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Compile Data Set for Download or QSAR

Found 59 hits Enz. Inhib. hit(s) with Target = 'Tyrosinase' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Mus musculus (Mouse))
BDBM50414514
PNG
(PROTOCATECHUAMIDE)
Show SMILES NC(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C7H7NO3/c8-7(11)4-1-2-5(9)6(10)3-4/h1-3,9-10H,(H2,8,11)
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3.70E+3n/an/an/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296245
PNG
(3,4-Dihydroxy-N-[2-(5-hydroxyindol-3-yl)ethyl]benz...)
Show SMILES Oc1ccc2[nH]cc(CCNC(=O)c3ccc(O)c(O)c3)c2c1
Show InChI InChI=1S/C17H16N2O4/c20-12-2-3-14-13(8-12)11(9-19-14)5-6-18-17(23)10-1-4-15(21)16(22)7-10/h1-4,7-9,19-22H,5-6H2,(H,18,23)
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6.40E+4n/an/an/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM29612
PNG
(CHEMBL33103 | N-ACETYL SEROTONIN | N-Acetyl-5-hydr...)
Show SMILES CC(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
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2.40E+5n/an/an/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50020713
PNG
(CHEMBL460860)
Show SMILES OC[C@H]1O[C@@H](Oc2c(O)cc(O)cc2\C=C\c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C20H22O9/c21-9-15-16(25)17(26)18(27)20(28-15)29-19-11(7-13(23)8-14(19)24)4-1-10-2-5-12(22)6-3-10/h1-8,15-18,20-27H,9H2/b4-1+/t15-,16-,17+,18-,20+/m1/s1
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2.50E+6n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 240 uM by Lineweaver-Burk plot


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50020713
PNG
(CHEMBL460860)
Show SMILES OC[C@H]1O[C@@H](Oc2c(O)cc(O)cc2\C=C\c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C20H22O9/c21-9-15-16(25)17(26)18(27)20(28-15)29-19-11(7-13(23)8-14(19)24)4-1-10-2-5-12(22)6-3-10/h1-8,15-18,20-27H,9H2/b4-1+/t15-,16-,17+,18-,20+/m1/s1
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2.80E+6n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plot


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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2.90E+6n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plot


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50020713
PNG
(CHEMBL460860)
Show SMILES OC[C@H]1O[C@@H](Oc2c(O)cc(O)cc2\C=C\c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C20H22O9/c21-9-15-16(25)17(26)18(27)20(28-15)29-19-11(7-13(23)8-14(19)24)4-1-10-2-5-12(22)6-3-10/h1-8,15-18,20-27H,9H2/b4-1+/t15-,16-,17+,18-,20+/m1/s1
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3.10E+6n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 60 uM by Lineweaver-Burk plot


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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5.50E+6n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plot


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM152929
PNG
(US8993596, Compound 24)
Show SMILES C[C@H](NC(=O)N1CCC(CC1)c1ccc(O)cc1O)c1ccccc1
Show InChI InChI=1/C20H24N2O3/c1-14(15-5-3-2-4-6-15)21-20(25)22-11-9-16(10-12-22)18-8-7-17(23)13-19(18)24/h2-8,13-14,16,23-24H,9-12H2,1H3,(H,21,25)/t14-/s2
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n/an/a 150n/an/an/an/an/an/a



Galderma Research & Development

US Patent


Assay Description
The activity of the inhibitors is measured using a lysate of B16F1 cells (murine melanoma line). In the presence of the L-tyrosine substrate, the tyr...


US Patent US8993596 (2015)

More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM152928
PNG
(US8993596, Compound 48)
Show SMILES O[C@H](C(=O)N1CCC(CC1)c1ccc(O)cc1O)c1ccccc1
Show InChI InChI=1/C19H21NO4/c21-15-6-7-16(17(22)12-15)13-8-10-20(11-9-13)19(24)18(23)14-4-2-1-3-5-14/h1-7,12-13,18,21-23H,8-11H2/t18-/s2
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n/an/a 200n/an/an/an/an/an/a



Galderma Research & Development

US Patent


Assay Description
The activity of the inhibitors is measured using a lysate of B16F1 cells (murine melanoma line). In the presence of the L-tyrosine substrate, the tyr...


US Patent US8993596 (2015)

More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50248158
PNG
(CHEMBL450195 | N-butylresorcinol | US8993596, 4-Bu...)
Show SMILES CCCCc1ccc(O)cc1O
Show InChI InChI=1S/C10H14O2/c1-2-3-4-8-5-6-9(11)7-10(8)12/h5-7,11-12H,2-4H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Galderma Research & Development

US Patent


Assay Description
The activity of the inhibitors is measured using a lysate of B16F1 cells (murine melanoma line). In the presence of the L-tyrosine substrate, the tyr...


US Patent US8993596 (2015)

More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175278
PNG
((E)-2,3-bis(4-Hydroxyphenyl)acrylonitrile (21))
Show SMILES Oc1ccc(\C=C(\C#N)c2ccc(O)cc2)cc1
Show InChI InChI=1S/C15H11NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-9,17-18H/b13-9-
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n/an/a 5.06E+3n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50095997
PNG
(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Show SMILES Oc1ccc2c(c1)occ(-c1ccc(O)c(O)c1)c2=O
Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H
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n/an/a 5.23E+3n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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n/an/a 1.08E+4n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50209568
PNG
(4',7,8-trihydroxyisoflavone | 7,8,4'-trihydroxyiso...)
Show SMILES Oc1ccc(cc1)-c1coc2c(O)c(O)ccc2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H
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n/an/a 1.12E+4n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175269
PNG
(Trans-4-Styryl-phenol (8))
Show SMILES Oc1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C14H12O/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11,15H/b7-6-
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n/an/a 1.74E+4n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296247
PNG
(3-(3,4-Dihydroxyphenyl)-N-[2-(5-hydroxyindol-3-yl)...)
Show SMILES Oc1ccc2[nH]cc(CCNC(=O)\C=C\c3ccc(O)c(O)c3)c2c1
Show InChI InChI=1S/C19H18N2O4/c22-14-3-4-16-15(10-14)13(11-21-16)7-8-20-19(25)6-2-12-1-5-17(23)18(24)9-12/h1-6,9-11,21-24H,7-8H2,(H,20,25)/b6-2+
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n/an/a 2.80E+4n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50219502
PNG
(4-hydroxyphenyl beta-D-glucopyranoside | Arbutin |...)
Show SMILES OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
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n/an/a 3.03E+4n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296244
PNG
(2,4-dihydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)...)
Show SMILES Oc1ccc(C(=O)NCCc2c[nH]c3ccc(O)cc23)c(O)c1
Show InChI InChI=1S/C17H16N2O4/c20-11-2-4-15-14(7-11)10(9-19-15)5-6-18-17(23)13-3-1-12(21)8-16(13)22/h1-4,7-9,19-22H,5-6H2,(H,18,23)
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n/an/a 4.20E+4n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175267
PNG
(Trans-4-Styrylbenzonitrile (6))
Show SMILES N#Cc1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C15H11N/c16-12-15-10-8-14(9-11-15)7-6-13-4-2-1-3-5-13/h1-11H/b7-6-
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n/an/a 5.00E+4n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175271
PNG
(Trans-1-fluoro-4-(4-methoxystyryl)benzene (10))
Show SMILES COc1ccc(\C=C/c2ccc(F)cc2)cc1
Show InChI InChI=1S/C15H13FO/c1-17-15-10-6-13(7-11-15)3-2-12-4-8-14(16)9-5-12/h2-11H,1H3/b3-2-
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n/an/a 5.00E+4n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50342164
PNG
(5-(3-Chlorobenzyloxy)benzene-1,3-diol | CHEMBL1766...)
Show SMILES Oc1cc(O)cc(OCc2cccc(Cl)c2)c1
Show InChI InChI=1S/C13H11ClO3/c14-10-3-1-2-9(4-10)8-17-13-6-11(15)5-12(16)7-13/h1-7,15-16H,8H2
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n/an/a 5.47E+4n/an/an/an/an/an/a



Catholic University of Daegu

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175272
PNG
(Trans-2-Bromo-1-methoxy-4-styryl-benzene (11))
Show SMILES COc1ccc(\C=C/c2ccccc2)cc1Br
Show InChI InChI=1S/C15H13BrO/c1-17-15-10-9-13(11-14(15)16)8-7-12-5-3-2-4-6-12/h2-11H,1H3/b8-7-
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n/an/a 5.62E+4n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 6.10E+4n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50342165
PNG
(5-(3,4-Dichlorobenzyloxy)benzene-1,3-diol | CHEMBL...)
Show SMILES Oc1cc(O)cc(OCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C13H10Cl2O3/c14-12-2-1-8(3-13(12)15)7-18-11-5-9(16)4-10(17)6-11/h1-6,16-17H,7H2
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n/an/a 6.64E+4n/an/an/an/an/an/a



