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Found 12 hits Enz. Inhib. hit(s) with Target = 'Transglutaminase-6 (TG6)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM50420459
PNG
(CHEMBL2086528)
Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H31N3O4S/c1-2-22(28)25-20-3-5-21(6-4-20)32(30,31)27-9-7-26(8-10-27)23(29)24-14-17-11-18(15-24)13-19(12-17)16-24/h2-6,17-19H,1,7-16H2,(H,25,28)
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n/an/a 840n/an/an/an/an/an/a



Evotec (UK) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TG6 by fluorescent transamidation assay


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM185173
PNG
(N-[2-[4-(adamantane-1-carbonyl)piperazin-1-yl]-2-o...)
Show SMILES C=CC(=O)NCC(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H29N3O3/c1-2-17(24)21-13-18(25)22-3-5-23(6-4-22)19(26)20-10-14-7-15(11-20)9-16(8-14)12-20/h2,14-16H,1,3-13H2,(H,21,24)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Aston University



Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa...


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM185181
PNG
(N-[2-[4-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pi...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N1CCN(CC1)C(=O)CNC(=O)C=C
Show InChI InChI=1S/C21H26N4O4S/c1-4-20(26)22-15-21(27)24-11-13-25(14-12-24)30(28,29)19-10-6-7-16-17(19)8-5-9-18(16)23(2)3/h4-10H,1,11-15H2,2-3H3,(H,22,26)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Aston University



Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa...


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM50392881
PNG
(CHEMBL2152090)
Show SMILES C=CC(=O)NC1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C22H25N3O5S/c1-2-21(26)23-19-12-14-25(15-13-19)31(28,29)20-10-8-18(9-11-20)24-22(27)30-16-17-6-4-3-5-7-17/h2-11,19H,1,12-16H2,(H,23,26)(H,24,27)
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n/an/a 8.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TGM6


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM185177
PNG
(1-Adamantylmethyl 4-[2-(prop-2-enoylamino)acetyl]p...)
Show SMILES C=CC(=O)NCC(=O)N1CCN(CC1)C(=O)OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H31N3O4/c1-2-18(25)22-13-19(26)23-3-5-24(6-4-23)20(27)28-14-21-10-15-7-16(11-21)9-17(8-15)12-21/h2,15-17H,1,3-14H2,(H,22,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Aston University



Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa...


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM185172
PNG
([2-[[2-[4-(Adamantane-1-carbonyl)piperazin-1-yl]-2...)
Show SMILES C[S+](C)CC(=O)NCC(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H33N3O3S/c1-28(2)14-18(25)22-13-19(26)23-3-5-24(6-4-23)20(27)21-10-15-7-16(11-21)9-17(8-15)12-21/h15-17H,3-14H2,1-2H3/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Aston University



Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa...


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM185176
PNG
([2-[[2-[4-(1-Adamantylmethoxycarbonyl)piperazin-1-...)
Show SMILES C[S+](C)CC(=O)NCC(=O)N1CCN(CC1)C(=O)OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H35N3O4S/c1-30(2)14-19(26)23-13-20(27)24-3-5-25(6-4-24)21(28)29-15-22-10-16-7-17(11-22)9-18(8-16)12-22/h16-18H,3-15H2,1-2H3/p+1
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Aston University



Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa...


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM185182
PNG
([2-[[2-[4-[[5-(Dimethylamino)-1-naphthyl]sulfonyl]...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N1CCN(CC1)C(=O)CNC(=O)C[S+](C)C
Show InChI InChI=1S/C22H30N4O4S2/c1-24(2)19-9-5-8-18-17(19)7-6-10-20(18)32(29,30)26-13-11-25(12-14-26)22(28)15-23-21(27)16-31(3)4/h5-10H,11-16H2,1-4H3/p+1
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Aston University



Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa...


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM50392906
PNG
(CHEMBL2152204)
Show SMILES COc1ccc(CCNC(=O)c2ccc(cc2)S(=O)(=O)N2CCC(CC2)NC(=O)C=C)cc1
Show InChI InChI=1S/C24H29N3O5S/c1-3-23(28)26-20-13-16-27(17-14-20)33(30,31)22-10-6-19(7-11-22)24(29)25-15-12-18-4-8-21(32-2)9-5-18/h3-11,20H,1,12-17H2,2H3,(H,25,29)(H,26,28)
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n/an/a 3.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TGM6


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM50400625
PNG
(CHEMBL2203469)
Show SMILES Clc1ccccc1N1CCN(CC1)C(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H33ClN4O4/c1-2-25(33)29-15-9-8-13-23(30-27(35)36-20-21-10-4-3-5-11-21)26(34)32-18-16-31(17-19-32)24-14-7-6-12-22(24)28/h2-7,10-12,14,23H,1,8-9,13,15-20H2,(H,29,33)(H,30,35)/t23-/m0/s1
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n/an/a 6.90E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of transglutaminase 6


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM50400619
PNG
(CHEMBL2203476)
Show SMILES CC(C)(C)OC(=O)CNC(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C23H33N3O6/c1-5-19(27)24-14-10-9-13-18(21(29)25-15-20(28)32-23(2,3)4)26-22(30)31-16-17-11-7-6-8-12-17/h5-8,11-12,18H,1,9-10,13-16H2,2-4H3,(H,24,27)(H,25,29)(H,26,30)/t18-/m0/s1
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TBA

Assay Description
Inhibition of transglutaminase 6


Citation and Details
More data for this
Ligand-Target Pair
Transglutaminase-6 (TG6)


(Homo sapiens (Human))
BDBM50400621
PNG
(CHEMBL2203451)
Show SMILES Cc1cccc(n1)N1CCN(CC1)C(=O)[C@H](CCCCNC(=O)C=C)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C27H35N5O3/c1-3-25(33)28-15-8-7-13-23(30-26(34)20-22-11-5-4-6-12-22)27(35)32-18-16-31(17-19-32)24-14-9-10-21(2)29-24/h3-6,9-12,14,23H,1,7-8,13,15-20H2,2H3,(H,28,33)(H,30,34)/t23-/m0/s1
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TBA

Assay Description
Inhibition of transglutaminase 6


Citation and Details
More data for this
Ligand-Target Pair