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Compile Data Set for Download or QSAR

Found 98 hits Enz. Inhib. hit(s) with Target = 'UDP-glucuronosyltransferase 2B7' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211740
PNG
((1R)-phenyl-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricy...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)c1ccccc1
Show InChI InChI=1S/C21H30O/c1-20(2)12-7-13-21(3)16-11-10-15(17(16)20)18(21)19(22)14-8-5-4-6-9-14/h4-6,8-9,15-19,22H,7,10-13H2,1-3H3/t15-,16+,17-,18+,19-,21-/m0/s1
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18.4n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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PubMed
1.50E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human kidney microsomes assessed as reduction in enzyme-mediated mycophenolic acid pheno...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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1.50E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human liver microsomes assessed as reduction in enzyme-mediated mycophenolic acid phenol...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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1.50E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in diabetic human liver microsomes assessed as reduction in enzyme-mediated mycophenolic acid phenolic 7...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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1.50E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in diabetic human kidney microsomes assessed as reduction in enzyme-mediated mycophenolic acid phenolic ...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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2.00E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human liver microsomes assessed as reduction in enzyme-mediated mycophenolic acid acyl g...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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2.00E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in diabetic human liver microsomes assessed as reduction in enzyme-mediated mycophenolic acid acyl glucu...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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2.00E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in diabetic human kidney microsomes assessed as reduction in enzyme-mediated mycophenolic acid acyl gluc...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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2.00E+3n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human kidney microsomes assessed as reduction in enzyme-mediated mycophenolic acid acyl ...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50183611
PNG
((rac)-5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES Cc1cc(C)c2CCCC(O)c2c1
Show InChI InChI=1S/C12H16O/c1-8-6-9(2)10-4-3-5-12(13)11(10)7-8/h6-7,12-13H,3-5H2,1-2H3
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1.01E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Competitive inhibition of UGT2B7-catalyzed scopoletin glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50183598
PNG
((rac)-6-methyl-3,4-dihydro-2H-chromen-4-ol | CHEMB...)
Show SMILES Cc1ccc2OCCC(O)c2c1
Show InChI InChI=1S/C10H12O2/c1-7-2-3-10-8(6-7)9(11)4-5-12-10/h2-3,6,9,11H,4-5H2,1H3
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1.13E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Competitive inhibition of UGT2B7-catalyzed scopoletin glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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1.50E+5n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human kidney microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide ...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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1.50E+5n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in diabetic human kidney microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide form...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50088511
PNG
(CHEBI:87620 | EPIESTRIOL | Epiestriol | Epioestrio...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@H](O)[C@@H]2O
Show InChI InChI=1/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16+,17+,18+/s2
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1.62E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal His-tagged UGT2B7 after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50183611
PNG
((rac)-5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES Cc1cc(C)c2CCCC(O)c2c1
Show InChI InChI=1S/C12H16O/c1-8-6-9(2)10-4-3-5-12(13)11(10)7-8/h6-7,12-13H,3-5H2,1-2H3
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1.92E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Non competitive inhibition of UGT2B7-catalyzed scopoletin glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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2.00E+5n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in diabetic human liver microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide forma...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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2.00E+5n/an/an/an/an/an/an/an/a



University of Rhode Island

Curated by ChEMBL


Assay Description
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human liver microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide f...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50183598
PNG
((rac)-6-methyl-3,4-dihydro-2H-chromen-4-ol | CHEMB...)
Show SMILES Cc1ccc2OCCC(O)c2c1
Show InChI InChI=1S/C10H12O2/c1-7-2-3-10-8(6-7)9(11)4-5-12-10/h2-3,6,9,11H,4-5H2,1H3
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2.58E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Non competitive inhibition of UGT2B7-catalyzed scopoletin glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50183609
PNG
((rac)-6-methyl-2,3-dihydro-1H-inden-1-ol | CHEMBL2...)
Show SMILES Cc1ccc2CCC(O)c2c1
Show InChI InChI=1S/C10H12O/c1-7-2-3-8-4-5-10(11)9(8)6-7/h2-3,6,10-11H,4-5H2,1H3
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3.01E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Competitive inhibition of UGT2B7-catalyzed scopoletin glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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5.90E+5n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Drug metabolism assessed as recombinant human UGT2B7 assessed as O-glucuronidation measured as inhibition constant at 10 to 400 uM incubated for 60 m...


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50183609
PNG
((rac)-6-methyl-2,3-dihydro-1H-inden-1-ol | CHEMBL2...)
Show SMILES Cc1ccc2CCC(O)c2c1
Show InChI InChI=1S/C10H12O/c1-7-2-3-8-4-5-10(11)9(8)6-7/h2-3,6,10-11H,4-5H2,1H3
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6.24E+5n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Non competitive inhibition of UGT2B7-catalyzed scopoletin glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50003616
PNG
(2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...)
Show SMILES CCCC(CCC)C(O)=O
Show InChI InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
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1.60E+6n/an/an/an/an/an/an/an/a



The University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of AZT glucuronidation by human recombinant UGT2B7


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211740
PNG
((1R)-phenyl-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricy...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)c1ccccc1
Show InChI InChI=1S/C21H30O/c1-20(2)12-7-13-21(3)16-11-10-15(17(16)20)18(21)19(22)14-8-5-4-6-9-14/h4-6,8-9,15-19,22H,7,10-13H2,1-3H3/t15-,16+,17-,18+,19-,21-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 by substrate-independent inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211740
PNG
((1R)-phenyl-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricy...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)c1ccccc1
Show InChI InChI=1S/C21H30O/c1-20(2)12-7-13-21(3)16-11-10-15(17(16)20)18(21)19(22)14-8-5-4-6-9-14/h4-6,8-9,15-19,22H,7,10-13H2,1-3H3/t15-,16+,17-,18+,19-,21-/m0/s1
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n/an/a 54n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211775
PNG
(((1S,3aR,4S,8aR,9S)-4,8,8-trimethyl-decahydro-1,4-...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2CO
Show InChI InChI=1S/C15H26O/c1-14(2)7-4-8-15(3)11-6-5-10(13(11)14)12(15)9-16/h10-13,16H,4-9H2,1-3H3/t10-,11-,12+,13+,15+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211762
PNG
((1S)-2-chloro-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethylt...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@H](O)CCl
Show InChI InChI=1S/C16H27ClO/c1-15(2)7-4-8-16(3)11-6-5-10(13(11)15)14(16)12(18)9-17/h10-14,18H,4-9H2,1-3H3/t10-,11+,12+,13-,14+,16-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211777
PNG
((1S)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)CC=C
Show InChI InChI=1S/C18H30O/c1-5-7-14(19)16-12-8-9-13-15(12)17(2,3)10-6-11-18(13,16)4/h5,12-16,19H,1,6-11H2,2-4H3/t12-,13+,14-,15-,16+,18-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211764
PNG
((1R)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@H](O)CCO
Show InChI InChI=1S/C17H30O2/c1-16(2)8-4-9-17(3)12-6-5-11(14(12)16)15(17)13(19)7-10-18/h11-15,18-19H,4-10H2,1-3H3/t11-,12+,13+,14-,15+,17-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211763
PNG
((1R)-2-chloro-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethylt...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)CCl
Show InChI InChI=1S/C16H27ClO/c1-15(2)7-4-8-16(3)11-6-5-10(13(11)15)14(16)12(18)9-17/h10-14,18H,4-9H2,1-3H3/t10-,11+,12-,13-,14+,16-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211780
PNG
((1S)-2,2-dimethyl-1-[(1R,2S,7S,8S,9S)-3,3,7-trimet...)
Show SMILES CC(C)(C)[C@@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C19H34O/c1-17(2,3)16(20)15-12-8-9-13-14(12)18(4,5)10-7-11-19(13,15)6/h12-16,20H,7-11H2,1-6H3/t12-,13+,14-,15+,16?,19-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211782
