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Compile Data Set for Download or QSAR

Found 172 hits Enz. Inhib. hit(s) with Target = 'Transcription factor AP-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50135483
PNG
(1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Show SMILES COc1ccc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1)-c1cccs1
Show InChI InChI=1S/C18H14N4O3S/c1-10-8-15(23)22(18(10)24)21-16-12-9-11(25-2)5-6-13(12)19-17(20-16)14-4-3-7-26-14/h3-9H,1-2H3,(H,19,20,21)
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n/an/a 3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50135482
PNG
(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Show SMILES COc1cccc2nc(nc(NN3C(=O)C=C(C)C3=O)c12)-c1cccs1
Show InChI InChI=1S/C18H14N4O3S/c1-10-9-14(23)22(18(10)24)21-17-15-11(5-3-6-12(15)25-2)19-16(20-17)13-7-4-8-26-13/h3-9H,1-2H3,(H,19,20,21)
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n/an/a 8n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092879
PNG
(2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C14H8ClF6N3O/c1-6-10(5-22-12(15)23-6)11(25)24-9-3-7(13(16,17)18)2-8(4-9)14(19,20)21/h2-5H,1H3,(H,24,25)
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n/an/a 20n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092879
PNG
(2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C14H8ClF6N3O/c1-6-10(5-22-12(15)23-6)11(25)24-9-3-7(13(16,17)18)2-8(4-9)14(19,20)21/h2-5H,1H3,(H,24,25)
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n/an/a 20n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50090430
PNG
(4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...)
Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1cccs1
Show InChI InChI=1S/C16H14N4O4S/c1-3-24-16(23)10-8-17-14(11-5-4-6-25-11)18-13(10)19-20-12(21)7-9(2)15(20)22/h4-8H,3H2,1-2H3,(H,17,18,19)
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n/an/a 20n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340608
PNG
(8-(6-methylpyridin-3-yl)-N-(4-(3-morpholino-1H-1,2...)
Show SMILES Cc1ccc(cn1)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12
Show InChI InChI=1S/C26H24N8O/c1-18-5-6-19(15-27-18)23-4-2-3-20-16-28-25(31-24(20)23)30-21-7-9-22(10-8-21)34-17-29-26(32-34)33-11-13-35-14-12-33/h2-10,15-17H,11-14H2,1H3,(H,28,30,31)
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n/an/a 20n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50295171
PNG
(AILANTHINONE | CHEMBL487194)
Show SMILES CCC(C)C(=O)O[C@@H]1[C@H]2[C@@H](C)[C@@H](O)[C@@]3(O)OC[C@@]22[C@H]3[C@]3(C)[C@@H](C[C@H]2OC1=O)C(C)CC(=O)C3=O
Show InChI InChI=1S/C25H34O9/c1-6-10(2)20(29)34-17-16-12(4)18(27)25(31)22-23(5)13(11(3)7-14(26)19(23)28)8-15(33-21(17)30)24(16,22)9-32-25/h10-13,15-18,22,27,31H,6-9H2,1-5H3/t10?,11?,12-,13+,15-,16-,17-,18-,22-,23-,24+,25-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044568
PNG
(CHEMBL85822)
Show SMILES CCOC(=O)c1cnc(nc1CC)N(C)N1C(=O)C=C(C)C1=O
Show InChI InChI=1S/C15H18N4O4/c1-5-11-10(14(22)23-6-2)8-16-15(17-11)18(4)19-12(20)7-9(3)13(19)21/h7-8H,5-6H2,1-4H3
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n/an/a 35n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340606
PNG
(CHEMBL1761561 | N-(4-(3-(6-methylpyridin-3-yl)-1H-...)
Show SMILES Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1
