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Compile Data Set for Download or QSAR

Found 104 hits Enz. Inhib. hit(s) with Target = 'Tyrosinase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Homo sapiens (Human))
BDBM50287127
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES Oc1coc(COC(=O)N[C@@H](Cc2ccccc2)C(=O)OCc2cc(=O)c(O)co2)cc1=O
Show InChI InChI=1S/C22H19NO10/c24-17-7-14(30-11-19(17)26)9-32-21(28)16(6-13-4-2-1-3-5-13)23-22(29)33-10-15-8-18(25)20(27)12-31-15/h1-5,7-8,11-12,16,26-27H,6,9-10H2,(H,23,29)/t16-/m0/s1
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n/an/a 60n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146416
PNG
((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C36H34N4O10/c41-24-12-10-22(11-13-24)15-30(35(46)47)39-34(45)29(16-23-18-37-27-9-5-4-8-26(23)27)38-33(44)28(14-21-6-2-1-3-7-21)40-36(48)50-19-25-17-31(42)32(43)20-49-25/h1-13,17-18,20,28-30,37,41,43H,14-16,19H2,(H,38,44)(H,39,45)(H,40,48)(H,46,47)/t28-,29-,30-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146418
PNG
((S)-2-{(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C34H33N3O10/c38-24-13-11-23(12-14-24)17-28(33(43)44)36-31(41)26(15-21-7-3-1-4-8-21)35-32(42)27(16-22-9-5-2-6-10-22)37-34(45)47-19-25-18-29(39)30(40)20-46-25/h1-14,18,20,26-28,38,40H,15-17,19H2,(H,35,42)(H,36,41)(H,37,45)(H,43,44)/t26-,27-,28-/m0/s1
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n/an/a 330n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50263336
PNG
(4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol | CHEMBL4...)
Show SMILES Oc1ccc(CCc2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C14H14O4/c15-11-5-3-9(13(17)7-11)1-2-10-4-6-12(16)8-14(10)18/h3-8,15-18H,1-2H2
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n/an/a 370n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146415
PNG
((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C34H33N3O11/c38-23-10-6-21(7-11-23)15-26(31(42)36-28(33(44)45)16-22-8-12-24(39)13-9-22)35-32(43)27(14-20-4-2-1-3-5-20)37-34(46)48-18-25-17-29(40)30(41)19-47-25/h1-13,17,19,26-28,38-39,41H,14-16,18H2,(H,35,43)(H,36,42)(H,37,46)(H,44,45)/t26-,27-,28-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50264086
PNG
((2S,3R,4S,5R)-2-(4-(2,4-dihydroxyphenethyl)-3-hydr...)
Show SMILES O[C@@H]1CO[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O)c2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C19H22O8/c20-12-5-3-10(14(21)7-12)1-2-11-4-6-13(8-15(11)22)27-19-18(25)17(24)16(23)9-26-19/h3-8,16-25H,1-2,9H2/t16-,17+,18-,19+/m1/s1
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n/an/a 430n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50292636
PNG
(4-hexyl resorcinol | ACRISORCIN | CHEMBL443605)
Show SMILES CCCCCCc1ccc(O)cc1O
Show InChI InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3
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n/an/a 560n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50340788
PNG
(4-(beta-D-Cellobiopyranosyl)-2,2',4'-trihydroxybib...)
Show SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H34O14/c27-9-17-19(32)20(33)22(35)26(38-17)40-24-18(10-28)39-25(23(36)21(24)34)37-14-6-4-12(16(31)8-14)2-1-11-3-5-13(29)7-15(11)30/h3-8,17-36H,1-2,9-10H2/t17-,18-,19-,20+,21-,22-,23-,24-,25-,26+/m1/s1
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n/an/a 680n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50366430
PNG
(CHEMBL1794031)
Show SMILES CC[C@H](C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C19H21NO10/c1-3-10(2)17(18(25)29-6-11-4-13(21)15(23)8-27-11)20-19(26)30-7-12-5-14(22)16(24)9-28-12/h4-5,8-10,17,23-24H,3,6-7H2,1-2H3,(H,20,26)/t10-,17-/m0/s1
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n/an/a 700n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50264087
PNG
((2S,2'S,3R,3'R,4S,4'S,5R,5'R)-2,2'-(4-(2,4-dihydro...)
Show SMILES O[C@@H]1CO[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C24H30O12/c25-13-5-3-11(15(26)7-13)1-2-12-4-6-14(35-23-21(31)19(29)16(27)9-33-23)8-18(12)36-24-22(32)20(30)17(28)10-34-24/h3-8,16-17,19-32H,1-2,9-10H2/t16-,17-,19+,20+,21-,22-,23+,24+/m1/s1
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n/an/a 730n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50340787
PNG
(4-(beta-D-Glucopyranosyl)-2,2',4'-trihydroxybibenz...)
Show SMILES OC[C@H]1O[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C20H24O9/c21-9-16-17(25)18(26)19(27)20(29-16)28-13-6-4-11(15(24)8-13)2-1-10-3-5-12(22)7-14(10)23/h3-8,16-27H,1-2,9H2/t16-,17-,18+,19-,20-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146414
PNG
((2S)-2-[(2S)-2-[(2S)-2-({[(5-hydroxy-4-oxo-4H-pyra...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C38H35N5O10/c44-24-11-9-21(10-12-24)13-32(37(49)50)42-35(47)30(14-22-17-39-28-7-3-1-5-26(22)28)41-36(48)31(15-23-18-40-29-8-4-2-6-27(23)29)43-38(51)53-19-25-16-33(45)34(46)20-52-25/h1-12,16-18,20,30-32,39-40,44,46H,13-15,19H2,(H,41,48)(H,42,47)(H,43,51)(H,49,50)/t30-,31-,32-/m0/s1
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n/an/a 780n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50340789
PNG
(2,2',4'-Trihydroxy-4-(beta-D-maltopyranosyl)bibenz...)
Show SMILES OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H34O14/c27-9-17-19(32)20(33)22(35)26(38-17)40-24-18(10-28)39-25(23(36)21(24)34)37-14-6-4-12(16(31)8-14)2-1-11-3-5-13(29)7-15(11)30/h3-8,17-36H,1-2,9-10H2/t17-,18-,19-,20+,21-,22-,23-,24-,25-,26-/m1/s1
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n/an/a 830n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120802
PNG
(CHEMBL3100130)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H34O13/c1-9(2-3-10-4-5-11(25)6-12(10)26)32-21-19(31)17(29)20(14(8-24)34-21)35-22-18(30)16(28)15(27)13(7-23)33-22/h4-6,9,13-31H,2-3,7-8H2,1H3/t9-,13-,14-,15-,16+,17-,18-,19-,20-,21-,22+/s2
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n/an/a 1.51E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50264085
PNG
((2S,3R,4S,5R)-2-(2-(2,4-dihydroxyphenethyl)-5-hydr...)
Show SMILES O[C@@H]1CO[C@@H](Oc2cc(O)ccc2CCc2ccc(O)cc2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C19H22O8/c20-12-5-3-10(14(22)7-12)1-2-11-4-6-13(21)8-16(11)27-19-18(25)17(24)15(23)9-26-19/h3-8,15,17-25H,1-2,9H2/t15-,17+,18-,19+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50193667
PNG
(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H14O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h3-8,15-18H,1-2H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120803
PNG
(CHEMBL3100134)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C15H22O7/c1-8(2-3-9-4-5-10(16)6-11(9)17)22-15-14(20)13(19)12(18)7-21-15/h4-6,8,12-20H,2-3,7H2,1H3/t8-,12-,13+,14-,15+/s2
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n/an/a 1.72E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218211
PNG
(1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl | CHEMBL3...)
Show SMILES Cc1ccc(CN2CCC(CC2)N2CCCCC2)cc1
Show InChI InChI=1S/C18H28N2/c1-16-5-7-17(8-6-16)15-19-13-9-18(10-14-19)20-11-3-2-4-12-20/h5-8,18H,2-4,9-15H2,1H3
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n/an/a 1.72E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120804
PNG
(CHEMBL3618459)
Show SMILES C[C@@H](O)CCc1ccc(O)cc1O
Show InChI InChI=1/C10H14O3/c1-7(11)2-3-8-4-5-9(12)6-10(8)13/h4-7,11-13H,2-3H2,1H3/t7-/s2
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n/an/a 1.78E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50240041
PNG
(1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263...)
Show SMILES NC(=S)Nc1ccccc1
Show InChI InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120800
PNG
(CHEMBL3618460)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H34O13/c1-9(2-3-10-4-5-11(25)6-12(10)26)32-21-19(31)17(29)20(14(8-24)34-21)35-22-18(30)16(28)15(27)13(7-23)33-22/h4-6,9,13-31H,2-3,7-8H2,1H3/t9-,13-,14-,15-,16+,17-,18-,19-,20-,21-,22-/s2
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n/an/a 1.98E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287124
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES CC(C)C[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C19H21NO10/c1-10(2)3-13(18(25)29-6-11-4-14(21)16(23)8-27-11)20-19(26)30-7-12-5-15(22)17(24)9-28-12/h4-5,8-10,13,23-24H,3,6-7H2,1-2H3,(H,20,26)/t13-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146413
PNG
(2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmeth...)
Show SMILES OC(=O)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C31H30N4O11/c36-25-12-19(45-16-26(25)37)15-46-31(44)35-22(10-17-6-2-1-3-7-17)28(40)33-23(29(41)34-24(30(42)43)13-27(38)39)11-18-14-32-21-9-5-4-8-20(18)21/h1-9,12,14,16,22-24,32,37H,10-11,13,15H2,(H,33,40)(H,34,41)(H,35,44)(H,38,39)(H,42,43)/t22-,23-,24-/m0/s1
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n/an/a 2.13E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120813
PNG
(CHEMBL3618457)
Show SMILES C[C@H](O)CCc1ccc(O)cc1O
Show InChI InChI=1/C10H14O3/c1-7(11)2-3-8-4-5-9(12)6-10(8)13/h4-7,11-13H,2-3H2,1H3/t7-/s2
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n/an/a 2.17E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146417
PNG
(2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmeth...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C33H36N4O9/c1-3-19(2)29(32(42)43)37-31(41)26(14-21-16-34-24-12-8-7-11-23(21)24)35-30(40)25(13-20-9-5-4-6-10-20)36-33(44)46-17-22-15-27(38)28(39)18-45-22/h4-12,15-16,18-19,25-26,29,34,39H,3,13-14,17H2,1-2H3,(H,35,40)(H,36,44)(H,37,41)(H,42,43)/t19-,25-,26-,29-/m0/s1
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n/an/a 2.18E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139369
PNG
(2-Hydroxy-4-isopropyl-benzaldehyde | CHEMBL353354)
Show SMILES CC(C)c1ccc(C=O)c(O)c1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-4-9(6-11)10(12)5-8/h3-7,12H,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)

More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120806
PNG
(CHEMBL3100132)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C16H24O8/c1-8(2-3-9-4-5-10(18)6-11(9)19)23-16-15(22)14(21)13(20)12(7-17)24-16/h4-6,8,12-22H,2-3,7H2,1H3/t8-,12-,13-,14+,15-,16-/s2
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n/an/a 2.30E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287123
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES CC(C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C18H19NO10/c1-9(2)16(17(24)28-5-10-3-12(20)14(22)7-26-10)19-18(25)29-6-11-4-13(21)15(23)8-27-11/h3-4,7-9,16,22-23H,5-6H2,1-2H3,(H,19,25)/t16-/m0/s1
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n/an/a 2.39E+3n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287126
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES C[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C16H15NO10/c1-8(15(22)26-4-9-2-11(18)13(20)6-24-9)17-16(23)27-5-10-3-12(19)14(21)7-25-10/h2-3,6-8,20-21H,4-5H2,1H3,(H,17,23)/t8-/m0/s1
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n/an/a 3.03E+3n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50198715
PNG
((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
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n/an/a 3.68E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120810
PNG
(CHEMBL3100135)
Show SMILES C[C@@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H34O13/c1-9(2-3-10-4-5-11(25)6-12(10)26)32-21-19(31)17(29)20(14(8-24)34-21)35-22-18(30)16(28)15(27)13(7-23)33-22/h4-6,9,13-31H,2-3,7-8H2,1H3/t9-,13+,14+,15+,16-,17+,18+,19+,20+,21+,22-/s2
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n/an/a 3.83E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120807
PNG
(CHEMBL3618458)
Show SMILES C[C@@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H34O13/c1-9(2-3-10-4-5-11(25)6-12(10)26)32-21-19(31)17(29)20(14(8-24)34-21)35-22-18(30)16(28)15(27)13(7-23)33-22/h4-6,9,13-31H,2-3,7-8H2,1H3/t9-,13+,14+,15+,16-,17+,18+,19+,20+,21+,22+/s2
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n/an/a 4.13E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146420
PNG
(2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmeth...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C36H34N4O9/c41-31-18-25(48-21-32(31)42)20-49-36(47)40-28(15-22-9-3-1-4-10-22)33(43)38-29(17-24-19-37-27-14-8-7-13-26(24)27)34(44)39-30(35(45)46)16-23-11-5-2-6-12-23/h1-14,18-19,21,28-30,37,42H,15-17,20H2,(H,38,43)(H,39,44)(H,40,47)(H,45,46)/t28-,29-,30-/m0/s1
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n/an/a 4.48E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120811
PNG
(CHEMBL3100133)
Show SMILES C[C@@H](CCc1ccc(O)cc1O)O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C15H22O7/c1-8(2-3-9-4-5-10(16)6-11(9)17)22-15-14(20)13(19)12(18)7-21-15/h4-6,8,12-20H,2-3,7H2,1H3/t8-,12+,13-,14+,15-/s2
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n/an/a 4.56E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120814
PNG
(CHEMBL3100131)
Show SMILES C[C@@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C16H24O8/c1-8(2-3-9-4-5-10(18)6-11(9)19)23-16-15(22)14(21)13(20)12(7-17)24-16/h4-6,8,12-22H,2-3,7H2,1H3/t8-,12+,13+,14-,15+,16+/s2
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n/an/a 4.72E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50109690
PNG
(3,4,5-Trihydroxy-benzoic acid 2-(4-hydroxy-phenyl)...)
Show SMILES Oc1ccc(CCOC(=O)c2cc(O)c(O)c(O)c2)cc1
Show InChI InChI=1S/C15H14O6/c16-11-3-1-9(2-4-11)5-6-21-15(20)10-7-12(17)14(19)13(18)8-10/h1-4,7-8,16-19H,5-6H2
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n/an/a 4.93E+3n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in Melan-a cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146419
PNG
(2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmeth...)
Show SMILES OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C38H35N5O9/c44-33-17-25(51-21-34(33)45)20-52-38(50)43-30(14-22-8-2-1-3-9-22)35(46)41-31(15-23-18-39-28-12-6-4-10-26(23)28)36(47)42-32(37(48)49)16-24-19-40-29-13-7-5-11-27(24)29/h1-13,17-19,21,30-32,39-40,45H,14-16,20H2,(H,41,46)(H,42,47)(H,43,50)(H,48,49)/t30-,31-,32-/m0/s1
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n/an/a 6.17E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218209
PNG
(CHEMBL250773 | Tyrosinase Inhibitor, 3 | naphthale...)
