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Found 32 hits Enz. Inhib. hit(s) with Target = 'Transcriptional activator protein luxR' AND taxid = 312309   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265812
PNG
((S)-3-(3-iodophenyl)-N-(2-oxotetrahydrofuran-3-yl)...)
Show SMILES Ic1cccc(CCC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H14INO3/c14-10-3-1-2-9(8-10)4-5-12(16)15-11-6-7-18-13(11)17/h1-3,8,11H,4-7H2,(H,15,16)/t11-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265861
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-3-(3-(trifluorom...)
Show SMILES FC(F)(F)c1cccc(CCC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C14H14F3NO3/c15-14(16,17)10-3-1-2-9(8-10)4-5-12(19)18-11-6-7-21-13(11)20/h1-3,8,11H,4-7H2,(H,18,19)/t11-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265810
PNG
((S)-3-(3-bromophenyl)-N-(2-oxotetrahydrofuran-3-yl...)
Show SMILES Brc1cccc(CCC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H14BrNO3/c14-10-3-1-2-9(8-10)4-5-12(16)15-11-6-7-18-13(11)17/h1-3,8,11H,4-7H2,(H,15,16)/t11-/m0/s1
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n/an/a 530n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266165
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluorom...)
Show SMILES FC(F)(F)c1ccc(CC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H12F3NO3/c14-13(15,16)9-3-1-8(2-4-9)7-11(18)17-10-5-6-20-12(10)19/h1-4,10H,5-7H2,(H,17,18)/t10-/m0/s1
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n/an/a 610n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265811
PNG
((S)-3-(4-iodophenyl)-N-(2-oxotetrahydrofuran-3-yl)...)
Show SMILES Ic1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H14INO3/c14-10-4-1-9(2-5-10)3-6-12(16)15-11-7-8-18-13(11)17/h1-2,4-5,11H,3,6-8H2,(H,15,16)/t11-/m0/s1
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n/an/a 630n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266163
PNG
((S)-2-(4-iodophenyl)-N-(2-oxotetrahydrofuran-3-yl)...)
Show SMILES Ic1ccc(CC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C12H12INO3/c13-9-3-1-8(2-4-9)7-11(15)14-10-5-6-17-12(10)16/h1-4,10H,5-7H2,(H,14,15)/t10-/m0/s1
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n/an/a 860n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265901
PNG
((S)-3-(3-nitrophenyl)-N-(2-oxotetrahydrofuran-3-yl...)
Show SMILES [O-][N+](=O)c1cccc(CCC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H14N2O5/c16-12(14-11-6-7-20-13(11)17)5-4-9-2-1-3-10(8-9)15(18)19/h1-3,8,11H,4-7H2,(H,14,16)/t11-/m0/s1
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n/an/a 880n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266238
PNG
((S)-2-(naphthalen-2-yl)-N-(2-oxotetrahydrofuran-3-...)
Show SMILES O=C(Cc1ccc2ccccc2c1)N[C@H]1CCOC1=O
Show InChI InChI=1S/C16H15NO3/c18-15(17-14-7-8-20-16(14)19)10-11-5-6-12-3-1-2-4-13(12)9-11/h1-6,9,14H,7-8,10H2,(H,17,18)/t14-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266164
PNG
((S)-2-(4-nitrophenyl)-N-(2-oxotetrahydrofuran-3-yl...)
Show SMILES [O-][N+](=O)c1ccc(CC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C12H12N2O5/c15-11(13-10-5-6-19-12(10)16)7-8-1-3-9(4-2-8)14(17)18/h1-4,10H,5-7H2,(H,13,15)/t10-/m0/s1
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n/an/a 960n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265809
PNG
((S)-3-(4-chlorophenyl)-N-(2-oxotetrahydrofuran-3-y...)
Show SMILES Clc1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H14ClNO3/c14-10-4-1-9(2-5-10)3-6-12(16)15-11-7-8-18-13(11)17/h1-2,4-5,11H,3,6-8H2,(H,15,16)/t11-/m0/s1
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n/an/a 970n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265900
PNG
((S)-3-(4-nitrophenyl)-N-(2-oxotetrahydrofuran-3-yl...)
