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Found 125 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3 (781-1124)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228718
PNG
(US9346810, 66)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228760
PNG
(US9346810, 209)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228759
PNG
(US9346810, 208)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228751
PNG
(US9346810, 182)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228743
PNG
(US9346810, 162)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228738
PNG
(US9346810, 134)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228736
PNG
(US9346810, 129)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228668
PNG
(US9346810, 42)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228716
PNG
(US9346810, 63)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228694
PNG
(US9346810, 236)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228669
PNG
(US9346810, 67)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228676
PNG
(US9346810, 121)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228735
PNG
(US9346810, 126)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.0550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192818
PNG
(US9187487, 83)
Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCNCC4)cc3)nc12
Show InChI InChI=1S/C24H26N8O2/c1-15(2)29-23(33)19-13-27-22-21(19)31-20(14-28-22)30-18-5-3-16(4-6-18)11-17(12-25)24(34)32-9-7-26-8-10-32/h3-6,11,13-15,26H,7-10H2,1-2H3,(H,27,28)(H,29,33)(H,30,31)/b17-11+
PDB

GoogleScholar
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PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192809
PNG
(US9187487, 71)
Show SMILES CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1)C#N
Show InChI InChI=1S/C23H25N7O2/c1-23(2,3)29-21(31)17-12-25-20-19(17)28-18(13-26-20)27-16-8-6-14(7-9-16)10-15(11-24)22(32)30(4)5/h6-10,12-13H,1-5H3,(H,25,26)(H,27,28)(H,29,31)/b15-10+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192804
PNG
(US9187487, 64)
Show SMILES CN1CCN(CC1)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)cc1)C#N
Show InChI InChI=1S/C26H29N7O2/c1-26(2,3)23(34)20-15-28-24-22(20)31-21(16-29-24)30-19-7-5-17(6-8-19)13-18(14-27)25(35)33-11-9-32(4)10-12-33/h5-8,13,15-16H,9-12H2,1-4H3,(H,28,29)(H,30,31)/b18-13+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192799
PNG
(US9187487, 50)
Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N(C)C)cc3)nc12
Show InChI InChI=1S/C22H23N7O2/c1-13(2)26-21(30)17-11-24-20-19(17)28-18(12-25-20)27-16-7-5-14(6-8-16)9-15(10-23)22(31)29(3)4/h5-9,11-13H,1-4H3,(H,24,25)(H,26,30)(H,27,28)/b15-9+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192803
PNG
(US9187487, 62)
Show SMILES CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(=O)N4CCC4)cc3)nc12
Show InChI InChI=1S/C24H24N6O2/c1-24(2,3)21(31)18-13-26-22-20(18)29-19(14-27-22)28-17-7-5-15(6-8-17)11-16(12-25)23(32)30-9-4-10-30/h5-8,11,13-14H,4,9-10H2,1-3H3,(H,26,27)(H,28,29)/b16-11+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.400n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192802
PNG
(US9187487, 60)
Show SMILES CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(N)=O)cc3)nc12
Show InChI InChI=1S/C21H20N6O2/c1-21(2,3)18(28)15-10-24-20-17(15)27-16(11-25-20)26-14-6-4-12(5-7-14)8-13(9-22)19(23)29/h4-8,10-11H,1-3H3,(H2,23,29)(H,24,25)(H,26,27)/b13-8+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.400n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM192807
PNG
(US9187487, 69)
Show SMILES CN(C)C(=O)C(=Cc1ccc(Nc2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)c(F)c1)C#N
Show InChI InChI=1S/C23H23FN6O2/c1-23(2,3)20(31)15-11-26-21-19(15)29-18(12-27-21)28-17-7-6-13(9-16(17)24)8-14(10-25)22(32)30(4)5/h6-9,11-12H,1-5H3,(H,26,27)(H,28,29)/b14-8+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.5n/an/an/an/a7.5-248.15



PRINCIPIA BIOPHARMA, INC.

US Patent


Assay Description
Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...


US Patent US9187487 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228747
PNG
(US9346810, 171)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228748
PNG
(US9346810, 174)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228750
PNG
(US9346810, 179)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228752
PNG
(US9346810, 184)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228754
PNG
(US9346810, 187)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228755
PNG
(US9346810, 190)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228757
PNG
(US9346810, 201)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228687
PNG
(US9346810, 202)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Citation and Details
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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228761
PNG
(US9346810, 210)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228661
PNG
(US9346810, 1)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228768
PNG
(US9346810, 17)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228799
PNG
(US9346810, 25)
PDB

GoogleScholar
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PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228709
PNG
(US9346810, 40)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228710
PNG
(US9346810, 41)
PDB

GoogleScholar
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PC sid
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228712
PNG
(US9346810, 48)
PDB

GoogleScholar
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PC sid
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228713
PNG
(US9346810, 60)
PDB

GoogleScholar
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228715
PNG
(US9346810, 62)
PDB

GoogleScholar
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PC sid
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228717
PNG
(US9346810, 64)
PDB

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PC sid
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228776
PNG
(US9346810, 70)
PDB

GoogleScholar
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PC sid
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228719
PNG
(US9346810, 71 | US9346810, 92)
PDB

GoogleScholar
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228720
PNG
(US9346810, 73)
PDB

GoogleScholar
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n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228671
PNG
(US9346810, 77)
PDB

GoogleScholar
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PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228778
PNG
(US9346810, 79)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228721
PNG
(US9346810, 80)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228722
PNG
(US9346810, 81)
PDB

GoogleScholar
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PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228723
PNG
(US9346810, 84)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Citation and Details
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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228672
PNG
(US9346810, 86)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


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Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228724
PNG
(US9346810, 87)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228725
PNG
(US9346810, 91)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM228719
PNG
(US9346810, 71 | US9346810, 92)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
n/an/a 0.550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
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