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Found 109 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase isozyme L1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53441
PNG
(MLS001000876 | N-(1H-benzimidazol-2-yl)-3-chlorany...)
Show SMILES Clc1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10ClN3O/c15-10-5-3-4-9(8-10)13(19)18-14-16-11-6-1-2-7-12(11)17-14/h1-8H,(H2,16,17,18,19)
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400 -36.5 880n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411563
PNG
(CHEMBL540117)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H12N2O4S/c20-14-12-8-13(19(24)25)17(23)21-18(12)26-16(14)15(22)11-6-5-9-3-1-2-4-10(9)7-11/h1-8H,20H2,(H,21,23)(H,24,25)
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740n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411574
PNG
(CHEMBL553923)
Show SMILES Cc1ccc(cc1)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O4S/c1-7-2-4-8(5-3-7)12(19)13-11(17)9-6-10(16(21)22)14(20)18-15(9)23-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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910n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411577
PNG
(CHEMBL536998)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H9ClN2O4S/c16-7-3-1-6(2-4-7)11(19)12-10(17)8-5-9(15(21)22)13(20)18-14(8)23-12/h1-5H,17H2,(H,18,20)(H,21,22)
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1.20E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411568
PNG
(CHEMBL536764)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C19H18N2O4S/c1-19(2,3)10-6-4-9(5-7-10)14(22)15-13(20)11-8-12(18(24)25)16(23)21-17(11)26-15/h4-8H,20H2,1-3H3,(H,21,23)(H,24,25)
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1.40E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411581
PNG
(CHEMBL537224)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H12N2O4S/c20-14-12-8-13(19(24)25)17(23)21-18(12)26-16(14)15(22)11-7-3-5-9-4-1-2-6-10(9)11/h1-8H,20H2,(H,21,23)(H,24,25)
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1.50E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411570
PNG
(CHEMBL537225)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)C1CCCCC1
Show InChI InChI=1S/C15H16N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h6-7H,1-5,16H2,(H,17,19)(H,20,21)
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2.00E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50326016
PNG
(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-6H,16H2,(H,17,19)(H,20,21)
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2.30E+3n/an/an/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50326016
PNG
(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-6H,16H2,(H,17,19)(H,20,21)
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2.80E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411572
PNG
(CHEMBL539345)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H9F3N2O4S/c17-16(18,19)7-3-1-6(2-4-7)11(22)12-10(20)8-5-9(15(24)25)13(23)21-14(8)26-12/h1-5H,20H2,(H,21,23)(H,24,25)
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3.60E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411573
PNG
(CHEMBL557989)
Show SMILES COc1ccccc1C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O5S/c1-23-10-5-3-2-4-7(10)12(19)13-11(17)8-6-9(16(21)22)14(20)18-15(8)24-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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5.30E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411575
PNG
(CHEMBL536763)
Show SMILES Cc1ccccc1C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O4S/c1-7-4-2-3-5-8(7)12(19)13-11(17)9-6-10(16(21)22)14(20)18-15(9)23-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411579
PNG
(CHEMBL539346)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C15H9ClN2O4S/c16-9-4-2-1-3-6(9)11(19)12-10(17)7-5-8(15(21)22)13(20)18-14(7)23-12/h1-5H,17H2,(H,18,20)(H,21,22)
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1.10E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411567
PNG
(CHEMBL537227)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1cccs1
Show InChI InChI=1S/C13H8N2O4S2/c14-8-5-4-6(13(18)19)11(17)15-12(5)21-10(8)9(16)7-2-1-3-20-7/h1-4H,14H2,(H,15,17)(H,18,19)
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2.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411566
PNG
(CHEMBL536995)
Show SMILES CC(C)(C)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C13H14N2O4S/c1-13(2,3)9(16)8-7(14)5-4-6(12(18)19)10(17)15-11(5)20-8/h4H,14H2,1-3H3,(H,15,17)(H,18,19)
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2.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411564
PNG
(CHEMBL536997)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C16H9F3N2O4S/c17-16(18,19)9-4-2-1-3-6(9)11(22)12-10(20)7-5-8(15(24)25)13(23)21-14(7)26-12/h1-5H,20H2,(H,21,23)(H,24,25)
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3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411569
PNG
(CHEMBL538583)
Show SMILES NC(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C9H7N3O4S/c10-4-2-1-3(9(15)16)7(14)12-8(2)17-5(4)6(11)13/h1H,10H2,(H2,11,13)(H,12,14)(H,15,16)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411571
PNG
(CHEMBL537226)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccncc1
Show InChI InChI=1S/C14H9N3O4S/c15-9-7-5-8(14(20)21)12(19)17-13(7)22-11(9)10(18)6-1-3-16-4-2-6/h1-5H,15H2,(H,17,19)(H,20,21)
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3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411576
PNG
(CHEMBL556784)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)N1CCCCC1
Show InChI InChI=1S/C14H15N3O4S/c15-9-7-6-8(14(20)21)11(18)16-12(7)22-10(9)13(19)17-4-2-1-3-5-17/h6H,1-5,15H2,(H,16,18)(H,20,21)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411578
PNG
(CHEMBL539094)
Show SMILES COc1ccc(cc1)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O5S/c1-23-8-4-2-7(3-5-8)12(19)13-11(17)9-6-10(16(21)22)14(20)18-15(9)24-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411580
PNG
(CHEMBL557988)
Show SMILES COC(=O)c1cc2c(N)c(sc2[nH]c1=O)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C17H14N2O4S/c1-8-3-5-9(6-4-8)13(20)14-12(18)10-7-11(17(22)23-2)15(21)19-16(10)24-14/h3-7H,18H2,1-2H3,(H,19,21)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50411562
PNG
(CHEMBL540118)
Show SMILES CC(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C10H8N2O4S/c1-3(13)7-6(11)4-2-5(10(15)16)8(14)12-9(4)17-7/h2H,11H2,1H3,(H,12,14)(H,15,16)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Bioorg Med Chem Lett 17: 3729-32 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.027
BindingDB Entry DOI: 10.7270/Q2HT2QJ5
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50326012
PNG
(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-12-7-11(18)3-5-15(12)22(17(16)24)8-10-2-4-13(19)14(20)6-10/h2-7H,8H2,1H3
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n/an/a 810n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53467
PNG
(1,3-Dimethyl-5-nitro-6-[2-(4-propoxy-phenyl)-vinyl...)
Show SMILES CCCOc1ccc(\C=C\c2c([N+]([O-])=O)c(=O)n(C)c(=O)n2C)cc1
Show InChI InChI=1S/C17H19N3O5/c1-4-11-25-13-8-5-12(6-9-13)7-10-14-15(20(23)24)16(21)19(3)17(22)18(14)2/h5-10H,4,11H2,1-3H3/b10-7+
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n/an/a 810n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50326013
PNG
(3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-13-7-11(18)2-5-15(13)22(17(16)24)8-10-6-12(19)3-4-14(10)20/h2-7H,8H2,1H3
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n/an/a 880n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50326014
PNG
(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(I)cc12
Show InChI InChI=1S/C17H11Cl2IN2O3/c1-9(23)25-21-16-12-7-11(20)3-5-15(12)22(17(16)24)8-10-2-4-13(18)14(19)6-10/h2-7H,8H2,1H3
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n/an/a 940n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53468
PNG
(2-[3-cyano-4-(2-methoxyphenyl)-6-phenyl-pyridin-2-...)
Show SMILES COc1ccccc1-c1cc(nc(SCC(O)=O)c1C#N)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-26-19-10-6-5-9-15(19)16-11-18(14-7-3-2-4-8-14)23-21(17(16)12-22)27-13-20(24)25/h2-11H,13H2,1H3,(H,24,25)
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n/an/a 940n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53442
PNG
((7-chloranyl-3,5-dimethyl-1-benzofuran-2-yl)-(4-ox...)
Show SMILES Cc1c(oc2c(Cl)cc(C)cc12)C(=O)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C22H22ClNO3/c1-14-12-17-15(2)19(27-20(17)18(23)13-14)21(25)24-10-8-22(26,9-11-24)16-6-4-3-5-7-16/h3-7,12-13,26H,8-11H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53443
PNG
(2-(3-chloro-4-methoxy-N-methylsulfonylanilino)-N-[...)
Show SMILES COc1ccc(cc1Cl)N(CC(=O)NCCSCc1cccc(Cl)c1)S(C)(=O)=O
Show InChI InChI=1S/C19H22Cl2N2O4S2/c1-27-18-7-6-16(11-17(18)21)23(29(2,25)26)12-19(24)22-8-9-28-13-14-4-3-5-15(20)10-14/h3-7,10-11H,8-9,12-13H2,1-2H3,(H,22,24)
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n/an/a 1.30E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53444
PNG
(3,5-dimethyl-4-[4-(4-methylphenoxy)butyl]-1H-pyraz...)
Show SMILES Cc1n[nH]c(C)c1CCCCOc1ccc(C)cc1
Show InChI InChI=1S/C16H22N2O/c1-12-7-9-15(10-8-12)19-11-5-4-6-16-13(2)17-18-14(16)3/h7-10H,4-6,11H2,1-3H3,(H,17,18)
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n/an/a 1.30E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53445
PNG
(2-(4-hydroxy-3-nitro-benzylidene)-3-keto-5-(2-meth...)
Show SMILES CCOC(=O)C1=C(C)N=c2s\c(=C/c3ccc(O)c(c3)[N+]([O-])=O)c(=O)n2C1c1ccccc1OC
Show InChI InChI=1S/C24H21N3O7S/c1-4-34-23(30)20-13(2)25-24-26(21(20)15-7-5-6-8-18(15)33-3)22(29)19(35-24)12-14-9-10-17(28)16(11-14)27(31)32/h5-12,21,28H,4H2,1-3H3/b19-12-
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n/an/a 1.80E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53423
PNG
(1,3,5,6-tetrahydroxy-4-(2-methylbut-3-en-2-yl)-2-(...)
Show SMILES CC(C)=CCc1c(O)c(c2oc3c(O)c(O)ccc3c(=O)c2c1O)C(C)(C)C=C
Show InChI InChI=1S/C23H24O6/c1-6-23(4,5)16-19(27)12(8-7-11(2)3)17(25)15-18(26)13-9-10-14(24)20(28)21(13)29-22(15)16/h6-7,9-10,24-25,27-28H,1,8H2,2-5H3
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n/an/a 1.80E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM65518
PNG
(5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Cl)cc12
Show InChI InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
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n/an/a 2.50E+3n/an/an/an/a7.525



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53469
PNG
(MLS001209351 | N-[1-(4-Bromo-phenyl)-ethylidene]-N...)
Show SMILES CC(N=Nc1cc(nc(C)n1)N1CCCCC1)c1ccc(Br)cc1
Show InChI InChI=1S/C18H22BrN5/c1-13(15-6-8-16(19)9-7-15)22-23-17-12-18(21-14(2)20-17)24-10-4-3-5-11-24/h6-9,12-13H,3-5,10-11H2,1-2H3
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n/an/a 2.60E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53446
PNG
(1-isopropyl-3-trityl-thiourea | 1-propan-2-yl-3-(t...)
Show SMILES CC(C)NC(=S)NC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H24N2S/c1-18(2)24-22(26)25-23(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h3-18H,1-2H3,(H2,24,25,26)
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n/an/a 2.70E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53470
PNG
(2-N,2-N,4-N,4-N-tetraethyl-6-N-(4-nitrophenyl)-1,3...)