Show SMILES [O-][N+](=O)c1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H14N2O5/c16-12(14-11-7-8-20-13(11)17)6-3-9-1-4-10(5-2-9)15(18)19/h1-2,4-5,11H,3,6-8H2,(H,14,16)/t11-/m0/s1
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n/an/a 990n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266236
PNG
((S)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(2-ox...)
Show SMILES Fc1ccc(CC(=O)N[C@H]2CCOC2=O)cc1C(F)(F)F
Show InChI InChI=1S/C13H11F4NO3/c14-9-2-1-7(5-8(9)13(15,16)17)6-11(19)18-10-3-4-21-12(10)20/h1-2,5,10H,3-4,6H2,(H,18,19)/t10-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266266
PNG
((S)-2-(naphthalen-1-yl)-N-(2-oxotetrahydrofuran-3-...)
Show SMILES O=C(Cc1cccc2ccccc12)N[C@H]1CCOC1=O
Show InChI InChI=1S/C16H15NO3/c18-15(17-14-8-9-20-16(14)19)10-12-6-3-5-11-4-1-2-7-13(11)12/h1-7,14H,8-10H2,(H,17,18)/t14-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266234
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluorom...)
Show SMILES FC(F)(F)Sc1ccc(CC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H12F3NO3S/c14-13(15,16)21-9-3-1-8(2-4-9)7-11(18)17-10-5-6-20-12(10)19/h1-4,10H,5-7H2,(H,17,18)/t10-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50241433
PNG
((S)-3-(4-bromophenyl)-N-(2-oxo-tetrahydrofuran-3-y...)
Show SMILES Brc1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H14BrNO3/c14-10-4-1-9(2-5-10)3-6-12(16)15-11-7-8-18-13(11)17/h1-2,4-5,11H,3,6-8H2,(H,15,16)/t11-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266201
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(3-(trifluorom...)
Show SMILES FC(F)(F)c1cccc(CC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H12F3NO3/c14-13(15,16)9-3-1-2-8(6-9)7-11(18)17-10-4-5-20-12(10)19/h1-3,6,10H,4-5,7H2,(H,17,18)/t10-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266233
PNG
((S)-2-(3-(methylthio)phenyl)-N-(2-oxotetrahydrofur...)
Show SMILES CSc1cccc(CC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H15NO3S/c1-18-10-4-2-3-9(7-10)8-12(15)14-11-5-6-17-13(11)16/h2-4,7,11H,5-6,8H2,1H3,(H,14,15)/t11-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265813
PNG
((S)-3-(4-(methylthio)phenyl)-N-(2-oxotetrahydrofur...)
Show SMILES CSc1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C14H17NO3S/c1-19-11-5-2-10(3-6-11)4-7-13(16)15-12-8-9-18-14(12)17/h2-3,5-6,12H,4,7-9H2,1H3,(H,15,16)/t12-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266308
PNG
((S)-2-(4-iodophenoxy)-N-(2-oxotetrahydrofuran-3-yl...)
Show SMILES Ic1ccc(OCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C12H12INO4/c13-8-1-3-9(4-2-8)18-7-11(15)14-10-5-6-17-12(10)16/h1-4,10H,5-7H2,(H,14,15)/t10-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266199
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-2-m-tolylacetami...)
Show SMILES Cc1cccc(CC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H15NO3/c1-9-3-2-4-10(7-9)8-12(15)14-11-5-6-17-13(11)16/h2-4,7,11H,5-6,8H2,1H3,(H,14,15)/t11-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266203
PNG
((S)-2-(4-(methylthio)phenyl)-N-(2-oxotetrahydrofur...)
Show SMILES CSc1ccc(CC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H15NO3S/c1-18-10-4-2-9(3-5-10)8-12(15)14-11-6-7-17-13(11)16/h2-5,11H,6-8H2,1H3,(H,14,15)/t11-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266313
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-3-m-tolylpropana...)
Show SMILES Cc1cccc(CCC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C14H17NO3/c1-10-3-2-4-11(9-10)5-6-13(16)15-12-7-8-18-14(12)17/h2-4,9,12H,5-8H2,1H3,(H,15,16)/t12-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265814
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-3-(4-(trifluorom...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C14H14F3NO3/c15-14(16,17)10-4-1-9(2-5-10)3-6-12(19)18-11-7-8-21-13(11)20/h1-2,4-5,11H,3,6-8H2,(H,18,19)/t11-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266312
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-3-p-tolylpropana...)
