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Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Transcription factor STAT5a (STAT5a)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM165193
PNG
(4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen ...)
Show SMILES CCCCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OP(O)(O)=O)c1
Show InChI InChI=1S/C16H27NO9P2/c1-2-3-4-5-6-7-8-16(18)17-12-13-9-10-14(25-27(19,20)21)15(11-13)26-28(22,23)24/h9-11H,2-8,12H2,1H3,(H,17,18)(H2,19,20,21)(H2,22,23,24)
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1.23E+4n/a 2.49E+4n/an/an/an/an/an/a



University of Leipzig



Assay Description
For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM165192
PNG
(4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(d...)
Show SMILES CC(C)CCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OP(O)(O)=O)c1
Show InChI InChI=1S/C17H29NO9P2/c1-13(2)7-5-3-4-6-8-17(19)18-12-14-9-10-15(26-28(20,21)22)16(11-14)27-29(23,24)25/h9-11,13H,3-8,12H2,1-2H3,(H,18,19)(H2,20,21,22)(H2,23,24,25)
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1.30E+4n/a 2.64E+4n/an/an/an/an/an/a



University of Leipzig



Assay Description
For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM165191
PNG
(2-Methoxy-4-(nonanamidomethyl)phenyl dihydrogen ph...)
Show SMILES CCCCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OC)c1
Show InChI InChI=1S/C17H28NO6P/c1-3-4-5-6-7-8-9-17(19)18-13-14-10-11-15(16(12-14)23-2)24-25(20,21)22/h10-12H,3-9,13H2,1-2H3,(H,18,19)(H2,20,21,22)
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4.90E+4n/a 9.80E+4n/an/an/an/an/an/a



University of Leipzig



Assay Description
For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM165190
PNG
(2-Methoxy-4-((8-methylnonanamido)methyl)phenyl dih...)
Show SMILES COc1cc(CNC(=O)CCCCCCC(C)C)ccc1OP(O)(O)=O
Show InChI InChI=1S/C18H30NO6P/c1-14(2)8-6-4-5-7-9-18(20)19-13-15-10-11-16(17(12-15)24-3)25-26(21,22)23/h10-12,14H,4-9,13H2,1-3H3,(H,19,20)(H2,21,22,23)
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7.50E+4n/a 1.52E+5n/an/an/an/an/an/a



University of Leipzig



Assay Description
For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM50335201
PNG
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1
Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



AstraZeneca R&D

Curated by ChEMBL


Assay Description
Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blotting


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM50335201
PNG
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1
Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



AstraZeneca R&D

Curated by ChEMBL


Assay Description
Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blotting


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM50295809
PNG
(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Show SMILES O[C@@H]1Cn2c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n(C[C@@H]1O)c4c23
Show InChI InChI=1S/C24H19N3O3/c28-17-10-26-15-7-3-1-5-12(15)19-14-9-25-24(30)21(14)20-13-6-2-4-8-16(13)27(11-18(17)29)23(20)22(19)26/h1-8,17-18,28-29H,9-11H2,(H,25,30)/t17-,18+/m1/s1
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n/an/a 689n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202

Curated by ChEMBL


Assay Description
Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by western blotting


Citation and Details
More data for this
Ligand-Target Pair
Transcription factor STAT5a (STAT5a)


(Homo sapiens (Human))
BDBM50446146
PNG
(CHEMBL3108909)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(cc1)C(O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)
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n/an/an/a 464n/an/an/an/an/a


TBA

Assay Description
Binding affinity to His-tagged STAT5 (unknown origin) by SPR spectroscopic analysis


Citation and Details
More data for this
Ligand-Target Pair