Show SMILES O=C(N1CCC(CC1)N1CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H26N2O/c24-21(19-9-8-17-6-2-3-7-18(17)16-19)23-14-10-20(11-15-23)22-12-4-1-5-13-22/h2-3,6-9,16,20H,1,4-5,10-15H2
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n/an/a 6.64E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287122
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C16H15NO7/c18-13-7-11(23-9-14(13)19)8-24-16(22)17-12(15(20)21)6-10-4-2-1-3-5-10/h1-5,7,9,12,19H,6,8H2,(H,17,22)(H,20,21)/t12-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM85773
PNG
(Tyrosinase Inhibitor, 8)
Show SMILES O=N(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C16H23N3O4S/c20-19(21)15-4-6-16(7-5-15)24(22,23)18-12-8-14(9-13-18)17-10-2-1-3-11-17/h4-7,14H,1-3,8-13H2
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n/an/a 8.76E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 9.15E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50108046
PNG
((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+
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n/an/a 1.27E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50176699
PNG
(CHEMBL411981 | askendoside B)
Show SMILES CC(=O)O[C@H]1[C@H](O)CO[C@@H](O[C@H]2CC[C@]34C[C@]33CC[C@]5(C)[C@H]([C@@H](O)C[C@@]5(C)[C@@H]3C[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H]4C2(C)C)[C@@]2(C)CC[C@@H](O2)C(C)(C)O)[C@@H]1O[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C47H76O18/c1-21(48)61-34-25(52)19-60-40(35(34)64-39-33(56)31(54)24(51)18-59-39)63-28-10-12-47-20-46(47)14-13-43(6)36(45(8)11-9-29(65-45)42(4,5)57)22(49)16-44(43,7)27(46)15-26(37(47)41(28,2)3)62-38-32(55)30(53)23(50)17-58-38/h22-40,49-57H,9-20H2,1-8H3/t22-,23+,24-,25+,26-,27-,28-,29+,30-,31-,32+,33+,34-,35+,36-,37-,38-,39-,40-,43+,44-,45+,46-,47+/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibitory activity against tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50219503
PNG
(2-hydroxyphenethyl 3,4,5-trihydroxybenzoate | CHEM...)
Show SMILES Oc1ccccc1CCOC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H14O6/c16-11-4-2-1-3-9(11)5-6-21-15(20)10-7-12(17)14(19)13(18)8-10/h1-4,7-8,16-19H,5-6H2
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n/an/a 1.45E+4n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in Melan-a cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287121
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES CC(C)C[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C13H17NO7/c1-7(2)3-9(12(17)18)14-13(19)21-5-8-4-10(15)11(16)6-20-8/h4,6-7,9,16H,3,5H2,1-2H3,(H,14,19)(H,17,18)/t9-/m0/s1
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n/an/a 1.45E+4n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50219504
PNG
(3-hydroxyphenethyl 3,4,5-trihydroxybenzoate | CHEM...)
Show SMILES Oc1cccc(CCOC(=O)c2cc(O)c(O)c(O)c2)c1
Show InChI InChI=1S/C15H14O6/c16-11-3-1-2-9(6-11)4-5-21-15(20)10-7-12(17)14(19)13(18)8-10/h1-3,6-8,16-19H,4-5H2
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n/an/a 1.52E+4n/an/an/an/an/an/a



AmorePacific Corporation

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in Melan-a cells


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50366429
PNG
(CHEMBL1793857)
Show SMILES CC[C@H](C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C13H17NO7/c1-3-7(2)11(12(17)18)14-13(19)21-5-8-4-9(15)10(16)6-20-8/h4,6-7,11,16H,3,5H2,1-2H3,(H,14,19)(H,17,18)/t7-,11-/m0/s1
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n/an/a 1.54E+4n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287120
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES CC(C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C12H15NO7/c1-6(2)10(11(16)17)13-12(18)20-4-7-3-8(14)9(15)5-19-7/h3,5-6,10,15H,4H2,1-2H3,(H,13,18)(H,16,17)/t10-/m0/s1
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n/an/a 1.67E+4n/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Citation and Details
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibitory activity against tyrosinase


Citation and Details
More data for this
Ligand-Target Pair
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