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Compile Data Set for Download or QSAR

Found 709 hits Enz. Inhib. hit(s) with Target = 'Tyrosine kinase non-receptor protein 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421256
PNG
(CHEMBL2087874)
Show SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NCC3SCCS3)c2c1-c1ccccc1
Show InChI InChI=1S/C26H28N4O2S2/c1-30(2)12-13-31-20-10-8-19(9-11-20)24-22(18-6-4-3-5-7-18)23-25(28-17-29-26(23)32-24)27-16-21-33-14-15-34-21/h3-11,17,21H,12-16H2,1-2H3,(H,27,28,29)
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0.200n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421255
PNG
(CHEMBL2087873)
Show SMILES CN(C)CCOc1ccc(cc1)-c1[nH]c2ncnc(NCC3SCCS3)c2c1-c1ccccc1
Show InChI InChI=1S/C26H29N5OS2/c1-31(2)12-13-32-20-10-8-19(9-11-20)24-22(18-6-4-3-5-7-18)23-25(28-17-29-26(23)30-24)27-16-21-33-14-15-34-21/h3-11,17,21H,12-16H2,1-2H3,(H2,27,28,29,30)
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0.300n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421256
PNG
(CHEMBL2087874)
Show SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NCC3SCCS3)c2c1-c1ccccc1
Show InChI InChI=1S/C26H28N4O2S2/c1-30(2)12-13-31-20-10-8-19(9-11-20)24-22(18-6-4-3-5-7-18)23-25(28-17-29-26(23)32-24)27-16-21-33-14-15-34-21/h3-11,17,21H,12-16H2,1-2H3,(H,27,28,29)
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0.300n/an/an/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Inhibition of ACK1 kinase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421257
PNG
(CHEMBL2087875)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1[nH]c2ncnc(NCC3SCCS3)c2c1-c1ccccc1
Show InChI InChI=1S/C28H31N5OS2/c1-2-6-20(7-3-1)24-25-27(29-18-23-35-16-17-36-23)30-19-31-28(25)32-26(24)21-8-10-22(11-9-21)34-15-14-33-12-4-5-13-33/h1-3,6-11,19,23H,4-5,12-18H2,(H2,29,30,31,32)
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0.300n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245854
PNG
(CHEMBL504331 | N3-(2,6-dichlorophenyl)-N6-(3-fluor...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccc(OCCN4CCCC4)c(F)c3)nc12
Show InChI InChI=1S/C29H34Cl2FN7O2/c1-29(2,40-3)11-14-39-27-20(26(37-39)35-25-21(30)7-6-8-22(25)31)18-33-28(36-27)34-19-9-10-24(23(32)17-19)41-16-15-38-12-4-5-13-38/h6-10,17-18H,4-5,11-16H2,1-3H3,(H,35,37)(H,33,34,36)
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2n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246214
PNG
(CHEMBL487897 | N3-(2,6-dimethylphenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C30H40N8O/c1-21-8-7-9-22(2)26(21)33-27-25-20-31-29(34-28(25)38(35-27)15-14-30(3,4)39-6)32-23-10-12-24(13-11-23)37-18-16-36(5)17-19-37/h7-13,20H,14-19H2,1-6H3,(H,33,35)(H,31,32,34)
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2n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246162
PNG
(CHEMBL472392 | N3-(2,6-dimethylphenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C29H38N8O/c1-20-7-6-8-21(2)25(20)33-26-24-19-31-28(34-27(24)37(35-26)16-13-29(3,4)38-5)32-22-9-11-23(12-10-22)36-17-14-30-15-18-36/h6-12,19,30H,13-18H2,1-5H3,(H,33,35)(H,31,32,34)
