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Compile Data Set for Download or QSAR

Found 304 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4 (TRPV4)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230228
PNG
(US9340500, I-072)
Show SMILES Cc1c(cc(C2CCCCC2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h5,9-10,17-18,20H,2-4,6-8,11-16H2,1H3,(H,30,33)
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21n/a 45n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230231
PNG
(US9340500, I-075)
Show SMILES Cc1c(cc(C2CCN(CC2)C(=O)OCc2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C33H39F3N4O4/c1-24-29(31(41)37-28-10-5-9-27(21-28)33(34,35)36)22-30(40(24)14-6-13-38-17-19-43-20-18-38)26-11-15-39(16-12-26)32(42)44-23-25-7-3-2-4-8-25/h2-5,7-10,21-22,26H,6,11-20,23H2,1H3,(H,37,41)
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130n/a 270n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230252
PNG
(US9340500, I-096)
Show SMILES CNC(C)CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H30F3N3O/c1-14(26-6)10-11-28-15(2)18(13-19(28)21(3,4)5)20(29)27-17-9-7-8-16(12-17)22(23,24)25/h7-9,12-14,26H,10-11H2,1-6H3,(H,27,29)
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130n/a 420n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230253
PNG
(US9340500, I-097)
Show SMILES CC(CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1/C25H34F3N3O2/c1-17(30-11-13-33-14-12-30)9-10-31-18(2)21(16-22(31)24(3,4)5)23(32)29-20-8-6-7-19(15-20)25(26,27)28/h6-8,15-17H,9-14H2,1-5H3,(H,29,32)
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130n/a 430n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230229
PNG
(US9340500, I-073)
Show SMILES Cc1c(cc(-c2ccccn2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-21(24(33)30-20-7-4-6-19(16-20)25(26,27)28)17-23(22-8-2-3-9-29-22)32(18)11-5-10-31-12-14-34-15-13-31/h2-4,6-9,16-17H,5,10-15H2,1H3,(H,30,33)
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160n/a 340n/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230187
PNG
(US9340500, I-031)
Show SMILES CNCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-2/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)
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160n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230174
PNG
(US9340500, I-018)
Show SMILES CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-17-21(23(31)28-20-12-7-11-19(15-20)24(25,26)27)16-22(18-9-5-4-6-10-18)30(17)14-8-13-29(2)3/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,28,31)
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169n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230264
PNG
(US9340500, I-108)
Show SMILES Cc1c(cc(n1CC(C)(C)CN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H36F3N3O2/c1-18-21(23(33)30-20-9-7-8-19(14-20)26(27,28)29)15-22(24(2,3)4)32(18)17-25(5,6)16-31-10-12-34-13-11-31/h7-9,14-15H,10-13,16-17H2,1-6H3,(H,30,33)
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170n/a 540n/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230172
PNG
(US9340500, I-016)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN(CCO)CCO)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F3N3O3/c1-19-23(25(35)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31(13-15-33)14-16-34/h2-5,7-10,17-18,33-34H,6,11-16H2,1H3,(H,30,35)
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191n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230227
PNG
(US9340500, I-071)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCNC(=O)C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O2/c1-18-22(25(35)31-21-10-5-9-20(15-21)26(27,28)29)16-23(19-7-3-2-4-8-19)33(18)13-6-12-32-14-11-30-24(34)17-32/h2-5,7-10,15-16H,6,11-14,17H2,1H3,(H,30,34)(H,31,35)
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196n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230158
PNG
(US9340500, I-002)
Show SMILES Cc1c(cc(n1CCCN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H32F3N3O2/c1-17-20(22(31)28-19-8-5-7-18(15-19)24(25,26)27)16-21(23(2,3)4)30(17)10-6-9-29-11-13-32-14-12-29/h5,7-8,15-16H,6,9-14H2,1-4H3,(H,28,31)
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197n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230278
PNG
(US9340500, I-122)
Show SMILES Cc1c(cc(n1CC(F)(F)CN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H30F5N3O2/c1-16-19(21(33)30-18-7-5-6-17(12-18)24(27,28)29)13-20(22(2,3)4)32(16)15-23(25,26)14-31-8-10-34-11-9-31/h5-7,12-13H,8-11,14-15H2,1-4H3,(H,30,33)
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240n/a 780n/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230219
PNG
(US9340500, I-063)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccno1
Show InChI InChI=1S/C27H25F3N4O3/c1-18-22(25(35)32-21-11-6-10-20(16-21)27(28,29)30)17-23(19-8-4-3-5-9-19)34(18)15-7-14-33(2)26(36)24-12-13-31-37-24/h3-6,8-13,16-17H,7,14-15H2,1-2H3,(H,32,35)
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251n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230195
PNG
(US9340500, I-039)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CCN(C)CC1
Show InChI InChI=1S/C30H37F3N4O/c1-22-27(29(38)34-26-12-7-11-25(19-26)30(31,32)33)20-28(24-9-5-4-6-10-24)37(22)16-8-15-36(3)21-23-13-17-35(2)18-14-23/h4-7,9-12,19-20,23H,8,13-18,21H2,1-3H3,(H,34,38)
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282n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230256
PNG
(US9340500, I-100)
Show SMILES CNCC(C)(C)Cn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H32F3N3O/c1-15-18(20(30)28-17-10-8-9-16(11-17)23(24,25)26)12-19(21(2,3)4)29(15)14-22(5,6)13-27-7/h8-12,27H,13-14H2,1-7H3,(H,28,30)
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290n/a 830n/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230243
PNG
(US9340500, I-087)
Show SMILES Cc1c(nc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)29-21-10-5-9-20(17-21)25(26,27)28)30-23(19-7-3-2-4-8-19)32(18)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17H,6,11-16H2,1H3,(H,29,33)
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320n/a 710n/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230203
PNG
(US9340500, I-047)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccncc1
Show InChI InChI=1S/C29H27F3N4O2/c1-20-25(27(37)34-24-11-6-10-23(18-24)29(30,31)32)19-26(21-8-4-3-5-9-21)36(20)17-7-16-35(2)28(38)22-12-14-33-15-13-22/h3-6,8-15,18-19H,7,16-17H2,1-2H3,(H,34,37)
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320n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230164
PNG
(US9340500, I-008)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCCCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N3O/c1-20-24(26(34)31-23-13-8-12-22(18-23)27(28,29)30)19-25(21-10-4-2-5-11-21)33(20)17-9-16-32-14-6-3-7-15-32/h2,4-5,8,10-13,18-19H,3,6-7,9,14-17H2,1H3,(H,31,34)
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327n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230194
PNG
(US9340500, I-038)
Show SMILES CN(C)CC(C)(C)CN(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H39F3N4O/c1-22-26(28(38)34-25-15-10-14-24(18-25)30(31,32)33)19-27(23-12-8-7-9-13-23)37(22)17-11-16-36(6)21-29(2,3)20-35(4)5/h7-10,12-15,18-19H,11,16-17,20-21H2,1-6H3,(H,34,38)
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352n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230170
PNG
(US9340500, I-014)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCNCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N4O/c1-19-23(25(34)31-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)33(19)14-6-13-32-15-11-30-12-16-32/h2-5,7-10,17-18,30H,6,11-16H2,1H3,(H,31,34)
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355n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230177
PNG
(US9340500, I-021)
Show SMILES Cc1c(cc(-c2cccnc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)30-21-7-2-6-20(15-21)25(26,27)28)16-23(19-5-3-8-29-17-19)32(18)10-4-9-31-11-13-34-14-12-31/h2-3,5-8,15-17H,4,9-14H2,1H3,(H,30,33)
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379n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230251
PNG
(US9340500, I-095)
Show SMILES Cc1c(cc(n1CCS(=O)(=O)N1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H30F3N3O4S/c1-16-19(21(30)27-18-7-5-6-17(14-18)23(24,25)26)15-20(22(2,3)4)29(16)10-13-34(31,32)28-8-11-33-12-9-28/h5-7,14-15H,8-13H2,1-4H3,(H,27,30)
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380n/a 970n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230246
PNG
(US9340500, I-090)
Show SMILES CCOC(=O)CCn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H27F3N2O3/c1-6-30-19(28)10-11-27-14(2)17(13-18(27)21(3,4)5)20(29)26-16-9-7-8-15(12-16)22(23,24)25/h7-9,12-13H,6,10-11H2,1-5H3,(H,26,29)
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380n/a 1.10E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230205
PNG
(US9340500, I-049)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCCC1
Show InChI InChI=1S/C29H32F3N3O2/c1-20-25(27(36)33-24-15-8-14-23(18-24)29(30,31)32)19-26(21-10-4-3-5-11-21)35(20)17-9-16-34(2)28(37)22-12-6-7-13-22/h3-5,8,10-11,14-15,18-19,22H,6-7,9,12-13,16-17H2,1-2H3,(H,33,36)
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418n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230182
PNG
(US9340500, I-026)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCNS(C)(=O)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O3S/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-33(2,31)32/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)
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427n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230239
PNG
(US9340500, I-083)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N3O2/c1-18-22(24(32)29-21-9-5-8-20(16-21)25(26,27)28)17-23(19-6-3-2-4-7-19)31(18)11-10-30-12-14-33-15-13-30/h2-9,16-17H,10-15H2,1H3,(H,29,32)
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443n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230279
PNG
(US9340500, I-123)
Show SMILES Cc1c(cc(n1CC(C)(C)CN1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H37F3N4O/c1-18-21(23(34)31-20-9-7-8-19(14-20)26(27,28)29)15-22(24(2,3)4)33(18)17-25(5,6)16-32-12-10-30-11-13-32/h7-9,14-15,30H,10-13,16-17H2,1-6H3,(H,31,34)
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450n/a 1.40E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230277
PNG
(US9340500, I-121)
Show SMILES CNCC(F)(F)Cn1c(C)c(cc1C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H26F5N3O/c1-13-16(18(30)28-15-8-6-7-14(9-15)21(24,25)26)10-17(19(2,3)4)29(13)12-20(22,23)11-27-5/h6-10,27H,11-12H2,1-5H3,(H,28,30)
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450n/a 1.40E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230169
PNG
(US9340500, I-013)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C25H28ClN3O2/c1-19-23(25(30)27-22-10-5-9-21(26)17-22)18-24(20-7-3-2-4-8-20)29(19)12-6-11-28-13-15-31-16-14-28/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,27,30)
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453n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230215
PNG
(US9340500, I-059)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CCC1
Show InChI InChI=1S/C28H30F3N3O2/c1-19-24(26(35)32-23-14-7-13-22(17-23)28(29,30)31)18-25(20-9-4-3-5-10-20)34(19)16-8-15-33(2)27(36)21-11-6-12-21/h3-5,7,9-10,13-14,17-18,21H,6,8,11-12,15-16H2,1-2H3,(H,32,35)
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472n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230185
PNG
(US9340500, I-029)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(-c3ccccc3)n(CCCN3CCOCC3)c2C)c1
Show InChI InChI=1S/C28H35N3O2/c1-21(2)24-11-7-12-25(19-24)29-28(32)26-20-27(23-9-5-4-6-10-23)31(22(26)3)14-8-13-30-15-17-33-18-16-30/h4-7,9-12,19-21H,8,13-18H2,1-3H3,(H,29,32)
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519n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230249
PNG
(US9340500, I-093)
Show SMILES Cc1c(cc(n1CCC(=O)N1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H31F3N4O2/c1-16-19(22(33)29-18-7-5-6-17(14-18)24(25,26)27)15-20(23(2,3)4)31(16)11-8-21(32)30-12-9-28-10-13-30/h5-7,14-15,28H,8-13H2,1-4H3,(H,29,33)
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530n/a 1.40E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230247
PNG
(US9340500, I-091)
Show SMILES Cc1c(cc(n1CCC(=O)N1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O3/c1-16-19(22(32)28-18-7-5-6-17(14-18)24(25,26)27)15-20(23(2,3)4)30(16)9-8-21(31)29-10-12-33-13-11-29/h5-7,14-15H,8-13H2,1-4H3,(H,28,32)
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560n/a 1.50E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230212
PNG
(US9340500, I-056)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C32H31F3N4O3/c1-21-28(30(41)37-27-12-7-11-25(19-27)32(33,34)35)20-29(23-9-5-4-6-10-23)39(21)18-8-17-38(3)31(42)24-13-15-26(16-14-24)36-22(2)40/h4-7,9-16,19-20H,8,17-18H2,1-3H3,(H,36,40)(H,37,41)
PDB

