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Found 17 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin C-terminal Hydrolase L3 (UCH-L3)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326016
PNG
(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-6H,16H2,(H,17,19)(H,20,21)
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1.00E+5n/an/an/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM53421
PNG
(4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2...)
Show SMILES C1CCC(CC1)c1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)21-20(22-19)16-11-5-2-6-12-16/h2,5-8,11-15H,1,3-4,9-10H2
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n/an/a 600n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326012
PNG
(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-12-7-11(18)3-5-15(12)22(17(16)24)8-10-2-4-13(19)14(20)6-10/h2-7H,8H2,1H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326014
PNG
(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(I)cc12
Show InChI InChI=1S/C17H11Cl2IN2O3/c1-9(23)25-21-16-12-7-11(20)3-5-15(12)22(17(16)24)8-10-2-4-13(18)14(19)6-10/h2-7H,8H2,1H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326013
PNG
(3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-13-7-11(18)2-5-15(13)22(17(16)24)8-10-6-12(19)3-4-14(10)20/h2-7H,8H2,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326015
PNG
(5-(4-butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-t...)
Show SMILES CCCCc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H25N3S/c1-4-5-6-16-7-9-18(10-8-16)20-22-23-21(25)24(20)19-13-11-17(12-14-19)15(2)3/h7-15H,4-6H2,1-3H3,(H,23,25)
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n/an/a 4.70E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM24778
PNG
(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Show SMILES CC1=CC(=O)c2ccccc2C1=O
Show InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
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n/an/a 7.10E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23421
PNG
(1-benzyl-3-hydroxy-4-[(5-methylfuran-2-yl)carbonyl...)
Show SMILES Cc1ccc(o1)C(=O)C1C(N(Cc2ccccc2)C(=O)C1=O)c1cccnc1
Show InChI InChI=1S/C22H18N2O4/c1-14-9-10-17(28-14)20(25)18-19(16-8-5-11-23-12-16)24(22(27)21(18)26)13-15-6-3-2-4-7-15/h2-12,18-19H,13H2,1H3
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n/an/a 1.03E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23427
PNG
(5-(4-fluorophenyl)-3-hydroxy-4-[(5-methylfuran-2-y...)
Show SMILES Cc1ccc(o1)C(=O)C1C(N(Cc2cccnc2)C(=O)C1=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN2O4/c1-13-4-9-17(29-13)20(26)18-19(15-5-7-16(23)8-6-15)25(22(28)21(18)27)12-14-3-2-10-24-11-14/h2-11,18-19H,12H2,1H3
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n/an/a 1.23E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23426
PNG
(3-hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-...)
Show SMILES COc1ccc(cc1)C1C(C(=O)c2cccs2)C(=O)C(=O)N1c1nncs1
Show InChI InChI=1S/C18H13N3O4S2/c1-25-11-6-4-10(5-7-11)14-13(15(22)12-3-2-8-26-12)16(23)17(24)21(14)18-20-19-9-27-18/h2-9,13-14H,1H3
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n/an/a 1.54E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23425
PNG
(ChemBridge CNS-Set 7909542, 5 | N-{3-[1-acetyl-5-(...)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)C1=NN(C(C1)c1cccs1)C(C)=O
Show InChI InChI=1S/C17H19N3O3S2/c1-3-25(22,23)19-14-7-4-6-13(10-14)15-11-16(17-8-5-9-24-17)20(18-15)12(2)21/h4-10,16,19H,3,11H2,1-2H3
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n/an/a>3.31E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23424
PNG
(ChemBridge CNS-Set 6382507, 4 | N-cyclopropyl-2-[(...)
Show SMILES COc1ccc(cc1)N(CC(=O)NC1CC1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H22N2O4S/c1-14-3-11-18(12-4-14)26(23,24)21(13-19(22)20-15-5-6-15)16-7-9-17(25-2)10-8-16/h3-4,7-12,15H,5-6,13H2,1-2H3,(H,20,22)
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n/an/a>3.34E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23429
PNG
(2-[benzene(3-methoxyphenyl)sulfonamido]-N-cyclopen...)
Show SMILES COc1cccc(c1)N(CC(=O)NC1CCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H24N2O4S/c1-26-18-11-7-10-17(14-18)22(15-20(23)21-16-8-5-6-9-16)27(24,25)19-12-3-2-4-13-19/h2-4,7,10-14,16H,5-6,8-9,15H2,1H3,(H,21,23)
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n/an/a>3.86E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23430
PNG
(4-({[5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl...)
Show SMILES Nc1nc(CSc2nnc(-c3ccco3)n2-c2ccccc2)cs1
Show InChI InChI=1S/C16H13N5OS2/c17-15-18-11(9-23-15)10-24-16-20-19-14(13-7-4-8-22-13)21(16)12-5-2-1-3-6-12/h1-9H,10H2,(H2,17,18)
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n/an/a>3.87E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23428
PNG
(ChemBridge CNS-Set 6699002, 8 | N-cyclopropyl-2-[(...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NC1CC1)c1ccc(C)cc1
Show InChI InChI=1S/C19H22N2O4S/c1-14-3-7-16(8-4-14)21(13-19(22)20-15-5-6-15)26(23,24)18-11-9-17(25-2)10-12-18/h3-4,7-12,15H,5-6,13H2,1-2H3,(H,20,22)
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n/an/a>4.01E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23431
PNG
(ChemBridge CNS-Set 7977303, 3 | N-{4-[5-(furan-2-y...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccco1)C(=O)c1ccco1
Show InChI InChI=1S/C19H17N3O5S/c1-28(24,25)21-14-8-6-13(7-9-14)15-12-16(17-4-2-10-26-17)22(20-15)19(23)18-5-3-11-27-18/h2-11,16,21H,12H2,1H3
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n/an/an/an/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23423
PNG
(5-({[5-(1H-indol-3-yl)-4-methyl-4H-1,2,4-triazol-3...)
Show SMILES Cn1c(SCc2nc(no2)-c2cccs2)nnc1-c1c[nH]c2ccccc12
Show InChI InChI=1S/C18H14N6OS2/c1-24-17(12-9-19-13-6-3-2-5-11(12)13)21-22-18(24)27-10-15-20-16(23-25-15)14-7-4-8-26-14/h2-9,19H,10H2,1H3
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n/an/an/an/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Citation and Details
More data for this
Ligand-Target Pair