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Found 979 hits Enz. Inhib. hit(s) with Target = 'Tyrosinase' AND taxid = 5341   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50269559
PNG
(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc(c(O)c1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H
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0.610 -53.5n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50330795
PNG
(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccc(O)c(=O)cc1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-5-9(11)10(12)6-4-8/h3-7H,1-2H3,(H,11,12)
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20n/an/an/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50343137
PNG
(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Show SMILES CC(C)=CC1Oc2cc(O)ccc2-c2oc3c4C=CC(C)(C)Oc4cc(O)c3c(=O)c12
Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3
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46.4 -42.6n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254430
PNG
(CHEMBL468906 | broussonin C)
Show SMILES CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O
Show InChI InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3
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48.5n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase by kinetic based assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM91591
PNG
(Mormin, 1)
Show SMILES C\C(CO)=C/Cc1c(oc2c3C=CC(C)(CO)Oc3cc(O)c2c1=O)-c1ccc(O)cc1O
Show InChI InChI=1S/C25H24O8/c1-13(11-26)3-5-17-22(31)21-19(30)10-20-16(7-8-25(2,12-27)33-20)24(21)32-23(17)15-6-4-14(28)9-18(15)29/h3-4,6-10,26-30H,5,11-12H2,1-2H3/b13-3+
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49.2 -42.4n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50330794
PNG
(2-Hydroxy-4-isopropyl-cyclohepta-2,4,6-trienone | ...)
Show SMILES CC(C)c1cccc(=O)c(O)c1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)
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60n/an/an/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50242015
PNG
(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Show SMILES CC(C)=CCc1c(O)cc(O)c2c1oc(-c1ccc(O)cc1O)c(CC=C(C)C)c2=O
Show InChI InChI=1S/C25H26O6/c1-13(2)5-8-17-20(28)12-21(29)22-23(30)18(9-6-14(3)4)24(31-25(17)22)16-10-7-15(26)11-19(16)27/h5-7,10-12,26-29H,8-9H2,1-4H3
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80.5 -41.2n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251001
PNG
(CHEMBL457677 | Kazinol F)
Show SMILES CC(C)=CCc1c(CCCc2ccc(O)cc2O)cc(O)c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H32O4/c1-16(2)8-12-21-19(7-5-6-18-10-11-20(26)15-23(18)27)14-24(28)25(29)22(21)13-9-17(3)4/h8-11,14-15,26-29H,5-7,12-13H2,1-4H3
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181n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase by kinetic based assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304605
PNG
(5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione...)
Show SMILES Oc1ccc(cc1)-c1nnc(S)s1
Show InChI InChI=1S/C8H6N2OS2/c11-6-3-1-5(2-4-6)7-9-10-8(12)13-7/h1-4,11H,(H,10,12)
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190n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254430
PNG
(CHEMBL468906 | broussonin C)
Show SMILES CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O
Show InChI InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3
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230n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot based kinetic assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254430
PNG
(CHEMBL468906 | broussonin C)
Show SMILES CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O
Show InChI InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3
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290n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of diphenolase activity of mushroom tyrosinase using as L-DOPA substrate by Lineweaver-Burk plot based kinetic assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251001
PNG
(CHEMBL457677 | Kazinol F)
Show SMILES CC(C)=CCc1c(CCCc2ccc(O)cc2O)cc(O)c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H32O4/c1-16(2)8-12-21-19(7-5-6-18-10-11-20(26)15-23(18)27)14-24(28)25(29)22(21)13-9-17(3)4/h8-11,14-15,26-29H,5-7,12-13H2,1-4H3
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410n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot based kinetic assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320717
PNG
(5,5'-methylenebis(1,3,4-thiadiazole-2(3H)-thione) ...)
Show SMILES Sc1nnc(Cc2nnc(S)s2)s1
Show InChI InChI=1S/C5H4N4S4/c10-4-8-6-2(12-4)1-3-7-9-5(11)13-3/h1H2,(H,8,10)(H,9,11)
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490n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304602
PNG
(5-(4-(tert-butyldimethylsilyloxy)phenyl)-1,3,4-thi...)
Show SMILES CC(C)(C)[Si](C)(C)Oc1ccc(cc1)-c1nnc(S)s1
Show InChI InChI=1S/C14H20N2OS2Si/c1-14(2,3)20(4,5)17-11-8-6-10(7-9-11)12-15-16-13(18)19-12/h6-9H,1-5H3,(H,16,18)
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530n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM33932
PNG
(4-(3H-1,3-benzothiazol-2-ylidene)-1-cyclohexa-2,5-...)
Show SMILES Oc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C13H9NOS/c15-10-7-5-9(6-8-10)13-14-11-3-1-2-4-12(11)16-13/h1-8,15H
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567n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 1.25 uM by Lineweaver-burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50339940
PNG
(4-(Benzo[d]thiazol-2-yl)benzene-1,3-diol | CHEMBL1...)
Show SMILES Oc1ccc(-c2nc3ccccc3s2)c(O)c1
Show InChI InChI=1S/C13H9NO2S/c15-8-5-6-9(11(16)7-8)13-14-10-3-1-2-4-12(10)17-13/h1-7,15-16H
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673n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 1.25 uM by Lineweaver-burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251001
PNG
(CHEMBL457677 | Kazinol F)
Show SMILES CC(C)=CCc1c(CCCc2ccc(O)cc2O)cc(O)c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H32O4/c1-16(2)8-12-21-19(7-5-6-18-10-11-20(26)15-23(18)27)14-24(28)25(29)22(21)13-9-17(3)4/h8-11,14-15,26-29H,5-7,12-13H2,1-4H3
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770n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of diphenolase activity of mushroom tyrosinase using as L-DOPA substrate by Lineweaver-Burk plot based kinetic assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50324036
PNG
(2-[5-(2,4-Dimethoxy-phenyl)-1H-pyrazol-3-yl]-6-(2-...)
Show SMILES COc1ccc(-c2cc([nH]n2)-c2c(OC)cc(OC)c(C3CCN(C)C3CO)c2O)c(OC)c1
Show InChI InChI=1S/C25H31N3O6/c1-28-9-8-16(19(28)13-29)23-21(33-4)12-22(34-5)24(25(23)30)18-11-17(26-27-18)15-7-6-14(31-2)10-20(15)32-3/h6-7,10-12,16,19,29-30H,8-9,13H2,1-5H3,(H,26,27)
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840n/an/an/an/an/an/an/an/a



