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Compile Data Set for Download or QSAR

Found 388 hits Enz. Inhib. hit(s) with Target = 'Tubulin' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tubulin


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding constant at colchicine site of bovine brain tubulin


Bioorg Med Chem Lett 12: 465-9 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50109343
PNG
(1-Methyl-5-[(S)-5-(3,4,5-trimethoxy-phenyl)-4,5-di...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1CN=C(O1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C21H22N2O4/c1-23-8-7-13-9-14(5-6-16(13)23)21-22-12-19(27-21)15-10-17(24-2)20(26-4)18(11-15)25-3/h5-11,19H,12H2,1-4H3/t19-/m1/s1
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630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding constant at colchicine site of bovine brain tubulin


Bioorg Med Chem Lett 12: 465-9 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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780n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding constant at colchicine site of bovine brain tubulin


Bioorg Med Chem Lett 12: 465-9 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Bos taurus)
BDBM50109342
PNG
(1-Methyl-5-[(R)-5-(3,4,5-trimethoxy-phenyl)-4,5-di...)
Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CN=C(O1)c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C21H22N2O4/c1-23-8-7-13-9-14(5-6-16(13)23)21-22-12-19(27-21)15-10-17(24-2)20(26-4)18(11-15)25-3/h5-11,19H,12H2,1-4H3/t19-/m0/s1
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3.69E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding constant at colchicine site of bovine brain tubulin


Bioorg Med Chem Lett 12: 465-9 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50159524
PNG
(CHEMBL20705 | N-(5-Chloro-1H-indol-7-yl)-4-methoxy...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cc(Cl)cc2cc[nH]c12
Show InChI InChI=1S/C15H13ClN2O3S/c1-21-12-2-4-13(5-3-12)22(19,20)18-14-9-11(16)8-10-6-7-17-15(10)14/h2-9,17-18H,1H3
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7.00E+3n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity against tubulin from goat brain relative to colchicine


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50120462
PNG
(CHEMBL20289 | N-(3-Chloro-1H-indol-7-yl)-4-methoxy...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12
Show InChI InChI=1S/C15H13ClN2O3S/c1-21-10-5-7-11(8-6-10)22(19,20)18-14-4-2-3-12-13(16)9-17-15(12)14/h2-9,17-18H,1H3
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1.40E+4n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity against tubulin from goat brain relative to colchicine


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50159525
PNG
(CHEMBL20827 | N-(4-Chloro-1H-indol-7-yl)-4-methoxy...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2cc[nH]c12
Show InChI InChI=1S/C15H13ClN2O3S/c1-21-10-2-4-11(5-3-10)22(19,20)18-14-7-6-13(16)12-8-9-17-15(12)14/h2-9,17-18H,1H3
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1.40E+4n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity against tubulin from goat brain relative to colchicine


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50159526
PNG
(CHEMBL280959 | N-(1H-Indol-7-yl)-4-methoxy-benzene...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc2cc[nH]c12
Show InChI InChI=1S/C15H14N2O3S/c1-20-12-5-7-13(8-6-12)21(18,19)17-14-4-2-3-11-9-10-16-15(11)14/h2-10,16-17H,1H3
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1.40E+4n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity against tubulin from goat brain relative to colchicine


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50120465
PNG
(CHEMBL281995 | N-(2-Chloro-1H-indol-7-yl)-4-methox...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc2cc(Cl)[nH]c12
Show InChI InChI=1S/C15H13ClN2O3S/c1-21-11-5-7-12(8-6-11)22(19,20)18-13-4-2-3-10-9-14(16)17-15(10)13/h2-9,17-18H,1H3
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2.80E+4n/an/an/an/an/an/an/an/a



Institute

Curated by ChEMBL


Assay Description
Binding affinity against tubulin from goat brain relative to colchicine


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50012278
PNG
((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Show SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
Show InChI InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding constant at colchicine site of bovine brain tubulin


Bioorg Med Chem Lett 12: 465-9 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Bos taurus)
BDBM50107672
PNG
((3-Fluoro-phenyl)-(5-methoxy-1H-indol-2-yl)-methan...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cccc(F)c1
Show InChI InChI=1S/C16H12FNO2/c1-20-13-5-6-14-11(8-13)9-15(18-14)16(19)10-3-2-4-12(17)7-10/h2-9,18H,1H3
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n/an/a 390n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50035218
PNG
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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n/an/a 460n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Bos taurus)
BDBM50035218
PNG
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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n/an/a 460n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Bos taurus)
BDBM50107678
PNG
((5-Methoxy-1H-indol-2-yl)-(3-methoxy-phenyl)-metha...)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C17H15NO3/c1-20-13-5-3-4-11(8-13)17(19)16-10-12-9-14(21-2)6-7-15(12)18-16/h3-10,18H,1-2H3
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n/an/a 530n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50107658
PNG
((5-Methoxy-1H-indol-2-yl)-phenyl-methanone | (5-me...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1ccccc1
Show InChI InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3
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n/an/a 530n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 530n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 530n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50037444
PNG
(6-(3-Methoxy-phenyl)-5H-[1,3]dioxolo[4,5-g]quinoli...)
Show SMILES COc1cccc(c1)-c1cc(O)c2cc3OCOc3cc2n1
Show InChI InChI=1S/C17H13NO4/c1-20-11-4-2-3-10(5-11)13-7-15(19)12-6-16-17(22-9-21-16)8-14(12)18-13/h2-8H,9H2,1H3,(H,18,19)
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n/an/a 570n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041130
PNG
(6-Methoxy-2-phenyl-1H-quinolin-4-one | CHEMBL14120...)
Show SMILES COc1ccc2nc(cc(O)c2c1)-c1ccccc1
Show InChI InChI=1S/C16H13NO2/c1-19-12-7-8-14-13(9-12)16(18)10-15(17-14)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
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n/an/a 610n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50059123
PNG
(2-(3-Methoxy-phenyl)-5-methyl-1H-[1,8]naphthyridin...)
Show SMILES COc1cccc(c1)-c1cc(O)c2c(C)ccnc2n1
Show InChI InChI=1S/C16H14N2O2/c1-10-6-7-17-16-15(10)14(19)9-13(18-16)11-4-3-5-12(8-11)20-2/h3-9H,1-2H3,(H,17,18,19)
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n/an/a 620n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041123
PNG
(6-(3,5-Dimethoxy-phenyl)-5H-[1,3]dioxolo[4,5-g]qui...)
Show SMILES COc1cc(OC)cc(c1)-c1cc(O)c2cc3OCOc3cc2n1
Show InChI InChI=1S/C18H15NO5/c1-21-11-3-10(4-12(5-11)22-2)14-7-16(20)13-6-17-18(24-9-23-17)8-15(13)19-14/h3-8H,9H2,1-2H3,(H,19,20)
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n/an/a 620n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50037464
PNG
(6-Phenyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | CH...)
Show SMILES Oc1cc(nc2cc3OCOc3cc12)-c1ccccc1
Show InChI InChI=1S/C16H11NO3/c18-14-7-12(10-4-2-1-3-5-10)17-13-8-16-15(6-11(13)14)19-9-20-16/h1-8H,9H2,(H,17,18)
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n/an/a 630n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50005478
PNG
(2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-ph...)
Show SMILES COc1ccc(CCc2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H22O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h7-11,19H,5-6H2,1-4H3
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n/an/a 630n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50107677
PNG
((3-Hydroxy-phenyl)-(5-methoxy-1H-indol-2-yl)-metha...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C16H13NO3/c1-20-13-5-6-14-11(8-13)9-15(17-14)16(19)10-3-2-4-12(18)7-10/h2-9,17-18H,1H3
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n/an/a 660n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin alpha chain /beta chain


(Bos taurus)
BDBM50369013
PNG
(CHEMBL1627442)
Show SMILES CCOc1cc2[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CCc2cc1O
Show InChI InChI=1S/C20H28O3/c1-3-23-18-11-15-12(10-17(18)21)4-5-14-13(15)8-9-20(2)16(14)6-7-19(20)22/h10-11,13-14,16,19,21-22H,3-9H2,1-2H3/t13-,14+,16-,19-,20-/m0/s1
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n/an/a 660n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of polymerization of purified bovine tubulin


J Med Chem 43: 2419-29 (2000)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50111568
PNG
(2-Methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-3H-imidaz...)
Show SMILES COc1ccc(cc1N)-c1nc[nH]c1-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H21N3O4/c1-23-14-6-5-11(7-13(14)20)17-18(22-10-21-17)12-8-15(24-2)19(26-4)16(9-12)25-3/h5-10H,20H2,1-4H3,(H,21,22)
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n/an/a 680n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration needed to inhibit tubulin polymerization by 50%


J Med Chem 45: 1697-711 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50037452
PNG
(6-(3-Dimethylamino-phenyl)-5H-[1,3]dioxolo[4,5-g]q...)
Show SMILES CN(C)c1cccc(c1)-c1cc(O)c2cc3OCOc3cc2n1
Show InChI InChI=1S/C18H16N2O3/c1-20(2)12-5-3-4-11(6-12)14-8-16(21)13-7-17-18(23-10-22-17)9-15(13)19-14/h3-9H,10H2,1-2H3,(H,19,21)
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n/an/a 700n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50111579
PNG
(2-Methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-3H-imidaz...)
Show SMILES COc1ccc(cc1O)-c1nc[nH]c1-c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H20N2O5/c1-23-14-6-5-11(7-13(14)22)17-18(21-10-20-17)12-8-15(24-2)19(26-4)16(9-12)25-3/h5-10,22H,1-4H3,(H,20,21)
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n/an/a 730n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration needed to inhibit tubulin polymerization by 50%


J Med Chem 45: 1697-711 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50059100
PNG
(6-Chloro-2-(3-methoxy-phenyl)-1H-[1,8]naphthyridin...)
Show SMILES COc1cccc(c1)-c1cc(O)c2cc(Cl)cnc2n1
Show InChI InChI=1S/C15H11ClN2O2/c1-20-11-4-2-3-9(5-11)13-7-14(19)12-6-10(16)8-17-15(12)18-13/h2-8H,1H3,(H,17,18,19)
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n/an/a 730n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin alpha chain /beta chain


(Bos taurus)
BDBM50125182
PNG
(CHEMBL3623606)
Show SMILES CCn1ccc2c1ccc1nc(cc(OC(=O)OCc3ccccc3)c21)-c1ccccc1
Show InChI InChI=1S/C27H22N2O3/c1-2-29-16-15-21-24(29)14-13-22-26(21)25(17-23(28-22)20-11-7-4-8-12-20)32-27(30)31-18-19-9-5-3-6-10-19/h3-17H,2,18H2,1H3
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n/an/a 740n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysis


J Med Chem 58: 7991-8010 (2015)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041100
PNG
(6-Methoxy-2-(3-methoxy-phenyl)-1H-quinolin-4-one |...)
Show SMILES COc1cccc(c1)-c1cc(O)c2cc(OC)ccc2n1
Show InChI InChI=1S/C17H15NO3/c1-20-12-5-3-4-11(8-12)16-10-17(19)14-9-13(21-2)6-7-15(14)18-16/h3-10H,1-2H3,(H,18,19)
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n/an/a 740n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin alpha chain /beta chain


(Bos taurus)
BDBM50125226
PNG
(CHEMBL3623611)
Show SMILES CCOC(=O)CCn1ccc2c1ccc1[nH]c(cc(=O)c21)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c1-2-27-21(26)11-13-24-12-10-16-19(24)9-8-17-22(16)20(25)14-18(23-17)15-6-4-3-5-7-15/h3-10,12,14H,2,11,13H2,1H3,(H,23,25)
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n/an/a 750n/an/an/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysis


J Med Chem 58: 7991-8010 (2015)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50059117
PNG
(2-(3-Methoxy-phenyl)-7-methyl-1H-[1,8]naphthyridin...)
Show SMILES COc1cccc(c1)-c1cc(O)c2ccc(C)nc2n1
Show InChI InChI=1S/C16H14N2O2/c1-10-6-7-13-15(19)9-14(18-16(13)17-10)11-4-3-5-12(8-11)20-2/h3-9H,1-2H3,(H,17,18,19)
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n/an/a 750n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50111574
PNG
(1-Methyl-5-[4-(3,4,5-trimethoxy-phenyl)-oxazol-5-y...)
Show SMILES COc1cc(cc(OC)c1OC)-c1ncoc1-c1ccc2n(C)ccc2c1
Show InChI InChI=1S/C21H20N2O4/c1-23-8-7-13-9-14(5-6-16(13)23)20-19(22-12-27-20)15-10-17(24-2)21(26-4)18(11-15)25-3/h5-12H,1-4H3
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n/an/a 790n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration needed to inhibit tubulin polymerization by 50%


