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Compile Data Set for Download or QSAR

Found 150 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4 (TRPV4)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426556
PNG
(CHEMBL2323962)
Show SMILES COc1ccc(CN2C[C@@]3(CCC[C@](CC#N)(Cn4cnc5ccc(cc45)C#N)C3)OC2=O)cc1
Show InChI InChI=1S/C27H27N5O3/c1-34-22-6-3-20(4-7-22)15-31-18-27(35-25(31)33)10-2-9-26(16-27,11-12-28)17-32-19-30-23-8-5-21(14-29)13-24(23)32/h3-8,13,19H,2,9-11,15-18H2,1H3/t26-,27+/m1/s1
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n/an/a 0.00100n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TRPV4 (unknown origin) by ligand-gated assay


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426557
PNG
(CHEMBL2323961)
Show SMILES C[C@]1(Cn2cnc3ccc(cc23)C#N)CCC[C@@]2(CN(Cc3ccccc3F)C(=O)O2)C1
Show InChI InChI=1S/C25H25FN4O2/c1-24(15-30-17-28-21-8-7-18(12-27)11-22(21)30)9-4-10-25(14-24)16-29(23(31)32-25)13-19-5-2-3-6-20(19)26/h2-3,5-8,11,17H,4,9-10,13-16H2,1H3/t24-,25-/m0/s1
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n/an/a 0.00100n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TRPV4 (unknown origin) by ligand-gated assay


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426558
PNG
(CHEMBL2323960)
Show SMILES Brc1cccc(CN2C[C@@]3(CCC[C@H](Cn4cnc5ccc(cc45)C#N)C3)OC2=O)c1
Show InChI InChI=1S/C24H23BrN4O2/c25-20-5-1-3-18(9-20)13-28-15-24(31-23(28)30)8-2-4-19(11-24)14-29-16-27-21-7-6-17(12-26)10-22(21)29/h1,3,5-7,9-10,16,19H,2,4,8,11,13-15H2/t19-,24-/m0/s1
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n/an/a 0.00100n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TRPV4 (unknown origin) by ligand-gated assay


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426532
PNG
(CHEMBL2323936)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(cc1)C1(CCOCC1)C#N
Show InChI InChI=1S/C30H36Cl2N6O2/c1-19(2)34-29-35-27-24(17-23(31)26(32)25(27)28(39)36(3)4)38(29)22-9-13-37(14-10-22)21-7-5-20(6-8-21)30(18-33)11-15-40-16-12-30/h5-8,17,19,22H,9-16H2,1-4H3,(H,34,35)
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n/an/a 3.20n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426535
PNG
(CHEMBL2323945)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(OC(C)C)cc1
Show InChI InChI=1S/C27H35Cl2N5O2/c1-16(2)30-27-31-25-22(15-21(28)24(29)23(25)26(35)32(5)6)34(27)19-11-13-33(14-12-19)18-7-9-20(10-8-18)36-17(3)4/h7-10,15-17,19H,11-14H2,1-6H3,(H,30,31)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426534
PNG
(CHEMBL2323944)
Show SMILES COC(=O)C(C)(C)c1ccc(cc1)N1CCC(CC1)n1c(NC(C)C)nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc12
Show InChI InChI=1S/C29H37Cl2N5O3/c1-17(2)32-28-33-25-22(16-21(30)24(31)23(25)26(37)34(5)6)36(28)20-12-14-35(15-13-20)19-10-8-18(9-11-19)29(3,4)27(38)39-7/h8-11,16-17,20H,12-15H2,1-7H3,(H,32,33)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426531
PNG
(CHEMBL2323935)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(cc1)C(C)(C)C#N
Show InChI InChI=1S/C28H34Cl2N6O/c1-17(2)32-27-33-25-22(15-21(29)24(30)23(25)26(37)34(5)6)36(27)20-11-13-35(14-12-20)19-9-7-18(8-10-19)28(3,4)16-31/h7-10,15,17,20H,11-14H2,1-6H3,(H,32,33)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426536
PNG
(CHEMBL2323946)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C30H39Cl2N5O/c1-19(2)33-30-34-28-25(18-24(31)27(32)26(28)29(38)35(3)4)37(30)23-14-16-36(17-15-23)22-12-10-21(11-13-22)20-8-6-5-7-9-20/h10-13,18-20,23H,5-9,14-17H2,1-4H3,(H,33,34)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426537
PNG
(CHEMBL2323947)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C28H37Cl2N5O/c1-17(2)31-27-32-25-22(16-21(29)24(30)23(25)26(36)33(6)7)35(27)20-12-14-34(15-13-20)19-10-8-18(9-11-19)28(3,4)5/h8-11,16-17,20H,12-15H2,1-7H3,(H,31,32)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426538
PNG
(CHEMBL2323948)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccc(C)cc1
Show InChI InChI=1S/C25H31Cl2N5O/c1-15(2)28-25-29-23-20(14-19(26)22(27)21(23)24(33)30(4)5)32(25)18-10-12-31(13-11-18)17-8-6-16(3)7-9-17/h6-9,14-15,18H,10-13H2,1-5H3,(H,28,29)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426539
PNG
(CHEMBL2323949)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1cccc(C)c1
Show InChI InChI=1S/C25H31Cl2N5O/c1-15(2)28-25-29-23-20(14-19(26)22(27)21(23)24(33)30(4)5)32(25)17-9-11-31(12-10-17)18-8-6-7-16(3)13-18/h6-8,13-15,17H,9-12H2,1-5H3,(H,28,29)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191666
PNG
(US9186360, 84)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3F)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H12F5N5O3S2/c1-28-15(31)12-9(27-34-16(12)29(2)18(28)32)5-11(30)26-17-25-10(6-33-17)7-3-4-8(19(22,23)24)14(21)13(7)20/h3-4,6H,5H2,1-2H3,(H,25,26,30)
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n/an/a 132n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191727
PNG
(US9186360, 78)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(cc3F)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)14-11(26-33-16(14)28(2)18(27)31)6-13(29)25-17-24-12(7-32-17)9-4-3-8(5-10(9)20)19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)
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n/an/a 153n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191734
PNG
(US9186360, 88)
Show SMILES Cn1c2nccc(CC(=O)Nc3nc(cs3)-c3ccc(OC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H15F4N5O4S/c1-29-17-16(18(32)30(2)20(29)33)11(5-6-26-17)8-15(31)28-19-27-13(9-35-19)10-3-4-14(12(22)7-10)34-21(23,24)25/h3-7,9H,8H2,1-2H3,(H,27,28,31)
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n/an/a 158n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191729
PNG
(US9186360, 81)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)14-11(26-33-16(14)28(2)18(27)31)6-13(29)25-17-24-12(7-32-17)8-3-4-9(10(20)5-8)19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)
