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Compile Data Set for Download or QSAR

Found 23 hits Enz. Inhib. hit(s) with Target = 'Trehalase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trehalase


(Rattus norvegicus)
BDBM50407255
PNG
(CHEMBL2114189)
Show SMILES CC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50407255
PNG
(CHEMBL2114189)
Show SMILES CC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO2/c1-2-4-6(9)5(8)3-7-4/h4-9H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50031485
PNG
((2R,3R,4R)-2-Hydroxymethyl-pyrrolidine-3,4-diol | ...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50259956
PNG
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase


J Med Chem 55: 10347-62 (2012)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase


J Med Chem 55: 10347-62 (2012)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50031484
PNG
((2R,3R,4R)-1-Butyl-2-hydroxymethyl-pyrrolidine-3,4...)
Show SMILES CCCCN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-10-5-8(12)9(13)7(10)6-11/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50031480
PNG
((2R,3R,4R)-2-Hydroxymethyl-1-methyl-pyrrolidine-3,...)
Show SMILES CN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C6H13NO3/c1-7-2-5(9)6(10)4(7)3-8/h4-6,8-10H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50031483
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrro...)
Show SMILES CN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-4(2-9)6(11)7(12)5(8)3-10/h4-7,9-12H,2-3H2,1H3/t4-,5-,6-,7-/m1/s1
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Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50031482
PNG
((2R,3R,4R,5R)-1-Butyl-2,5-bis-hydroxymethyl-pyrrol...)
Show SMILES CCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-7(5-12)9(14)10(15)8(11)6-13/h7-10,12-15H,2-6H2,1H3/t7-,8-,9-,10-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50375511
PNG
(CHEMBL406973)
Show SMILES OC[C@@H]1NC[C@H](O)[C@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m0/s1
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n/an/a 7.50E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase


J Med Chem 55: 10347-62 (2012)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50065255
PNG
((R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol |...)
Show SMILES OCC1NC(CO)[C@@H](O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3?,4?,5-,6?,7?/m1/s1
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n/an/a 1.40E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM18361
PNG
((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Show SMILES CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1
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n/an/a 1.67E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal trehalase


J Med Chem 55: 10347-62 (2012)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50037814
PNG
(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Show SMILES OCC1NC(CO)C(O)C1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2
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n/an/a 2.00E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50031481
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 3.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50408432
PNG
(CHEMBL2115215)
Show SMILES OC[C@H]1N[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4+,5-,6-,7+/m1/s1
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n/an/a 3.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50037814
PNG
(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Show SMILES OCC1NC(CO)C(O)C1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2
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n/an/a 3.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Trehalase


(Rattus norvegicus)
BDBM50408431
PNG
(CHEMBL2114210)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 4.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against trehalase of porcine kidney by colorimetric assay using the D-glucose oxidase-peroxidase method


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair