2-4-6-10/h2-8H,1H3,(H,18,21)(H2,17,19,20)
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n/an/a 1.05E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43513
PNG
(3-(4-Phenyl-6-trifluoromethyl-pyrimidine-2-sulfony...)
Show SMILES COC(=O)CCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C15H13F3N2O4S/c1-24-13(21)7-8-25(22,23)14-19-11(10-5-3-2-4-6-10)9-12(20-14)15(16,17)18/h2-6,9H,7-8H2,1H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50440926
PNG
(CHEMBL2431955)
Show SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cc1)C1CCCCC1)C(=O)CN(Cc1ccccc1C(F)(F)F)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C36H30F8N2O6S/c37-29-30(38)32(40)34(33(41)31(29)39)53(51,52)45(18-23-8-4-5-9-26(23)36(42,43)44)19-28(48)46(24-14-15-25(35(49)50)27(47)16-24)17-20-10-12-22(13-11-20)21-6-2-1-3-7-21/h4-5,8-16,21,47H,1-3,6-7,17-19H2,(H,49,50)
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n/an/a 1.09E+4n/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Binding affinity to Stat1 (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after 30 mins by fluorescenc...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43453
PNG
(MLS000729576 | N-(2-chloranylpyridin-3-yl)-4-[4-(3...)
Show SMILES COc1ccc(cc1OC)-c1cc(nc(n1)S(=O)(=O)CCCC(=O)Nc1cccnc1Cl)C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N4O5S/c1-34-16-8-7-13(11-17(16)35-2)15-12-18(22(24,25)26)30-21(29-15)36(32,33)10-4-6-19(31)28-14-5-3-9-27-20(14)23/h3,5,7-9,11-12H,4,6,10H2,1-2H3,(H,28,31)
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n/an/a 1.11E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM31347
PNG
(2-(3,4-dimethoxyphenyl)-N-[3-[5-(3-methylphenyl)-1...)
Show SMILES COc1ccc(CC(=O)Nc2cccc(c2)-c2nnc(o2)-c2cccc(C)c2)cc1OC
Show InChI InChI=1S/C25H23N3O4/c1-16-6-4-7-18(12-16)24-27-28-25(32-24)19-8-5-9-20(15-19)26-23(29)14-17-10-11-21(30-2)22(13-17)31-3/h4-13,15H,14H2,1-3H3,(H,26,29)
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n/an/a 1.14E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43540
PNG
(4-[(E)-3-[5-chloro-1-(4-fluorophenyl)-3-methyl-4-p...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)\C=C\c1c(C)nn(c1Cl)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22ClFN4O3/c1-3-29-20(28)25-12-10-24(11-13-25)18(27)9-8-17-14(2)23-26(19(17)21)16-6-4-15(22)5-7-16/h4-9H,3,10-13H2,1-2H3/b9-8+
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n/an/a 1.14E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM46397
PNG
(2-(6-methoxy-2-naphthalenyl)-4-quinolinecarboxylic...)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(C(=O)OCC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)c2ccccc2n1
Show InChI InChI=1S/C34H28N4O5/c1-21-32(33(40)38(37(21)2)25-9-5-4-6-10-25)36-31(39)20-43-34(41)28-19-30(35-29-12-8-7-11-27(28)29)24-14-13-23-18-26(42-3)16-15-22(23)17-24/h4-19H,20H2,1-3H3,(H,36,39)
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n/an/a 1.17E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM46379
PNG
(3-[(2-bromanylphenoxy)methyl]benzohydrazide | 3-[(...)
Show SMILES NNC(=O)c1cccc(COc2ccccc2Br)c1
Show InChI InChI=1S/C14H13BrN2O2/c15-12-6-1-2-7-13(12)19-9-10-4-3-5-11(8-10)14(18)17-16/h1-8H,9,16H2,(H,17,18)
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n/an/a 1.17E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM50016098
PNG
(CHEMBL3261195)
Show SMILES CCCCCC(=O)O[C@@H]1C=C2COC(=O)C2(O)[C@@]2(C)CCCC(C)(C)[C@H]12
Show InChI InChI=1S/C21H32O5/c1-5-6-7-9-16(22)26-15-12-14-13-25-18(23)21(14,24)20(4)11-8-10-19(2,3)17(15)20/h12,15,17,24H,5-11,13H2,1-4H3/t15-,17+,20+,21?/m1/s1
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Article
PubMed
n/an/a 1.18E+4n/an/an/an/an/an/a



Institute of Biotechnology and Drug Research (IBWF)

Curated by ChEMBL


Assay Description
Inhibition of Stat1 (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 ...


Citation and Details
More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43539
PNG
((2R,3R,4S)-2-ethoxy-4-(4-ethynylphenyl)-3-(3-hydro...)
Show SMILES CCO[C@@H]1OC(=C[C@@H]([C@H]1CCCO)c1ccc(cc1)C#C)C(=O)OCC=C
Show InChI InChI=1S/C22H26O5/c1-4-14-26-21(24)20-15-19(17-11-9-16(5-2)10-12-17)18(8-7-13-23)22(27-20)25-6-3/h2,4,9-12,15,18-19,22-23H,1,6-8,13-14H2,3H3/t18-,19-,22-/m1/s1
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n/an/a 1.19E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43501
PNG
(3-[4-(4-methoxyphenyl)-6-(trifluoromethyl)pyrimidi...)
Show SMILES COCC(C)NC(=O)CCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(OC)cc1
Show InChI InChI=1S/C19H22F3N3O5S/c1-12(11-29-2)23-17(26)8-9-31(27,28)18-24-15(10-16(25-18)19(20,21)22)13-4-6-14(30-3)7-5-13/h4-7,10,12H,8-9,11H2,1-3H3,(H,23,26)
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n/an/a 1.19E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43524
PNG
(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
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n/an/a 1.21E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 1-alpha/beta


(Homo sapiens (human))
BDBM50103759
PNG
(CHEMBL1603850 | DNDI1417175)
Show SMILES Cc1cc(C)c2nc(Nc3nc(C)cc(O)n3)nc(C)c2c1
Show InChI InChI=1S/C16H17N5O/c1-8-5-9(2)14-12(6-8)11(4)18-16(20-14)21-15-17-10(3)7-13(22)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
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n/an/a 1.21E+4n/an/an/an/an/an/a



University of Pittsburgh Chemical Diversity Center

Curated by ChEMBL


Assay Description
Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis


Bioorg Med Chem Lett 24: 5081-5 (2014)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43527
PNG
(2-[(7-hydroxy-2-keto-chromen-4-yl)methylthio]-1H-q...)
Show SMILES Oc1ccc2c(CSc3nc4ccccc4c(=O)[nH]3)cc(=O)oc2c1
Show InChI InChI=1S/C18H12N2O4S/c21-11-5-6-12-10(7-16(22)24-15(12)8-11)9-25-18-19-14-4-2-1-3-13(14)17(23)20-18/h1-8,21H,9H2,(H,19,20,23)
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n/an/a 1.22E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM39043
PNG
(2-(5-methylpyridin-2-yl)-3-oxidanyl-3H-isoindol-1-...)
Show SMILES Cc1ccc(nc1)N1C(O)c2ccccc2C1=O
Show InChI InChI=1S/C14H12N2O2/c1-9-6-7-12(15-8-9)16-13(17)10-4-2-3-5-11(10)14(16)18/h2-8,13,17H,1H3
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n/an/a 1.29E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43532
PNG
(11,11-dimethyl-3-(pyrrolidine-1-carbonyl)-10H-naph...)
Show SMILES CC1(C)Cc2c(ccc3ccccc23)C2=C(C(=O)N3CCCC3)C(=O)C(=O)N12
Show InChI InChI=1S/C23H22N2O3/c1-23(2)13-17-15-8-4-3-7-14(15)9-10-16(17)19-18(20(26)22(28)25(19)23)21(27)24-11-5-6-12-24/h3-4,7-10H,5-6,11-13H2,1-2H3
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n/an/a 1.33E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM43538
PNG
(1-methyl-2-[4-(4-nitrophenyl)piperazin-1-yl]carbon...)
Show SMILES Cn1c(cc2c1c1ccccc1[nH]c2=O)C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H21N5O4/c1-25-20(14-18-21(25)17-4-2-3-5-19(17)24-22(18)29)23(30)27-12-10-26(11-13-27)15-6-8-16(9-7-15)28(31)32/h2-9,14H,10-13H2,1H3,(H,24,29)
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n/an/a 1.35E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Transcription Factor STAT1


(Homo sapiens (human))
BDBM67136
PNG
(3-[[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]methyl]-2...)
Show SMILES COc1cccc(c1)-c1csc(Cn2c(CN3CCOCC3)nc3ccccc3c2=O)n1
Show InChI InChI=1S/C24H24N4O3S/c1-30-18-6-4-5-17(13-18)21-16-32-23(26-21)15-28-22(14-27-9-11-31-12-10-27)25-20-8-3-2-7-19(20)24(28)29/h2-8,13,16H,9-12,14-15H2,1H3
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n/an/a 1.36E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
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