PNG
((1R)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@H](O)C=C
Show InChI InChI=1S/C17H28O/c1-5-13(18)15-11-7-8-12-14(11)16(2,3)9-6-10-17(12,15)4/h5,11-15,18H,1,6-10H2,2-4H3/t11-,12+,13+,14-,15+,17-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211778
PNG
((1S)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)CCO
Show InChI InChI=1S/C17H30O2/c1-16(2)8-4-9-17(3)12-6-5-11(14(12)16)15(17)13(19)7-10-18/h11-15,18-19H,4-10H2,1-3H3/t11-,12+,13-,14-,15+,17-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211765
PNG
(CHEMBL226344 | ethyl (3S)-3-hydroxy-3-[(1R,2S,7S,8...)
Show SMILES CCOC(=O)C[C@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C19H32O3/c1-5-22-15(21)11-14(20)17-12-7-8-13-16(12)18(2,3)9-6-10-19(13,17)4/h12-14,16-17,20H,5-11H2,1-4H3/t12-,13+,14-,16-,17+,19-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211753
PNG
((1R)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@H](O)CC=C
Show InChI InChI=1S/C18H30O/c1-5-7-14(19)16-12-8-9-13-15(12)17(2,3)10-6-11-18(13,16)4/h5,12-16,19H,1,6-11H2,2-4H3/t12-,13+,14+,15-,16+,18-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211741
PNG
((1S)-2-methyl-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethylt...)
Show SMILES CC(C)[C@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C18H32O/c1-11(2)16(19)15-12-7-8-13-14(12)17(3,4)9-6-10-18(13,15)5/h11-16,19H,6-10H2,1-5H3/t12-,13+,14-,15+,16-,18-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211749
PNG
(CHEMBL390574 | ethyl (3R)-3-hydroxy-3-[(1R,2S,7S,8...)
Show SMILES CCOC(=O)C[C@@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C19H32O3/c1-5-22-15(21)11-14(20)17-12-7-8-13-16(12)18(2,3)9-6-10-19(13,17)4/h12-14,16-17,20H,5-11H2,1-4H3/t12-,13+,14+,16-,17+,19-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211739
PNG
((1R)-2-methyl-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethylt...)
Show SMILES CC(C)[C@@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C18H32O/c1-11(2)16(19)15-12-7-8-13-14(12)17(3,4)9-6-10-18(13,15)5/h11-16,19H,6-10H2,1-5H3/t12-,13+,14-,15+,16+,18-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211743
PNG
(2-[(1R,2S,7R,8S,9R)-3,3,7-trimethyltricyclo[5.4.0....)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2CCO
Show InChI InChI=1S/C16H28O/c1-15(2)8-4-9-16(3)12(7-10-17)11-5-6-13(16)14(11)15/h11-14,17H,4-10H2,1-3H3/t11-,12+,13-,14+,16-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211750
PNG
((1S)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES CC[C@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C17H30O/c1-5-13(18)15-11-7-8-12-14(11)16(2,3)9-6-10-17(12,15)4/h11-15,18H,5-10H2,1-4H3/t11-,12+,13-,14-,15+,17-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211769
PNG
((1R)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES CC[C@@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C17H30O/c1-5-13(18)15-11-7-8-12-14(11)16(2,3)9-6-10-17(12,15)4/h11-15,18H,5-10H2,1-4H3/t11-,12+,13+,14-,15+,17-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211773
PNG
((1R)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C16H28O/c1-10(17)13-11-6-7-12-14(11)15(2,3)8-5-9-16(12,13)4/h10-14,17H,5-9H2,1-4H3/t10-,11-,12-,13+,14+,16+/m1/s1
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PubMed
n/an/a 500n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211781
PNG
((1S)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)C=C
