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Found 77 hits Enz. Inhib. hit(s) with Target = 'UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166414
PNG
(US9073821, 402)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)-c1ccc2n(C)ccc2c1)C(=O)NO
Show InChI InChI=1/C22H24N4O4/c1-22(20(28)23-2,21(29)24-30)26(4)19(27)15-7-5-14(6-8-15)16-9-10-18-17(13-16)11-12-25(18)3/h5-13,30H,1-4H3,(H,23,28)(H,24,29)/t22-/s2
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n/an/a 4.90n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166421
PNG
(US9073821, 507)
Show SMILES CNC(=O)C(N(C)C(=O)c1ccc(cc1)C#CC#CC1CC1)C(=O)NO
Show InChI InChI=1/C19H19N3O4/c1-20-17(23)16(18(24)21-26)22(2)19(25)15-11-9-14(10-12-15)6-4-3-5-13-7-8-13/h9-13,16,26H,7-8H2,1-2H3,(H,20,23)(H,21,24)
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n/an/a 12n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166423
PNG
(US9073821, 550)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1coc(COC)c1)C(=O)NO
Show InChI InChI=1/C21H23N3O6/c1-21(19(26)22-2,20(27)23-28)24(3)18(25)16-9-7-14(8-10-16)5-6-15-11-17(13-29-4)30-12-15/h7-12,28H,13H2,1-4H3,(H,22,26)(H,23,27)/t21-/s2
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n/an/a 12n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166413
PNG
(US9073821, 399)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)[C@@](C)(C(=O)NC)C(=O)NO
Show InChI InChI=1/C21H25N3O5/c1-5-29-17-12-10-15(11-13-17)14-6-8-16(9-7-14)18(25)24(4)21(2,19(26)22-3)20(27)23-28/h6-13,28H,5H2,1-4H3,(H,22,26)(H,23,27)/t21-/s2
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n/an/a 13n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074943
PNG
(2-(3-Benzyloxy-4-methoxy-5-propyl-phenyl)-4,5-dihy...)
Show SMILES CCCc1cc(cc(OCc2ccccc2)c1OC)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C21H24N2O5/c1-3-7-15-10-16(21-22-17(13-28-21)20(24)23-25)11-18(19(15)26-2)27-12-14-8-5-4-6-9-14/h4-6,8-11,17,25H,3,7,12-13H2,1-2H3,(H,23,24)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166422
PNG
(US9073821, 528)
Show SMILES CNC(=O)C(C)(N(C)C(=O)c1ccc(cc1)C#Cc1coc(COC)c1)C(=O)NO
Show InChI InChI=1/C21H23N3O6/c1-21(19(26)22-2,20(27)23-28)24(3)18(25)16-9-7-14(8-10-16)5-6-15-11-17(13-29-4)30-12-15/h7-12,28H,13H2,1-4H3,(H,22,26)(H,23,27)
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n/an/a 25n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074960
PNG
((R)-2-(3,4-Dimethoxy-5-propyl-phenyl)-4,5-dihydro-...)
Show SMILES CCCc1cc(cc(OC)c1OC)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C15H20N2O5/c1-4-5-9-6-10(7-12(20-2)13(9)21-3)15-16-11(8-22-15)14(18)17-19/h6-7,11,19H,4-5,8H2,1-3H3,(H,17,18)/t11-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166429
PNG
(US9073821, 561)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1)C(=O)NO
Show InChI InChI=1/C26H30N4O5/c1-26(24(32)27-2,25(33)28-34)29(3)23(31)22-12-10-20(11-13-22)5-4-19-6-8-21(9-7-19)18-30-14-16-35-17-15-30/h6-13,34H,14-18H2,1-3H3,(H,27,32)(H,28,33)/t26-/s2
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n/an/a 30n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166419
PNG
(US9073821, 477)
Show SMILES CNC(=O)C(N(C)C(=O)c1ccc(\C=C\C#Cc2ccc(CNC3CC3)cc2)cc1)C(=O)NO
Show InChI InChI=1/C26H28N4O4/c1-27-24(31)23(25(32)29-34)30(2)26(33)21-13-11-19(12-14-21)6-4-3-5-18-7-9-20(10-8-18)17-28-22-15-16-22/h4,6-14,22-23,28,34H,15-17H2,1-2H3,(H,27,31)(H,29,32)/b6-4+
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n/an/a 33n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166412
PNG
(US9073821, 396)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CNC2COC2)cc1)C(=O)NO
Show InChI InChI=1/C25H28N4O5/c1-25(23(31)26-2,24(32)28-33)29(3)22(30)20-12-10-18(11-13-20)5-4-17-6-8-19(9-7-17)14-27-21-15-34-16-21/h6-13,21,27,33H,14-16H2,1-3H3,(H,26,31)(H,28,32)/t25-/s2
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n/an/a 46n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074944
PNG
(2-(3,4-Dimethoxy-5-propyl-phenyl)-4,5-dihydro-oxaz...)
Show SMILES CCCc1cc(cc(OC)c1OC)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C15H20N2O5/c1-4-5-9-6-10(7-12(20-2)13(9)21-3)15-16-11(8-22-15)14(18)17-19/h6-7,11,19H,4-5,8H2,1-3H3,(H,17,18)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074941
PNG
((R)-2-(3-Propyl-phenyl)-4,5-dihydro-oxazole-4-carb...)
Show SMILES CCCc1cccc(c1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C13H16N2O3/c1-2-4-9-5-3-6-10(7-9)13-14-11(8-18-13)12(16)15-17/h3,5-7,11,17H,2,4,8H2,1H3,(H,15,16)/t11-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166418
PNG
(US9073821, 434)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(\C=C\c2ccc(CN3CCOCC3)cc2)cc1)C(=O)NO
Show InChI InChI=1/C26H32N4O5/c1-26(24(32)27-2,25(33)28-34)29(3)23(31)22-12-10-20(11-13-22)5-4-19-6-8-21(9-7-19)18-30-14-16-35-17-15-30/h4-13,34H,14-18H2,1-3H3,(H,27,32)(H,28,33)/b5-4+/t26-/s2
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n/an/a 55n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166416
PNG
(US9073821, 410)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CCN2CCOCC2)cc1)C(=O)NO
Show InChI InChI=1/C27H32N4O5/c1-27(25(33)28-2,26(34)29-35)30(3)24(32)23-12-10-21(11-13-23)5-4-20-6-8-22(9-7-20)14-15-31-16-18-36-19-17-31/h6-13,35H,14-19H2,1-3H3,(H,28,33)(H,29,34)/t27-/s2
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n/an/a 78n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166420
PNG
(US9073821, 481)
Show SMILES CNC(=O)C(N(C)C(=O)c1ccc(cc1)C#C\C=C\c1ccc(CNC2CC2)cc1)C(=O)NO
Show InChI InChI=1/C26H28N4O4/c1-27-24(31)23(25(32)29-34)30(2)26(33)21-13-11-19(12-14-21)6-4-3-5-18-7-9-20(10-8-18)17-28-22-15-16-22/h3,5,7-14,22-23,28,34H,15-17H2,1-2H3,(H,27,31)(H,29,32)/b5-3+
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n/an/a 78n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166432
PNG
(US9073821, 585)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1coc(CNC2CC2)c1)C(=O)NO
Show InChI InChI=1/C23H26N4O5/c1-23(21(29)24-2,22(30)26-31)27(3)20(28)17-8-6-15(7-9-17)4-5-16-12-19(32-14-16)13-25-18-10-11-18/h6-9,12,14,18,25,31H,10-11,13H2,1-3H3,(H,24,29)(H,26,30)/t23-/s2
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n/an/a 88n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074949
PNG
((R)-2-(4-Propyl-phenyl)-4,5-dihydro-oxazole-4-carb...)
Show SMILES CCCc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C13H16N2O3/c1-2-3-9-4-6-10(7-5-9)13-14-11(8-18-13)12(16)15-17/h4-7,11,17H,2-3,8H2,1H3,(H,15,16)/t11-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074940
PNG
(2-(3-Hydroxy-4-methoxy-5-propyl-phenyl)-4,5-dihydr...)
Show SMILES CCCc1cc(cc(O)c1OC)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C14H18N2O5/c1-3-4-8-5-9(6-11(17)12(8)20-2)14-15-10(7-21-14)13(18)16-19/h5-6,10,17,19H,3-4,7H2,1-2H3,(H,16,18)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166410
PNG
(US9073821, 301)
Show SMILES CNC(=O)C(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CNC2CC2)cc1)C(=O)NO
Show InChI InChI=1/C24H26N4O4/c1-25-22(29)21(23(30)27-32)28(2)24(31)19-11-9-17(10-12-19)4-3-16-5-7-18(8-6-16)15-26-20-13-14-20/h5-12,20-21,26,32H,13-15H2,1-2H3,(H,25,29)(H,27,30)
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n/an/a 100n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166426
PNG
(US9073821, 557)
Show SMILES CCOC1CN(Cc2ccc(cc2)C#Cc2ccc(cc2)C(=O)N(C)[C@@](C)(C(=O)NC)C(=O)NO)C1
Show InChI InChI=1/C27H32N4O5/c1-5-36-23-17-31(18-23)16-21-10-8-19(9-11-21)6-7-20-12-14-22(15-13-20)24(32)30(4)27(2,25(33)28-3)26(34)29-35/h8-15,23,35H,5,16-18H2,1-4H3,(H,28,33)(H,29,34)/t27-/s2
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n/an/a 108n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166409
PNG
(US9073821, 211)
Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)C(=O)N(C)C(C(=O)NC)C(=O)NO
