Compile Data Set for Download or QSAR

Found 1066 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [828-1132]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197717 (US9216984, 2) Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM197716 (US9216984, 1) Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.8	25
Incyte Corporation US Patent					Assay Description The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...				US Patent US9216984 (2015) BindingDB Entry DOI: 10.7270/Q26M35PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400341 (US10695337, Example 95 | US9999619, Example 96) Show SMILES FC(F)(F)c1cccc2cc(sc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C29H25F3N8OS/c30-29(31,32)22-3-1-2-18-12-23(42-25(18)22)27(41)38-10-5-20(6-11-38)39-15-28(16-39,7-8-33)40-14-19(13-37-40)24-21-4-9-34-26(21)36-17-35-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,34,35,36)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400365 (US10695337, Example 119 | US9999619, Example 120) Show SMILES Fc1cc(ccc1C#N)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C33H27F2N9O/c34-28-13-21(1-2-23(28)15-37)26-4-3-22(14-29(26)35)32(45)42-11-6-25(7-12-42)43-18-33(19-43,8-9-36)44-17-24(16-41-44)30-27-5-10-38-31(27)40-20-39-30/h1-5,10,13-14,16-17,20,25H,6-8,11-12,18-19H2,(H,38,39,40)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400366 (US10695337, Example 120 | US9999619, Example 121) Show SMILES Fc1cc(ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)-c1cccnc1 Show InChI InChI=1S/C31H28FN9O/c32-27-14-21(22-2-1-10-34-15-22)3-4-25(27)30(42)39-12-6-24(7-13-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-11-35-29(26)37-20-36-28/h1-5,10-11,14-17,20,24H,6-8,12-13,18-19H2,(H,35,36,37)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400368 (US10695337, Example 122 | US9999619, Example 123) Show SMILES Fc1cc(ccc1-c1nccs1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C29H26FN9OS/c30-24-13-19(1-2-22(24)27-33-9-12-41-27)28(40)37-10-4-21(5-11-37)38-16-29(17-38,6-7-31)39-15-20(14-36-39)25-23-3-8-32-26(23)35-18-34-25/h1-3,8-9,12-15,18,21H,4-6,10-11,16-17H2,(H,32,34,35)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400369 (US10695337, Example 123 | US9999619, Example 124) Show SMILES Fc1cc(ccc1-c1cccnc1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C31H28FN9O/c32-27-14-21(3-4-25(27)22-2-1-10-34-15-22)30(42)39-12-6-24(7-13-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-11-35-29(26)37-20-36-28/h1-5,10-11,14-17,20,24H,6-8,12-13,18-19H2,(H,35,36,37)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400374 (US10695337, Example 128 | US9999619, Example 129) Show SMILES Fc1cc(cc(c1)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N Show InChI InChI=1S/C33H27F2N9O/c34-25-12-21(15-37)11-23(13-25)27-2-1-22(14-29(27)35)32(45)42-9-4-26(5-10-42)43-18-33(19-43,6-7-36)44-17-24(16-41-44)30-28-3-8-38-31(28)40-20-39-30/h1-3,8,11-14,16-17,20,26H,4-6,9-10,18-19H2,(H,38,39,40)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400375 (US10695337, Example 129 | US9999619, Example 130) Show SMILES Fc1cc(ccc1-c1cccc2ncccc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-30-17-23(6-7-27(30)26-3-1-5-31-28(26)4-2-13-38-31)34(46)43-15-9-25(10-16-43)44-20-35(21-44,11-12-37)45-19-24(18-42-45)32-29-8-14-39-33(29)41-22-40-32/h1-8,13-14,17-19,22,25H,9-11,15-16,20-21H2,(H,39,40,41)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400377 (US10695337, Example 131 | US9999619, Example 132) Show SMILES Fc1cc(ccc1-c1cccc2ccncc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-31-16-24(4-5-28(31)27-3-1-2-23-6-12-38-18-30(23)27)34(46)43-14-8-26(9-15-43)44-20-35(21-44,10-11-37)45-19-25(17-42-45)32-29-7-13-39-33(29)41-22-40-32/h1-7,12-13,16-19,22,26H,8-10,14-15,20-21H2,(H,39,40,41)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400251 (US10695337, Example 6 | US9999619, Example 7) Show SMILES Oc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H25FN8O2/c27-21-11-17(1-2-22(21)36)25(37)33-9-4-19(5-10-33)34-14-26(15-34,6-7-28)35-13-18(12-32-35)23-20-3-8-29-24(20)31-16-30-23/h1-3,8,11-13,16,19,36H,4-6,9-10,14-15H2,(H,29,30,31)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400263 (US10695337, Example 18 | US9999619, Example 19) Show SMILES Fc1cc(cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N Show InChI InChI=1S/C27H24FN9O/c28-21-10-18(12-30)9-19(11-21)26(38)35-7-2-22(3-8-35)36-15-27(16-36,4-5-29)37-14-20(13-34-37)24-23-1-6-31-25(23)33-17-32-24/h1,6,9-11,13-14,17,22H,2-4,7-8,15-16H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400264 (US10695337, Example 19 | US9999619, Example 20) Show SMILES Clc1cccc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H25ClN8O/c27-20-3-1-2-18(12-20)25(36)33-10-5-21(6-11-33)34-15-26(16-34,7-8-28)35-14-19(13-32-35)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,29,30,31)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400268 (US10695337, Example 23 | US9999619, Example 24) Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H24F4N8O/c28-20-10-17(9-19(11-20)27(29,30)31)25(40)37-7-2-21(3-8-37)38-14-26(15-38,4-5-32)39-13-18(12-36-39)23-22-1-6-33-24(22)35-16-34-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,33,34,35)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400270 (US10695337, Example 25 | US9999619, Example 26) Show SMILES Fc1cccc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H25FN8O/c27-20-3-1-2-18(12-20)25(36)33-10-5-21(6-11-33)34-15-26(16-34,7-8-28)35-14-19(13-32-35)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,29,30,31)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400272 (US10695337, Example 27 | US9999619, Example 28) Show SMILES COc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H27FN8O2/c1-38-20-2-3-23(28)22(12-20)26(37)34-10-5-19(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-21-4-9-30-25(21)32-17-31-24/h2-4,9,12-14,17,19H,5-7,10-11,15-16H2,1H3,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400273 (US10695337, Example 28 | US9999619, Example 29) Show SMILES Fc1cc(Cl)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H24ClFN8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400274 (US10695337, Example 29 | US9999619, Example 30) Show SMILES Fc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H24BrFN8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400275 (US10695337, Example 30 | US9999619, Example 31) Show SMILES Clc1cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(Cl)s1 Show InChI InChI=1S/C24H22Cl2N8OS/c25-19-9-18(21(26)36-19)23(35)32-7-2-16(3-8-32)33-12-24(13-33,4-5-27)34-11-15(10-31-34)20-17-1-6-28-22(17)30-14-29-20/h1,6,9-11,14,16H,2-4,7-8,12-13H2,(H,28,29,30)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400277 (US10695337, Example 32 | US9999619, Example 33) Show SMILES COc1c(F)c(F)cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F Show InChI InChI=1S/C27H25F3N8O2/c1-40-24-21(29)19(10-20(28)22(24)30)26(39)36-8-3-17(4-9-36)37-13-27(14-37,5-6-31)38-12-16(11-35-38)23-18-2-7-32-25(18)34-15-33-23/h2,7,10-12,15,17H,3-5,8-9,13-14H2,1H3,(H,32,33,34)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400280 (US10695337, Example 35 | US9999619, Example 36) Show SMILES Fc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H24F2N8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400281 (US10695337, Example 36 | US9999619, Example 37) Show SMILES COc1cc(F)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H27FN8O2/c1-38-22-11-18(10-20(28)12-22)26(37)34-8-3-21(4-9-34)35-15-27(16-35,5-6-29)36-14-19(13-33-36)24-23-2-7-30-25(23)32-17-31-24/h2,7,10-14,17,21H,3-5,8-9,15-16H2,1H3,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400282 (US10695337, Example 37 | US9999619, Example 38) Show SMILES COc1cc(cc(Cl)n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H26ClN9O2/c1-38-22-11-17(10-21(27)33-22)25(37)34-8-3-19(4-9-34)35-14-26(15-35,5-6-28)36-13-18(12-32-36)23-20-2-7-29-24(20)31-16-30-23/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,29,30,31)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400283 (US10695337, Example 38 | US9999619, Example 39) Show SMILES COc1ccc(F)cc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H27FN8O2/c1-38-23-3-2-19(28)12-22(23)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-21-4-9-30-25(21)32-17-31-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400285 (US10695337, Example 39 | US9999619, Example 40) Show SMILES COc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H27FN8O2/c1-38-22-4-2-3-21(28)23(22)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-29)36-14-18(13-33-36)24-20-5-10-30-25(20)32-17-31-24/h2-5,10,13-14,17,19H,6-8,11-12,15-16H2,1H3,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400286 (US10695337, Example 40 | US9999619, Example 41) Show SMILES COc1cc(F)ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H27FN8O2/c1-38-23-12-19(28)2-3-21(23)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-22-4-9-30-25(22)32-17-31-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400287 (US10695337, Example 41 | US9999619, Example 42) Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400289 (US10695337, Example 43 | US9999619, Example 44) Show SMILES Fc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H24F2N8O/c27-18-1-2-22(28)21(11-18)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-17(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400292 (US10695337, Example 46 | US9999619, Example 47) Show SMILES Fc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1F Show InChI InChI=1S/C26H23F3N8O/c27-20-2-1-18(21(28)22(20)29)25(38)35-9-4-17(5-10-35)36-13-26(14-36,6-7-30)37-12-16(11-34-37)23-19-3-8-31-24(19)33-15-32-23/h1-3,8,11-12,15,17H,4-6,9-10,13-14H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400294 (US10695337, Example 48 | US9999619, Example 49) Show SMILES Fc1cc(F)c(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H23F3N8O/c27-20-10-22(29)21(28)9-19(20)25(38)35-7-2-17(3-8-35)36-13-26(14-36,4-5-30)37-12-16(11-34-37)23-18-1-6-31-24(18)33-15-32-23/h1,6,9-12,15,17H,2-4,7-8,13-14H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400295 (US10695337, Example 49 | US9999619, Example 50) Show SMILES Fc1cc(F)c(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1 Show InChI InChI=1S/C26H23F3N8O/c27-17-9-20(28)22(21(29)10-17)25(38)35-7-2-18(3-8-35)36-13-26(14-36,4-5-30)37-12-16(11-34-37)23-19-1-6-31-24(19)33-15-32-23/h1,6,9-12,15,18H,2-4,7-8,13-14H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400296 (US10695337, Example 50 | US9999619, Example 51) Show SMILES COc1c(Br)cc(cc1Br)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H26Br2N8O2/c1-39-24-21(28)10-17(11-22(24)29)26(38)35-8-3-19(4-9-35)36-14-27(15-36,5-6-30)37-13-18(12-34-37)23-20-2-7-31-25(20)33-16-32-23/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400301 (US10695337, Example 55 | US9999619, Example 56) Show SMILES COc1ccc(cc1C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C28H27N9O2/c1-39-24-3-2-19(12-20(24)13-30)27(38)35-10-5-22(6-11-35)36-16-28(17-36,7-8-29)37-15-21(14-34-37)25-23-4-9-31-26(23)33-18-32-25/h2-4,9,12,14-15,18,22H,5-7,10-11,16-17H2,1H3,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400304 (US10695337, Example 58 | US9999619, Example 59) Show SMILES Oc1cc(ccc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H25FN8O2/c27-21-2-1-17(11-22(21)36)25(37)33-9-4-19(5-10-33)34-14-26(15-34,6-7-28)35-13-18(12-32-35)23-20-3-8-29-24(20)31-16-30-23/h1-3,8,11-13,16,19,36H,4-6,9-10,14-15H2,(H,29,30,31)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400305 (US10695337, Example 59 | US9999619, Example 60) Show SMILES