Solapur University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254431
PNG
(5'-(2-methylbut-3-en-2-yl)-6''-(3-methylbut-2-enyl...)
Show SMILES CC(C)=CCc1c(CCCc2cc(c(O)cc2O)C(C)(C)C=C)cc(O)c(O)c1CC1OC1(C)C
Show InChI InChI=1S/C30H40O5/c1-8-29(4,5)23-14-20(24(31)17-25(23)32)11-9-10-19-15-26(33)28(34)22(16-27-30(6,7)35-27)21(19)13-12-18(2)3/h8,12,14-15,17,27,31-34H,1,9-11,13,16H2,2-7H3
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870n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase by kinetic based assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50324036
PNG
(2-[5-(2,4-Dimethoxy-phenyl)-1H-pyrazol-3-yl]-6-(2-...)
Show SMILES COc1ccc(-c2cc([nH]n2)-c2c(OC)cc(OC)c(C3CCN(C)C3CO)c2O)c(OC)c1
Show InChI InChI=1S/C25H31N3O6/c1-28-9-8-16(19(28)13-29)23-21(33-4)12-22(34-5)24(25(23)30)18-11-17(26-27-18)15-7-6-14(31-2)10-20(15)32-3/h6-7,10-12,16,19,29-30H,8-9,13H2,1-5H3,(H,26,27)
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960n/an/an/an/an/an/an/an/a



Solapur University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase assessed as oxidation of L-DOPA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320721
PNG
(4-Amino-5-pyridin-4-yl-4H-[1,2,4]triazole-3-thiol ...)
Show SMILES Nn1c(n[nH]c1=S)-c1ccncc1
Show InChI InChI=1S/C7H7N5S/c8-12-6(10-11-7(12)13)5-1-3-9-4-2-5/h1-4H,8H2,(H,11,13)
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1.01E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50336361
PNG
(4-Hydroxybenzyl 2,4-dihydroxybenzoate | CHEMBL1668...)
Show SMILES Oc1ccc(COC(=O)c2ccc(O)cc2O)cc1
Show InChI InChI=1S/C14H12O5/c15-10-3-1-9(2-4-10)8-19-14(18)12-6-5-11(16)7-13(12)17/h1-7,15-17H,8H2
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1.11E+3n/an/an/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50183699
PNG
(CHEMBL437510 | N-(2,4-dihydroxybenzyl)-3,5-dihydro...)
Show SMILES Oc1ccc(CNC(=O)c2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H13NO5/c16-10-2-1-8(13(19)6-10)7-15-14(20)9-3-11(17)5-12(18)4-9/h1-6,16-19H,7H2,(H,15,20)
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1.30E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320718
PNG
(5-phenyl-1,3,4-thiadiazole-2(3H)-thione | CHEMBL59...)
Show SMILES Sc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C8H6N2S2/c11-8-10-9-7(12-8)6-4-2-1-3-5-6/h1-5H,(H,10,11)
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1.31E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304606
PNG
(5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Sc1nnc(o1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H12N2O2S/c20-15-17-16-14(19-15)12-6-8-13(9-7-12)18-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,17,20)
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1.35E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM33932
PNG
(4-(3H-1,3-benzothiazol-2-ylidene)-1-cyclohexa-2,5-...)
Show SMILES Oc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C13H9NOS/c15-10-7-5-9(6-8-10)13-14-11-3-1-2-4-12(11)16-13/h1-8,15H
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1.70E+3n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 20 uM by Lineweaver-burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320723
PNG
(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol | 5-(4-h...)
Show SMILES Oc1ccc(cc1)-c1nnc(S)o1
Show InChI InChI=1S/C8H6N2O2S/c11-6-3-1-5(2-4-6)7-9-10-8(13)12-7/h1-4,11H,(H,10,13)
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1.77E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304608
PNG
(5,5'-(propane-1,3-diyl)bis(1,3,4-oxadiazole-2(3H)-...)
Show SMILES Sc1nnc(CCCc2nnc(S)o2)o1
Show InChI InChI=1S/C7H8N4O2S2/c14-6-10-8-4(12-6)2-1-3-5-9-11-7(15)13-5/h1-3H2,(H,10,14)(H,11,15)
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1.90E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320722
PNG
(4-amino-3-(4-hydroxyphenyl)-1H-1,2,4-triazole-5(4H...)
Show SMILES Nn1c(n[nH]c1=S)-c1ccc(O)cc1
Show InChI InChI=1S/C8H8N4OS/c9-12-7(10-11-8(12)14)5-1-3-6(13)4-2-5/h1-4,13H,9H2,(H,11,14)
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2.40E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304604
PNG
(5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3H)-thione | ...)
Show SMILES Sc1nnc(s1)-c1ccncc1
Show InChI InChI=1S/C7H5N3S2/c11-7-10-9-6(12-7)5-1-3-8-4-2-5/h1-4H,(H,10,11)
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2.47E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50066275
PNG
(CHEMBL3401548)
Show SMILES OC(\C=C\c1ccccn1)c1ccccc1O
Show InChI InChI=1/C14H13NO2/c16-13-7-2-1-6-12(13)14(17)9-8-11-5-3-4-10-15-11/h1-10,14,16-17H/b9-8+
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2.62E+3n/an/an/an/an/an/an/an/a



University of Technology Sydney

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase assessed as inhibition of L-DOPA oxidase activity at 5 uM active compound by Lineweaver-Burk plot analy...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320719
PNG
(2,2'-bi(1,3,4-thiadiazole)-5,5'(4H,4'H)-dithione |...)
Show SMILES Sc1nnc(s1)-c1nnc(S)s1
Show InChI InChI=1S/C4H2N4S4/c9-3-7-5-1(11-3)2-6-8-4(10)12-2/h(H,7,9)(H,8,10)
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2.90E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50068224
PNG
((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...)
Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1
Show InChI InChI=1S/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+
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2.90E+3n/an/an/an/an/an/an/an/a



Department of Functional Crop

Curated by ChEMBL


Assay Description
Competitive inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50203986
PNG
(2,2',4,4',6'-pentahydroxychalcone | CHEMBL244249)
Show SMILES Oc1ccc(\C=C\C(=O)c2c(O)cc(O)cc2O)c(O)c1
Show InChI InChI=1S/C15H12O6/c16-9-3-1-8(12(19)5-9)2-4-11(18)15-13(20)6-10(17)7-14(15)21/h1-7,16-17,19-21H/b4-2+
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3.10E+3n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50330793
PNG
(2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccccc(=O)c1O
Show InChI InChI=1S/C10H12O2/c1-7(2)8-5-3-4-6-9(11)10(8)12/h3-7H,1-2H3,(H,11,12)
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3.30E+3n/an/an/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304607
PNG
(5-(3-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Sc1nnc(o1)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C15H12N2O2S/c20-15-17-16-14(19-15)12-7-4-8-13(9-12)18-10-11-5-2-1-3-6-11/h1-9H,10H2,(H,17,20)
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3.64E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320724
PNG
(5-benzyl-1,3,4-oxadiazole-2(3H)-thione | CHEMBL116...)
Show SMILES Sc1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C9H8N2OS/c13-9-11-10-8(12-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,13)
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3.67E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50174839
PNG
(1-(4-aminophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-o...)
Show SMILES Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1
Show InChI InChI=1S/C15H13NO2/c16-13-6-4-12(5-7-13)15(18)10-3-11-1-8-14(17)9-2-11/h1-10,17H,16H2/b10-3+
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3.90E+3n/an/an/an/an/an/an/an/a