J Med Chem 45: 1697-711 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Bos taurus)
BDBM50059111
PNG
(2-(3-Methoxy-phenyl)-6-methyl-1H-[1,8]naphthyridin...)
Show SMILES COc1cccc(c1)-c1cc(O)c2cc(C)cnc2n1
Show InChI InChI=1S/C16H14N2O2/c1-10-6-13-15(19)8-14(18-16(13)17-9-10)11-4-3-5-12(7-11)20-2/h3-9H,1-2H3,(H,17,18,19)
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n/an/a 800n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Bos taurus)
BDBM50107656
PNG
((3,5-Dimethoxy-phenyl)-(5-methoxy-1H-indol-2-yl)-m...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C18H17NO4/c1-21-13-4-5-16-11(6-13)9-17(19-16)18(20)12-7-14(22-2)10-15(8-12)23-3/h4-10,19H,1-3H3
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n/an/a 810n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50107676
PNG
((3,4-Dimethoxy-phenyl)-(5-methoxy-1H-indol-2-yl)-m...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C18H17NO4/c1-21-13-5-6-14-12(8-13)9-15(19-14)18(20)11-4-7-16(22-2)17(10-11)23-3/h4-10,19H,1-3H3
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n/an/a 810n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041121
PNG
(2-(3-Dimethylamino-phenyl)-6-methoxy-1H-quinolin-4...)
Show SMILES COc1ccc2nc(cc(O)c2c1)-c1cccc(c1)N(C)C
Show InChI InChI=1S/C18H18N2O2/c1-20(2)13-6-4-5-12(9-13)17-11-18(21)15-10-14(22-3)7-8-16(15)19-17/h4-11H,1-3H3,(H,19,21)
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n/an/a 840n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041119
PNG
(2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-on...)
Show SMILES Oc1cc(nc2cc3OCOc3cc12)-c1ccccc1F
Show InChI InChI=1S/C16H10FNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19)
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n/an/a 850n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50107664
PNG
((5-Methoxy-1H-indol-2-yl)-(3-nitro-phenyl)-methano...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H12N2O4/c1-22-13-5-6-14-11(8-13)9-15(17-14)16(19)10-3-2-4-12(7-10)18(20)21/h2-9,17H,1H3
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n/an/a 850n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50107674
PNG
(Butyric acid 3-(5-methoxy-1H-indole-2-carbonyl)-ph...)
Show SMILES CCCC(=O)Oc1cccc(c1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C20H19NO4/c1-3-5-19(22)25-16-7-4-6-13(10-16)20(23)18-12-14-11-15(24-2)8-9-17(14)21-18/h4,6-12,21H,3,5H2,1-2H3
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n/an/a 850n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin alpha chain /beta chain


(Bos taurus)
BDBM50089336
PNG
(9-Ethoxy-12a-methyl-1,2,3,3a,3b,4,10b,11,12,12a-de...)
Show SMILES CCOc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CC=Cc2cc1O
Show InChI InChI=1S/C21H28O3/c1-3-24-19-12-16-13(11-18(19)22)5-4-6-15-14(16)9-10-21(2)17(15)7-8-20(21)23/h4-5,11-12,14-15,17,20,22-23H,3,6-10H2,1-2H3/t14?,15?,17?,20-,21-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of polymerization of purified bovine tubulin


J Med Chem 43: 2419-29 (2000)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50107693
PNG
((5-Methyl-1H-indol-2-yl)-(3,4,5-trimethoxy-phenyl)...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)c1cc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C19H19NO4/c1-11-5-6-14-12(7-11)8-15(20-14)18(21)13-9-16(22-2)19(24-4)17(10-13)23-3/h5-10,20H,1-4H3
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n/an/a 860n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization.


J Med Chem 44: 4535-53 (2001)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50111554
PNG
(CHEMBL296066 | Dimethyl-{4-[4-(3,4,5-trimethoxy-ph...)
Show SMILES COc1cc(cc(OC)c1OC)-c1ncoc1-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C20H22N2O4/c1-22(2)15-8-6-13(7-9-15)19-18(21-12-26-19)14-10-16(23-3)20(25-5)17(11-14)24-4/h6-12H,1-5H3
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n/an/a 870n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Concentration needed to inhibit tubulin polymerization by 50%


J Med Chem 45: 1697-711 (2002)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50059103
PNG
(2-(3-Methoxy-phenyl)-5,7-dimethyl-1H-[1,8]naphthyr...)
Show SMILES COc1cccc(c1)-c1cc(O)c2c(C)cc(C)nc2n1
Show InChI InChI=1S/C17H16N2O2/c1-10-7-11(2)18-17-16(10)15(20)9-14(19-17)12-5-4-6-13(8-12)21-3/h4-9H,1-3H3,(H,18,19,20)
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n/an/a 880n/an/an/an/an/an/a



University of North Carolina at Chapel Hill 27599

Curated by ChEMBL


Assay Description
Inhibition of bovine tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50041106
PNG
(6-(2-Chloro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin...)
Show SMILES Oc1cc(nc2cc3OCOc3cc12)-c1ccccc1Cl
Show InChI InChI=1S/C16H10ClNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19)
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n/an/a 890n/an/an/an/an/an/a



School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of tubulin polymerization


J Med Chem 37: 1126-35 (1994)

More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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n/an/a 900n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain tubulin polymerization


Citation and Details
More data for this
Ligand-Target Pair
Tubulin


(Bos taurus)
BDBM50369013
PNG
(CHEMBL1627442)
Show SMILES CCOc1cc2[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CCc2cc1O
Show InChI InChI=1S/C20H28O3/c1-3-23-18-11-15-12(10-17(18)21)4-5-14-13(15)8-9-20(2)16(14)6-7-19(20)22/h10-11,13-14,16,19,21-22H,3-9H2,1-2H3/t13-,14+,16-,19-,20-/m0/s1
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n/an/a 910n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
In vitro inhibition of tubulin polymerization.


J Med Chem 38: 2041-9 (1995)

More data for this
Ligand-Target Pair
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