Show InChI InChI=1/C20H23N3O5/c1-4-28-16-11-9-14(10-12-16)13-5-7-15(8-6-13)20(26)23(3)17(18(24)21-2)19(25)22-27/h5-12,17,27H,4H2,1-3H3,(H,21,24)(H,22,25)
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n/an/a 109n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166428
PNG
(US9073821, 559)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CN2CC(C2)OCCF)cc1)C(=O)NO
Show InChI InChI=1/C27H31FN4O5/c1-27(25(34)29-2,26(35)30-36)31(3)24(33)22-12-10-20(11-13-22)5-4-19-6-8-21(9-7-19)16-32-17-23(18-32)37-15-14-28/h6-13,23,36H,14-18H2,1-3H3,(H,29,34)(H,30,35)/t27-/s2
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n/an/a 115n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166408
PNG
(US9073821, 168)
Show SMILES CNC(=O)C(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CN2CCCOCC2)cc1)C(=O)NO
Show InChI InChI=1/C26H30N4O5/c1-27-24(31)23(25(32)28-34)29(2)26(33)22-12-10-20(11-13-22)5-4-19-6-8-21(9-7-19)18-30-14-3-16-35-17-15-30/h6-13,23,34H,3,14-18H2,1-2H3,(H,27,31)(H,28,32)
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n/an/a 119n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166425
PNG
(US9073821, 554)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CNCCF)cc1)C(=O)NO
Show InChI InChI=1/C24H27FN4O4/c1-24(22(31)26-2,23(32)28-33)29(3)21(30)20-12-10-18(11-13-20)5-4-17-6-8-19(9-7-17)16-27-15-14-25/h6-13,27,33H,14-16H2,1-3H3,(H,26,31)(H,28,32)/t24-/s2
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n/an/a 120n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166417
PNG
(US9073821, 425)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(CCc2ccc(CN3CCOCC3)cc2)cc1)C(=O)NO
Show InChI InChI=1/C26H34N4O5/c1-26(24(32)27-2,25(33)28-34)29(3)23(31)22-12-10-20(11-13-22)5-4-19-6-8-21(9-7-19)18-30-14-16-35-17-15-30/h6-13,34H,4-5,14-18H2,1-3H3,(H,27,32)(H,28,33)/t26-/s2
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n/an/a 121n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166411
PNG
(US9073821, 376)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CN2CCCOCC2)cc1)C(=O)NO
Show InChI InChI=1/C27H32N4O5/c1-27(25(33)28-2,26(34)29-35)30(3)24(32)23-13-11-21(12-14-23)6-5-20-7-9-22(10-8-20)19-31-15-4-17-36-18-16-31/h7-14,35H,4,15-19H2,1-3H3,(H,28,33)(H,29,34)/t27-/s2
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n/an/a 129n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166424
PNG
(US9073821, 553)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CNC2CC2)cc1)C(=O)NO
Show InChI InChI=1/C25H28N4O4/c1-25(23(31)26-2,24(32)28-33)29(3)22(30)20-12-10-18(11-13-20)5-4-17-6-8-19(9-7-17)16-27-21-14-15-21/h6-13,21,27,33H,14-16H2,1-3H3,(H,26,31)(H,28,32)/t25-/s2
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n/an/a 159n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166431
PNG
(US9073821, 567)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CN2CC(C2)OC)cc1)C(=O)NO
Show InChI InChI=1/C26H30N4O5/c1-26(24(32)27-2,25(33)28-34)29(3)23(31)21-13-11-19(12-14-21)6-5-18-7-9-20(10-8-18)15-30-16-22(17-30)35-4/h7-14,22,34H,15-17H2,1-4H3,(H,27,32)(H,28,33)/t26-/s2
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n/an/a 177n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074951
PNG
((R)-2-(4-Ethyl-phenyl)-4,5-dihydro-oxazole-4-carbo...)
Show SMILES CCc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C12H14N2O3/c1-2-8-3-5-9(6-4-8)12-13-10(7-17-12)11(15)14-16/h3-6,10,16H,2,7H2,1H3,(H,14,15)/t10-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM166427
PNG
(US9073821, 558)
Show SMILES CNC(=O)[C@](C)(N(C)C(=O)c1ccc(cc1)C#Cc1ccc(CN2CC(C)(C2)OC)cc1)C(=O)NO
Show InChI InChI=1/C27H32N4O5/c1-26(36-5)17-31(18-26)16-21-10-8-19(9-11-21)6-7-20-12-14-22(15-13-20)23(32)30(4)27(2,24(33)28-3)25(34)29-35/h8-15,35H,16-18H2,1-5H3,(H,28,33)(H,29,34)/t27-/s2
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n/an/a 235n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD; TOYAMA CHEMICAL CO., LTD.

