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Compile Data Set for Download or QSAR

Found 1066 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [828-1132]'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.260n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.290n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197717
PNG
(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197717
PNG
(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.650n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197717
PNG
(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400341
PNG
(US10695337, Example 95 | US9999619, Example 96)
Show SMILES FC(F)(F)c1cccc2cc(sc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C29H25F3N8OS/c30-29(31,32)22-3-1-2-18-12-23(42-25(18)22)27(41)38-10-5-20(6-11-38)39-15-28(16-39,7-8-33)40-14-19(13-37-40)24-21-4-9-34-26(21)36-17-35-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,34,35,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400365
PNG
(US10695337, Example 119 | US9999619, Example 120)
Show SMILES Fc1cc(ccc1C#N)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C33H27F2N9O/c34-28-13-21(1-2-23(28)15-37)26-4-3-22(14-29(26)35)32(45)42-11-6-25(7-12-42)43-18-33(19-43,8-9-36)44-17-24(16-41-44)30-27-5-10-38-31(27)40-20-39-30/h1-5,10,13-14,16-17,20,25H,6-8,11-12,18-19H2,(H,38,39,40)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400366
PNG
(US10695337, Example 120 | US9999619, Example 121)
Show SMILES Fc1cc(ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)-c1cccnc1
Show InChI InChI=1S/C31H28FN9O/c32-27-14-21(22-2-1-10-34-15-22)3-4-25(27)30(42)39-12-6-24(7-13-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-11-35-29(26)37-20-36-28/h1-5,10-11,14-17,20,24H,6-8,12-13,18-19H2,(H,35,36,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400368
PNG
(US10695337, Example 122 | US9999619, Example 123)
Show SMILES Fc1cc(ccc1-c1nccs1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C29H26FN9OS/c30-24-13-19(1-2-22(24)27-33-9-12-41-27)28(40)37-10-4-21(5-11-37)38-16-29(17-38,6-7-31)39-15-20(14-36-39)25-23-3-8-32-26(23)35-18-34-25/h1-3,8-9,12-15,18,21H,4-6,10-11,16-17H2,(H,32,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400369
PNG
(US10695337, Example 123 | US9999619, Example 124)
Show SMILES Fc1cc(ccc1-c1cccnc1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C31H28FN9O/c32-27-14-21(3-4-25(27)22-2-1-10-34-15-22)30(42)39-12-6-24(7-13-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-11-35-29(26)37-20-36-28/h1-5,10-11,14-17,20,24H,6-8,12-13,18-19H2,(H,35,36,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400374
PNG
(US10695337, Example 128 | US9999619, Example 129)
Show SMILES Fc1cc(cc(c1)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N
Show InChI InChI=1S/C33H27F2N9O/c34-25-12-21(15-37)11-23(13-25)27-2-1-22(14-29(27)35)32(45)42-9-4-26(5-10-42)43-18-33(19-43,6-7-36)44-17-24(16-41-44)30-28-3-8-38-31(28)40-20-39-30/h1-3,8,11-14,16-17,20,26H,4-6,9-10,18-19H2,(H,38,39,40)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400375
PNG
(US10695337, Example 129 | US9999619, Example 130)
Show SMILES Fc1cc(ccc1-c1cccc2ncccc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C35H30FN9O/c36-30-17-23(6-7-27(30)26-3-1-5-31-28(26)4-2-13-38-31)34(46)43-15-9-25(10-16-43)44-20-35(21-44,11-12-37)45-19-24(18-42-45)32-29-8-14-39-33(29)41-22-40-32/h1-8,13-14,17-19,22,25H,9-11,15-16,20-21H2,(H,39,40,41)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400377
PNG
(US10695337, Example 131 | US9999619, Example 132)
Show SMILES Fc1cc(ccc1-c1cccc2ccncc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C35H30FN9O/c36-31-16-24(4-5-28(31)27-3-1-2-23-6-12-38-18-30(23)27)34(46)43-14-8-26(9-15-43)44-20-35(21-44,10-11-37)45-19-25(17-42-45)32-29-7-13-39-33(29)41-22-40-32/h1-7,12-13,16-19,22,26H,8-10,14-15,20-21H2,(H,39,40,41)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400251
PNG
(US10695337, Example 6 | US9999619, Example 7)
Show SMILES Oc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25FN8O2/c27-21-11-17(1-2-22(21)36)25(37)33-9-4-19(5-10-33)34-14-26(15-34,6-7-28)35-13-18(12-32-35)23-20-3-8-29-24(20)31-16-30-23/h1-3,8,11-13,16,19,36H,4-6,9-10,14-15H2,(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400263
PNG
(US10695337, Example 18 | US9999619, Example 19)
Show SMILES Fc1cc(cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N
Show InChI InChI=1S/C27H24FN9O/c28-21-10-18(12-30)9-19(11-21)26(38)35-7-2-22(3-8-35)36-15-27(16-36,4-5-29)37-14-20(13-34-37)24-23-1-6-31-25(23)33-17-32-24/h1,6,9-11,13-14,17,22H,2-4,7-8,15-16H2,(H,31,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400264
PNG
(US10695337, Example 19 | US9999619, Example 20)
Show SMILES Clc1cccc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25ClN8O/c27-20-3-1-2-18(12-20)25(36)33-10-5-21(6-11-33)34-15-26(16-34,7-8-28)35-14-19(13-32-35)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400268
PNG
(US10695337, Example 23 | US9999619, Example 24)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H24F4N8O/c28-20-10-17(9-19(11-20)27(29,30)31)25(40)37-7-2-21(3-8-37)38-14-26(15-38,4-5-32)39-13-18(12-36-39)23-22-1-6-33-24(22)35-16-34-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,33,34,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400270
PNG
(US10695337, Example 25 | US9999619, Example 26)
Show SMILES Fc1cccc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25FN8O/c27-20-3-1-2-18(12-20)25(36)33-10-5-21(6-11-33)34-15-26(16-34,7-8-28)35-14-19(13-32-35)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400272
PNG
(US10695337, Example 27 | US9999619, Example 28)
Show SMILES COc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-20-2-3-23(28)22(12-20)26(37)34-10-5-19(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-21-4-9-30-25(21)32-17-31-24/h2-4,9,12-14,17,19H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
PDB

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PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400273
PNG
(US10695337, Example 28 | US9999619, Example 29)
Show SMILES Fc1cc(Cl)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24ClFN8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400274
PNG
(US10695337, Example 29 | US9999619, Example 30)
Show SMILES Fc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24BrFN8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400275
PNG
(US10695337, Example 30 | US9999619, Example 31)
Show SMILES Clc1cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(Cl)s1
Show InChI InChI=1S/C24H22Cl2N8OS/c25-19-9-18(21(26)36-19)23(35)32-7-2-16(3-8-32)33-12-24(13-33,4-5-27)34-11-15(10-31-34)20-17-1-6-28-22(17)30-14-29-20/h1,6,9-11,14,16H,2-4,7-8,12-13H2,(H,28,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400277
PNG
(US10695337, Example 32 | US9999619, Example 33)
Show SMILES COc1c(F)c(F)cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H25F3N8O2/c1-40-24-21(29)19(10-20(28)22(24)30)26(39)36-8-3-17(4-9-36)37-13-27(14-37,5-6-31)38-12-16(11-35-38)23-18-2-7-32-25(18)34-15-33-23/h2,7,10-12,15,17H,3-5,8-9,13-14H2,1H3,(H,32,33,34)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400280
PNG
(US10695337, Example 35 | US9999619, Example 36)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24F2N8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400281
PNG
(US10695337, Example 36 | US9999619, Example 37)
Show SMILES COc1cc(F)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-22-11-18(10-20(28)12-22)26(37)34-8-3-21(4-9-34)35-15-27(16-35,5-6-29)36-14-19(13-33-36)24-23-2-7-30-25(23)32-17-31-24/h2,7,10-14,17,21H,3-5,8-9,15-16H2,1H3,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400282
PNG
(US10695337, Example 37 | US9999619, Example 38)
Show SMILES COc1cc(cc(Cl)n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H26ClN9O2/c1-38-22-11-17(10-21(27)33-22)25(37)34-8-3-19(4-9-34)35-14-26(15-35,5-6-28)36-13-18(12-32-36)23-20-2-7-29-24(20)31-16-30-23/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,29,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400283
PNG
(US10695337, Example 38 | US9999619, Example 39)