Show SMILES Cc1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C14H17NO3/c1-10-2-4-11(5-3-10)6-7-13(16)15-12-8-9-18-14(12)17/h2-5,12H,6-9H2,1H3,(H,15,16)/t12-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266311
PNG
((S)-2-(3-nitrophenoxy)-N-(2-oxotetrahydrofuran-3-y...)
Show SMILES [O-][N+](=O)c1cccc(OCC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C12H12N2O6/c15-11(13-10-4-5-19-12(10)16)7-20-9-3-1-2-8(6-9)14(17)18/h1-3,6,10H,4-5,7H2,(H,13,15)/t10-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266200
PNG
((S)-2-(3-methoxyphenyl)-N-(2-oxotetrahydrofuran-3-...)
Show SMILES COc1cccc(CC(=O)N[C@H]2CCOC2=O)c1
Show InChI InChI=1S/C13H15NO4/c1-17-10-4-2-3-9(7-10)8-12(15)14-11-5-6-18-13(11)16/h2-4,7,11H,5-6,8H2,1H3,(H,14,15)/t11-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265808
PNG
((S)-3-(4-fluorophenyl)-N-(2-oxotetrahydrofuran-3-y...)
Show SMILES Fc1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H14FNO3/c14-10-4-1-9(2-5-10)3-6-12(16)15-11-7-8-18-13(11)17/h1-2,4-5,11H,3,6-8H2,(H,15,16)/t11-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266272
PNG
((S)-2-(4-bromophenoxy)-N-(2-oxotetrahydrofuran-3-y...)
Show SMILES Brc1ccc(OCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C12H12BrNO4/c13-8-1-3-9(4-2-8)18-7-11(15)14-10-5-6-17-12(10)16/h1-4,10H,5-7H2,(H,14,15)/t10-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265902
PNG
((S)-3-(benzo[d][1,3]dioxol-5-yl)-N-(2-oxotetrahydr...)
Show SMILES O=C(CCc1ccc2OCOc2c1)N[C@H]1CCOC1=O
Show InChI InChI=1S/C14H15NO5/c16-13(15-10-5-6-18-14(10)17)4-2-9-1-3-11-12(7-9)20-8-19-11/h1,3,7,10H,2,4-6,8H2,(H,15,16)/t10-/m0/s1
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n/an/an/an/a 370n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at Vibrio fischeri ES114 LuxR receptor by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50265811
PNG
((S)-3-(4-iodophenyl)-N-(2-oxotetrahydrofuran-3-yl)...)
Show SMILES Ic1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H14INO3/c14-10-4-1-9(2-5-10)3-6-12(16)15-11-7-8-18-13(11)17/h1-2,4-5,11H,3,6-8H2,(H,15,16)/t11-/m0/s1
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n/an/an/an/a 300n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at Vibrio fischeri ES114 LuxR receptor by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266234
PNG
((S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluorom...)
Show SMILES FC(F)(F)Sc1ccc(CC(=O)N[C@H]2CCOC2=O)cc1
Show InChI InChI=1S/C13H12F3NO3S/c14-13(15,16)21-9-3-1-8(2-4-9)7-11(18)17-10-5-6-20-12(10)19/h1-4,10H,5-7H2,(H,17,18)/t10-/m0/s1
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n/an/an/an/a 350n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at Vibrio fischeri ES114 LuxR receptor by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Transcriptional activator protein luxR


(Vibrio fischeri (strain ATCC 700601 / ES114))
BDBM50266202
PNG
((S)-2-(3-cyanophenyl)-N-(2-oxotetrahydrofuran-3-yl...)
Show SMILES O=C(Cc1cccc(c1)C#N)N[C@H]1CCOC1=O
Show InChI InChI=1S/C13H12N2O3/c14-8-10-3-1-2-9(6-10)7-12(16)15-11-4-5-18-13(11)17/h1-3,6,11H,4-5,7H2,(H,15,16)/t11-/m0/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Agonist activity at Vibrio fischeri ES114 LuxR receptor by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair