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Compile Data Set for Download or QSAR

Found 18 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase TEC' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154582
PNG
(6-[1,3]Dioxan-2-yl-quinolin-2-ylamine | CHEMBL4266...)
Show SMILES Nc1ccc2cc(ccc2n1)C1OCCCO1
Show InChI InChI=1S/C13H14N2O2/c14-12-5-3-9-8-10(2-4-11(9)15-12)13-16-6-1-7-17-13/h2-5,8,13H,1,6-7H2,(H2,14,15)
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n/an/an/an/a 2.60E+4n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154591
PNG
(6-Bromo-quinolin-2-ylamine | CHEMBL189197)
Show SMILES Nc1ccc2cc(Br)ccc2n1
Show InChI InChI=1S/C9H7BrN2/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H,(H2,11,12)
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n/an/an/an/a 5.80E+4n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154583
PNG
(6-Methyl-quinolin-2-ylamine | CHEMBL361660)
Show SMILES Cc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C10H10N2/c1-7-2-4-9-8(6-7)3-5-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/an/a 6.10E+4n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154584
PNG
(6-Fluoro-quinolin-2-ylamine | CHEMBL185917)
Show SMILES Nc1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C9H7FN2/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H,(H2,11,12)
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n/an/an/an/a 1.50E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154585
PNG
(CHEMBL187951 | Quinazolin-2-ylamine)
Show SMILES Nc1ncc2ccccc2n1
Show InChI InChI=1S/C8H7N3/c9-8-10-5-6-3-1-2-4-7(6)11-8/h1-5H,(H2,9,10,11)
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n/an/an/a 8.00E+5n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154586
PNG
(6-(5,5-Dimethyl-[1,3]dioxan-2-yl)-quinolin-2-ylami...)
Show SMILES CC1(C)COC(OC1)c1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C15H18N2O2/c1-15(2)8-18-14(19-9-15)11-3-5-12-10(7-11)4-6-13(16)17-12/h3-7,14H,8-9H2,1-2H3,(H2,16,17)
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n/an/an/a 2.20E+4n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154583
PNG
(6-Methyl-quinolin-2-ylamine | CHEMBL361660)
Show SMILES Cc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C10H10N2/c1-7-2-4-9-8(6-7)3-5-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/an/an/a 7.50E+4n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM14322
PNG
(2-Aminoquinoline 1 | 2-aminoquinoline | CHEMBL6123...)
Show SMILES Nc1ccc2ccccc2n1
Show InChI InChI=1S/C9H8N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H2,10,11)
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n/an/an/an/a 1.60E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM14320
PNG
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
Show SMILES Nc1nccc2ccccc12
Show InChI InChI=1S/C9H8N2/c10-9-8-4-2-1-3-7(8)5-6-11-9/h1-6H,(H2,10,11)
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n/an/an/a 6.50E+5n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50013712
PNG
(2-aminopyridin | 2-aminopyridine | CHEMBL21619 | P...)
Show SMILES Nc1ccccn1
Show InChI InChI=1S/C5H6N2/c6-5-3-1-2-4-7-5/h1-4H,(H2,6,7)
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n/an/an/a>4.00E+6n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154587
PNG
(6-[1,3]Dioxolan-2-yl-quinolin-2-ylamine | CHEMBL36...)
Show SMILES Nc1ccc2cc(ccc2n1)C1OCCO1
Show InChI InChI=1S/C12H12N2O2/c13-11-4-2-8-7-9(1-3-10(8)14-11)12-15-5-6-16-12/h1-4,7,12H,5-6H2,(H2,13,14)
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n/an/an/a 4.00E+4n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50084506
PNG
(CHEMBL319543 | Methyl-quinolin-2-yl-amine)
Show SMILES CNc1ccc2ccccc2n1
Show InChI InChI=1S/C10H10N2/c1-11-10-7-6-8-4-2-3-5-9(8)12-10/h2-7H,1H3,(H,11,12)
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n/an/an/a 3.80E+5n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154588
PNG
(5,6,7,8-Tetrahydro-quinolin-2-ylamine | CHEMBL1888...)
Show SMILES Nc1ccc2CCCCc2n1
Show InChI InChI=1S/C9H12N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h5-6H,1-4H2,(H2,10,11)
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n/an/an/an/a 2.15E+5n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154590
PNG
(6-Methoxy-quinolin-2-ylamine | CHEMBL188730)
Show SMILES COc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C10H10N2O/c1-13-8-3-4-9-7(6-8)2-5-10(11)12-9/h2-6H,1H3,(H2,11,12)
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n/an/an/an/a 6.30E+4n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154589
PNG
(6-Chloro-quinolin-2-ylamine | CHEMBL189514)
Show SMILES Nc1ccc2cc(Cl)ccc2n1
Show InChI InChI=1S/C9H7ClN2/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H,(H2,11,12)
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n/an/an/an/a 7.60E+4n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154587
PNG
(6-[1,3]Dioxolan-2-yl-quinolin-2-ylamine | CHEMBL36...)
Show SMILES Nc1ccc2cc(ccc2n1)C1OCCO1
Show InChI InChI=1S/C12H12N2O2/c13-11-4-2-8-7-9(1-3-10(8)14-11)12-15-5-6-16-12/h1-4,7,12H,5-6H2,(H2,13,14)
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n/an/an/an/a 3.40E+4n/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM50154582
PNG
(6-[1,3]Dioxan-2-yl-quinolin-2-ylamine | CHEMBL4266...)
Show SMILES Nc1ccc2cc(ccc2n1)C1OCCCO1
Show InChI InChI=1S/C13H14N2O2/c14-12-5-3-9-8-10(2-4-11(9)15-12)13-16-6-1-7-17-13/h2-5,8,13H,1,6-7H2,(H2,14,15)
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n/an/an/a 5.20E+4n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TEC


(Mus musculus)
BDBM14322
PNG
(2-Aminoquinoline 1 | 2-aminoquinoline | CHEMBL6123...)
Show SMILES Nc1ccc2ccccc2n1
Show InChI InChI=1S/C9H8N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H2,10,11)
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n/an/an/a 1.25E+5n/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization


J Med Chem 47: 5405-17 (2004)

More data for this
Ligand-Target Pair