Show SMILES COc1ccc(F)cc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-23-3-2-19(28)12-22(23)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-21-4-9-30-25(21)32-17-31-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400285
PNG
(US10695337, Example 39 | US9999619, Example 40)
Show SMILES COc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-22-4-2-3-21(28)23(22)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-29)36-14-18(13-33-36)24-20-5-10-30-25(20)32-17-31-24/h2-5,10,13-14,17,19H,6-8,11-12,15-16H2,1H3,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400286
PNG
(US10695337, Example 40 | US9999619, Example 41)
Show SMILES COc1cc(F)ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-23-12-19(28)2-3-21(23)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-22-4-9-30-25(22)32-17-31-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400287
PNG
(US10695337, Example 41 | US9999619, Example 42)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400289
PNG
(US10695337, Example 43 | US9999619, Example 44)
Show SMILES Fc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24F2N8O/c27-18-1-2-22(28)21(11-18)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-17(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400292
PNG
(US10695337, Example 46 | US9999619, Example 47)
Show SMILES Fc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1F
Show InChI InChI=1S/C26H23F3N8O/c27-20-2-1-18(21(28)22(20)29)25(38)35-9-4-17(5-10-35)36-13-26(14-36,6-7-30)37-12-16(11-34-37)23-19-3-8-31-24(19)33-15-32-23/h1-3,8,11-12,15,17H,4-6,9-10,13-14H2,(H,31,32,33)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400294
PNG
(US10695337, Example 48 | US9999619, Example 49)
Show SMILES Fc1cc(F)c(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H23F3N8O/c27-20-10-22(29)21(28)9-19(20)25(38)35-7-2-17(3-8-35)36-13-26(14-36,4-5-30)37-12-16(11-34-37)23-18-1-6-31-24(18)33-15-32-23/h1,6,9-12,15,17H,2-4,7-8,13-14H2,(H,31,32,33)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400295
PNG
(US10695337, Example 49 | US9999619, Example 50)
Show SMILES Fc1cc(F)c(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C26H23F3N8O/c27-17-9-20(28)22(21(29)10-17)25(38)35-7-2-18(3-8-35)36-13-26(14-36,4-5-30)37-12-16(11-34-37)23-19-1-6-31-24(19)33-15-32-23/h1,6,9-12,15,18H,2-4,7-8,13-14H2,(H,31,32,33)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400296
PNG
(US10695337, Example 50 | US9999619, Example 51)
Show SMILES COc1c(Br)cc(cc1Br)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H26Br2N8O2/c1-39-24-21(28)10-17(11-22(24)29)26(38)35-8-3-19(4-9-35)36-14-27(15-36,5-6-30)37-13-18(12-34-37)23-20-2-7-31-25(20)33-16-32-23/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,31,32,33)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400301
PNG
(US10695337, Example 55 | US9999619, Example 56)
Show SMILES COc1ccc(cc1C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H27N9O2/c1-39-24-3-2-19(12-20(24)13-30)27(38)35-10-5-22(6-11-35)36-16-28(17-36,7-8-29)37-15-21(14-34-37)25-23-4-9-31-26(23)33-18-32-25/h2-4,9,12,14-15,18,22H,5-7,10-11,16-17H2,1H3,(H,31,32,33)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400304
PNG
(US10695337, Example 58 | US9999619, Example 59)
Show SMILES Oc1cc(ccc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25FN8O2/c27-21-2-1-17(11-22(21)36)25(37)33-9-4-19(5-10-33)34-14-26(15-34,6-7-28)35-13-18(12-32-35)23-20-3-8-29-24(20)31-16-30-23/h1-3,8,11-13,16,19,36H,4-6,9-10,14-15H2,(H,29,30,31)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400305
PNG
(US10695337, Example 59 | US9999619, Example 60)
Show SMILES CN(C)c1ccc(cc1C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C29H30N10O/c1-36(2)25-4-3-20(13-21(25)14-31)28(40)37-11-6-23(7-12-37)38-17-29(18-38,8-9-30)39-16-22(15-35-39)26-24-5-10-32-27(24)34-19-33-26/h3-5,10,13,15-16,19,23H,6-8,11-12,17-18H2,1-2H3,(H,32,33,34)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400309
PNG
(US10695337, Example 63 | US9999619, Example 64)
Show SMILES Fc1cc(ccc1Cl)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24ClFN8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400599
PNG
(US10695337, Example 355 | US9999619, Example 355 |...)