US Patent


Assay Description
To assay the activity of E. coli LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxytetradecanoyl)-N-acetylglucosamine and the amou...


US Patent US9073821 (2015)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074938
PNG
((R)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazole-4-car...)
Show SMILES COc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C11H12N2O4/c1-16-8-4-2-7(3-5-8)11-12-9(6-17-11)10(14)13-15/h2-5,9,15H,6H2,1H3,(H,13,14)/t9-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074956
PNG
((R)-2-(3,4,5-Trimethoxy-phenyl)-4,5-dihydro-oxazol...)
Show SMILES COc1cc(cc(OC)c1OC)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C13H16N2O6/c1-18-9-4-7(5-10(19-2)11(9)20-3)13-14-8(6-21-13)12(16)15-17/h4-5,8,17H,6H2,1-3H3,(H,15,16)/t8-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074957
PNG
(2-(4-Methoxy-3-propyl-phenyl)-4,5-dihydro-oxazole-...)
Show SMILES CCCc1cc(ccc1OC)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C14H18N2O4/c1-3-4-9-7-10(5-6-12(9)19-2)14-15-11(8-20-14)13(17)16-18/h5-7,11,18H,3-4,8H2,1-2H3,(H,16,17)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074951
PNG
((R)-2-(4-Ethyl-phenyl)-4,5-dihydro-oxazole-4-carbo...)
Show SMILES CCc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C12H14N2O3/c1-2-8-3-5-9(6-4-8)12-13-10(7-17-12)11(15)14-16/h3-6,10,16H,2,7H2,1H3,(H,14,15)/t10-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074947
PNG
(2-m-Tolyl-4,5-dihydro-oxazole-4-carboxylic acid hy...)
Show SMILES Cc1cccc(c1)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C11H12N2O3/c1-7-3-2-4-8(5-7)11-12-9(6-16-11)10(14)13-15/h2-5,9,15H,6H2,1H3,(H,13,14)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074938
PNG
((R)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazole-4-car...)
Show SMILES COc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C11H12N2O4/c1-16-8-4-2-7(3-5-8)11-12-9(6-17-11)10(14)13-15/h2-5,9,15H,6H2,1H3,(H,13,14)/t9-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074946
PNG
(2-(4-Hydroxy-3-methoxy-5-propyl-phenyl)-4,5-dihydr...)
Show SMILES CCCc1cc(cc(OC)c1O)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C14H18N2O5/c1-3-4-8-5-9(6-11(20-2)12(8)17)14-15-10(7-21-14)13(18)16-19/h5-6,10,17,19H,3-4,7H2,1-2H3,(H,16,18)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074958
PNG
((R)-2-Phenyl-4,5-dihydro-oxazole-4-carboxylic acid...)
Show SMILES ONC(=O)[C@H]1COC(=N1)c1ccccc1
Show InChI InChI=1S/C10H10N2O3/c13-9(12-14)8-6-15-10(11-8)7-4-2-1-3-5-7/h1-5,8,14H,6H2,(H,12,13)/t8-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074941
PNG
((R)-2-(3-Propyl-phenyl)-4,5-dihydro-oxazole-4-carb...)
Show SMILES CCCc1cccc(c1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C13H16N2O3/c1-2-4-9-5-3-6-10(7-9)13-14-11(8-18-13)12(16)15-17/h3,5-7,11,17H,2,4,8H2,1H3,(H,15,16)/t11-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074961
PNG
(2-p-Tolyl-4,5-dihydro-oxazole-4-carboxylic acid hy...)
Show SMILES Cc1ccc(cc1)C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C11H12N2O3/c1-7-2-4-8(5-3-7)11-12-9(6-16-11)10(14)13-15/h2-5,9,15H,6H2,1H3,(H,13,14)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074963
PNG
(2-o-Tolyl-4,5-dihydro-oxazole-4-carboxylic acid hy...)
Show SMILES Cc1ccccc1C1=NC(CO1)C(=O)NO
Show InChI InChI=1S/C11H12N2O3/c1-7-4-2-3-5-8(7)11-12-9(6-16-11)10(14)13-15/h2-5,9,15H,6H2,1H3,(H,13,14)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074938
PNG
((R)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazole-4-car...)
Show SMILES COc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO
Show InChI InChI=1S/C11H12N2O4/c1-16-8-4-2-7(3-5-8)11-12-9(6-17-11)10(14)13-15/h2-5,9,15H,6H2,1H3,(H,13,14)/t9-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibition of E. coli LpxC(UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase.


J Med Chem 45: 4359-70 (2002)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074939
PNG
(2-Phenyl-4,5-dihydro-oxazole-4-carboxylic acid hyd...)
Show SMILES ONC(=O)C1COC(=N1)c1ccccc1
Show InChI InChI=1S/C10H10N2O3/c13-9(12-14)8-6-15-10(11-8)7-4-2-1-3-5-7/h1-5,8,14H,6H2,(H,12,13)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50118596
PNG
((R/S)-[3-(4-Methoxy-phenyl)-4,5-dihydro-isoxazol-5...)
Show SMILES COc1ccc(cc1)-c1cc(on1)P(O)(O)O
Show InChI InChI=1S/C10H12NO5P/c1-15-8-4-2-7(3-5-8)9-6-10(16-11-9)17(12,13)14/h2-6,12-14,17H,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibition of E. coli LpxC(UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase.


J Med Chem 45: 4359-70 (2002)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50409600
PNG
(CHEMBL2111931)
Show SMILES COc1ccc(cc1)C1=NO[C@H](C1)C(=O)NO
Show InChI InChI=1S/C11H12N2O4/c1-16-8-4-2-7(3-5-8)9-6-10(17-13-9)11(14)12-15/h2-5,10,15H,6H2,1H3,(H,12,14)/t10-/m1/s1
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n/an/a 4.37E+3n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibition of E. coli LpxC(UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase.


J Med Chem 45: 4359-70 (2002)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074958
PNG
((R)-2-Phenyl-4,5-dihydro-oxazole-4-carboxylic acid...)
Show SMILES ONC(=O)[C@H]1COC(=N1)c1ccccc1
Show InChI InChI=1S/C10H10N2O3/c13-9(12-14)8-6-15-10(11-8)7-4-2-1-3-5-7/h1-5,8,14H,6H2,(H,12,13)/t8-/m1/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074939
PNG
(2-Phenyl-4,5-dihydro-oxazole-4-carboxylic acid hyd...)
Show SMILES ONC(=O)C1COC(=N1)c1ccccc1
Show InChI InChI=1S/C10H10N2O3/c13-9(12-14)8-6-15-10(11-8)7-4-2-1-3-5-7/h1-5,8,14H,6H2,(H,12,13)
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n/an/a 8.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50074955
PNG
((R)-2-Furan-2-yl-4,5-dihydro-oxazole-4-carboxylic ...)
Show SMILES ONC(=O)[C@H]1COC(=N1)c1ccco1
Show InChI InChI=1S/C8H8N2O4/c11-7(10-12)5-4-14-8(9-5)6-2-1-3-13-6/h1-3,5,12H,4H2,(H,10,11)/t5-/m1/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in E. coli strain JB 1104


Bioorg Med Chem Lett 9: 313-8 (1999)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50118597
PNG
((R/S)-Thioacetic acid S-{2-[3-(4-methoxy-phenyl)-4...)
Show SMILES COc1ccc(cc1)C1=NOC(C1)C(=O)CSC(C)=O
Show InChI InChI=1S/C14H15NO4S/c1-9(16)20-8-13(17)14-7-12(15-19-14)10-3-5-11(18-2)6-4-10/h3-6,14H,7-8H2,1-2H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibition of E. coli LpxC(UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase.


J Med Chem 45: 4359-70 (2002)

More data for this
Ligand-Target Pair
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC)


(Escherichia coli)
BDBM50118582
PNG
((R)3-(4-Methoxy-phenyl)-4,5-dihydro-isoxazole-5-ca...)
Show SMILES COc1ccc(cc1)C1=NOC(C1)C(=O)NO
Show InChI InChI=1S/C11H12N2O4/c1-16-8-4-2-7(3-5-8)9-6-10(17-13-9)11(14)12-15/h2-5,10,15H,6H2,1H3,(H,12,14)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibition of E. coli LpxC(UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase.


J Med Chem 45: 4359-70 (2002)

More data for this
Ligand-Target Pair
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