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Found 13 hits Enz. Inhib. hit(s) with Target = 'Tyrosine kinase receptor c-Met (c-Met)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM60588
PNG
(3-(3-fluoro-4-{[2-(pyridin-3-yl)-1H-pyrrolo[2,3-b]...)
Show SMILES Fc1ccc(CNC(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)-c3cccnc3)c(F)c2)cc1
Show InChI InChI=1S/C26H19F2N5O2/c27-18-5-3-16(4-6-18)14-31-26(34)32-19-7-8-24(21(28)12-19)35-23-9-11-30-25-20(23)13-22(33-25)17-2-1-10-29-15-17/h1-13,15H,14H2,(H,30,33)(H2,31,32,34)
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n/an/a 2n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM60589
PNG
(6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
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n/an/a 4n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM60587
PNG
(3-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}ph...)
Show SMILES Fc1ccc(CNC(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)cc1
Show InChI InChI=1S/C21H16F2N4O2/c22-14-3-1-13(2-4-14)12-26-21(28)27-15-5-6-19(17(23)11-15)29-18-8-10-25-20-16(18)7-9-24-20/h1-11H,12H2,(H,24,25)(H2,26,27,28)
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n/an/a 11n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM60590
PNG
(6-(1-{6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazi...)
Show SMILES C1CC1(c1nnc2ncc(nn12)-c1ccccc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H16N6/c1-2-5-15(6-3-1)19-14-24-21-26-25-20(28(21)27-19)22(10-11-22)17-8-9-18-16(13-17)7-4-12-23-18/h1-9,12-14H,10-11H2
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n/an/a 13n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a 13.7n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179803
PNG
(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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n/an/a 14.6n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179801
PNG
(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Show SMILES Fc1ccc(Cl)c(Sc2n[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)c1Cl
Show InChI InChI=1S/C20H17Cl2FN6S/c21-15-1-2-16(23)17(22)18(15)30-20-14-7-11(8-25-19(14)27-28-20)12-9-26-29(10-12)13-3-5-24-6-4-13/h1-2,7-10,13,24H,3-6H2,(H,25,27,28)
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n/an/a 22.8n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179802
PNG
(3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...)
Show SMILES Fc1ccc(Cl)c(c1Cl)C1(CC1)c1n[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H21Cl2FN6/c24-17-1-2-18(26)20(25)19(17)23(5-6-23)21-16-9-13(10-28-22(16)31-30-21)14-11-29-32(12-14)15-3-7-27-8-4-15/h1-2,9-12,15,27H,3-8H2,(H,28,30,31)
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n/an/a 47.4n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179804
PNG
(3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...)
Show SMILES CC(Sc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C21H22Cl2FN5S/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)
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n/an/a 51.2n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179800
PNG
(3-((2,6-dichloro-3-fluorophenyl)sulfide)-5-(1-(pip...)
Show SMILES Fc1ccc(Cl)c(c1Cl)S(=O)c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1/C21H18Cl2FN5OS/c22-16-1-2-17(24)19(23)20(16)31(30)18-10-27-21-15(18)7-12(8-26-21)13-9-28-29(11-13)14-3-5-25-6-4-14/h1-2,7-11,14,25H,3-6H2,(H,26,27)
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n/an/a 63n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM60586
PNG
(4-(4-{3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-...)
Show SMILES CC(c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C23H22Cl2FN5/c1-13(21-19(24)2-3-20(26)22(21)25)18-11-29-23-17(18)8-14(9-28-23)15-10-30-31(12-15)16-4-6-27-7-5-16/h2-3,8-13,16,27H,4-7H2,1H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179798
PNG
(3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...)
Show SMILES CC(c1c(C)[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C24H24Cl2FN5/c1-13(22-19(25)3-4-20(27)23(22)26)21-14(2)31-24-18(21)9-15(10-29-24)16-11-30-32(12-16)17-5-7-28-8-6-17/h3-4,9-13,17,28H,5-8H2,1-2H3,(H,29,31)
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n/an/a 286n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine kinase receptor c-Met (c-Met)


(Homo sapiens (Human))
BDBM179799
PNG
(4-(4-{2-chloro-3-[1-(2,6-dichloro-3-fluorophenyl)e...)
Show SMILES CC(c1c(Cl)[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C23H21Cl3FN5/c1-12(20-17(24)2-3-18(27)21(20)25)19-16-8-13(9-29-23(16)31-22(19)26)14-10-30-32(11-14)15-4-6-28-7-5-15/h2-3,8-12,15,28H,4-7H2,1H3,(H,29,31)
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n/an/a 982n/an/an/an/an/an/a



Tianjin University of Science and Technology



Assay Description
The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...


Citation and Details
More data for this
Ligand-Target Pair