Catholic University of Daegu

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM32212
PNG
(1H-indol-5-ol | cid_16054)
Show SMILES Oc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H
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n/an/a 6.80E+4n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296245
PNG
(3,4-Dihydroxy-N-[2-(5-hydroxyindol-3-yl)ethyl]benz...)
Show SMILES Oc1ccc2[nH]cc(CCNC(=O)c3ccc(O)c(O)c3)c2c1
Show InChI InChI=1S/C17H16N2O4/c20-12-2-3-14-13(8-12)11(9-19-14)5-6-18-17(23)10-1-4-15(21)16(22)7-10/h1-4,7-9,19-22H,5-6H2,(H,18,23)
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n/an/a 7.30E+4n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175263
PNG
(Trans-1-Fluoro-4-styryl-benzene (2))
Show SMILES Fc1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C14H11F/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11H/b7-6-
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n/an/a 7.94E+4n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50342166
PNG
(5-(4-Fluorobenzyloxy)benzene-1,3-diol | CHEMBL1766...)
Show SMILES Oc1cc(O)cc(OCc2ccc(F)cc2)c1
Show InChI InChI=1S/C13H11FO3/c14-10-3-1-9(2-4-10)8-17-13-6-11(15)5-12(16)7-13/h1-7,15-16H,8H2
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n/an/a 9.00E+4n/an/an/an/an/an/a



Catholic University of Daegu

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50065388
PNG
(CHEMBL465182)
Show SMILES COc1cc(\C=C\C(=O)NC[C@@H](O)c2ccc(O)cc2)ccc1O
Show InChI InChI=1/C18H19NO5/c1-24-17-10-12(2-8-15(17)21)3-9-18(23)19-11-16(22)13-4-6-14(20)7-5-13/h2-10,16,20-22H,11H2,1H3,(H,19,23)/b9-3+/t16-/s2
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n/an/a>9.60E+4n/an/an/an/an/an/a



Gansu College of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in alpha-MSH-induced melanin content


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175275
PNG
(Trans-9-Styryl-anthracene (15))
Show SMILES C(=C\c1c2ccccc2cc2ccccc12)\c1ccccc1
Show InChI InChI=1S/C22H16/c1-2-8-17(9-3-1)14-15-22-20-12-6-4-10-18(20)16-19-11-5-7-13-21(19)22/h1-16H/b15-14-
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n/an/a 1.66E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM26190
PNG
(1,4-Dihydroxybenzene, XIII | 1,4-dihydroxybenzene ...)
Show SMILES Oc1ccc(O)cc1
Show InChI InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
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n/an/a 1.88E+5n/an/an/an/a6.825



National Tsing Hua University



Assay Description
The enzyme activity was monitored by dopachrome formation at 475nm for an appropriate period.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296243
PNG
(4-hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-3-m...)
Show SMILES COc1cc(ccc1O)C(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C18H18N2O4/c1-24-17-8-11(2-5-16(17)22)18(23)19-7-6-12-10-20-15-4-3-13(21)9-14(12)15/h2-5,8-10,20-22H,6-7H2,1H3,(H,19,23)
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n/an/a 2.11E+5n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296246
PNG
(CHEMBL564482 | N-Feruloylserotonin)
Show SMILES COc1cc(\C=C\C(=O)NCCc2c[nH]c3ccc(O)cc23)ccc1O
Show InChI InChI=1S/C20H20N2O4/c1-26-19-10-13(2-6-18(19)24)3-7-20(25)21-9-8-14-12-22-17-5-4-15(23)11-16(14)17/h2-7,10-12,22-24H,8-9H2,1H3,(H,21,25)/b7-3+
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n/an/a 2.16E+5n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296242
PNG
(4-hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)benz...)
Show SMILES Oc1ccc(cc1)C(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C17H16N2O3/c20-13-3-1-11(2-4-13)17(22)18-8-7-12-10-19-16-6-5-14(21)9-15(12)16/h1-6,9-10,19-21H,7-8H2,(H,18,22)
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n/an/a 2.33E+5n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175279
PNG
((E)-2-(4-Hydroxyphenyl)-3-(pyridin-3-yl)acrylonitr...)
Show SMILES Oc1ccc(cc1)C(=C/c1cccnc1)\C#N
Show InChI InChI=1S/C14H10N2O/c15-9-13(8-11-2-1-7-16-10-11)12-3-5-14(17)6-4-12/h1-8,10,17H/b13-8-
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n/an/a 2.70E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175277
PNG
((E)-3-(4-Methoxyphenyl)-2-phenylpropenal (20))
Show SMILES COc1ccc(\C=C(\C=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H14O2/c1-18-16-9-7-13(8-10-16)11-15(12-17)14-5-3-2-4-6-14/h2-12H,1H3/b15-11-
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n/an/a 2.76E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175265
PNG
(Trans-1-Bromo-4-styrylbenzene (4))
Show SMILES Brc1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C14H11Br/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11H/b7-6-
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n/an/a 2.77E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM29612
PNG
(CHEMBL33103 | N-ACETYL SEROTONIN | N-Acetyl-5-hydr...)
Show SMILES CC(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
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n/an/a 3.11E+5n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175264
PNG
(Trans-1-Chloro-4-styrylbenzene (3))
Show SMILES Clc1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C14H11Cl/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11H/b7-6-
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n/an/a 3.20E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50296248
PNG
(CHEMBL564775 | N-(2-(5-hydroxy-1H-indol-3-yl)ethyl...)
Show SMILES Oc1ccc2[nH]cc(CCNC(=O)c3ccccc3)c2c1
Show InChI InChI=1S/C17H16N2O2/c20-14-6-7-16-15(10-14)13(11-19-16)8-9-18-17(21)12-4-2-1-3-5-12/h1-7,10-11,19-20H,8-9H2,(H,18,21)
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n/an/a 3.33E+5n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175266
PNG
(Trans-1-Nitro-4-styrylbenzene (5))
Show SMILES [O-][N+](=O)c1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C14H11NO2/c16-15(17)14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11H/b7-6-
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n/an/a 3.61E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175273
PNG
(Trans-1,3-Difluoro-5-styrylbenzene (12))
Show SMILES Fc1cc(F)cc(\C=C/c2ccccc2)c1
Show InChI InChI=1S/C14H10F2/c15-13-8-12(9-14(16)10-13)7-6-11-4-2-1-3-5-11/h1-10H/b7-6-
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n/an/a 3.94E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175270
PNG
(Trans-1-Methoxy-4-styryl-benzene (9))
Show SMILES COc1ccc(\C=C/c2ccccc2)cc1
Show InChI InChI=1S/C15H14O/c1-16-15-11-9-14(10-12-15)8-7-13-5-3-2-4-6-13/h2-12H,1H3/b8-7-
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n/an/a 4.33E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50006677
PNG
(1,2,3-Trimethoxy-5-[(Z)-2-(4-methoxy-phenyl)-vinyl...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1
Show InChI InChI=1S/C18H20O4/c1-19-15-9-7-13(8-10-15)5-6-14-11-16(20-2)18(22-4)17(12-14)21-3/h5-12H,1-4H3/b6-5-
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n/an/a>5.00E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50222303
PNG
(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)c(O)cc2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-14-6-13(18)12(17)5-10(14)15(11)19/h1-7,16-18H
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n/an/a>5.00E+5n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM23420
PNG
(7,4′-Dihydroxy-isoflavone (3a) | 7-hydroxy-3...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)ccc2c1=O
Show InChI InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
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n/an/a>5.00E+5n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50241530
PNG
(CHEMBL513024 | glycitein)
Show SMILES COc1cc2c(cc1O)occ(-c1ccc(O)cc1)c2=O
Show InChI InChI=1S/C16H12O5/c1-20-15-6-11-14(7-13(15)18)21-8-12(16(11)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
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n/an/a>5.00E+5n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in mouse Melan-a cells by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175268
PNG
(Trans-Acetic acid 4-styryl-phenyl ester (7))
Show SMILES CC(=O)Oc1ccc(C=Cc2ccccc2)cc1
Show InChI InChI=1S/C16H14O2/c1-13(17)18-16-11-9-15(10-12-16)8-7-14-5-3-2-4-6-14/h2-12H,1H3/b8-7+
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n/an/a>5.00E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM175274
PNG
(Trans-1,2,3,4,5-Pentafluoro-6-styryl-benzene (14))
Show SMILES Fc1c(F)c(F)c(\C=C/c2ccccc2)c(F)c1F
Show InChI InChI=1S/C14H7F5/c15-10-9(7-6-8-4-2-1-3-5-8)11(16)13(18)14(19)12(10)17/h1-7H/b7-6-
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n/an/a>5.00E+5n/an/an/an/an/an/a



Indian Institute of Integrative Medicine



Assay Description
The reaction mixture contained 50 mM phosphate buffer, pH 6.8, 0.05% L-DOPA and the supernatant (tyrosinase). After incubation in the absence or pres...


Citation and Details
More data for this
Ligand-Target Pair
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