Show InChI InChI=1S/C25H19N9/c1-16-2-3-19(12-26-16)24-28-15-34(33-24)22-8-6-21(7-9-22)31-25-27-11-18-5-4-17(10-23(18)32-25)20-13-29-30-14-20/h2-15H,1H3,(H,29,30)(H,27,31,32)
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n/an/a 40n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50349194
PNG
(GLAUCARUBINONE | NSC-14975)
Show SMILES CC[C@](C)(O)C(=O)O[C@@H]1[C@H]2[C@@H](C)[C@@H](O)[C@]3(O)OC[C@@]22[C@H]3[C@]3(C)[C@@H](C[C@H]2OC1=O)C(C)CC(=O)C3=O
Show InChI InChI=1S/C25H34O10/c1-6-22(4,31)21(30)35-16-15-11(3)17(27)25(32)20-23(5)12(10(2)7-13(26)18(23)28)8-14(34-19(16)29)24(15,20)9-33-25/h10-12,14-17,20,27,31-32H,6-9H2,1-5H3/t10?,11-,12+,14-,15-,16-,17-,20-,22+,23-,24+,25+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340628
PNG
(7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1-c1ccccc1
Show InChI InChI=1S/C30H27N9O/c1-37-19-23(18-33-37)26-12-7-22-17-31-29(35-28(22)27(26)21-5-3-2-4-6-21)34-24-8-10-25(11-9-24)39-20-32-30(36-39)38-13-15-40-16-14-38/h2-12,17-20H,13-16H2,1H3,(H,31,34,35)
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n/an/a 40n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340627
PNG
(7,8-bis(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholi...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1-c1cnn(C)c1
Show InChI InChI=1S/C28H27N11O/c1-36-16-20(14-31-36)24-8-3-19-13-29-27(34-26(19)25(24)21-15-32-37(2)17-21)33-22-4-6-23(7-5-22)39-18-30-28(35-39)38-9-11-40-12-10-38/h3-8,13-18H,9-12H2,1-2H3,(H,29,33,34)
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n/an/a 40n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044567
PNG
(CHEMBL86615)
Show SMILES CCOC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1-c1ccc(C)s1
Show InChI InChI=1S/C17H16N4O4S/c1-4-25-16(24)11-8-18-17(19-14(11)12-6-5-10(3)26-12)20-21-13(22)7-9(2)15(21)23/h5-8H,4H2,1-3H3,(H,18,19,20)
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n/an/a 45n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50062648
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)
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n/an/a 50n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340629
PNG
(8-methoxy-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-mor...)
Show SMILES COc1c(ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12)-c1cnn(C)c1
Show InChI InChI=1S/C25H25N9O2/c1-32-15-18(14-28-32)21-8-3-17-13-26-24(30-22(17)23(21)35-2)29-19-4-6-20(7-5-19)34-16-27-25(31-34)33-9-11-36-12-10-33/h3-8,13-16H,9-12H2,1-2H3,(H,26,29,30)
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n/an/a 50n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50062648
PNG
(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)
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n/an/a 50n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50213931
PNG
(CHEMBL250854 | tylophorinidine)
Show SMILES COc1ccc2c3[C@H](O)[C@@H]4CCCN4Cc3c3cc(OC)c(O)cc3c2c1
Show InChI InChI=1S/C22H23NO4/c1-26-12-5-6-13-14(8-12)15-9-19(24)20(27-2)10-16(15)17-11-23-7-3-4-18(23)22(25)21(13)17/h5-6,8-10,18,22,24-25H,3-4,7,11H2,1-2H3/t18-,22+/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50213932
PNG
(CHEMBL250474 | [(R)-(+)-deoxytylophorinidine)
Show SMILES COc1ccc2c3C[C@H]4CCCN4Cc3c3cc(OC)c(O)cc3c2c1
Show InChI InChI=1S/C22H23NO3/c1-25-14-5-6-15-16-8-13-4-3-7-23(13)12-20(16)19-11-22(26-2)21(24)10-18(19)17(15)9-14/h5-6,9-11,13,24H,3-4,7-8,12H2,1-2H3/t13-/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50295170
PNG
(6R-senecionylchaparrin | CHEMBL564009)
Show SMILES C[C@H]1[C@@H](O)[C@@]2(O)OC[C@]34[C@H]2[C@@]2(C)[C@H](O)[C@@H](O)C=C(C)[C@@H]2[C@@H](OC(=O)C=C(C)C)[C@H]3OC(=O)C[C@@H]14
Show InChI InChI=1S/C25H34O9/c1-10(2)6-15(27)33-18-17-11(3)7-14(26)20(30)23(17,5)22-24-9-32-25(22,31)19(29)12(4)13(24)8-16(28)34-21(18)24/h6-7,12-14,17-22,26,29-31H,8-9H2,1-5H3/t12-,13+,14+,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 71n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044564
PNG
(CHEMBL315804)
Show SMILES CC1=CC(=O)N(Nc2ncc(C(=O)c3ccccc3)c(n2)C(F)(F)F)C1=O
Show InChI InChI=1S/C17H11F3N4O3/c1-9-7-12(25)24(15(9)27)23-16-21-8-11(14(22-16)17(18,19)20)13(26)10-5-3-2-4-6-10/h2-8H,1H3,(H,21,22,23)
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n/an/a 98n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50090444
PNG
(4-(3-Methyl-2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino...)
Show SMILES CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)-c1ccccc1
Show InChI InChI=1S/C18H16N4O4/c1-3-26-18(25)13-10-19-15(12-7-5-4-6-8-12)20-16(13)21-22-14(23)9-11(2)17(22)24/h4-10H,3H2,1-2H3,(H,19,20,21)
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n/an/a 100n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044572
PNG
(CHEMBL3341912)
Show SMILES FC(F)(F)c1ccc2Sc3nc(Cl)ncc3C(=O)Nc2c1
Show InChI InChI=1S/C12H5ClF3N3OS/c13-11-17-4-6-9(20)18-7-3-5(12(14,15)16)1-2-8(7)21-10(6)19-11/h1-4H,(H,18,20)
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University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092877
PNG
(2-Fluoro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES Fc1ncc(C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(n1)C(F)(F)F
Show InChI InChI=1S/C14H5F10N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)
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n/an/a 100n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340622
PNG
(8-chloro-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morp...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1Cl
Show InChI InChI=1S/C24H22ClN9O/c1-32-14-17(13-28-32)20-7-2-16-12-26-23(30-22(16)21(20)25)29-18-3-5-19(6-4-18)34-15-27-24(31-34)33-8-10-35-11-9-33/h2-7,12-15H,8-11H2,1H3,(H,26,29,30)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092877
PNG
(2-Fluoro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Show SMILES Fc1ncc(C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(n1)C(F)(F)F
Show InChI InChI=1S/C14H5F10N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)
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University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50213934
PNG
(CHEMBL398325 | tylophorinine)
Show SMILES COc1ccc2c3[C@@H](O)[C@@H]4CCCN4Cc3c3cc(OC)c(OC)cc3c2c1
Show InChI InChI=1S/C23H25NO4/c1-26-13-6-7-14-15(9-13)16-10-20(27-2)21(28-3)11-17(16)18-12-24-8-4-5-19(24)23(25)22(14)18/h6-7,9-11,19,23,25H,4-5,8,12H2,1-3H3/t19-,23-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340600
PNG
(CHEMBL1761555 | N-(4-(3-morpholino-1H-1,2,4-triazo...)
Show SMILES C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1