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2n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421286
PNG
(CHEMBL2087662)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c1-31(2)26(32)19-12-10-18(11-13-19)23-21(17-7-4-3-5-8-17)22-24(28-16-29-25(22)30-23)27-15-20-9-6-14-33-20/h3-5,7-8,10-13,16,20H,6,9,14-15H2,1-2H3,(H2,27,28,29,30)/t20-/m0/s1
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2n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421276
PNG
(CHEMBL2087652)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C25H27N5O3S/c1-30(2)34(31,32)20-12-10-18(11-13-20)23-21(17-7-4-3-5-8-17)22-24(27-16-28-25(22)29-23)26-15-19-9-6-14-33-19/h3-5,7-8,10-13,16,19H,6,9,14-15H2,1-2H3,(H2,26,27,28,29)/t19-/m0/s1
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2n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421278
PNG
(CHEMBL2087654)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C24H25N5O3S/c1-25-33(30,31)19-11-9-17(10-12-19)22-20(16-6-3-2-4-7-16)21-23(27-15-28-24(21)29-22)26-14-18-8-5-13-32-18/h2-4,6-7,9-12,15,18,25H,5,8,13-14H2,1H3,(H2,26,27,28,29)/t18-/m0/s1
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2n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246164
PNG
(CHEMBL487242 | N3-(2,6-dimethylphenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccccc3)nc12
Show InChI InChI=1S/C25H30N6O/c1-17-10-9-11-18(2)21(17)28-22-20-16-26-24(27-19-12-7-6-8-13-19)29-23(20)31(30-22)15-14-25(3,4)32-5/h6-13,16H,14-15H2,1-5H3,(H,28,30)(H,26,27,29)
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3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245852
PNG
(CHEMBL458333 | N3-(2,6-dimethylphenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCN4CCCC4)cc3)nc12
Show InChI InChI=1S/C31H41N7O2/c1-22-9-8-10-23(2)27(22)34-28-26-21-32-30(35-29(26)38(36-28)18-15-31(3,4)39-5)33-24-11-13-25(14-12-24)40-20-19-37-16-6-7-17-37/h8-14,21H,6-7,15-20H2,1-5H3,(H,34,36)(H,32,33,35)
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3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245853
PNG
(CHEMBL502156 | N3-(2,6-dimethylphenyl)-N6-(3-fluor...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCN4CCCC4)c(F)c3)nc12
Show InChI InChI=1S/C31H40FN7O2/c1-21-9-8-10-22(2)27(21)35-28-24-20-33-30(36-29(24)39(37-28)16-13-31(3,4)40-5)34-23-11-12-26(25(32)19-23)41-18-17-38-14-6-7-15-38/h8-12,19-20H,6-7,13-18H2,1-5H3,(H,35,37)(H,33,34,36)
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3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245855
PNG
(CHEMBL450918 | N3-(2,6-dimethylphenyl)-N6-(3-fluor...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCCN4CCCCC4)c(F)c3)nc12
Show InChI InChI=1S/C33H44FN7O2/c1-23-11-9-12-24(2)29(23)37-30-26-22-35-32(38-31(26)41(39-30)19-15-33(3,4)42-5)36-25-13-14-28(27(34)21-25)43-20-10-18-40-16-7-6-8-17-40/h9,11-14,21-22H,6-8,10,15-20H2,1-5H3,(H,37,39)(H,35,36,38)
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3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421287
PNG
(CHEMBL2087664)
Show SMILES CNC(=O)c1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C25H25N5O2/c1-26-25(31)18-11-9-17(10-12-18)22-20(16-6-3-2-4-7-16)21-23(28-15-29-24(21)30-22)27-14-19-8-5-13-32-19/h2-4,6-7,9-12,15,19H,5,8,13-14H2,1H3,(H,26,31)(H2,27,28,29,30)/t19-/m0/s1
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3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421277
PNG
(CHEMBL2087653)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C24H24N4O4S/c1-25-33(29,30)19-11-9-17(10-12-19)22-20(16-6-3-2-4-7-16)21-23(27-15-28-24(21)32-22)26-14-18-8-5-13-31-18/h2-4,6-7,9-12,15,18,25H,5,8,13-14H2,1H3,(H,26,27,28)/t18-/m0/s1
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421254
PNG
(CHEMBL2087872)
Show SMILES Fc1ccccc1-c1c([nH]c2ncnc(NC[C@@H]3CCCO3)c12)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C29H32FN5O2/c30-24-8-2-1-7-23(24)25-26-28(31-18-22-6-5-16-36-22)32-19-33-29(26)34-27(25)20-9-11-21(12-10-20)37-17-15-35-13-3-4-14-35/h1-2,7-12,19,22H,3-6,13-18H2,(H2,31,32,33,34)/t22-/m0/s1
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421261
PNG
(CHEMBL2087879)
Show SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NCC3SCCCS3)c2c1-c1ccccc1
Show InChI InChI=1S/C27H30N4O2S2/c1-31(2)13-14-32-21-11-9-20(10-12-21)25-23(19-7-4-3-5-8-19)24-26(29-18-30-27(24)33-25)28-17-22-34-15-6-16-35-22/h3-5,7-12,18,22H,6,13-17H2,1-2H3,(H,28,29,30)
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421284
PNG
(CHEMBL2087660)
Show SMILES O=C1CCCN1CCOc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C29H31N5O3/c35-24-9-4-14-34(24)15-17-37-22-12-10-21(11-13-22)27-25(20-6-2-1-3-7-20)26-28(31-19-32-29(26)33-27)30-18-23-8-5-16-36-23/h1-3,6-7,10-13,19,23H,4-5,8-9,14-18H2,(H2,30,31,32,33)/t23-/m0/s1
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421283
PNG
(CHEMBL2087659)
Show SMILES O=C1CCCN1CCOc1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C29H30N4O4/c34-24-9-4-14-33(24)15-17-36-22-12-10-21(11-13-22)27-25(20-6-2-1-3-7-20)26-28(31-19-32-29(26)37-27)30-18-23-8-5-16-35-23/h1-3,6-7,10-13,19,23H,4-5,8-9,14-18H2,(H,30,31,32)/t23-/m0/s1
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421280
PNG
(CHEMBL2087656)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C29H32N4O4/c1-2-5-21(6-3-1)25-26-28(30-19-24-7-4-15-35-24)31-20-32-29(26)37-27(25)22-8-10-23(11-9-22)36-18-14-33-12-16-34-17-13-33/h1-3,5-6,8-11,20,24H,4,7,12-19H2,(H,30,31,32)/t24-/m0/s1
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421272
PNG
(CHEMBL2087648)
Show SMILES COc1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C24H23N3O3/c1-28-18-11-9-17(10-12-18)22-20(16-6-3-2-4-7-16)21-23(26-15-27-24(21)30-22)25-14-19-8-5-13-29-19/h2-4,6-7,9-12,15,19H,5,8,13-14H2,1H3,(H,25,26,27)/t19-/m0/s1
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5n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246260
PNG
(CHEMBL487241 | N3-(2,6-dichlorophenyl)-1-(2-(dimet...)
Show SMILES CN(C)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccccc3)nc12
Show InChI InChI=1S/C21H21Cl2N7/c1-29(2)11-12-30-20-15(13-24-21(27-20)25-14-7-4-3-5-8-14)19(28-30)26-18-16(22)9-6-10-17(18)23/h3-10,13H,11-12H2,1-2H3,(H,26,28)(H,24,25,27)
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5n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246261
PNG
(CHEMBL487054 | N3-(2,6-dichlorophenyl)-1-(3-(dimet...)
