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Compile Data Set for Download or QSAR

Found 12 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 57n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 320n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50240777
PNG
(4alpha-phorbol-didecanoate | CHEMBL118987 | Decano...)
Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCC
Show InChI InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34?,36-,38+,39-,40-/m1/s1
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n/an/an/an/a 370n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277486
PNG
(4alpha-Phorbol 13-decanoate | CHEMBL541720)
Show SMILES CCCCCCCCCC(=O)O[C@]12[C@H]([C@@H]3C=C(CO)C[C@]4(O)[C@@H](C=C(C)C4=O)[C@@]3(O)[C@H](C)[C@H]1O)C2(C)C
Show InChI InChI=1S/C30H46O7/c1-6-7-8-9-10-11-12-13-23(32)37-30-24(27(30,4)5)21-15-20(17-31)16-28(35)22(14-18(2)25(28)33)29(21,36)19(3)26(30)34/h14-15,19,21-22,24,26,31,34-36H,6-13,16-17H2,1-5H3/t19-,21+,22-,24?,26-,28+,29-,30-/m1/s1
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n/an/an/an/a 450n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277490
PNG
(4alpha-Phorbol 12,13-dimyristate | CHEMBL451849)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCCCCCC
Show InChI InChI=1S/C48H80O8/c1-7-9-11-13-15-17-19-21-23-25-27-29-40(50)55-44-36(4)47(54)38(32-37(34-49)33-46(53)39(47)31-35(3)43(46)52)42-45(5,6)48(42,44)56-41(51)30-28-26-24-22-20-18-16-14-12-10-8-2/h31-32,36,38-39,42,44,49,53-54H,7-30,33-34H2,1-6H3/t36-,38+,39-,42?,44-,46+,47-,48-/m1/s1
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n/an/an/an/a 2.83E+3n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277739
PNG
(4alpha-phorbol diacetate | CHEMBL484343)
Show SMILES C[C@@H]1[C@@H](OC(C)=O)[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
Show InChI InChI=1S/C24H32O8/c1-11-7-17-22(29,19(11)28)9-15(10-25)8-16-18-21(5,6)24(18,32-14(4)27)20(31-13(3)26)12(2)23(16,17)30/h7-8,12,16-18,20,25,29-30H,9-10H2,1-6H3/t12-,16+,17-,18?,20-,22+,23-,24-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277488
PNG
(4alpha-Phorbol 12,13-dioctanoate | CHEMBL507303)
Show SMILES CCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCC
Show InChI InChI=1S/C36H56O8/c1-7-9-11-13-15-17-28(38)43-32-24(4)35(42)26(20-25(22-37)21-34(41)27(35)19-23(3)31(34)40)30-33(5,6)36(30,32)44-29(39)18-16-14-12-10-8-2/h19-20,24,26-27,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,26+,27-,30?,32-,34+,35-,36-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277489
PNG
(4alpha-Phorbol 12,13-dinonanoate | CHEMBL130626)
Show SMILES CCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCC
Show InChI InChI=1S/C38H60O8/c1-7-9-11-13-15-17-19-30(40)45-34-26(4)37(44)28(22-27(24-39)23-36(43)29(37)21-25(3)33(36)42)32-35(5,6)38(32,34)46-31(41)20-18-16-14-12-10-8-2/h21-22,26,28-29,32,34,39,43-44H,7-20,23-24H2,1-6H3/t26-,28+,29-,32-,34-,36+,37-,38-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277740
PNG
(4-Deoxy-4alpha-Phorbol 12,13-didecanoate | CHEMBL5...)
Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@H]3CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCC
Show InChI InChI=1S/C40H64O7/c1-7-9-11-13-15-17-19-21-33(42)46-37-28(4)39(45)31-23-27(3)35(44)30(31)24-29(26-41)25-32(39)36-38(5,6)40(36,37)47-34(43)22-20-18-16-14-12-10-8-2/h23,25,28,30-32,36-37,41,45H,7-22,24,26H2,1-6H3/t28-,30-,31-,32+,36?,37-,39+,40-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277491
PNG
(CHEMBL504955 | Lumi-4alpha-Phorbol 12,13-didecanoa...)
Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@@H]3C(C)(C)[C@]13OC(=O)CCCCCCCCC)C1C3[C@@H]2[C@H]2CC1(CO)C3(C)C2=O
Show InChI InChI=1S/C40H64O7/c1-7-9-11-13-15-17-19-21-27(42)46-35-25(3)39(45)29-26-23-38(24-41)31(30(29)37(38,6)34(26)44)32(39)33-36(4,5)40(33,35)47-28(43)22-20-18-16-14-12-10-8-2/h25-26,29-33,35,41,45H,7-24H2,1-6H3/t25-,26-,29+,30?,31?,32+,33?,35-,37?,38?,39+,40-/m1/s1
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n/an/an/an/a 175n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277487
PNG
(4alpha-Phorbol 12,13-dihexanoate | CHEMBL490470)
Show SMILES CCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCC
Show InChI InChI=1S/C32H48O8/c1-7-9-11-13-24(34)39-28-20(4)31(38)22(16-21(18-33)17-30(37)23(31)15-19(3)27(30)36)26-29(5,6)32(26,28)40-25(35)14-12-10-8-2/h15-16,20,22-23,26,28,33,37-38H,7-14,17-18H2,1-6H3/t20-,22+,23-,26?,28-,30+,31-,32-/m1/s1
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n/an/an/an/a 70n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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n/an/an/an/a 2.25E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair