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Compile Data Set for Download or QSAR

Found 113 hits Enz. Inhib. hit(s) with Target = 'Transmembrane protease serine 6' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032697
PNG
(CHEMBL3354675)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C33H46N12O6S/c34-20(5-3-15-40-32(36)37)28(49)43-23(13-14-26(35)47)29(50)44-24(17-18-9-11-19(46)12-10-18)30(51)42-22(7-4-16-41-33(38)39)27(48)31-45-21-6-1-2-8-25(21)52-31/h1-2,6,8-12,20,22-24,46H,3-5,7,13-17,34H2,(H2,35,47)(H,42,51)(H,43,49)(H,44,50)(H4,36,37,40)(H4,38,39,41)/t20-,22-,23-,24-/s2
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0.740n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032706
PNG
(CHEMBL3354683)
Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C36H41N9O5S2/c37-24(17-21-18-41-25-7-2-1-6-23(21)25)32(48)44-29(19-51)34(50)43-28(16-20-11-13-22(46)14-12-20)33(49)42-27(9-5-15-40-36(38)39)31(47)35-45-26-8-3-4-10-30(26)52-35/h1-4,6-8,10-14,18,24,27-29,41,46,51H,5,9,15-17,19,37H2,(H,42,49)(H,43,50)(H,44,48)(H4,38,39,40)/t24-,27-,28-,29-/s2
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1n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032698
PNG
(CHEMBL3354676)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C33H46N12O5S/c34-20(10-6-16-40-32(36)37)28(48)43-23(14-15-26(35)46)29(49)44-24(18-19-8-2-1-3-9-19)30(50)42-22(12-7-17-41-33(38)39)27(47)31-45-21-11-4-5-13-25(21)51-31/h1-5,8-9,11,13,20,22-24H,6-7,10,12,14-18,34H2,(H2,35,46)(H,42,50)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t20-,22-,23-,24-/s2
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1.40n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032708
PNG
(CHEMBL3354685)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C41H48N10O4S/c1-23(2)18-28(42)37(53)49-33(19-24-21-46-29-12-5-3-10-26(24)29)39(55)50-34(20-25-22-47-30-13-6-4-11-27(25)30)38(54)48-32(15-9-17-45-41(43)44)36(52)40-51-31-14-7-8-16-35(31)56-40/h3-8,10-14,16,21-23,28,32-34,46-47H,9,15,17-20,42H2,1-2H3,(H,48,54)(H,49,53)(H,50,55)(H4,43,44,45)/t28-,32-,33-,34-/s2
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2n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032709
PNG
(CHEMBL3354686)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C28H45N11O5S/c1-15(2)13-19(37-23(42)16(29)7-5-11-34-27(30)31)24(43)38-20(14-40)25(44)36-18(9-6-12-35-28(32)33)22(41)26-39-17-8-3-4-10-21(17)45-26/h3-4,8,10,15-16,18-20,40H,5-7,9,11-14,29H2,1-2H3,(H,36,44)(H,37,42)(H,38,43)(H4,30,31,34)(H4,32,33,35)/t16-,18-,19-,20-/s2
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2.5n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032707
PNG
(CHEMBL3354684)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C36H44N8O6S/c1-20(2)30(34(50)41-27(7-5-17-40-36(38)39)31(47)35-43-26-6-3-4-8-29(26)51-35)44-33(49)28(19-22-11-15-24(46)16-12-22)42-32(48)25(37)18-21-9-13-23(45)14-10-21/h3-4,6,8-16,20,25,27-28,30,45-46H,5,7,17-19,37H2,1-2H3,(H,41,50)(H,42,48)(H,44,49)(H4,38,39,40)/t25-,27-,28-,30-/s2
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2.60n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50420334
PNG
(CHEMBL2086421)
Show SMILES C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C27H42N12O5S/c1-14(36-24(44)18(10-11-20(29)40)38-23(43)15(28)6-4-12-34-26(30)31)22(42)37-17(8-5-13-35-27(32)33)21(41)25-39-16-7-2-3-9-19(16)45-25/h2-3,7,9,14-15,17-18H,4-6,8,10-13,28H2,1H3,(H2,29,40)(H,36,44)(H,37,42)(H,38,43)(H4,30,31,34)(H4,32,33,35)/t14-,15-,17-,18-/m0/s1
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3.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tight binding inhibition of human matriptase2 expressed in Drosophila melanogaster S2 cells using Boc-QAR-AMC as substrate incubated for 15 mins prio...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032699
PNG
(CHEMBL3354677)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C31H43N11O5S/c1-17(26(45)40-22(8-5-15-38-31(35)36)25(44)29-42-21-7-2-3-9-24(21)48-29)39-28(47)23(16-18-10-12-19(43)13-11-18)41-27(46)20(32)6-4-14-37-30(33)34/h2-3,7,9-13,17,20,22-23,43H,4-6,8,14-16,32H2,1H3,(H,39,47)(H,40,45)(H,41,46)(H4,33,34,37)(H4,35,36,38)/t17-,20-,22-,23-/s2
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6.30n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032696
PNG
(CHEMBL3354674)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C29H44N12O5S/c30-16(6-3-13-36-28(32)33)24(44)39-19(11-12-22(31)42)27(46)41-15-5-9-20(41)25(45)38-18(8-4-14-37-29(34)35)23(43)26-40-17-7-1-2-10-21(17)47-26/h1-2,7,10,16,18-20H,3-6,8-9,11-15,30H2,(H2,31,42)(H,38,45)(H,39,44)(H4,32,33,36)(H4,34,35,37)/t16-,18-,19-,20-/s2
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7.80n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032701
PNG
(CHEMBL3354679)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C27H41N9O5S/c1-14(2)13-16(28)24(40)35-19(10-11-21(29)37)25(41)33-15(3)23(39)34-18(8-6-12-32-27(30)31)22(38)26-36-17-7-4-5-9-20(17)42-26/h4-5,7,9,14-16,18-19H,6,8,10-13,28H2,1-3H3,(H2,29,37)(H,33,41)(H,34,39)(H,35,40)(H4,30,31,32)/t15-,16-,18-,19-/s2
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13n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032700
PNG
(CHEMBL3354678)
Show SMILES C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C28H46N14O4S/c1-15(39-24(46)19(10-6-14-38-28(34)35)41-23(45)16(29)7-4-12-36-26(30)31)22(44)40-18(9-5-13-37-27(32)33)21(43)25-42-17-8-2-3-11-20(17)47-25/h2-3,8,11,15-16,18-19H,4-7,9-10,12-14,29H2,1H3,(H,39,46)(H,40,44)(H,41,45)(H4,30,31,36)(H4,32,33,37)(H4,34,35,38)/t15-,16-,18-,19-/s2
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15n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032710
PNG
(CHEMBL3354687)
Show SMILES C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C31H43N9O5S/c1-18(37-29(45)24(8-4-5-15-32)39-28(44)21(33)17-19-11-13-20(41)14-12-19)27(43)38-23(9-6-16-36-31(34)35)26(42)30-40-22-7-2-3-10-25(22)46-30/h2-3,7,10-14,18,21,23-24,41H,4-6,8-9,15-17,32-33H2,1H3,(H,37,45)(H,38,43)(H,39,44)(H4,34,35,36)/t18-,21-,23-,24-/s2
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21n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032705
PNG
(CHEMBL3354682)
Show SMILES C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C26H40N10O5S/c1-14(33-24(41)18(13-20(29)37)35-23(40)15(28)7-4-5-11-27)22(39)34-17(9-6-12-32-26(30)31)21(38)25-36-16-8-2-3-10-19(16)42-25/h2-3,8,10,14-15,17-18H,4-7,9,11-13,27-28H2,1H3,(H2,29,37)(H,33,41)(H,34,39)(H,35,40)(H4,30,31,32)/t14-,15-,17-,18-/s2
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25n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032702
PNG
(CHEMBL3352840)
Show SMILES C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C24H35N9O6S/c1-12(30-22(39)16(8-9-18(26)35)32-21(38)13(25)11-34)20(37)31-15(6-4-10-29-24(27)28)19(36)23-33-14-5-2-3-7-17(14)40-23/h2-3,5,7,12-13,15-16,34H,4,6,8-11,25H2,1H3,(H2,26,35)(H,30,39)(H,31,37)(H,32,38)(H4,27,28,29)/t12-,13-,15-,16-/s2
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35n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032703
PNG
(CHEMBL3354680)
Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C35H46N12O6S/c36-21(17-19-18-43-22-8-2-1-7-20(19)22)30(51)45-25(11-6-16-42-35(39)40)31(52)46-26(13-14-28(48)49)32(53)44-24(10-5-15-41-34(37)38)29(50)33-47-23-9-3-4-12-27(23)54-33/h1-4,7-9,12,18,21,24-26,43H,5-6,10-11,13-17,36H2,(H,44,53)(H,45,51)(H,46,52)(H,48,49)(H4,37,38,41)(H4,39,40,42)/t21-,24-,25-,26-/s2
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47n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50032704
PNG
(CHEMBL3354681)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
Show InChI InChI=1/C28H42N12O5S/c29-15(6-3-11-35-27(31)32)23(43)38-18(14-21(30)41)26(45)40-13-5-9-19(40)24(44)37-17(8-4-12-36-28(33)34)22(42)25-39-16-7-1-2-10-20(16)46-25/h1-2,7,10,15,17-19H,3-6,8-9,11-14,29H2,(H2,30,41)(H,37,44)(H,38,43)(H4,31,32,35)(H4,33,34,36)/t15-,17-,18-,19-/s2
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48n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50125048
PNG
(CHEMBL3623788)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)[C@@H](C)O
Show InChI InChI=1/C55H93N21O15S2/c1-4-28(2)41-52(89)76-20-10-15-39(76)51(88)75-19-9-14-38(75)49(86)67-33(13-8-18-64-55(60)61)45(82)71-36(47(84)69-34(53(90)91)21-30-23-62-27-65-30)25-92-93-26-37(72-43(80)31(66-40(79)22-57)12-7-17-63-54(58)59)48(85)74-42(29(3)78)50(87)68-32(11-5-6-16-56)44(81)70-35(24-77)46(83)73-41/h23,27-29,31-39,41-42,77-78H,4-22,24-26,56-57H2,1-3H3,(H,62,65)(H,66,79)(H,67,86)(H,68,87)(H,69,84)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H,74,85)(H,90,91)(H4,58,59,63)(H4,60,61,64)/t28-,29+,31-,32-,33-,34-,35-,36-,37-,38-,39-,41-,42-/s2
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82n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Ac-RQFRpNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50125047
PNG
(CHEMBL3623789)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CN
Show InChI InChI=1/C53H87N21O17S2/c1-26(76)40-48(87)66-29(8-2-3-13-54)42(81)69-33(22-75)44(83)67-31(19-39(78)79)49(88)74-17-7-12-37(74)50(89)73-16-6-11-36(73)47(86)65-30(10-5-15-62-53(58)59)43(82)70-34(45(84)68-32(51(90)91)18-27-21-60-25-63-27)23-92-93-24-35(46(85)72-40)71-41(80)28(64-38(77)20-55)9-4-14-61-52(56)57/h21,25-26,28-37,40,75-76H,2-20,22-24,54-55H2,1H3,(H,60,63)(H,64,77)(H,65,86)(H,66,87)(H,67,83)(H,68,84)(H,69,81)(H,70,82)(H,71,80)(H,72,85)(H,78,79)(H,90,91)(H4,56,57,61)(H4,58,59,62)/t26-,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,40+/s2
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87n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Ac-RQFRpNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324475
PNG
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)
Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1
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170n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324475
PNG
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)
Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1
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170n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of matriptase 2


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324475
PNG
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)
Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1
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190n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324477
PNG
(Benzylsulfonyl-D-cyclohexylalanyl-proline-(4-amidi...)
Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CCCCC2)NS(=O)(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C29H39N5O4S/c30-27(31)24-15-13-22(14-16-24)19-32-28(35)26-12-7-17-34(26)29(36)25(18-21-8-3-1-4-9-21)33-39(37,38)20-23-10-5-2-6-11-23/h2,5-6,10-11,13-16,21,25-26,33H,1,3-4,7-9,12,17-20H2,(H3,30,31)(H,32,35)/t25-,26+/m1/s1
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290n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324477
PNG
(Benzylsulfonyl-D-cyclohexylalanyl-proline-(4-amidi...)
Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CCCCC2)NS(=O)(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C29H39N5O4S/c30-27(31)24-15-13-22(14-16-24)19-32-28(35)26-12-7-17-34(26)29(36)25(18-21-8-3-1-4-9-21)33-39(37,38)20-23-10-5-2-6-11-23/h2,5-6,10-11,13-16,21,25-26,33H,1,3-4,7-9,12,17-20H2,(H3,30,31)(H,32,35)/t25-,26+/m1/s1
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460n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50125046
PNG
(CHEMBL3623792)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)C(O)=O)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1/C67H104N20O18S2/c1-6-34(3)50-60(99)81-43-32-106-107-33-44(80-53(92)38(18-11-23-72-66(68)69)75-49(91)30-74-48(90)29-41(65(104)105)78-58(97)45-20-13-25-85(45)62(101)40(77-56(43)95)28-37-16-9-8-10-17-37)57(96)84-52(36(5)89)61(100)76-39(19-12-24-73-67(70)71)54(93)79-42(31-88)55(94)83-51(35(4)7-2)64(103)87-27-15-22-47(87)63(102)86-26-14-21-46(86)59(98)82-50/h8-10,16-17,34-36,38-47,50-52,88-89H,6-7,11-15,18-33H2,1-5H3,(H,74,90)(H,75,91)(H,76,100)(H,77,95)(H,78,97)(H,79,93)(H,80,92)(H,81,99)(H,82,98)(H,83,94)(H,84,96)(H,104,105)(H4,68,69,72)(H4,70,71,73)/t34-,35-,36+,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,50-,51-,52-/s2
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546n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Ac-RQFRpNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189309
PNG
(CHEMBL9126)
Show SMILES NC(=N)c1ccc(cc1)N1CCN(CC1)c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C18H22N6/c19-17(20)13-1-5-15(6-2-13)23-9-11-24(12-10-23)16-7-3-14(4-8-16)18(21)22/h1-8H,9-12H2,(H3,19,20)(H3,21,22)
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1.16E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189306
PNG
(CHEMBL3594083)
Show SMILES NC(=N)c1ccc(NCCCCCCCCNc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C22H32N6/c23-21(24)17-7-11-19(12-8-17)27-15-5-3-1-2-4-6-16-28-20-13-9-18(10-14-20)22(25)26/h7-14,27-28H,1-6,15-16H2,(H3,23,24)(H3,25,26)
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1.64E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50286441
PNG
((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C20H38N6O5/c1-11(2)9-15(24-13(5)27)17(28)26-16(10-12(3)4)18(29)25-14(19(30)31)7-6-8-23-20(21)22/h11-12,14-16H,6-10H2,1-5H3,(H,24,27)(H,25,29)(H,26,28)(H,30,31)(H4,21,22,23)/t14-,15-,16-/m0/s1
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2.40E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189307
PNG
(CHEMBL3594082)
Show SMILES NC(=N)c1ccc(NCCCCCCCNc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C21H30N6/c22-20(23)16-6-10-18(11-7-16)26-14-4-2-1-3-5-15-27-19-12-8-17(9-13-19)21(24)25/h6-13,26-27H,1-5,14-15H2,(H3,22,23)(H3,24,25)
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3.68E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50286441
PNG
((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C20H38N6O5/c1-11(2)9-15(24-13(5)27)17(28)26-16(10-12(3)4)18(29)25-14(19(30)31)7-6-8-23-20(21)22/h11-12,14-16H,6-10H2,1-5H3,(H,24,27)(H,25,29)(H,26,28)(H,30,31)(H4,21,22,23)/t14-,15-,16-/m0/s1
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4.10E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189308
PNG
(CHEMBL269032)
Show SMILES NC(=N)c1ccc(cc1)N1CCCN(CC1)c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C19H24N6/c20-18(21)14-2-6-16(7-3-14)24-10-1-11-25(13-12-24)17-8-4-15(5-9-17)19(22)23/h2-9H,1,10-13H2,(H3,20,21)(H3,22,23)
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4.39E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189311
PNG
(4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...)
Show SMILES NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C22H22N4O2/c23-21(24)15-5-9-19(10-6-15)27-13-17-3-1-2-4-18(17)14-28-20-11-7-16(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)
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5.20E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189310
PNG
(4,4''-(1,4-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...)
Show SMILES NC(=N)c1ccc(OCc2ccc(COc3ccc(cc3)C(N)=N)cc2)cc1
Show InChI InChI=1S/C22H22N4O2/c23-21(24)17-5-9-19(10-6-17)27-13-15-1-2-16(4-3-15)14-28-20-11-7-18(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)
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5.70E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50189305
PNG
(CHEMBL3828410)
Show SMILES NC(=N)c1ccc(NC(=O)C(=O)Nc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C16H16N6O2/c17-13(18)9-1-5-11(6-2-9)21-15(23)16(24)22-12-7-3-10(4-8-12)14(19)20/h1-8H,(H3,17,18)(H3,19,20)(H,21,23)(H,22,24)
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6.23E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394279
PNG
(CHEMBL2159291)
Show SMILES CC(C)(C)OC(=O)c1ccc(NC(=O)CCNS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C21H26N4O5S/c1-21(2,3)30-20(27)14-7-9-16(10-8-14)25-18(26)11-12-24-31(28,29)17-6-4-5-15(13-17)19(22)23/h4-10,13,24H,11-12H2,1-3H3,(H3,22,23)(H,25,26)/p+1
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7.60E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394259
PNG
(CHEMBL2159271)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)CCNS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C18H22N6O3S/c19-17(20)13-6-4-12(5-7-13)11-23-16(25)8-9-24-28(26,27)15-3-1-2-14(10-15)18(21)22/h1-7,10,24H,8-9,11H2,(H3,19,20)(H3,21,22)(H,23,25)/p+2
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8.90E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324476
PNG
(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Show SMILES NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H36ClN7O4S/c27-21-11-10-19(15-28)20(14-21)16-32-24(35)23-9-5-13-34(23)25(36)22(8-4-12-31-26(29)30)33-39(37,38)17-18-6-2-1-3-7-18/h1-3,6-7,10-11,14,22-23,33H,4-5,8-9,12-13,15-17,28H2,(H,32,35)(H4,29,30,31)/t22-,23+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324478
PNG
(Benzylsulfonyl-D-cyclohexylalanyl-proline-(2-amino...)
Show SMILES NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C29H39ClN4O4S/c30-25-14-13-23(18-31)24(17-25)19-32-28(35)27-12-7-15-34(27)29(36)26(16-21-8-3-1-4-9-21)33-39(37,38)20-22-10-5-2-6-11-22/h2,5-6,10-11,13-14,17,21,26-27,33H,1,3-4,7-9,12,15-16,18-20,31H2,(H,32,35)/t26-,27+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324476
PNG
(Benzylsulfonyl-D-arginyl-proline-(2-aminomethyl-5-...)
Show SMILES NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H36ClN7O4S/c27-21-11-10-19(15-28)20(14-21)16-32-24(35)23-9-5-13-34(23)25(36)22(8-4-12-31-26(29)30)33-39(37,38)17-18-6-2-1-3-7-18/h1-3,6-7,10-11,14,22-23,33H,4-5,8-9,12-13,15-17,28H2,(H,32,35)(H4,29,30,31)/t22-,23+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50324478
PNG
(Benzylsulfonyl-D-cyclohexylalanyl-proline-(2-amino...)
Show SMILES NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC1CCCCC1)NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C29H39ClN4O4S/c30-25-14-13-23(18-31)24(17-25)19-32-28(35)27-12-7-15-34(27)29(36)26(16-21-8-3-1-4-9-21)33-39(37,38)20-22-10-5-2-6-11-22/h2,5-6,10-11,13-14,17,21,26-27,33H,1,3-4,7-9,12,15-16,18-20,31H2,(H,32,35)/t26-,27+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394260
PNG
(CHEMBL2159270)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)CNS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C17H20N6O3S/c18-16(19)12-6-4-11(5-7-12)9-22-15(24)10-23-27(25,26)14-3-1-2-13(8-14)17(20)21/h1-8,23H,9-10H2,(H3,18,19)(H3,20,21)(H,22,24)/p+2
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1.07E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394257
PNG
(CHEMBL2159273)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C24H26N6O3S/c25-22(26)18-8-6-17(7-9-18)15-29-24(31)21(14-16-4-2-1-3-5-16)30-34(32,33)20-12-10-19(11-13-20)23(27)28/h1-13,21,30H,14-15H2,(H3,25,26)(H3,27,28)(H,29,31)/p+2/t21-/m0/s1
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1.18E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394250
PNG
(CHEMBL2159280)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)[C@@H](COCc2ccccc2)NS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C25H28N6O4S/c26-23(27)19-11-9-17(10-12-19)14-30-25(32)22(16-35-15-18-5-2-1-3-6-18)31-36(33,34)21-8-4-7-20(13-21)24(28)29/h1-13,22,31H,14-16H2,(H3,26,27)(H3,28,29)(H,30,32)/p+2/t22-/m1/s1
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1.25E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50124906
PNG
(CHEMBL3623776)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O)[C@@H](C)CC
Show InChI InChI=1/C60H97N19O19S2/c1-7-27(3)43-54(93)71-35-25-99-100-26-36(72-55(94)45(29(5)81)73-42(85)23-66-47(86)32(21-40(61)83)68-52(91)37-14-10-18-77(37)57(96)33(22-41(62)84)69-50(35)89)51(90)76-46(30(6)82)56(95)67-31(13-9-17-65-60(63)64)48(87)70-34(24-80)49(88)75-44(28(4)8-2)59(98)79-20-12-16-39(79)58(97)78-19-11-15-38(78)53(92)74-43/h27-39,43-46,80-82H,7-26H2,1-6H3,(H2,61,83)(H2,62,84)(H,66,86)(H,67,95)(H,68,91)(H,69,89)(H,70,87)(H,71,93)(H,72,94)(H,73,85)(H,74,92)(H,75,88)(H,76,90)(H4,63,64,65)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,43-,44-,45-,46-/s2
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1.36E+4n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Ac-RQFRpNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394253
PNG
(CHEMBL2159277)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C24H26N6O3S/c25-22(26)18-11-9-17(10-12-18)15-29-24(31)21(13-16-5-2-1-3-6-16)30-34(32,33)20-8-4-7-19(14-20)23(27)28/h1-12,14,21,30H,13,15H2,(H3,25,26)(H3,27,28)(H,29,31)/p+2/t21-/m0/s1
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1.63E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394262
PNG
(CHEMBL2159363)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)CCNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C18H22N6O3S/c19-17(20)13-3-1-12(2-4-13)11-23-16(25)9-10-24-28(26,27)15-7-5-14(6-8-15)18(21)22/h1-8,24H,9-11H2,(H3,19,20)(H3,21,22)(H,23,25)/p+2
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1.90E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394258
PNG
(CHEMBL2159272)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)CCCNS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C19H24N6O3S/c20-18(21)14-8-6-13(7-9-14)12-24-17(26)5-2-10-25-29(27,28)16-4-1-3-15(11-16)19(22)23/h1,3-4,6-9,11,25H,2,5,10,12H2,(H3,20,21)(H3,22,23)(H,24,26)/p+2
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1.90E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50125021
PNG
(CHEMBL3623779)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2)[C@@H](C)O
Show InChI InChI=1/C58H92N20O20S2/c1-5-25(2)42-52(93)71-33-23-99-100-24-34(72-53(94)43(26(3)80)73-41(85)21-65-45(86)29(18-38(59)82)67-50(91)35-11-7-15-76(35)55(96)30(19-39(60)83)69-48(33)89)49(90)75-44(27(4)81)54(95)66-28(10-6-14-64-58(62)63)46(87)70-32(22-79)47(88)68-31(20-40(61)84)56(97)78-17-9-13-37(78)57(98)77-16-8-12-36(77)51(92)74-42/h25-37,42-44,79-81H,5-24H2,1-4H3,(H2,59,82)(H2,60,83)(H2,61,84)(H,65,86)(H,66,95)(H,67,91)(H,68,88)(H,69,89)(H,70,87)(H,71,93)(H,72,94)(H,73,85)(H,74,92)(H,75,90)(H4,62,63,64)/t25-,26+,27+,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,42-,43-,44-/s2
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1.93E+4n/an/an/an/an/an/an/an/a



Queensland University of Technology

Curated by ChEMBL


Assay Description
Inhibition of matriptase (unknown origin) using Ac-RQFRpNA substrate by spectrophotometry method


J Med Chem 58: 8257-68 (2015)

More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394263
PNG
(CHEMBL2159362)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)CNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C17H20N6O3S/c18-16(19)12-3-1-11(2-4-12)9-22-15(24)10-23-27(25,26)14-7-5-13(6-8-14)17(20)21/h1-8,23H,9-10H2,(H3,18,19)(H3,20,21)(H,22,24)/p+2
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2.20E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394261
PNG
(CHEMBL2159364)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)CCCNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C19H24N6O3S/c20-18(21)14-5-3-13(4-6-14)12-24-17(26)2-1-11-25-29(27,28)16-9-7-15(8-10-16)19(22)23/h3-10,25H,1-2,11-12H2,(H3,20,21)(H3,22,23)(H,24,26)/p+2
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2.40E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
Transmembrane protease serine 6


(Homo sapiens)
BDBM50394251
PNG
(CHEMBL2159279)
Show SMILES NC(=[NH2+])c1ccc(CNC(=O)[C@H](COCc2ccccc2)NS(=O)(=O)c2cccc(c2)C(N)=[NH2+])cc1
Show InChI InChI=1S/C25H28N6O4S/c26-23(27)19-11-9-17(10-12-19)14-30-25(32)22(16-35-15-18-5-2-1-3-6-18)31-36(33,34)21-8-4-7-20(13-21)24(28)29/h1-13,22,31H,14-16H2,(H3,26,27)(H3,28,29)(H,30,32)/p+2/t22-/m0/s1
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2.40E+4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrop...


Citation and Details
More data for this
Ligand-Target Pair
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