Department of Functional Crop

Curated by ChEMBL


Assay Description
Competitive inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304603
PNG
(5,5'-methylenebis(1,3,4-oxadiazole-2(3H)-thione) |...)
Show SMILES Sc1nnc(Cc2nnc(S)o2)o1
Show InChI InChI=1S/C5H4N4O2S2/c12-4-8-6-2(10-4)1-3-7-9-5(13)11-3/h1H2,(H,8,12)(H,9,13)
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4.42E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50193667
PNG
(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H14O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h3-8,15-18H,1-2H2
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4.80E+3n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 1.2 uM


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320725
PNG
(5-Cyclohexyl-3H-[1,3,4]oxadiazole-2-thione | 5-cyc...)
Show SMILES Sc1nnc(o1)C1CCCCC1
Show InChI InChI=1S/C8H12N2OS/c12-8-10-9-7(11-8)6-4-2-1-3-5-6/h6H,1-5H2,(H,10,12)
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4.94E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320720
PNG
(5-Diphenylmethyl-1,3,4-thiadiazole-2(3H)-thione | ...)
Show SMILES Sc1nnc(s1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2S2/c18-15-17-16-14(19-15)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H,(H,17,18)
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5.20E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50193667
PNG
(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H14O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h3-8,15-18H,1-2H2
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5.60E+3n/an/an/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 2.4 uM


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86064
PNG
(Iso-pentyl xanthate, III)
Show SMILES CC(C)CCOC(=S)S[Na]
Show InChI InChI=1S/C6H12OS2.Na/c1-5(2)3-4-7-6(8)9;/h5H,3-4H2,1-2H3,(H,8,9);/q;+1/p-1
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6.10E+3 -29.3n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50121842
PNG
(CHEMBL3617039)
Show SMILES O\N=C(/C=C/c1cccnc1)\c1cc2ccccc2cc1O
Show InChI InChI=1S/C18H14N2O2/c21-18-11-15-6-2-1-5-14(15)10-16(18)17(20-22)8-7-13-4-3-9-19-12-13/h1-12,21-22H/b8-7+,20-17+
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6.46E+3n/an/an/an/an/an/an/an/a



University of Technology Sydney

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase assessed as reduction in L-DOPA oxidase activity using L-DOPA substrate at 5 uM by Dixon plot


Bioorg Med Chem Lett 25: 4085-91 (2015)

More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320726
PNG
(5-phenyl-1,3,4-oxadiazole-2(3H)-thione | CHEMBL116...)
Show SMILES Sc1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C8H6N2OS/c12-8-10-9-7(11-8)6-4-2-1-3-5-6/h1-5H,(H,10,12)
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6.47E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320727
PNG
(5-Diphenylmethyl-1,3,4-oxadiazole-2(3H)-thione | 5...)
Show SMILES Sc1nnc(o1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2OS/c19-15-17-16-14(18-15)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H,(H,17,19)
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6.76E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM86063
PNG
(Iso-butyl xanthate, II)
Show SMILES CC(C)COC(=S)S[Na]
Show InChI InChI=1S/C5H10OS2.Na/c1-4(2)3-6-5(7)8;/h4H,3H2,1-2H3,(H,7,8);/q;+1/p-1
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7.20E+3 -28.9n/an/an/an/an/a6.820



University of Tehran



Assay Description
Kinetic assay of catecholase and cresolase activities was carried out through depletion of MeBACat and MePAPh for 1 or 2 min with enzyme concentratio...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50339940
PNG
(4-(Benzo[d]thiazol-2-yl)benzene-1,3-diol | CHEMBL1...)
Show SMILES Oc1ccc(-c2nc3ccccc3s2)c(O)c1
Show InChI InChI=1S/C13H9NO2S/c15-8-5-6-9(11(16)7-8)13-14-10-3-1-2-4-12(10)17-13/h1-7,15-16H
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7.70E+3n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 20 uM by Lineweaver-burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50121843
PNG
(CHEMBL3617128)
Show SMILES O\N=C(/C=C/c1ccncc1)\c1cc2ccccc2cc1O
Show InChI InChI=1S/C18H14N2O2/c21-18-12-15-4-2-1-3-14(15)11-16(18)17(20-22)6-5-13-7-9-19-10-8-13/h1-12,21-22H/b6-5+,20-17+
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7.82E+3n/an/an/an/an/an/an/an/a



University of Technology Sydney

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase assessed as reduction in L-DOPA oxidase activity using L-DOPA substrate at 5 uM by Dixon plot


Bioorg Med Chem Lett 25: 4085-91 (2015)

More data for this
Ligand-Target Pair
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