Show InChI InChI=1S/C17H28O/c1-5-13(18)15-11-7-8-12-14(11)16(2,3)9-6-10-17(12,15)4/h5,11-15,18H,1,6-10H2,2-4H3/t11-,12+,13-,14-,15+,17-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211766
PNG
((1S)-1-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C16H28O/c1-10(17)13-11-6-7-12-14(11)15(2,3)8-5-9-16(12,13)4/h10-14,17H,5-9H2,1-4H3/t10-,11+,12+,13-,14-,16-/m0/s1
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PubMed
n/an/a 700n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211744
PNG
((2Z)-3-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2\C=C/CO
Show InChI InChI=1S/C17H28O/c1-16(2)9-5-10-17(3)13(6-4-11-18)12-7-8-14(17)15(12)16/h4,6,12-15,18H,5,7-11H2,1-3H3/b6-4-/t12-,13+,14-,15+,17-/m1/s1
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PubMed
n/an/a 700n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211752
PNG
((2E)-3-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricyclo[5...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2\C=C\CO
Show InChI InChI=1S/C17H28O/c1-16(2)9-5-10-17(3)13(6-4-11-18)12-7-8-14(17)15(12)16/h4,6,12-15,18H,5,7-11H2,1-3H3/b6-4+/t12-,13+,14-,15+,17-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211748
PNG
((1R)-2,2-dimethyl-1-[(1R,2S,7S,8S,9S)-3,3,7-trimet...)
Show SMILES CC(C)(C)[C@H](O)[C@H]1[C@H]2CC[C@@H]3[C@H]2C(C)(C)CCC[C@]13C
Show InChI InChI=1S/C19H34O/c1-17(2,3)16(20)15-12-8-9-13-14(12)18(4,5)10-7-11-19(13,15)6/h12-16,20H,7-11H2,1-6H3/t12-,13+,14-,15+,16?,19-/m0/s1
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PubMed
n/an/a 800n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211786
PNG
((1S)-phenyl-[(1R,2S,7S,8S,9S)-3,3,7-trimethyltricy...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@H](O)c1ccccc1
Show InChI InChI=1S/C21H30O/c1-20(2)12-7-13-21(3)16-11-10-15(17(16)20)18(21)19(22)14-8-5-4-6-9-14/h4-6,8-9,15-19,22H,7,10-13H2,1-3H3/t15-,16+,17-,18+,19+,21-/m0/s1
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PubMed
n/an/a 900n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211761
PNG
(3-[(1R,2S,7R,8S,9R)-3,3,7-trimethyltricyclo[5.4.0....)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2CCCO
Show InChI InChI=1S/C17H30O/c1-16(2)9-5-10-17(3)13(6-4-11-18)12-7-8-14(17)15(12)16/h12-15,18H,4-11H2,1-3H3/t12-,13+,14-,15+,17-/m1/s1
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PubMed
n/an/a 900n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211759
PNG
((3R)-3-hydroxy-3-[(1R,2S,7S,8S,9S)-3,3,7-trimethyl...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@H](O)CC(O)=O
Show InChI InChI=1S/C17H28O3/c1-16(2)7-4-8-17(3)11-6-5-10(14(11)16)15(17)12(18)9-13(19)20/h10-12,14-15,18H,4-9H2,1-3H3,(H,19,20)/t10-,11+,12+,14-,15+,17-/m0/s1
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PubMed
n/an/a 900n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
UDP-glucuronosyltransferase 2B7


(Homo sapiens)
BDBM50211756
PNG
((3S)-3-hydroxy-3-[(1R,2S,7S,8S,9S)-3,3,7-trimethyl...)
Show SMILES C[C@]12CCCC(C)(C)[C@H]3[C@H](CC[C@@H]13)[C@@H]2[C@@H](O)CC(O)=O
Show InChI InChI=1S/C17H28O3/c1-16(2)7-4-8-17(3)11-6-5-10(14(11)16)15(17)12(18)9-13(19)20/h10-12,14-15,18H,4-9H2,1-3H3,(H,19,20)/t10-,11+,12-,14-,15+,17-/m0/s1
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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of human UGT2B7 assessed as reduction of estriol glucuronidation


Citation and Details
More data for this
Ligand-Target Pair
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