CN(C)c1ccc(cc1C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C29H30N10O/c1-36(2)25-4-3-20(13-21(25)14-31)28(40)37-11-6-23(7-12-37)38-17-29(18-38,8-9-30)39-16-22(15-35-39)26-24-5-10-32-27(24)34-19-33-26/h3-5,10,13,15-16,19,23H,6-8,11-12,17-18H2,1-2H3,(H,32,33,34)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400309 (US10695337, Example 63 | US9999619, Example 64) Show SMILES Fc1cc(ccc1Cl)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H24ClFN8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400599 (US10695337, Example 355 | US9999619, Example 355 |...) Show SMILES CS(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12 Show InChI InChI=1S/C21H24FN7O2S/c1-32(30,31)28-8-3-16(4-9-28)27-13-21(14-27,5-6-23)29-12-15(10-26-29)19-17-2-7-24-20(17)25-11-18(19)22/h2,7,10-12,16H,3-5,8-9,13-14H2,1H3,(H,24,25)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400514 (US10695337, Example 270 | US9999619, Example 270) Show SMILES Fc1ccc(F)c(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F Show InChI InChI=1S/C27H24F3N7O/c28-20-1-2-21(29)23(30)22(20)26(38)35-10-5-18(6-11-35)36-14-27(15-36,7-8-31)37-12-4-17(13-37)24-19-3-9-32-25(19)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400517 (US10695337, Example 273 | US9999619, Example 273) Show SMILES Fc1ccc(cc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12)C(F)(F)F Show InChI InChI=1S/C28H25F4N7O/c29-23-2-1-19(28(30,31)32)13-22(23)26(40)37-10-5-20(6-11-37)38-15-27(16-38,7-8-33)39-12-4-18(14-39)24-21-3-9-34-25(21)36-17-35-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,34,35,36)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400520 (US10695337, Example 276 | US9999619, Example 276) Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F Show InChI InChI=1S/C27H25F2N7O/c28-22-3-1-2-20(23(22)29)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-21-4-10-31-25(21)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400522 (US10695337, Example 278 | US9999619, Example 278) Show SMILES Fc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H25F2N7O/c28-19-1-2-23(29)22(13-19)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-30)36-12-4-18(14-36)24-21-3-9-31-25(21)33-17-32-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400523 (US10695337, Example 279 | US9999619, Example 279) Show SMILES Fc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H25F2N7O/c28-21-2-1-3-22(29)23(21)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-20-4-10-31-25(20)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400524 (US10695337, Example 280 | US9999619, Example 280) Show SMILES Fc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c(F)c1F Show InChI InChI=1S/C27H24F3N7O/c28-21-2-1-19(22(29)23(21)30)26(38)35-10-5-18(6-11-35)36-14-27(15-36,7-8-31)37-12-4-17(13-37)24-20-3-9-32-25(20)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400532 (US10695337, Example 288 | US9999619, Example 288) Show SMILES COc1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C28H30N8O2/c1-38-24-5-3-2-4-23(24)33-27(37)34-13-8-21(9-14-34)35-17-28(18-35,10-11-29)36-15-7-20(16-36)25-22-6-12-30-26(22)32-19-31-25/h2-7,12,15-16,19,21H,8-10,13-14,17-18H2,1H3,(H,33,37)(H,30,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400541 (US10695337, Example 297 | US9999619, Example 297) Show SMILES Oc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ccnc3[nH]ccc23)c(F)c1 Show InChI InChI=1S/C27H26FN7O2/c28-24-13-20(36)1-2-23(24)26(37)33-11-5-19(6-12-33)34-16-27(17-34,7-8-29)35-15-18(14-32-35)21-3-9-30-25-22(21)4-10-31-25/h1-4,9-10,13-15,19,36H,5-7,11-12,16-17H2,(H,30,31)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400566 (US10695337, Example 322 | US9999619, Example 322) Show SMILES Oc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12 Show InChI InChI=1S/C27H25F2N7O2/c28-21-11-17(1-2-23(21)37)26(38)34-9-4-19(5-10-34)35-15-27(16-35,6-7-30)36-14-18(12-33-36)24-20-3-8-31-25(20)32-13-22(24)29/h1-3,8,11-14,19,37H,4-6,9-10,15-16H2,(H,31,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair

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