Show InChI InChI=1S/C23H21N9O/c1-2-17-12-24-22(29-21(17)11-16(1)18-13-26-27-14-18)28-19-3-5-20(6-4-19)32-15-25-23(30-32)31-7-9-33-10-8-31/h1-6,11-15H,7-10H2,(H,26,27)(H,24,28,29)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340626
PNG
(8-cyclopropyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1C1CC1
Show InChI InChI=1S/C27H27N9O/c1-34-16-20(15-30-34)23-9-4-19-14-28-26(32-25(19)24(23)18-2-3-18)31-21-5-7-22(8-6-21)36-17-29-27(33-36)35-10-12-37-13-11-35/h4-9,14-18H,2-3,10-13H2,1H3,(H,28,31,32)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340624
PNG
(8-methyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morp...)
Show SMILES Cc1c(ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12)-c1cnn(C)c1
Show InChI InChI=1S/C25H25N9O/c1-17-22(19-14-28-32(2)15-19)8-3-18-13-26-24(30-23(17)18)29-20-4-6-21(7-5-20)34-16-27-25(31-34)33-9-11-35-12-10-33/h3-8,13-16H,9-12H2,1-2H3,(H,26,29,30)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092882
PNG
(2,4-Dichloro-pyrimidine-5-carboxylic acid (3,5-bis...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2Cl)cc(c1)C(F)(F)F
Show InChI InChI=1S/C13H5Cl2F6N3O/c14-9-8(4-22-11(15)24-9)10(25)23-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,23,25)
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Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340614
PNG
(CHEMBL1761569 | N-(4-(3-methyl-1H-1,2,4-triazol-1-...)
Show SMILES Cc1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4nccs4)c3n2)cc1
Show InChI InChI=1S/C20H15N7S/c1-13-23-12-27(26-13)16-7-5-15(6-8-16)24-20-22-11-14-3-2-4-17(18(14)25-20)19-21-9-10-28-19/h2-12H,1H3,(H,22,24,25)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092882
PNG
(2,4-Dichloro-pyrimidine-5-carboxylic acid (3,5-bis...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2Cl)cc(c1)C(F)(F)F
Show InChI InChI=1S/C13H5Cl2F6N3O/c14-9-8(4-22-11(15)24-9)10(25)23-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,23,25)
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University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044566
PNG
(CHEMBL87274)
Show SMILES CC1=CC(=O)N(Nc2ncc(C(=O)OC(C)(C)C)c(n2)C(F)(F)F)C1=O
Show InChI InChI=1S/C15H15F3N4O4/c1-7-5-9(23)22(11(7)24)21-13-19-6-8(10(20-13)15(16,17)18)12(25)26-14(2,3)4/h5-6H,1-4H3,(H,19,20,21)
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University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340610
PNG
(8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-morpholino-1H...)
Show SMILES COc1ccc(cc1F)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12
Show InChI InChI=1S/C27H24FN7O2/c1-36-24-10-5-18(15-23(24)28)22-4-2-3-19-16-29-26(32-25(19)22)31-20-6-8-21(9-7-20)35-17-30-27(33-35)34-11-13-37-14-12-34/h2-10,15-17H,11-14H2,1H3,(H,29,31,32)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340607
PNG
(7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)-c3ccccn3)nc2c1
Show InChI InChI=1S/C25H19N9/c1-33-15-19(14-29-33)17-5-6-18-13-27-25(31-23(18)12-17)30-20-7-9-21(10-8-20)34-16-28-24(32-34)22-4-2-3-11-26-22/h2-16H,1H3,(H,27,30,31)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50213936
PNG
((S)-2,3,6,7-tetramethoxy-8b,9,10,11,12,12a-hexahyd...)
Show SMILES COc1cc2C3CN4CCC[C@H]4C=C3c3cc(OC)c(OC)cc3-c2cc1OC
Show InChI InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h8-12,14,20H,5-7,13H2,1-4H3/t14-,20?/m0/s1
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Yale University

