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Compile Data Set for Download or QSAR

Found 95 hits Enz. Inhib. hit(s) with Target = 'Tryptophan 5-hydroxylase 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300929
PNG
((S)-2-amino-3-(4-(4-amino-6-(biphenyl-2-ylmethylam...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccccc2-c2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C25H24N6O2/c26-21(23(32)33)14-16-10-12-18(13-11-16)22-29-24(27)31-25(30-22)28-15-19-8-4-5-9-20(19)17-6-2-1-3-7-17/h1-13,21H,14-15,26H2,(H,32,33)(H3,27,28,29,30,31)/t21-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243565
PNG
((S)-2-amino-3-(4-(5-(naphthalen-2-ylmethylamino)py...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc(NCc2ccc3ccccc3c2)cn1)C(O)=O
Show InChI InChI=1S/C24H22N4O2/c25-21(24(29)30)12-16-5-9-19(10-6-16)22-14-28-23(15-26-22)27-13-17-7-8-18-3-1-2-4-20(18)11-17/h1-11,14-15,21H,12-13,25H2,(H,27,28)(H,29,30)/t21-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300932
PNG
((S)-2-amino-3-(4-(4-amino-6-((4'-methylbiphenyl-4-...)
Show SMILES Cc1ccc(cc1)-c1ccc(CNc2nc(N)nc(n2)-c2ccc(C[C@H](N)C(O)=O)cc2)cc1
Show InChI InChI=1S/C26H26N6O2/c1-16-2-8-19(9-3-16)20-10-6-18(7-11-20)15-29-26-31-23(30-25(28)32-26)21-12-4-17(5-13-21)14-22(27)24(33)34/h2-13,22H,14-15,27H2,1H3,(H,33,34)(H3,28,29,30,31,32)/t22-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145648
PNG
(LP-778902 | TELOTRISTAT | Telotristat)
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n/an/a 16n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300935
PNG
((S)-3-{4-[4-(1-Adamantan-1-yl-ethylamino)-6-amino-...)
Show SMILES CC(Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H32N6O2/c1-13(24-10-15-6-16(11-24)8-17(7-15)12-24)27-23-29-20(28-22(26)30-23)18-4-2-14(3-5-18)9-19(25)21(31)32/h2-5,13,15-17,19H,6-12,25H2,1H3,(H,31,32)(H3,26,27,28,29,30)/t13?,15?,16?,17?,19-,24?/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243618
PNG
((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccccc2-c2ccco2)C(F)(F)F)nc(N)n1)C(O)=O
Show InChI InChI=1S/C25H21F3N4O4/c26-25(27,28)22(17-5-2-1-4-16(17)20-6-3-11-35-20)36-21-13-19(31-24(30)32-21)15-9-7-14(8-10-15)12-18(29)23(33)34/h1-11,13,18,22H,12,29H2,(H,33,34)(H2,30,31,32)/t18-,22?/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243613
PNG
((S)-2-Amino-3-(4-(4-amino-6-((naphthalene-2-ylmeth...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc3ccccc3c2)n1)C(O)=O
Show InChI InChI=1S/C23H22N6O2/c24-19(21(30)31)12-14-5-9-17(10-6-14)20-27-22(25)29-23(28-20)26-13-15-7-8-16-3-1-2-4-18(16)11-15/h1-11,19H,12-13,24H2,(H,30,31)(H3,25,26,27,28,29)/t19-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243613
PNG
((S)-2-Amino-3-(4-(4-amino-6-((naphthalene-2-ylmeth...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc3ccccc3c2)n1)C(O)=O
Show InChI InChI=1S/C23H22N6O2/c24-19(21(30)31)12-14-5-9-17(10-6-14)20-27-22(25)29-23(28-20)26-13-15-7-8-16-3-1-2-4-18(16)11-15/h1-11,19H,12-13,24H2,(H,30,31)(H3,25,26,27,28,29)/t19-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300934
PNG
((2S)-2-amino-3-(4-(4-amino-6-(1-(biphenyl-4-yl)eth...)
Show SMILES CC(Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-16(18-11-13-20(14-12-18)19-5-3-2-4-6-19)29-26-31-23(30-25(28)32-26)21-9-7-17(8-10-21)15-22(27)24(33)34/h2-14,16,22H,15,27H2,1H3,(H,33,34)(H3,28,29,30,31,32)/t16?,22-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243020
PNG
((S)-2-amino-3-(4-(4-amino-6-((R)-1-(naphthalen-2-y...)
Show SMILES C[C@@H](Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H24N6O2/c1-14(18-11-10-16-4-2-3-5-19(16)13-18)27-24-29-21(28-23(26)30-24)17-8-6-15(7-9-17)12-20(25)22(31)32/h2-11,13-14,20H,12,25H2,1H3,(H,31,32)(H3,26,27,28,29,30)/t14-,20+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145634
PNG
(CHEMBL3764999)
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n/an/a 26n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243020
PNG
((S)-2-amino-3-(4-(4-amino-6-((R)-1-(naphthalen-2-y...)
Show SMILES C[C@@H](Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H24N6O2/c1-14(18-11-10-16-4-2-3-5-19(16)13-18)27-24-29-21(28-23(26)30-24)17-8-6-15(7-9-17)12-20(25)22(31)32/h2-11,13-14,20H,12,25H2,1H3,(H,31,32)(H3,26,27,28,29,30)/t14-,20+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243619
PNG
((S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccccc2-n2ccc(n2)C(F)(F)F)C(F)(F)F)nc(N)n1)C(O)=O
Show InChI InChI=1S/C25H20F6N6O3/c26-24(27,28)19-9-10-37(36-19)18-4-2-1-3-15(18)21(25(29,30)31)40-20-12-17(34-23(33)35-20)14-7-5-13(6-8-14)11-16(32)22(38)39/h1-10,12,16,21H,11,32H2,(H,38,39)(H2,33,34,35)/t16-,21?/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50242929
PNG
((S)-2-amino-3-(4-(5-((9-ethyl-9H-carbazol-3-yl)met...)
Show SMILES CCn1c2ccccc2c2cc(CNc3cnc(cn3)-c3ccc(C[C@H](N)C(O)=O)cc3)ccc12
Show InChI InChI=1S/C28H27N5O2/c1-2-33-25-6-4-3-5-21(25)22-13-19(9-12-26(22)33)15-31-27-17-30-24(16-32-27)20-10-7-18(8-11-20)14-23(29)28(34)35/h3-13,16-17,23H,2,14-15,29H2,1H3,(H,31,32)(H,34,35)/t23-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243022
PNG
((S)-2-amino-3-(4-(2-amino-6-((R)-1-(naphthalen-2-y...)
Show SMILES C[C@@H](Nc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25N5O2/c1-15(19-11-10-17-4-2-3-5-20(17)13-19)28-23-14-22(29-25(27)30-23)18-8-6-16(7-9-18)12-21(26)24(31)32/h2-11,13-15,21H,12,26H2,1H3,(H,31,32)(H3,27,28,29,30)/t15-,21+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300930
PNG
((S)-2-amino-3-(4-(4-amino-6-(biphenyl-3-ylmethylam...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2cccc(c2)-c2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C25H24N6O2/c26-21(23(32)33)14-16-9-11-19(12-10-16)22-29-24(27)31-25(30-22)28-15-17-5-4-8-20(13-17)18-6-2-1-3-7-18/h1-13,21H,14-15,26H2,(H,32,33)(H3,27,28,29,30,31)/t21-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243019
PNG
((S)-2-amino-3-(4-(5-((2'-methylbiphenyl-2-yl)methy...)
Show SMILES Cc1ccccc1-c1ccccc1CNc1cnc(cn1)-c1ccc(C[C@H](N)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O2/c1-18-6-2-4-8-22(18)23-9-5-3-7-21(23)15-30-26-17-29-25(16-31-26)20-12-10-19(11-13-20)14-24(28)27(32)33/h2-13,16-17,24H,14-15,28H2,1H3,(H,30,31)(H,32,33)/t24-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243018
PNG
((S)-2-Amino-3-(4-{5-[(biphenyl-4-ylmethyl)-amino]-...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc(NCc2ccc(cc2)-c2ccccc2)cn1)C(O)=O
Show InChI InChI=1S/C26H24N4O2/c27-23(26(31)32)14-18-6-12-22(13-7-18)24-16-30-25(17-28-24)29-15-19-8-10-21(11-9-19)20-4-2-1-3-5-20/h1-13,16-17,23H,14-15,27H2,(H,29,30)(H,31,32)/t23-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300936
PNG
((S)-2-amino-3-(4-(4-amino-6-((S)-1-(naphthalen-2-y...)
Show SMILES C[C@H](Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H24N6O2/c1-14(18-11-10-16-4-2-3-5-19(16)13-18)27-24-29-21(28-23(26)30-24)17-8-6-15(7-9-17)12-20(25)22(31)32/h2-11,13-14,20H,12,25H2,1H3,(H,31,32)(H3,26,27,28,29,30)/t14-,20-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50242928
PNG
((S)-2-amino-3-{4-[5-(3-cyclopentyloxy-4-methoxy-be...)
Show SMILES COc1ccc(CNc2cnc(cn2)-c2ccc(C[C@H](N)C(O)=O)cc2)c(OC2CCCC2)c1
Show InChI InChI=1S/C26H30N4O4/c1-33-21-11-10-19(24(13-21)34-20-4-2-3-5-20)14-29-25-16-28-23(15-30-25)18-8-6-17(7-9-18)12-22(27)26(31)32/h6-11,13,15-16,20,22H,2-5,12,14,27H2,1H3,(H,29,30)(H,31,32)/t22-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243564
PNG
((2S)-2-amino-3-(4-(5-((1,2,3,4-tetrahydronaphthale...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc(NCC2CCc3ccccc3C2)cn1)C(O)=O
Show InChI InChI=1S/C24H26N4O2/c25-21(24(29)30)12-16-5-9-19(10-6-16)22-14-28-23(15-26-22)27-13-17-7-8-18-3-1-2-4-20(18)11-17/h1-6,9-10,14-15,17,21H,7-8,11-13,25H2,(H,27,28)(H,29,30)/t17?,21-/m0/s1
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n/an/a 46n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145635
PNG
(CHEMBL3764206)
PDB
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n/an/a 50n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300940
PNG
((S)-2-amino-3-(4-(4-amino-6-(methyl((R)-1-(naphtha...)
Show SMILES C[C@@H](N(C)c1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H26N6O2/c1-15(19-12-11-17-5-3-4-6-20(17)14-19)31(2)25-29-22(28-24(27)30-25)18-9-7-16(8-10-18)13-21(26)23(32)33/h3-12,14-15,21H,13,26H2,1-2H3,(H,32,33)(H2,27,28,29,30)/t15-,21+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243655
PNG
((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2sccc2-c2ccco2)C(F)(F)F)nc(N)n1)C(O)=O
Show InChI InChI=1S/C23H19F3N4O4S/c24-23(25,26)20(19-14(7-9-35-19)17-2-1-8-33-17)34-18-11-16(29-22(28)30-18)13-5-3-12(4-6-13)10-15(27)21(31)32/h1-9,11,15,20H,10,27H2,(H,31,32)(H2,28,29,30)/t15-,20?/m0/s1
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n/an/a 54n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145636
PNG
(CHEMBL3764034)
PDB
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n/an/a 55n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300937
PNG
((S)-2-amino-3-(4-(4-amino-6-(2-(naphthalen-2-yl)pr...)
Show SMILES CC(C)(Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H26N6O2/c1-25(2,19-12-11-16-5-3-4-6-18(16)14-19)31-24-29-21(28-23(27)30-24)17-9-7-15(8-10-17)13-20(26)22(32)33/h3-12,14,20H,13,26H2,1-2H3,(H,32,33)(H3,27,28,29,30,31)/t20-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300928
PNG
((S)-2-amino-3-(4-(4-amino-6-(biphenyl-4-ylmethylam...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc(cc2)-c2ccccc2)n1)C(O)=O
Show InChI InChI=1S/C25H24N6O2/c26-21(23(32)33)14-16-6-12-20(13-7-16)22-29-24(27)31-25(30-22)28-15-17-8-10-19(11-9-17)18-4-2-1-3-5-18/h1-13,21H,14-15,26H2,(H,32,33)(H3,27,28,29,30,31)/t21-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145672
PNG
(CHEMBL3763889)
PDB
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n/an/a 65n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50242930
PNG
((S)-2-amino-3-(4-(5-(3,4-dimethoxybenzylamino)pyra...)
Show SMILES COc1ccc(CNc2cnc(cn2)-c2ccc(C[C@H](N)C(O)=O)cc2)cc1OC
Show InChI InChI=1S/C22H24N4O4/c1-29-19-8-5-15(10-20(19)30-2)11-25-21-13-24-18(12-26-21)16-6-3-14(4-7-16)9-17(23)22(27)28/h3-8,10,12-13,17H,9,11,23H2,1-2H3,(H,25,26)(H,27,28)/t17-/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243617
PNG
((S)-2-Amino-3-(4-{2-amino-6-[2,2,2-trifluoro-1-(3'...)
Show SMILES Cc1cccc(c1)-c1ccccc1C(Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C28H25F3N4O3/c1-16-5-4-6-19(13-16)20-7-2-3-8-21(20)25(28(29,30)31)38-24-15-23(34-27(33)35-24)18-11-9-17(10-12-18)14-22(32)26(36)37/h2-13,15,22,25H,14,32H2,1H3,(H,36,37)(H2,33,34,35)/t22-,25?/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145673
PNG
(CHEMBL3765147)
PDB
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n/an/a 79n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145637
PNG
(CHEMBL3765301)
PDB
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n/an/a 96n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300925
PNG
((S)-2-amino-3-(4-(4-amino-6-(3,4-dimethylbenzylami...)
Show SMILES Cc1ccc(CNc2nc(N)nc(n2)-c2ccc(C[C@H](N)C(O)=O)cc2)cc1C
Show InChI InChI=1S/C21H24N6O2/c1-12-3-4-15(9-13(12)2)11-24-21-26-18(25-20(23)27-21)16-7-5-14(6-8-16)10-17(22)19(28)29/h3-9,17H,10-11,22H2,1-2H3,(H,28,29)(H3,23,24,25,26,27)/t17-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243507
PNG
((S)-2-amino-3-(4-(5-(4-cyanobenzylamino)pyrazin-2-...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc(NCc2ccc(cc2)C#N)cn1)C(O)=O
Show InChI InChI=1S/C21H19N5O2/c22-10-15-1-3-16(4-2-15)11-25-20-13-24-19(12-26-20)17-7-5-14(6-8-17)9-18(23)21(27)28/h1-8,12-13,18H,9,11,23H2,(H,25,26)(H,27,28)/t18-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300926
PNG
((S)-2-amino-3-(4-(4-amino-6-(4-(trifluoromethyl)be...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc(cc2)C(F)(F)F)n1)C(O)=O
Show InChI InChI=1S/C20H19F3N6O2/c21-20(22,23)14-7-3-12(4-8-14)10-26-19-28-16(27-18(25)29-19)13-5-1-11(2-6-13)9-15(24)17(30)31/h1-8,15H,9-10,24H2,(H,30,31)(H3,25,26,27,28,29)/t15-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300924
PNG
((S)-2-amino-3-(4-(4-amino-6-(cyclohexylmethylamino...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCC2CCCCC2)n1)C(O)=O
Show InChI InChI=1S/C19H26N6O2/c20-15(17(26)27)10-12-6-8-14(9-7-12)16-23-18(21)25-19(24-16)22-11-13-4-2-1-3-5-13/h6-9,13,15H,1-5,10-11,20H2,(H,26,27)(H3,21,22,23,24,25)/t15-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300942
PNG
((2S)-2-amino-3-(4-(4-amino-6-(3-methyl-1-(naphthal...)
Show SMILES CC(C)CC(Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N6O2/c1-16(2)13-23(21-12-11-18-5-3-4-6-20(18)15-21)30-27-32-24(31-26(29)33-27)19-9-7-17(8-10-19)14-22(28)25(34)35/h3-12,15-16,22-23H,13-14,28H2,1-2H3,(H,34,35)(H3,29,30,31,32,33)/t22-,23?/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145649
PNG
(CHEMBL3764908)
PDB
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n/an/a 128n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300941
PNG
((2S)-2-amino-3-(4-(4-amino-6-(1-(naphthalen-2-yl)p...)