Show SMILES CCN(CC)c1nc(Nc2ccc(cc2)[N+]([O-])=O)nc(n1)N(CC)CC
Show InChI InChI=1S/C17H25N7O2/c1-5-22(6-2)16-19-15(20-17(21-16)23(7-3)8-4)18-13-9-11-14(12-10-13)24(25)26/h9-12H,5-8H2,1-4H3,(H,18,19,20,21)
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n/an/a 2.90E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50437695
PNG
(CHEMBL1923233)
Show SMILES CCC[C@H](NC(=O)C(=C\c1cccc(Br)n1)\C#N)c1ccccc1
Show InChI InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Tokyo University of Agriculture

Curated by ChEMBL


Assay Description
Inhibition of UCH-L1 in human Z138 cells after 1 hr by immunoblotting analysis


Bioorg Med Chem Lett 23: 4328-31 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.093
BindingDB Entry DOI: 10.7270/Q2T15528
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53471
PNG
((3-Ethyl-5-hydroxy-5-phenyl-4,5-dihydro-pyrazol-1-...)
Show SMILES CCC1=NN(C(=O)c2ccccc2O)C(O)(C1)c1ccccc1
Show InChI InChI=1S/C18H18N2O3/c1-2-14-12-18(23,13-8-4-3-5-9-13)20(19-14)17(22)15-10-6-7-11-16(15)21/h3-11,21,23H,2,12H2,1H3
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n/an/a 3.40E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53447
PNG
(4,4'-[1,4-phenylenebis(oxy)]diphenol | 4-[4-(4...)
Show SMILES Oc1ccc(Oc2ccc(Oc3ccc(O)cc3)cc2)cc1
Show InChI InChI=1S/C18H14O4/c19-13-1-5-15(6-2-13)21-17-9-11-18(12-10-17)22-16-7-3-14(20)4-8-16/h1-12,19-20H
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n/an/a 3.40E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53424
PNG
((1R,12bR)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a...)
Show SMILES O[C@@H]1CCCN2CCc3c([nH]c4ccccc34)[C@H]12
Show InChI InChI=1S/C15H18N2O/c18-13-6-3-8-17-9-7-11-10-4-1-2-5-12(10)16-14(11)15(13)17/h1-2,4-5,13,15-16,18H,3,6-9H2/t13-,15+/m1/s1
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n/an/a 3.40E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53425
PNG
(2,3,3-trimethyl-4,8,9-tris(oxidanyl)-2H-furo[3,2-b...)
Show SMILES CC1Oc2cc3oc4c(O)c(O)ccc4c(=O)c3c(O)c2C1(C)C
Show InChI InChI=1S/C18H16O6/c1-7-18(2,3)13-11(23-7)6-10-12(16(13)22)14(20)8-4-5-9(19)15(21)17(8)24-10/h4-7,19,21-22H,1-3H3
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n/an/a 3.40E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53426
PNG
(Acylated oxime isatin derivative, 15 | MLS00069763...)
Show SMILES CC1Oc2cc3oc4c(O)c5OC(C)(C)C=Cc5cc4c(=O)c3c(O)c2C1(C)C
Show InChI InChI=1S/C23H22O6/c1-10-23(4,5)16-14(27-10)9-13-15(18(16)25)17(24)12-8-11-6-7-22(2,3)29-20(11)19(26)21(12)28-13/h6-10,25-26H,1-5H3
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n/an/a 4.10E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53472
PNG
(2-(2,6-Dichloro-phenyl)-2,3-dihydro-1H-perimidine ...)
Show SMILES Clc1cccc(Cl)c1C1Nc2cccc3cccc(N1)c23
Show InChI InChI=1S/C17H12Cl2N2/c18-11-6-3-7-12(19)16(11)17-20-13-8-1-4-10-5-2-9-14(21-17)15(10)13/h1-9,17,20-21H
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n/an/a 4.10E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53448
PNG
(1-methyl-1-[4-(4-methylphenyl)-6-phenyl-2-pyrimidi...)
