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Compile Data Set for Download or QSAR

Found 12 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 57n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 320n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50240777
PNG
(4alpha-phorbol-didecanoate | CHEMBL118987 | Decano...)
Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCC
Show InChI InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34?,36-,38+,39-,40-/m1/s1
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n/an/an/an/a 370n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277486
PNG
(4alpha-Phorbol 13-decanoate | CHEMBL541720)
Show SMILES CCCCCCCCCC(=O)O[C@]12[C@H]([C@@H]3C=C(CO)C[C@]4(O)[C@@H](C=C(C)C4=O)[C@@]3(O)[C@H](C)[C@H]1O)C2(C)C
Show InChI InChI=1S/C30H46O7/c1-6-7-8-9-10-11-12-13-23(32)37-30-24(27(30,4)5)21-15-20(17-31)16-28(35)22(14-18(2)25(28)33)29(21,36)19(3)26(30)34/h14-15,19,21-22,24,26,31,34-36H,6-13,16-17H2,1-5H3/t19-,21+,22-,24?,26-,28+,29-,30-/m1/s1
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n/an/an/an/a 450n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277490
PNG
(4alpha-Phorbol 12,13-dimyristate | CHEMBL451849)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCCCCCC
Show InChI InChI=1S/C48H80O8/c1-7-9-11-13-15-17-19-21-23-25-27-29-40(50)55-44-36(4)47(54)38(32-37(34-49)33-46(53)39(47)31-35(3)43(46)52)42-45(5,6)48(42,44)56-41(51)30-28-26-24-22-20-18-16-14-12-10-8-2/h31-32,36,38-39,42,44,49,53-54H,7-30,33-34H2,1-6H3/t36-,38+,39-,42?,44-,46+,47-,48-/m1/s1
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n/an/an/an/a 2.83E+3n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277739
PNG
(4alpha-phorbol diacetate | CHEMBL484343)
Show SMILES C[C@@H]1[C@@H](OC(C)=O)[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
Show InChI InChI=1S/C24H32O8/c1-11-7-17-22(29,19(11)28)9-15(10-25)8-16-18-21(5,6)24(18,32-14(4)27)20(31-13(3)26)12(2)23(16,17)30/h7-8,12,16-18,20,25,29-30H,9-10H2,1-6H3/t12-,16+,17-,18?,20-,22+,23-,24-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277488
PNG
(4alpha-Phorbol 12,13-dioctanoate | CHEMBL507303)
Show SMILES CCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCC
Show InChI InChI=1S/C36H56O8/c1-7-9-11-13-15-17-28(38)43-32-24(4)35(42)26(20-25(22-37)21-34(41)27(35)19-23(3)31(34)40)30-33(5,6)36(30,32)44-29(39)18-16-14-12-10-8-2/h19-20,24,26-27,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,26+,27-,30?,32-,34+,35-,36-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277489
PNG
(4alpha-Phorbol 12,13-dinonanoate | CHEMBL130626)
Show SMILES CCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCC
Show InChI InChI=1S/C38H60O8/c1-7-9-11-13-15-17-19-30(40)45-34-26(4)37(44)28(22-27(24-39)23-36(43)29(37)21-25(3)33(36)42)32-35(5,6)38(32,34)46-31(41)20-18-16-14-12-10-8-2/h21-22,26,28-29,32,34,39,43-44H,7-20,23-24H2,1-6H3/t26-,28+,29-,32-,34-,36+,37-,38-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277740
PNG
(4-Deoxy-4alpha-Phorbol 12,13-didecanoate | CHEMBL5...)
Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@H]3CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCCCCCC
Show InChI InChI=1S/C40H64O7/c1-7-9-11-13-15-17-19-21-33(42)46-37-28(4)39(45)31-23-27(3)35(44)30(31)24-29(26-41)25-32(39)36-38(5,6)40(36,37)47-34(43)22-20-18-16-14-12-10-8-2/h23,25,28,30-32,36-37,41,45H,7-22,24,26H2,1-6H3/t28-,30-,31-,32+,36?,37-,39+,40-/m1/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277491
PNG
(CHEMBL504955 | Lumi-4alpha-Phorbol 12,13-didecanoa...)
Show SMILES CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@@H]3C(C)(C)[C@]13OC(=O)CCCCCCCCC)C1C3[C@@H]2[C@H]2CC1(CO)C3(C)C2=O
Show InChI InChI=1S/C40H64O7/c1-7-9-11-13-15-17-19-21-27(42)46-35-25(3)39(45)29-26-23-38(24-41)31(30(29)37(38,6)34(26)44)32(39)33-36(4,5)40(33,35)47-28(43)22-20-18-16-14-12-10-8-2/h25-26,29-33,35,41,45H,7-24H2,1-6H3/t25-,26-,29+,30?,31?,32+,33?,35-,37?,38?,39+,40-/m1/s1
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n/an/an/an/a 175n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50277487
PNG
(4alpha-Phorbol 12,13-dihexanoate | CHEMBL490470)
Show SMILES CCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCCCC
Show InChI InChI=1S/C32H48O8/c1-7-9-11-13-24(34)39-28-20(4)31(38)22(16-21(18-33)17-30(37)23(31)15-19(3)27(30)36)26-29(5,6)32(26,28)40-25(35)14-12-10-8-2/h15-16,20,22-23,26,28,33,37-38H,7-14,17-18H2,1-6H3/t20-,22+,23-,26?,28-,30+,31-,32-/m1/s1
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n/an/an/an/a 70n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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n/an/an/an/a 2.25E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration


J Med Chem 52: 2933-9 (2009)

More data for this
Ligand-Target Pair