Show SMILES CN(C)CCCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccccc3)nc12
Show InChI InChI=1S/C22H23Cl2N7/c1-30(2)12-7-13-31-21-16(14-25-22(28-21)26-15-8-4-3-5-9-15)20(29-31)27-19-17(23)10-6-11-18(19)24/h3-6,8-11,14H,7,12-13H2,1-2H3,(H,27,29)(H,25,26,28)
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5n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50204587
PNG
((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C27H30N4O3/c1-31(2)14-16-33-21-12-10-20(11-13-21)25-23(19-7-4-3-5-8-19)24-26(29-18-30-27(24)34-25)28-17-22-9-6-15-32-22/h3-5,7-8,10-13,18,22H,6,9,14-17H2,1-2H3,(H,28,29,30)/t22-/m0/s1
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5n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421282
PNG
(CHEMBL2087658)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C29H33N5O2/c1-2-7-21(8-3-1)25-26-28(30-19-24-9-6-17-35-24)31-20-32-29(26)33-27(25)22-10-12-23(13-11-22)36-18-16-34-14-4-5-15-34/h1-3,7-8,10-13,20,24H,4-6,9,14-19H2,(H2,30,31,32,33)/t24-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421281
PNG
(CHEMBL2087657)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C29H33N5O3/c1-2-5-21(6-3-1)25-26-28(30-19-24-7-4-15-36-24)31-20-32-29(26)33-27(25)22-8-10-23(11-9-22)37-18-14-34-12-16-35-17-13-34/h1-3,5-6,8-11,20,24H,4,7,12-19H2,(H2,30,31,32,33)/t24-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421279
PNG
(CHEMBL2087655)
Show SMILES CN(C)CCOc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C27H31N5O2/c1-32(2)14-16-34-21-12-10-20(11-13-21)25-23(19-7-4-3-5-8-19)24-26(29-18-30-27(24)31-25)28-17-22-9-6-15-33-22/h3-5,7-8,10-13,18,22H,6,9,14-17H2,1-2H3,(H2,28,29,30,31)/t22-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421273
PNG
(CHEMBL2087649)
Show SMILES COc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-29-18-11-9-17(10-12-18)22-20(16-6-3-2-4-7-16)21-23(26-15-27-24(21)28-22)25-14-19-8-5-13-30-19/h2-4,6-7,9-12,15,19H,5,8,13-14H2,1H3,(H2,25,26,27,28)/t19-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421271
PNG
(CHEMBL2087647)
Show SMILES C(Nc1ncnc2[nH]c(c(-c3ccccc3)c12)-c1ccccc1)[C@@H]1CCCO1
Show InChI InChI=1S/C23H22N4O/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-28-18)25-15-26-23(20)27-21(19)17-10-5-2-6-11-17/h1-6,8-11,15,18H,7,12-14H2,(H2,24,25,26,27)/t18-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421289
PNG
(CHEMBL2087666)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C28H29N5O3/c34-28(33-12-15-35-16-13-33)21-10-8-20(9-11-21)25-23(19-5-2-1-3-6-19)24-26(30-18-31-27(24)32-25)29-17-22-7-4-14-36-22/h1-3,5-6,8-11,18,22H,4,7,12-17H2,(H2,29,30,31,32)/t22-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421288
PNG
(CHEMBL2087665)
Show SMILES O=C(N1CCOCC1)c1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C28H28N4O4/c33-28(32-12-15-34-16-13-32)21-10-8-20(9-11-21)25-23(19-5-2-1-3-6-19)24-26(30-18-31-27(24)36-25)29-17-22-7-4-14-35-22/h1-3,5-6,8-11,18,22H,4,7,12-17H2,(H,29,30,31)/t22-/m0/s1
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6n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421275
PNG
(CHEMBL2087651)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C24H24N4O3S/c1-32(29,30)19-11-9-17(10-12-19)22-20(16-6-3-2-4-7-16)21-23(26-15-27-24(21)28-22)25-14-18-8-5-13-31-18/h2-4,6-7,9-12,15,18H,5,8,13-14H2,1H3,(H2,25,26,27,28)/t18-/m0/s1
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7n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246165
PNG
(CHEMBL487243 | N3-(2,6-dichlorophenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccccc3)nc12
Show InChI InChI=1S/C23H24Cl2N6O/c1-23(2,32-3)12-13-31-21-16(14-26-22(29-21)27-15-8-5-4-6-9-15)20(30-31)28-19-17(24)10-7-11-18(19)25/h4-11,14H,12-13H2,1-3H3,(H,28,30)(H,26,27,29)
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7n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421274
PNG
(CHEMBL2087650)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C24H23N3O4S/c1-32(28,29)19-11-9-17(10-12-19)22-20(16-6-3-2-4-7-16)21-23(26-15-27-24(21)31-22)25-14-18-8-5-13-30-18/h2-4,6-7,9-12,15,18H,5,8,13-14H2,1H3,(H,25,26,27)/t18-/m0/s1
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8n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421258
PNG
(CHEMBL2087876)
Show SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NCC3CCCS3)c2c1-c1ccccc1
Show InChI InChI=1S/C27H30N4O2S/c1-31(2)14-15-32-21-12-10-20(11-13-21)25-23(19-7-4-3-5-8-19)24-26(29-18-30-27(24)33-25)28-17-22-9-6-16-34-22/h3-5,7-8,10-13,18,22H,6,9,14-17H2,1-2H3,(H,28,29,30)
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8n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246216
PNG
((R)-N3-(2,6-dichlorophenyl)-1-(2-(3-(dimethylamino...)
Show SMILES CN(C)[C@@H]1CCN(CCn2nc(Nc3c(Cl)cccc3Cl)c3cnc(Nc4ccccc4)nc23)C1
Show InChI InChI=1S/C25H28Cl2N8/c1-33(2)18-11-12-34(16-18)13-14-35-24-19(15-28-25(31-24)29-17-7-4-3-5-8-17)23(32-35)30-22-20(26)9-6-10-21(22)27/h3-10,15,18H,11-14,16H2,1-2H3,(H,30,32)(H,28,29,31)/t18-/m1/s1
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245906
PNG
(CHEMBL462189 | N3-(2,6-dichlorophenyl)-1-(2-(4-met...)
Show SMILES CN1CCN(CCn2nc(Nc3c(Cl)cccc3Cl)c3cnc(Nc4ccccc4)nc23)CC1
Show InChI InChI=1S/C24H26Cl2N8/c1-32-10-12-33(13-11-32)14-15-34-23-18(16-27-24(30-23)28-17-6-3-2-4-7-17)22(31-34)29-21-19(25)8-5-9-20(21)26/h2-9,16H,10-15H2,1H3,(H,29,31)(H,27,28,30)
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421285
PNG
(CHEMBL2087661)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C26H26N4O3/c1-30(2)26(31)19-12-10-18(11-13-19)23-21(17-7-4-3-5-8-17)22-24(28-16-29-25(22)33-23)27-15-20-9-6-14-32-20/h3-5,7-8,10-13,16,20H,6,9,14-15H2,1-2H3,(H,27,28,29)/t20-/m0/s1
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246213
PNG
(CHEMBL487896 | N3-(2,6-dichlorophenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C27H32Cl2N8O/c1-27(2,38-3)11-14-37-25-20(24(35-37)33-23-21(28)5-4-6-22(23)29)17-31-26(34-25)32-18-7-9-19(10-8-18)36-15-12-30-13-16-36/h4-10,17,30H,11-16H2,1-3H3,(H,33,35)(H,31,32,34)
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of flag-tagged ACK1 (unknown origin) autophosphorylation expressed in human 293 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246162
PNG
(CHEMBL472392 | N3-(2,6-dimethylphenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C29H38N8O/c1-20-7-6-8-21(2)25(20)33-26-24-19-31-28(34-27(24)37(35-26)16-13-29(3,4)38-5)32-22-9-11-23(12-10-22)36-17-14-30-15-18-36/h6-12,19,30H,13-18H2,1-5H3,(H,33,35)(H,31,32,34)
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of flag-tagged ACK1 (unknown origin) autophosphorylation expressed in human 293 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421290
PNG
(CHEMBL2087667)
Show SMILES CN(C)CCOc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1C1=CCCCC1
Show InChI InChI=1S/C27H35N5O2/c1-32(2)14-16-34-21-12-10-20(11-13-21)25-23(19-7-4-3-5-8-19)24-26(29-18-30-27(24)31-25)28-17-22-9-6-15-33-22/h7,10-13,18,22H,3-6,8-9,14-17H2,1-2H3,(H2,28,29,30,31)/t22-/m0/s1
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421270
PNG
(CHEMBL2087671)
Show SMILES COc1cccc(c1)-c1c([nH]c2ncnc(NC[C@@H]3CCCO3)c12)-c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C30H35N5O3/c1-36-24-7-4-6-22(18-24)26-27-29(31-19-25-8-5-16-37-25)32-20-33-30(27)34-28(26)21-9-11-23(12-10-21)38-17-15-35-13-2-3-14-35/h4,6-7,9-12,18,20,25H,2-3,5,8,13-17,19H2,1H3,(H2,31,32,33,34)/t25-/m0/s1
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245860
PNG
((R)-4-(3-(2,6-dichlorophenylamino)-6-(phenylamino)...)