Show SMILES CS(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C21H24FN7O2S/c1-32(30,31)28-8-3-16(4-9-28)27-13-21(14-27,5-6-23)29-12-15(10-26-29)19-17-2-7-24-20(17)25-11-18(19)22/h2,7,10-12,16H,3-5,8-9,13-14H2,1H3,(H,24,25)
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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400514
PNG
(US10695337, Example 270 | US9999619, Example 270)
Show SMILES Fc1ccc(F)c(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H24F3N7O/c28-20-1-2-21(29)23(30)22(20)26(38)35-10-5-18(6-11-35)36-14-27(15-36,7-8-31)37-12-4-17(13-37)24-19-3-9-32-25(19)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)
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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400517
PNG
(US10695337, Example 273 | US9999619, Example 273)
Show SMILES Fc1ccc(cc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C28H25F4N7O/c29-23-2-1-19(28(30,31)32)13-22(23)26(40)37-10-5-20(6-11-37)38-15-27(16-38,7-8-33)39-12-4-18(14-39)24-21-3-9-34-25(21)36-17-35-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,34,35,36)
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Incyte Holdings Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400520
PNG
(US10695337, Example 276 | US9999619, Example 276)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H25F2N7O/c28-22-3-1-2-20(23(22)29)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-21-4-10-31-25(21)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400522
PNG
(US10695337, Example 278 | US9999619, Example 278)
Show SMILES Fc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H25F2N7O/c28-19-1-2-23(29)22(13-19)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-30)36-12-4-18(14-36)24-21-3-9-31-25(21)33-17-32-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,31,32,33)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400523
PNG
(US10695337, Example 279 | US9999619, Example 279)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H25F2N7O/c28-21-2-1-3-22(29)23(21)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-20-4-10-31-25(20)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400524
PNG
(US10695337, Example 280 | US9999619, Example 280)
Show SMILES Fc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c(F)c1F
Show InChI InChI=1S/C27H24F3N7O/c28-21-2-1-19(22(29)23(21)30)26(38)35-10-5-18(6-11-35)36-14-27(15-36,7-8-31)37-12-4-17(13-37)24-20-3-9-32-25(20)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400532
PNG
(US10695337, Example 288 | US9999619, Example 288)
Show SMILES COc1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H30N8O2/c1-38-24-5-3-2-4-23(24)33-27(37)34-13-8-21(9-14-34)35-17-28(18-35,10-11-29)36-15-7-20(16-36)25-22-6-12-30-26(22)32-19-31-25/h2-7,12,15-16,19,21H,8-10,13-14,17-18H2,1H3,(H,33,37)(H,30,31,32)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400541
PNG
(US10695337, Example 297 | US9999619, Example 297)
Show SMILES Oc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C27H26FN7O2/c28-24-13-20(36)1-2-23(24)26(37)33-11-5-19(6-12-33)34-16-27(17-34,7-8-29)35-15-18(14-32-35)21-3-9-30-25-22(21)4-10-31-25/h1-4,9-10,13-15,19,36H,5-7,11-12,16-17H2,(H,30,31)
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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM400566
PNG
(US10695337, Example 322 | US9999619, Example 322)
Show SMILES Oc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C27H25F2N7O2/c28-21-11-17(1-2-23(21)37)26(38)34-9-4-19(5-10-34)35-15-27(16-35,6-7-30)36-14-18(12-33-36)24-20-3-8-31-25(20)32-13-22(24)29/h1-3,8,11-14,19,37H,4-6,9-10,15-16H2,(H,31,32)
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Incyte Holdings Corporation

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Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9999619 (2018)


BindingDB Entry DOI: 10.7270/Q2C82CNM
More data for this
Ligand-Target Pair
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