Curated by ChEMBL


Assay Description
Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50213935
PNG
((12aS,13R)-2,3,6,7-tetramethoxy-9,10,11,12,12a,13-...)
Show SMILES COc1cc2c3CN4CCC[C@H]4[C@H](O)c3c3cc(OC)c(OC)cc3c2cc1OC
Show InChI InChI=1S/C24H27NO5/c1-27-19-8-13-14-9-20(28-2)22(30-4)11-16(14)23-17(15(13)10-21(19)29-3)12-25-7-5-6-18(25)24(23)26/h8-11,18,24,26H,5-7,12H2,1-4H3/t18-,24-/m0/s1
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Yale University

Curated by ChEMBL


Assay Description
Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092890
PNG
(2-Chloro-pyrimidine-5-carboxylic acid (3,5-bis-tri...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C13H6ClF6N3O/c14-11-21-4-6(5-22-11)10(24)23-9-2-7(12(15,16)17)1-8(3-9)13(18,19)20/h1-5H,(H,23,24)
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Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092872
PNG
(2-Chloro-4-ethyl-pyrimidine-5-carboxylic acid (3,5...)
Show SMILES CCc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H10ClF6N3O/c1-2-11-10(6-23-13(16)25-11)12(26)24-9-4-7(14(17,18)19)3-8(5-9)15(20,21)22/h3-6H,2H2,1H3,(H,24,26)
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Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044570
PNG
(CHEMBL87433)
Show SMILES CCOC(=O)c1cnc(nc1C(F)(F)F)N(C)N1C(=O)C=C(C)C1=O
Show InChI InChI=1S/C14H13F3N4O4/c1-4-25-12(24)8-6-18-13(19-10(8)14(15,16)17)20(3)21-9(22)5-7(2)11(21)23/h5-6H,4H2,1-3H3
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University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340599
PNG
(7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C24H23N9O/c1-31-15-19(14-27-31)17-2-3-18-13-25-23(29-22(18)12-17)28-20-4-6-21(7-5-20)33-16-26-24(30-33)32-8-10-34-11-9-32/h2-7,12-16H,8-11H2,1H3,(H,25,28,29)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340609
PNG
(8-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H...)
Show SMILES Cn1cc(cn1)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12
Show InChI InChI=1S/C24H23N9O/c1-31-15-18(14-27-31)21-4-2-3-17-13-25-23(29-22(17)21)28-19-5-7-20(8-6-19)33-16-26-24(30-33)32-9-11-34-12-10-32/h2-8,13-16H,9-12H2,1H3,(H,25,28,29)
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092883
PNG
(2-Chloro-4-phenyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2-c2ccccc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C19H10ClF6N3O/c20-17-27-9-14(15(29-17)10-4-2-1-3-5-10)16(30)28-13-7-11(18(21,22)23)6-12(8-13)19(24,25)26/h1-9H,(H,28,30)
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University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044569
PNG
(CHEMBL83026)
Show SMILES CCOC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1CC
Show InChI InChI=1S/C14H16N4O4/c1-4-10-9(13(21)22-5-2)7-15-14(16-10)17-18-11(19)6-8(3)12(18)20/h6-7H,4-5H2,1-3H3,(H,15,16,17)
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n/an/a 400n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092883
PNG
(2-Chloro-4-phenyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2-c2ccccc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C19H10ClF6N3O/c20-17-27-9-14(15(29-17)10-4-2-1-3-5-10)16(30)28-13-7-11(18(21,22)23)6-12(8-13)19(24,25)26/h1-9H,(H,28,30)
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n/an/a 400n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044552
PNG
(CHEMBL3341901)
Show SMILES Cc1nc(Cl)ncc1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C12H8Cl3N3O/c1-6-10(5-16-12(15)17-6)11(19)18-9-3-7(13)2-8(14)4-9/h2-5H,1H3,(H,18,19)
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n/an/a 500n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092871
PNG
(2-Chloro-4-propyl-pyrimidine-5-carboxylic acid (3,...)
Show SMILES CCCc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H12ClF6N3O/c1-2-3-12-11(7-24-14(17)26-12)13(27)25-10-5-8(15(18,19)20)4-9(6-10)16(21,22)23/h4-7H,2-3H2,1H3,(H,25,27)
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n/an/a 500n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50044553
PNG
(CHEMBL3341956)
Show SMILES CNc1nc(c(s1)-c1nc2ccccc2c(=O)n1-c1ccccc1OC)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S/c1-26-25-28-21(16-10-4-3-5-11-16)22(32-25)23-27-18-13-7-6-12-17(18)24(30)29(23)19-14-8-9-15-20(19)31-2/h3-15H,1-2H3,(H,26,28)
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n/an/a 500n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in HEK293 cells by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50340613
PNG
(8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-methyl-1H-1,2...)
Show SMILES COc1ccc(cc1F)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(C)n3)nc12
Show InChI InChI=1S/C24H19FN6O/c1-15-27-14-31(30-15)19-9-7-18(8-10-19)28-24-26-13-17-4-3-5-20(23(17)29-24)16-6-11-22(32-2)21(25)12-16/h3-14H,1-2H3,(H,26,28,29)
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n/an/a 500n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-Jun


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50092880
PNG
(2-Chloro-4-pentafluoroethyl-pyrimidine-5-carboxyli...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)C(F)(F)F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H5ClF11N3O/c16-11-28-4-8(9(30-11)12(17,18)15(25,26)27)10(31)29-7-2-5(13(19,20)21)1-6(3-7)14(22,23)24/h1-4H,(H,29,31)
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n/an/a 600n/an/an/an/an/an/a



Signal Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells


J Med Chem 43: 3995-4004 (2000)

More data for this
Ligand-Target Pair
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