Show SMILES OC[C@H](O)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccccc3)nc12
Show InChI InChI=1S/C21H20Cl2N6O2/c22-16-7-4-8-17(23)18(16)26-19-15-11-24-21(25-13-5-2-1-3-6-13)27-20(15)29(28-19)10-9-14(31)12-30/h1-8,11,14,30-31H,9-10,12H2,(H,26,28)(H,24,25,27)/t14-/m1/s1
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10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50246213
PNG
(CHEMBL487896 | N3-(2,6-dichlorophenyl)-1-(3-methox...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C27H32Cl2N8O/c1-27(2,38-3)11-14-37-25-20(24(35-37)33-23-21(28)5-4-6-22(23)29)17-31-26(34-25)32-18-7-9-19(10-8-18)36-15-12-30-13-16-36/h4-10,17,30H,11-16H2,1-3H3,(H,33,35)(H,31,32,34)
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12n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245905
PNG
(CHEMBL459220 | N3-mesityl-1-(3-methoxy-3-methylbut...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cc(C)cc2C)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C31H42N8O/c1-21-18-22(2)27(23(3)19-21)34-28-26-20-32-30(35-29(26)39(36-28)13-12-31(4,5)40-7)33-24-8-10-25(11-9-24)38-16-14-37(6)15-17-38/h8-11,18-20H,12-17H2,1-7H3,(H,34,36)(H,32,33,35)
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12n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421259
PNG
(CHEMBL2087877)
Show SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NCC3OCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C26H28N4O4/c1-30(2)12-13-31-20-10-8-19(9-11-20)24-22(18-6-4-3-5-7-18)23-25(28-17-29-26(23)34-24)27-16-21-32-14-15-33-21/h3-11,17,21H,12-16H2,1-2H3,(H,27,28,29)
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13n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421294
PNG
(CHEMBL2087663)
Show SMILES CNC(=O)c1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1
Show InChI InChI=1S/C25H24N4O3/c1-26-24(30)18-11-9-17(10-12-18)22-20(16-6-3-2-4-7-16)21-23(28-15-29-25(21)32-22)27-14-19-8-5-13-31-19/h2-4,6-7,9-12,15,19H,5,8,13-14H2,1H3,(H,26,30)(H,27,28,29)/t19-/m0/s1
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13n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50245857
PNG
(CHEMBL514919 | N3-(4-fluoro-2,6-dimethylphenyl)-1-...)
Show SMILES COC(C)(C)CCn1nc(Nc2c(C)cc(F)cc2C)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C30H39FN8O/c1-20-17-22(31)18-21(2)26(20)34-27-25-19-32-29(35-28(25)39(36-27)12-11-30(3,4)40-6)33-23-7-9-24(10-8-23)38-15-13-37(5)14-16-38/h7-10,17-19H,11-16H2,1-6H3,(H,34,36)(H,32,33,35)
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18n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) (unknown origin) expressed in SF9 cells


Citation and Details
More data for this
Ligand-Target Pair
Activated CDC42 kinase 1 (ACK1)


(Homo sapiens (Human))
BDBM50421291
PNG
(CHEMBL2087668)
Show SMILES CN(C)CCOc1ccc(cc1)-c1[nH]c2ncnc(NC[C@@H]3CCCO3)c2c1C1=CCCC1
Show InChI InChI=1S/C26H33N5O2/c1-31(2)13-15-33-20-11-9-19(10-12-20)24-22(18-6-3-4-7-18)23-25(28-17-29-26(23)30-24)27-16-21-8-5-14-32-21/h6,9-12,17,21H,3-5,7-8,13-16H2,1-2H3,(H2,27,28,29,30)/t21-/m0/s1
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20n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...


Citation and Details
More data for this
Ligand-Target Pair
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