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Found 7 hits Enz. Inhib. hit(s) with Target = 'Transforming growth factor beta-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transforming growth factor beta-1


(Homo sapiens)
BDBM50353187
PNG
(CHEMBL1829511)
Show SMILES CN(C)CCCOc1ccc(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C23H24N6O/c1-29(2)12-5-13-30-22-8-7-18(15-26-22)21-14-17(9-11-25-21)19-16-27-28-23(19)20-6-3-4-10-24-20/h3-4,6-11,14-16H,5,12-13H2,1-2H3,(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens)
BDBM50184879
PNG
(CHEMBL424676 | dimethyl-{2-[(4-{4-[3-(pyridin-2-yl...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C23H23N5O/c1-28(2)13-14-29-19-8-6-17(7-9-19)22-15-18(10-12-25-22)20-16-26-27-23(20)21-5-3-4-11-24-21/h3-12,15-16H,13-14H2,1-2H3,(H,26,27)
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n/an/a 19n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens)
BDBM50353188
PNG
(CHEMBL1829512)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C23H23N7/c1-29-10-12-30(13-11-29)22-6-5-18(15-26-22)21-14-17(7-9-25-21)19-16-27-28-23(19)20-4-2-3-8-24-20/h2-9,14-16H,10-13H2,1H3,(H,27,28)
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n/an/a 32n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens)
BDBM50353184
PNG
(CHEMBL1828640)
Show SMILES Cn1cc(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C17H14N6/c1-23-11-13(9-21-23)16-8-12(5-7-19-16)14-10-20-22-17(14)15-4-2-3-6-18-15/h2-11H,1H3,(H,20,22)
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n/an/a 68n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens)
BDBM50353185
PNG
(CHEMBL1829504)
Show SMILES c1cnn(c1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C16H12N6/c1-2-6-17-14(4-1)16-13(11-19-21-16)12-5-8-18-15(10-12)22-9-3-7-20-22/h1-11H,(H,19,21)
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n/an/a 77n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens)
BDBM50353186
PNG
(CHEMBL1829505)
Show SMILES c1cn(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C16H12N6/c1-2-5-18-14(3-1)16-13(10-20-21-16)12-4-6-19-15(9-12)22-8-7-17-11-22/h1-11H,(H,20,21)
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n/an/a 88n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens)
BDBM50184872
PNG
(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Show SMILES O=C(NC1CCOCC1)c1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
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Article
PubMed
n/an/a 446n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Citation and Details
More data for this
Ligand-Target Pair