Show SMILES CN(N)c1nc(cc(n1)-c1ccc(C)cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-13-8-10-15(11-9-13)17-12-16(14-6-4-3-5-7-14)20-18(21-17)22(2)19/h3-12H,19H2,1-2H3
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n/an/a 4.10E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens (Human))
BDBM50442907
PNG
(Acetyl Isogambogic Acid | CHEMBL3039433)
Show SMILES CC(=O)Oc1c2C=CC(C)(CCC=C(C)C)Oc2c(CC=C(C)C)c2O[C@@]34C5C[C@@H](C=C3C(=O)c12)C(=O)C4(C\C=C(/C)C(O)=O)OC5(C)C
Show InChI InChI=1S/C40H46O9/c1-21(2)11-10-16-38(9)17-15-27-32(47-38)26(13-12-22(3)4)34-30(33(27)46-24(6)41)31(42)28-19-25-20-29-37(7,8)49-39(35(25)43,40(28,29)48-34)18-14-23(5)36(44)45/h11-12,14-15,17,19,25,29H,10,13,16,18,20H2,1-9H3,(H,44,45)/b23-14+/t25-,29?,38?,39?,40-/m1/s1
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n/an/a 5.40E+3n/an/an/an/a7.525



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53473
PNG
((4,5-dimethylthiazol-2-yl)-(piperonylideneamino)am...)
Show SMILES Cc1nc(N=NCc2ccc3OCOc3c2)sc1C
Show InChI InChI=1S/C13H13N3O2S/c1-8-9(2)19-13(15-8)16-14-6-10-3-4-11-12(5-10)18-7-17-11/h3-5H,6-7H2,1-2H3
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n/an/a 5.80E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53413
PNG
((2S)-2-[[[4-[(4-methylanilino)-oxomethyl]-1H-imida...)
Show SMILES Cc1ccc(NC(=O)c2[nH]cnc2C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C27H39N5O6/c1-17-11-13-18(14-12-17)31-22(33)20-21(30-16-29-20)23(34)32-19(24(35)37-26(2,3)4)10-8-9-15-28-25(36)38-27(5,6)7/h11-14,16,19H,8-10,15H2,1-7H3,(H,28,36)(H,29,30)(H,31,33)(H,32,34)/t19-/m0/s1
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n/an/a 6.00E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53449
PNG
(4-(4-bromophenyl)-2-(o-toluoylamino)-3-thenoic aci...)
Show SMILES Cc1ccccc1C(=O)Nc1scc(c1C(O)=O)-c1ccc(Br)cc1
Show InChI InChI=1S/C19H14BrNO3S/c1-11-4-2-3-5-14(11)17(22)21-18-16(19(23)24)15(10-25-18)12-6-8-13(20)9-7-12/h2-10H,1H3,(H,21,22)(H,23,24)
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n/an/a 6.00E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53474
PNG
(1-butyl-2-hydroxy-4-oxo-N-(phenylmethyl)-3-quinoli...)
Show SMILES CCCCn1c2ccccc2c(O)c(C(=O)NCc2ccccc2)c1=O
Show InChI InChI=1S/C21H22N2O3/c1-2-3-13-23-17-12-8-7-11-16(17)19(24)18(21(23)26)20(25)22-14-15-9-5-4-6-10-15/h4-12,24H,2-3,13-14H2,1H3,(H,22,25)
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n/an/a 6.10E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1)


(Mus musculus (Mouse))
BDBM53475
PNG
((6E)-2-methoxy-6-[[2-(6-morpholin-4-ylpyrimidin-4-...)
Show SMILES COc1cccc(CN=Nc2cc(ncn2)N2CCOCC2)c1O
Show InChI InChI=1S/C16H19N5O3/c1-23-13-4-2-3-12(16(13)22)10-19-20-14-9-15(18-11-17-14)21-5-7-24-8-6-21/h2-4,9,11,22H,5-8,10H2,1H3
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n/an/a 6.10E+3n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)


Article DOI: 10.1016/j.chembiol.2003.08.010
BindingDB Entry DOI: 10.7270/Q20Z71P9
More data for this
Ligand-Target Pair
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