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560n/an/an/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230241
PNG
(US9340500, I-085)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2cc(nn2CCCN2CCOCC2)-c2ccccc2)c1
Show InChI InChI=1S/C24H25F3N4O2/c25-24(26,27)19-8-4-9-20(16-19)28-23(32)22-17-21(18-6-2-1-3-7-18)29-31(22)11-5-10-30-12-14-33-15-13-30/h1-4,6-9,16-17H,5,10-15H2,(H,28,32)
PDB

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590n/a 1.30E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230254
PNG
(US9340500, I-098)
Show SMILES Cc1c(cc(n1CCS(=O)(=O)N1CCNCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H31F3N4O3S/c1-16-19(21(31)28-18-7-5-6-17(14-18)23(24,25)26)15-20(22(2,3)4)30(16)12-13-34(32,33)29-10-8-27-9-11-29/h5-7,14-15,27H,8-13H2,1-4H3,(H,28,31)
PDB

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590n/a 1.90E+3n/an/an/an/an/an/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230207
PNG
(US9340500, I-051)
Show SMILES CC(C)C(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N3O2/c1-18(2)26(35)32(4)14-9-15-33-19(3)23(17-24(33)20-10-6-5-7-11-20)25(34)31-22-13-8-12-21(16-22)27(28,29)30/h5-8,10-13,16-18H,9,14-15H2,1-4H3,(H,31,34)
PDB

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590n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230179
PNG
(US9340500, I-023)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O/c1-15-19(21(29)27-18-10-5-9-17(13-18)22(23,24)25)14-20(28(15)12-6-11-26)16-7-3-2-4-8-16/h2-5,7-10,13-14H,6,11-12,26H2,1H3,(H,27,29)
PDB

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605n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230189
PNG
(US9340500, I-033)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CC1
Show InChI InChI=1S/C27H30F3N3O/c1-19-24(26(34)31-23-11-6-10-22(16-23)27(28,29)30)17-25(21-8-4-3-5-9-21)33(19)15-7-14-32(2)18-20-12-13-20/h3-6,8-11,16-17,20H,7,12-15,18H2,1-2H3,(H,31,34)
PDB

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655n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230222
PNG
(US9340500, I-066)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cnc2ccccc2n1
Show InChI InChI=1S/C32H28F3N5O2/c1-21-25(30(41)37-24-13-8-12-23(18-24)32(33,34)35)19-29(22-10-4-3-5-11-22)40(21)17-9-16-39(2)31(42)28-20-36-26-14-6-7-15-27(26)38-28/h3-8,10-15,18-20H,9,16-17H2,1-2H3,(H,37,41)
PDB

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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230165
PNG
(US9340500, I-009)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H29N3O2/c1-20-23(25(29)26-22-11-6-3-7-12-22)19-24(21-9-4-2-5-10-21)28(20)14-8-13-27-15-17-30-18-16-27/h2-7,9-12,19H,8,13-18H2,1H3,(H,26,29)
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230186
PNG
(US9340500, I-030)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H32F3N3O3/c1-19-23(25(35)32-22-14-9-13-21(17-22)28(29,30)31)18-24(20-11-7-6-8-12-20)34(19)16-10-15-33(5)26(36)37-27(2,3)4/h6-9,11-14,17-18H,10,15-16H2,1-5H3,(H,32,35)
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230208
PNG
(US9340500, I-052)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C27H28F3N3O2/c1-18-23(25(34)31-22-11-6-10-21(16-22)27(28,29)30)17-24(19-8-4-3-5-9-19)33(18)15-7-14-32(2)26(35)20-12-13-20/h3-6,8-11,16-17,20H,7,12-15H2,1-2H3,(H,31,34)
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230220
PNG
(US9340500, I-064)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)C(Cl)(Cl)Cl
Show InChI InChI=1S/C25H23Cl3F3N3O2/c1-16-20(22(35)32-19-11-6-10-18(14-19)25(29,30)31)15-21(17-8-4-3-5-9-17)34(16)13-7-12-33(2)23(36)24(26,27)28/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,32,35)
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230166
PNG
(US9340500, I-010)
Show SMILES COCCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N2O2/c1-16-20(22(29)27-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)28(16)12-7-13-30-2/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,27,29)
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230180
PNG
(US9340500, I-024)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-8-21(9-11-22)26(27,28)29)18-24(20-6-3-2-4-7-20)32(19)13-5-12-31-14-16-34-17-15-31/h2-4,6-11,18H,5,12-17H2,1H3,(H,30,33)
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230191
PNG
(US9340500, I-035)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC[C@H](O)[C@H](O)CO
Show InChI InChI=1/C28H34F3N3O4/c1-19-23(27(38)32-22-11-6-10-21(16-22)28(29,30)31)17-24(20-8-4-3-5-9-20)34(19)14-7-13-33(2)15-12-25(36)26(37)18-35/h3-6,8-11,16-17,25-26,35-37H,7,12-15,18H2,1-2H3,(H,32,38)/t25-,26+/s2
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230230
PNG
(US9340500, I-074)
Show SMILES Cc1c(cc(-c2ccncc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-18-22(24(33)30-21-5-2-4-20(16-21)25(26,27)28)17-23(19-6-8-29-9-7-19)32(18)11-3-10-31-12-14-34-15-13-31/h2,4-9,16-17H,3,10-15H2,1H3,(H,30,33)
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230225
PNG
(US9340500, I-069)
Show SMILES CN(C)c1cccc(c1)C(=O)N(C)CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C32H33F3N4O2/c1-22-28(30(40)36-26-15-9-14-25(20-26)32(33,34)35)21-29(23-11-6-5-7-12-23)39(22)18-10-17-38(4)31(41)24-13-8-16-27(19-24)37(2)3/h5-9,11-16,19-21H,10,17-18H2,1-4H3,(H,36,40)
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230200
PNG
(US9340500, I-044)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cccs1
Show InChI InChI=1S/C28H26F3N3O2S/c1-19-23(26(35)32-22-12-6-11-21(17-22)28(29,30)31)18-24(20-9-4-3-5-10-20)34(19)15-8-14-33(2)27(36)25-13-7-16-37-25/h3-7,9-13,16-18H,8,14-15H2,1-2H3,(H,32,35)
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US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)

More data for this
Ligand-Target Pair
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