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Found 585 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor FLT4' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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<0.300n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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17n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331613
PNG
(CHEMBL1290177 | N-(4-chlorobenzyl)benzofuro[2,3-b]...)
Show SMILES Clc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C18H13ClN2O/c19-13-7-5-12(6-8-13)11-21-15-9-10-20-18-17(15)14-3-1-2-4-16(14)22-18/h1-10H,11H2,(H,20,21)
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680n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331618
PNG
(CHEMBL1289976 | N-benzylbenzofuro[2,3-b]pyridin-4-...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1ccccc1
Show InChI InChI=1S/C18H14N2O/c1-2-6-13(7-3-1)12-20-15-10-11-19-18-17(15)14-8-4-5-9-16(14)21-18/h1-11H,12H2,(H,19,20)
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1.09E+3n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331616
PNG
(CHEMBL1290071 | N-(naphthalen-1-ylmethyl)benzofuro...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1cccc2ccccc12
Show InChI InChI=1S/C22H16N2O/c1-2-9-17-15(6-1)7-5-8-16(17)14-24-19-12-13-23-22-21(19)18-10-3-4-11-20(18)25-22/h1-13H,14H2,(H,23,24)
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1.09E+3n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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6.85E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FLT4


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331617
PNG
(CHEMBL1289977 | N-phenethylbenzofuro[2,3-b]pyridin...)
Show SMILES C(Cc1ccccc1)Nc1ccnc2oc3ccccc3c12
Show InChI InChI=1S/C19H16N2O/c1-2-6-14(7-3-1)10-12-20-16-11-13-21-19-18(16)15-8-4-5-9-17(15)22-19/h1-9,11,13H,10,12H2,(H,20,21)
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9.39E+3n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331615
PNG
(CHEMBL1290073 | N-(3-chlorobenzyl)benzofuro[2,3-b]...)
Show SMILES Clc1cccc(CNc2ccnc3oc4ccccc4c23)c1
Show InChI InChI=1S/C18H13ClN2O/c19-13-5-3-4-12(10-13)11-21-15-8-9-20-18-17(15)14-6-1-2-7-16(14)22-18/h1-10H,11H2,(H,20,21)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331612
PNG
(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331614
PNG
(CHEMBL1290178 | N-(pyridin-3-ylmethyl)benzofuro[2,...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1cccnc1
Show InChI InChI=1S/C17H13N3O/c1-2-6-15-13(5-1)16-14(7-9-19-17(16)21-15)20-11-12-4-3-8-18-10-12/h1-10H,11H2,(H,19,20)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50362065
PNG
(CHEMBL1940109)
Show SMILES COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC
Show InChI InChI=1S/C24H25N5O6/c1-31-7-8-34-22-11-20-19(10-21(22)33-3)24(26-15-25-20)35-18-12-27-29(13-18)14-23(30)28-16-5-4-6-17(9-16)32-2/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,28,30)
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n/an/a 0.200n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 phosphorylation by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
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n/an/a 0.240n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50362064
PNG
(CHEMBL1940108)
Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1
Show InChI InChI=1S/C22H21N5O5/c1-29-15-6-4-5-14(7-15)26-21(28)12-27-11-16(10-25-27)32-22-17-8-19(30-2)20(31-3)9-18(17)23-13-24-22/h4-11,13H,12H2,1-3H3,(H,26,28)
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n/an/a 0.400n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 phosphorylation by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50336457
PNG
((3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-m...)
Show SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O)c1
Show InChI InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h9-11,22H,3-8H2,1-2H3/t11-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



National University of Ireland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR3 in cell free system after 90 mins


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50321892
PNG
((Z)-5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-di...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4[nH]cc(C(O)=O)c4C)C(=O)Nc3c2)cc1
Show InChI InChI=1S/C23H20N4O5/c1-12-18(22(29)30)11-24-19(12)10-17-16-8-5-14(9-20(16)27-21(17)28)26-23(31)25-13-3-6-15(32-2)7-4-13/h3-11,24H,1-2H3,(H,27,28)(H,29,30)(H2,25,26,31)/b17-10-
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n/an/a 0.800n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316775
PNG
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)
Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3
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n/an/a 0.960n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202409
PNG
(US9238644, 16)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C27H31ClN6O/c1-34-14-10-19(11-15-34)23-9-7-20(16-30-23)32-26-31-17-22(28)24(33-26)8-6-18-4-2-3-5-21(18)27(12-13-27)25(29)35/h2-5,7,9,16-17,19H,6,8,10-15H2,1H3,(H2,29,35)(H,31,32,33)
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US Patent
n/an/a 1n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50399537
PNG
(CHEMBL2180604)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1
Show InChI InChI=1S/C23H23N7O3/c1-13-4-7-16(11-17(13)24-23(32)18-10-14(2)27-29(18)3)33-21-9-8-20-25-19(12-30(20)28-21)26-22(31)15-5-6-15/h4,7-12,15H,5-6H2,1-3H3,(H,24,32)(H,26,31)
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n/an/a 1.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by AlphaScreen assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50399537
PNG
(CHEMBL2180604)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1
Show InChI InChI=1S/C23H23N7O3/c1-13-4-7-16(11-17(13)24-23(32)18-10-14(2)27-29(18)3)33-21-9-8-20-25-19(12-30(20)28-21)26-22(31)15-5-6-15/h4,7-12,15H,5-6H2,1-3H3,(H,24,32)(H,26,31)
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n/an/a 1.10n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316779
PNG
(2-{5-(4-Methoxyphenethoxy)-1-{5-[4-(methylthio)-ph...)
Show SMILES COc1ccc(CCOc2ccc3n(CCCCCc4ccc(SC)cc4)cc(CCN)c3c2)cc1
Show InChI InChI=1S/C31H38N2O2S/c1-34-27-11-7-25(8-12-27)18-21-35-28-13-16-31-30(22-28)26(17-19-32)23-33(31)20-5-3-4-6-24-9-14-29(36-2)15-10-24/h7-16,22-23H,3-6,17-21,32H2,1-2H3
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n/an/a 1.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316780
PNG
(4-(2-(3-Amino-9-(5-(4-(dimethylamino)phenyl)pentyl...)
Show SMILES Cl.Cl.CN(C)c1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C33H41N3O2/c1-35(2)27-12-7-24(8-13-27)6-4-3-5-20-36-32-17-11-26(34)22-30(32)31-23-29(16-18-33(31)36)38-21-19-25-9-14-28(37)15-10-25/h7-10,12-16,18,23,26,37H,3-6,11,17,19-22,34H2,1-2H3
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n/an/a 1.70n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316781
PNG
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)
Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3
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n/an/a 1.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50428367
PNG
(CHEMBL2332119 | Vegfrecine)
Show SMILES NC(=O)C1=C(N)C(=O)C=C(Nc2ccccc2O)C1=O
Show InChI InChI=1S/C13H11N3O4/c14-11-9(18)5-7(12(19)10(11)13(15)20)16-6-3-1-2-4-8(6)17/h1-5,16-17H,14H2,(H2,15,20)
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n/an/a 1.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Flt4 (unknown origin) after 20 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of FLT4


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202417
PNG
(US9238644, 24)
Show SMILES CC(NC(=O)OC(C)(C)C)c1ccc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cc1
Show InChI InChI=1/C29H34ClN5O3/c1-18(33-27(37)38-28(2,3)4)19-9-12-21(13-10-19)34-26-32-17-23(30)24(35-26)14-11-20-7-5-6-8-22(20)29(15-16-29)25(31)36/h5-10,12-13,17-18H,11,14-16H2,1-4H3,(H2,31,36)(H,33,37)(H,32,34,35)
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US Patent
n/an/a 2n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM98618
PNG
(2-amino-1-ethyl-7-[3-hydroxy-3-(3-thienyl)but-1-yn...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccsc1
Show InChI InChI=1S/C20H20N4O3S/c1-4-24-17(21)15(19(26)22-3)16(25)14-6-5-13(23-18(14)24)7-9-20(2,27)12-8-10-28-11-12/h5-6,8,10-11,27H,4,21H2,1-3H3,(H,22,26)
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n/an/a 2n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.


US Patent US8470847 (2013)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50236362
PNG
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316790
PNG
(2-{5-(4-Hydroxyphenethoxy)-1-[5-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(CCCCCn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C30H36N2O3/c1-34-27-12-8-23(9-13-27)5-3-2-4-19-32-22-25(16-18-31)29-21-28(14-15-30(29)32)35-20-17-24-6-10-26(33)11-7-24/h6-15,21-22,33H,2-5,16-20,31H2,1H3
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n/an/a 2.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316783
PNG
(4-(2-(3-Amino-9-(5-(pyridine-2-yl)pentyl)-2,3,4,9-...)
Show SMILES Cl.Cl.NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccn1
Show InChI InChI=1S/C30H35N3O2/c31-23-10-14-29-27(20-23)28-21-26(35-19-16-22-8-11-25(34)12-9-22)13-15-30(28)33(29)18-5-1-2-6-24-7-3-4-17-32-24/h3-4,7-9,11-13,15,17,21,23,34H,1-2,5-6,10,14,16,18-20,31H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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n/an/a 2.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316791
PNG
(2-{5-(4-Hydroxyphenethoxy)-1-{5-[4-(methylthio)-ph...)
Show SMILES CSc1ccc(CCCCCn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C30H36N2O2S/c1-35-28-13-8-23(9-14-28)5-3-2-4-19-32-22-25(16-18-31)29-21-27(12-15-30(29)32)34-20-17-24-6-10-26(33)11-7-24/h6-15,21-22,33H,2-5,16-20,31H2,1H3
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n/an/a 2.5n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50345579
PNG
(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Show SMILES CNC(=O)c1ncc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(c2)C(F)(F)F)n1C
Show InChI InChI=1S/C30H33F3N6O3/c1-20-4-5-22(16-21(20)7-9-25-18-35-27(37(25)3)29(42)34-2)28(41)36-24-8-6-23(26(17-24)30(31,32)33)19-39-12-10-38(11-13-39)14-15-40/h4-6,8,16-18,40H,10-15,19H2,1-3H3,(H,34,42)(H,36,41)
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n/an/a 2.60n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3 using poly[Glu:Tyr] by Hotspot assay


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316777
PNG
(2-[5-(4-Hydroxyphenethoxy)-1H-indole-3-yl]ethanami...)
Show SMILES NCCc1c[nH]c2ccc(OCCc3ccc(O)cc3)cc12
Show InChI InChI=1S/C18H20N2O2/c19-9-7-14-12-20-18-6-5-16(11-17(14)18)22-10-8-13-1-3-15(21)4-2-13/h1-6,11-12,20-21H,7-10,19H2
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n/an/a 2.60n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50300026
PNG
((S)-1-Acryloyl-N-[4-(3-chloro-2-fluorophenylamino)...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1NC(=O)[C@@H]1CCCN1C(=O)C=C
Show InChI InChI=1S/C25H25ClFN5O4/c1-3-22(33)32-9-5-8-20(32)25(34)31-19-12-15-18(13-21(19)36-11-10-35-2)28-14-29-24(15)30-17-7-4-6-16(26)23(17)27/h3-4,6-7,12-14,20H,1,5,8-11H2,2H3,(H,31,34)(H,28,29,30)/t20-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Hanmi Research Center

Curated by ChEMBL


Assay Description
Inhibition of Flt4


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 2.80n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 2.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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n/an/a 2.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50331096
PNG
(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Show SMILES COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202440
PNG
(US9238644, 45)
Show SMILES Cn1cc(Nc2ncc(Cl)c(CCc3ccccc3C(C)(C)C(N)=O)n2)cn1
Show InChI InChI=1S/C20H23ClN6O/c1-20(2,18(22)28)15-7-5-4-6-13(15)8-9-17-16(21)11-23-19(26-17)25-14-10-24-27(3)12-14/h4-7,10-12H,8-9H2,1-3H3,(H2,22,28)(H,23,25,26)
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n/an/a 3n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202412
PNG
(US9238644, 19)
Show SMILES NC(=O)C1(CC1)c1ccccc1CCc1nc(Nc2cn[nH]c2)ncc1Cl
Show InChI InChI=1S/C19H19ClN6O/c20-15-11-22-18(25-13-9-23-24-10-13)26-16(15)6-5-12-3-1-2-4-14(12)19(7-8-19)17(21)27/h1-4,9-11H,5-8H2,(H2,21,27)(H,23,24)(H,22,25,26)
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n/an/a 3n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202411
PNG
(US9238644, 18)
Show SMILES CN1CCC(CC1)n1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C25H30ClN7O/c1-32-12-8-19(9-13-32)33-16-18(14-29-33)30-24-28-15-21(26)22(31-24)7-6-17-4-2-3-5-20(17)25(10-11-25)23(27)34/h2-5,14-16,19H,6-13H2,1H3,(H2,27,34)(H,28,30,31)
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n/an/a 3n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316792
PNG
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)
Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12
Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2
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n/an/a 3n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM50316792
PNG
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)
Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12
Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2
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n/an/a 3n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202476
PNG
(US9238644, 77)
Show SMILES COCCn1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(CC3)C(N)=O)n2)cn1
Show InChI InChI=1S/C22H25ClN6O2/c1-31-11-10-29-14-16(12-26-29)27-21-25-13-18(23)19(28-21)7-6-15-4-2-3-5-17(15)22(8-9-22)20(24)30/h2-5,12-14H,6-11H2,1H3,(H2,24,30)(H,25,27,28)
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n/an/a 3n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM202463
PNG
(US9238644, 65)
Show SMILES Cn1cc(Nc2ncc(c(CCc3ccccc3C3(CC3)C(N)=O)n2)C(F)(F)F)cn1
Show InChI InChI=1S/C21H21F3N6O/c1-30-12-14(10-27-30)28-19-26-11-16(21(22,23)24)17(29-19)7-6-13-4-2-3-5-15(13)20(8-9-20)18(25)31/h2-5,10-12H,6-9H2,1H3,(H2,25,31)(H,26,28,29)
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n/an/a 3n/an/an/an/an/an/a



CANCER THERAPEUTICS CRC PTY LIMITED

US Patent


Assay Description
A biotin labelled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)....


US Patent US9238644 (2016)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT4


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 3n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3


Citation and Details
More data for this
Ligand-Target Pair
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