Show SMILES CCC(Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H26N6O2/c1-2-21(19-12-11-16-5-3-4-6-18(16)14-19)28-25-30-22(29-24(27)31-25)17-9-7-15(8-10-17)13-20(26)23(32)33/h3-12,14,20-21H,2,13,26H2,1H3,(H,32,33)(H3,27,28,29,30,31)/t20-,21?/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300931
PNG
((S)-2-amino-3-(4-(4-amino-6-(4-phenoxybenzylamino)...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc(Oc3ccccc3)cc2)n1)C(O)=O
Show InChI InChI=1S/C25H24N6O3/c26-21(23(32)33)14-16-6-10-18(11-7-16)22-29-24(27)31-25(30-22)28-15-17-8-12-20(13-9-17)34-19-4-2-1-3-5-19/h1-13,21H,14-15,26H2,(H,32,33)(H3,27,28,29,30,31)/t21-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300933
PNG
((S)-2-amino-3-(4-(4-amino-6-((4'-(trifluoromethyl)...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NCc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)n1)C(O)=O
Show InChI InChI=1S/C26H23F3N6O2/c27-26(28,29)20-11-9-18(10-12-20)17-5-3-16(4-6-17)14-32-25-34-22(33-24(31)35-25)19-7-1-15(2-8-19)13-21(30)23(36)37/h1-12,21H,13-14,30H2,(H,36,37)(H3,31,32,33,34,35)/t21-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243024
PNG
((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(n...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccc3ccccc3c2)C(F)(F)F)nc(N)n1)C(O)=O
Show InChI InChI=1S/C25H21F3N4O3/c26-25(27,28)22(18-10-9-15-3-1-2-4-17(15)12-18)35-21-13-20(31-24(30)32-21)16-7-5-14(6-8-16)11-19(29)23(33)34/h1-10,12-13,19,22H,11,29H2,(H,33,34)(H2,30,31,32)/t19-,22?/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243563
PNG
((S)-2-amino-3-(4-{5-[(quinolin-3-ylmethyl)-amino]-...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc(NCc2cnc3ccccc3c2)cn1)C(O)=O
Show InChI InChI=1S/C23H21N5O2/c24-19(23(29)30)10-15-5-7-17(8-6-15)21-13-28-22(14-26-21)27-12-16-9-18-3-1-2-4-20(18)25-11-16/h1-9,11,13-14,19H,10,12,24H2,(H,27,28)(H,29,30)/t19-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300946
PNG
((2S)-2-amino-3-(4-(4-(1-(naphthalen-2-yl)ethylamin...)
Show SMILES CC(Nc1ncnc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H23N5O2/c1-15(19-11-10-17-4-2-3-5-20(17)13-19)28-24-27-14-26-22(29-24)18-8-6-16(7-9-18)12-21(25)23(30)31/h2-11,13-15,21H,12,25H2,1H3,(H,30,31)(H,26,27,28,29)/t15?,21-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243021
PNG
(2-Amino-3-(4-(4-amino-6-(R)-1-(naphthalene-2-yl)et...)
Show SMILES C[C@@H](Nc1nc(N)nc(n1)-c1ccc(CC(N)C(O)=O)c(F)c1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H23FN6O2/c1-13(15-7-6-14-4-2-3-5-16(14)10-15)28-24-30-21(29-23(27)31-24)18-9-8-17(19(25)11-18)12-20(26)22(32)33/h2-11,13,20H,12,26H2,1H3,(H,32,33)(H3,27,28,29,30,31)/t13-,20?/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145650
PNG
(CHEMBL3765094)
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n/an/a 211n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50145638
PNG
(CHEMBL3765770)
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n/an/a 211n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50243505
PNG
((S)-2-amino-3-(4-(5-(cyclohexylmethylamino)pyrazin...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc(NCC2CCCCC2)cn1)C(O)=O
Show InChI InChI=1S/C20H26N4O2/c21-17(20(25)26)10-14-6-8-16(9-7-14)18-12-24-19(13-22-18)23-11-15-4-2-1-3-5-15/h6-9,12-13,15,17H,1-5,10-11,21H2,(H,23,24)(H,25,26)/t17-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300943
PNG
((2S)-2-amino-3-(4-(4-amino-6-(2-methyl-1-(naphthal...)
Show SMILES CC(C)C(Nc1nc(N)nc(n1)-c1ccc(C[C@H](N)C(O)=O)cc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N6O2/c1-15(2)22(20-12-11-17-5-3-4-6-19(17)14-20)29-26-31-23(30-25(28)32-26)18-9-7-16(8-10-18)13-21(27)24(33)34/h3-12,14-15,21-22H,13,27H2,1-2H3,(H,33,34)(H3,28,29,30,31,32)/t21-,22?/m0/s1
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n/an/a 250n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Homo sapiens)
BDBM50300938
PNG
((2S)-2-amino-3-(4-(4-amino-6-(2,2,2-trifluoro-1-(n...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(OC(c2ccc3ccccc3c2)C(F)(F)F)n1)C(O)=O
Show InChI InChI=1S/C24H20F3N5O3/c25-24(26,27)19(17-10-9-14-3-1-2-4-16(14)12-17)35-23-31-20(30-22(29)32-23)15-7-5-13(6-8-15)11-18(28)21(33)34/h1-10,12,18-19H,11,28H2,(H,33,34)(H2,29,30,31,32)/t18-,19?/m0/s1
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n/an/a 320n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
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