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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Mus musculus)
BDBM50323040
PNG
(1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylamin...)
Show SMILES CC(=NOC(=O)Nc1ccccc1)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C19H16N2O2S/c1-14(21-23-19(22)20-17-9-3-2-4-10-17)15-7-5-8-16(13-15)18-11-6-12-24-18/h2-13H,1H3,(H,20,22)
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibition of mouse TRPV1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Mus musculus)
BDBM50345471
PNG
((R)-N-((S)-1-((6S,9S,12R,13R,Z)-3-ethylidene-9-iso...)
Show SMILES CCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@@H](C)OC(=O)\C(NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)C(C)C)=C\C
Show InChI InChI=1S/C43H59N7O9/c1-9-30-43(58)59-27(8)36(42(57)49-35(25(5)6)41(56)44-26(7)37(52)46-30)50-40(55)33(23-29-19-15-12-16-20-29)48-38(53)31(21-24(3)4)47-39(54)32(45-34(51)10-2)22-28-17-13-11-14-18-28/h9,11-20,24-27,31-33,35-36H,10,21-23H2,1-8H3,(H,44,56)(H,45,51)(H,46,52)(H,47,54)(H,48,53)(H,49,57)(H,50,55)/b30-9-/t26-,27+,31+,32+,33-,35-,36+/m0/s1
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n/an/a 2.27E+5n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 channel in C57B1 mouse dorsal root ganglion cells assessed as inhibition of capsaicin-induced calcium flux by fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Mus musculus)
BDBM50345472
PNG
(CHEMBL1784750 | Nobilamide B)
Show SMILES CCC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N\C(=C/C)C(O)=O
Show InChI InChI=1S/C43H61N7O10/c1-9-30(43(59)60)46-37(53)26(7)44-41(57)35(25(5)6)49-42(58)36(27(8)51)50-40(56)33(23-29-19-15-12-16-20-29)48-38(54)31(21-24(3)4)47-39(55)32(45-34(52)10-2)22-28-17-13-11-14-18-28/h9,11-20,24-27,31-33,35-36,51H,10,21-23H2,1-8H3,(H,44,57)(H,45,52)(H,46,53)(H,47,55)(H,48,54)(H,49,58)(H,50,56)(H,59,60)/b30-9-/t26-,27+,31+,32+,33-,35-,36+/m0/s1
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n/an/a 2.75E+5n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 channel in C57B1 mouse dorsal root ganglion cells assessed as inhibition of capsaicin-induced calcium flux by fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Mus musculus)
BDBM50345473
PNG
((R)-2-((R)-2-acetamido-3-phenylpropanamido)-N-((S)...)
Show SMILES C\C=C1/NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](C)OC1=O)C(C)C
Show InChI InChI=1S/C42H57N7O9/c1-9-30-42(57)58-26(7)35(41(56)48-34(24(4)5)40(55)43-25(6)36(51)45-30)49-39(54)33(22-29-18-14-11-15-19-29)47-37(52)31(20-23(2)3)46-38(53)32(44-27(8)50)21-28-16-12-10-13-17-28/h9-19,23-26,31-35H,20-22H2,1-8H3,(H,43,55)(H,44,50)(H,45,51)(H,46,53)(H,47,52)(H,48,56)(H,49,54)/b30-9-/t25-,26+,31+,32+,33-,34-,35+/m0/s1
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n/an/a 1.32E+6n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 channel in C57B1 mouse dorsal root ganglion cells assessed as inhibition of capsaicin-induced calcium flux by fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Mus musculus)
BDBM50345474
PNG
(CHEMBL1784749 | Nobilamide A)
Show SMILES C\C=C(/NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@@H](C)O)C(C)C)C(O)=O
Show InChI InChI=1S/C42H59N7O10/c1-9-30(42(58)59)45-36(52)25(6)43-40(56)34(24(4)5)48-41(57)35(26(7)50)49-39(55)33(22-29-18-14-11-15-19-29)47-37(53)31(20-23(2)3)46-38(54)32(44-27(8)51)21-28-16-12-10-13-17-28/h9-19,23-26,31-35,50H,20-22H2,1-8H3,(H,43,56)(H,44,51)(H,45,52)(H,46,54)(H,47,53)(H,48,57)(H,49,55)(H,58,59)/b30-9-/t25-,26+,31+,32+,33-,34-,35+/m0/s1
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n/an/a 1.67E+6n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 channel in C57B1 mouse dorsal root ganglion cells assessed as inhibition of capsaicin-induced calcium flux by fluorometr...


Citation and Details
More data for this
Ligand-Target Pair