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n/an/a 162n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191730
PNG
(US9186360, 82)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(OC(F)(F)F)c(F)c3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H13F4N5O4S2/c1-27-15(30)14-10(26-34-16(14)28(2)18(27)31)6-13(29)25-17-24-11(7-33-17)8-3-4-12(9(20)5-8)32-19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)
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n/an/a 172n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426542
PNG
(CHEMBL2323942)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H29Cl2N5O/c1-15(2)27-24-28-22-19(14-18(25)21(26)20(22)23(32)29(3)4)31(24)17-10-12-30(13-11-17)16-8-6-5-7-9-16/h5-9,14-15,17H,10-13H2,1-4H3,(H,27,28)
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TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191731
PNG
(US9186360, 83)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3cc(F)cc(c3)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)14-11(26-33-16(14)28(2)18(27)31)6-13(29)25-17-24-12(7-32-17)8-3-9(19(21,22)23)5-10(20)4-8/h3-5,7H,6H2,1-2H3,(H,24,25,29)
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n/an/a 237n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117640
PNG
(CHEMBL3613639)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)cc1
Show InChI InChI=1S/C20H24F5N3O3S2/c1-15(2)27-11-13-28(14-12-27)32(30,31)18-7-5-17(6-8-18)26-20(29)16-3-9-19(10-4-16)33(21,22,23,24)25/h3-10,15H,11-14H2,1-2H3,(H,26,29)
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n/an/a 260n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191657
PNG
(US9186360, 80)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(OC(F)(F)F)c(Cl)c3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H13ClF3N5O4S2/c1-27-15(30)14-10(26-34-16(14)28(2)18(27)31)6-13(29)25-17-24-11(7-33-17)8-3-4-12(9(20)5-8)32-19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)
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n/an/a 279n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117639
PNG
(CHEMBL3613640)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F4N3O3S/c1-14(2)27-9-11-28(12-10-27)32(30,31)17-6-4-16(5-7-17)26-20(29)18-8-3-15(13-19(18)22)21(23,24)25/h3-8,13-14H,9-12H2,1-2H3,(H,26,29)
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n/an/a 380n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117646
PNG
(CHEMBL3613628)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Show InChI InChI=1S/C24H33N3O3S/c1-18(2)26-14-16-27(17-15-26)31(29,30)22-12-10-21(11-13-22)25-23(28)19-6-8-20(9-7-19)24(3,4)5/h6-13,18H,14-17H2,1-5H3,(H,25,28)
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n/an/a 390n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 420n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191646
PNG
(US9186360, 21)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(Cl)c(c3)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C22H16ClF3N4O3S/c1-29-16-5-3-4-12(18(16)19(32)30(2)21(29)33)9-17(31)28-20-27-15(10-34-20)11-6-7-14(23)13(8-11)22(24,25)26/h3-8,10H,9H2,1-2H3,(H,27,28,31)
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n/an/a 520n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117638
PNG
(CHEMBL3613641)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H23F6N3O3S/c1-14(2)30-9-11-31(12-10-30)35(33,34)17-6-4-16(5-7-17)29-20(32)18-8-3-15(21(23,24)25)13-19(18)22(26,27)28/h3-8,13-14H,9-12H2,1-2H3,(H,29,32)
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n/an/a 540n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191726
PNG
(US9186360, 77)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3ccc(F)c(c3F)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H12F5N5O3S2/c1-28-15(31)12-9(27-34-16(12)29(2)18(28)32)5-11(30)26-17-25-10(6-33-17)7-3-4-8(20)13(14(7)21)19(22,23)24/h3-4,6H,5H2,1-2H3,(H,25,26,30)
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n/an/a 553n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 570n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191732
PNG
(US9186360, 85)
Show SMILES Cn1c2nccc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H15F4N5O3S/c1-29-17-16(18(32)30(2)20(29)33)11(5-6-26-17)8-15(31)28-19-27-14(9-34-19)10-3-4-12(13(22)7-10)21(23,24)25/h3-7,9H,8H2,1-2H3,(H,27,28,31)
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n/an/a 620n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426544
PNG
(CHEMBL2323940)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1-c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C24H29Cl2N5O/c1-15(2)27-24-28-22-19(14-18(25)21(26)20(22)23(32)29(3)4)31(24)17-10-8-16(9-11-17)30-12-6-5-7-13-30/h8-11,14-15H,5-7,12-13H2,1-4H3,(H,27,28)
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n/an/a 631n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117645
PNG
(CHEMBL3613629)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N3O3S/c1-15(2)26-11-13-27(14-12-26)31(29,30)19-9-7-18(8-10-19)25-20(28)16-3-5-17(6-4-16)21(22,23)24/h3-10,15H,11-14H2,1-2H3,(H,25,28)
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n/an/a 710n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117650
PNG
(CHEMBL3613638)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1CCCC1
Show InChI InChI=1S/C23H26F3N3O3S/c24-23(25,26)18-7-5-17(6-8-18)22(30)27-19-9-11-21(12-10-19)33(31,32)29-15-13-28(14-16-29)20-3-1-2-4-20/h5-12,20H,1-4,13-16H2,(H,27,30)
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n/an/a 800n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191728
PNG
(US9186360, 79)
Show SMILES Cn1c2snc(CC(=O)Nc3nc(cs3)-c3cccc(c3F)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H13F4N5O3S2/c1-27-15(30)13-10(26-33-16(13)28(2)18(27)31)6-12(29)25-17-24-11(7-32-17)8-4-3-5-9(14(8)20)19(21,22)23/h3-5,7H,6H2,1-2H3,(H,24,25,29)
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n/an/a 826n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191689
PNG
(US9186360, 28)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(c(F)c3F)C(F)(F)F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C22H15F5N4O3S/c1-30-14-5-3-4-10(16(14)19(33)31(2)21(30)34)8-15(32)29-20-28-13(9-35-20)11-6-7-12(22(25,26)27)18(24)17(11)23/h3-7,9H,8H2,1-2H3,(H,28,29,32)
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n/an/a 903n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117652
PNG
(CHEMBL3613636)
Show SMILES CCN(CC)C1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H28F3N3O3S/c1-3-28(4-2)20-13-15-29(16-14-20)33(31,32)21-11-9-19(10-12-21)27-22(30)17-5-7-18(8-6-17)23(24,25)26/h5-12,20H,3-4,13-16H2,1-2H3,(H,27,30)
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n/an/a 910n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117637
PNG
(CHEMBL3613643)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2N)C(F)(F)F)cc1
Show InChI InChI=1S/C21H25F3N4O3S/c1-14(2)27-9-11-28(12-10-27)32(30,31)17-6-4-16(5-7-17)26-20(29)18-8-3-15(13-19(18)25)21(22,23)24/h3-8,13-14H,9-12,25H2,1-2H3,(H,26,29)
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n/an/a 930n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117647
PNG
(CHEMBL3613627)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2Cl)cc1
Show InChI InChI=1S/C25H27ClN4O3S/c1-18(2)29-14-16-30(17-15-29)34(32,33)22-11-9-21(10-12-22)28-25(31)20-7-5-19(6-8-20)24-23(26)4-3-13-27-24/h3-13,18H,14-17H2,1-2H3,(H,28,31)
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n/an/a 930n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191668
PNG
(US9186360, 3)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(Br)cc3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H17BrN4O3S/c1-25-16-5-3-4-13(18(16)19(28)26(2)21(25)29)10-17(27)24-20-23-15(11-30-20)12-6-8-14(22)9-7-12/h3-9,11H,10H2,1-2H3,(H,23,24,27)
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n/an/a 969n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426545
PNG
(CHEMBL2323939)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C25H31Cl2N5O/c1-16(2)28-25-29-23-20(14-19(26)22(27)21(23)24(33)30(3)4)32(25)18-10-12-31(13-11-18)15-17-8-6-5-7-9-17/h5-9,14,16,18H,10-13,15H2,1-4H3,(H,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191669
PNG
(US9186360, 4)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H16Cl2N4O3S/c1-26-16-5-3-4-12(18(16)19(29)27(2)21(26)30)9-17(28)25-20-24-15(10-31-20)11-6-7-13(22)14(23)8-11/h3-8,10H,9H2,1-2H3,(H,24,25,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191643
PNG
(US9186360, 5)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(I)cc3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H17IN4O3S/c1-25-16-5-3-4-13(18(16)19(28)26(2)21(25)29)10-17(27)24-20-23-15(11-30-20)12-6-8-14(22)9-7-12/h3-9,11H,10H2,1-2H3,(H,23,24,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191670
PNG
(US9186360, 6)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)Cc2cccc3n(C)c(=O)n(C)c(=O)c23)n1
Show InChI InChI=1S/C22H20N4O3S/c1-13-7-9-14(10-8-13)16-12-30-21(23-16)24-18(27)11-15-5-4-6-17-19(15)20(28)26(3)22(29)25(17)2/h4-10,12H,11H2,1-3H3,(H,23,24,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191672
PNG
(US9186360, 8)
Show SMILES Cn1c2cccc(CC(=O)Nc3ccn(n3)-c3ccc(Cl)cc3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H18ClN5O3/c1-25-16-5-3-4-13(19(16)20(29)26(2)21(25)30)12-18(28)23-17-10-11-27(24-17)15-8-6-14(22)7-9-15/h3-11H,12H2,1-2H3,(H,23,24,28)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191673
PNG
(US9186360, 9)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3cccc(Cl)c3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H17ClN4O3S/c1-25-16-8-4-6-13(18(16)19(28)26(2)21(25)29)10-17(27)24-20-23-15(11-30-20)12-5-3-7-14(22)9-12/h3-9,11H,10H2,1-2H3,(H,23,24,27)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191675
PNG
(US9186360, 12)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(cc3)C(C)(C)C)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C25H26N4O3S/c1-25(2,3)17-11-9-15(10-12-17)18-14-33-23(26-18)27-20(30)13-16-7-6-8-19-21(16)22(31)29(5)24(32)28(19)4/h6-12,14H,13H2,1-5H3,(H,26,27,30)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191677
PNG
(US9186360, 14)
Show SMILES CC(C)c1ccc(cc1)-c1csc(NC(=O)Cc2cccc3n(C)c(=O)n(C)c(=O)c23)n1
Show InChI InChI=1S/C24H24N4O3S/c1-14(2)15-8-10-16(11-9-15)18-13-32-23(25-18)26-20(29)12-17-6-5-7-19-21(17)22(30)28(4)24(31)27(19)3/h5-11,13-14H,12H2,1-4H3,(H,25,26,29)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191678
PNG
(US9186360, 15)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3ccc(F)c(Cl)c3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H16ClFN4O3S/c1-26-16-5-3-4-12(18(16)19(29)27(2)21(26)30)9-17(28)25-20-24-15(10-31-20)11-6-7-14(23)13(22)8-11/h3-8,10H,9H2,1-2H3,(H,24,25,28)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191680
PNG
(US9186360, 17)
Show SMILES CCc1ccc(cc1)-c1csc(NC(=O)Cc2cccc3n(C)c(=O)n(C)c(=O)c23)n1
Show InChI InChI=1S/C23H22N4O3S/c1-4-14-8-10-15(11-9-14)17-13-31-22(24-17)25-19(28)12-16-6-5-7-18-20(16)21(29)27(3)23(30)26(18)2/h5-11,13H,4,12H2,1-3H3,(H,24,25,28)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191683
PNG
(US9186360, 22)
Show SMILES CC(C)CCOc1ccc(cc1)-c1csc(NC(=O)Cc2cccc3n(C)c(=O)n(C)c(=O)c23)n1
Show InChI InChI=1S/C26H28N4O4S/c1-16(2)12-13-34-19-10-8-17(9-11-19)20-15-35-25(27-20)28-22(31)14-18-6-5-7-21-23(18)24(32)30(4)26(33)29(21)3/h5-11,15-16H,12-14H2,1-4H3,(H,27,28,31)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191684
PNG
(US9186360, 23)
Show SMILES CC(C)COc1ccc(cc1)-c1csc(NC(=O)Cc2cccc3n(C)c(=O)n(C)c(=O)c23)n1
Show InChI InChI=1S/C25H26N4O4S/c1-15(2)13-33-18-10-8-16(9-11-18)19-14-34-24(26-19)27-21(30)12-17-6-5-7-20-22(17)23(31)29(4)25(32)28(20)3/h5-11,14-15H,12-13H2,1-4H3,(H,26,27,30)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM191686
PNG
(US9186360, 25)
Show SMILES Cn1c2cccc(CC(=O)Nc3nc(cs3)-c3cccc(Cl)c3F)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C21H16ClFN4O3S/c1-26-15-8-3-5-11(17(15)19(29)27(2)21(26)30)9-16(28)25-20-24-14(10-31-20)12-6-4-7-13(22)18(12)23/h3-8,10H,9H2,1-2H3,(H,24,25,28)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



GLENMARK PHARMACEUTICALS S.A.

US Patent


Assay Description
The inhibition of TRPA1 receptor activation was measured as inhibition of allylisothiocyanate (AITC) induced cellular uptake of radioactive calcium. ...


US Patent US9186360 (2015)

More data for this
Ligand-Target Pair
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