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Found 29 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase isozyme L1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411563
PNG
(CHEMBL540117)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H12N2O4S/c20-14-12-8-13(19(24)25)17(23)21-18(12)26-16(14)15(22)11-6-5-9-3-1-2-4-10(9)7-11/h1-8H,20H2,(H,21,23)(H,24,25)
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740n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411574
PNG
(CHEMBL553923)
Show SMILES Cc1ccc(cc1)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O4S/c1-7-2-4-8(5-3-7)12(19)13-11(17)9-6-10(16(21)22)14(20)18-15(9)23-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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910n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411577
PNG
(CHEMBL536998)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H9ClN2O4S/c16-7-3-1-6(2-4-7)11(19)12-10(17)8-5-9(15(21)22)13(20)18-14(8)23-12/h1-5H,17H2,(H,18,20)(H,21,22)
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1.20E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411568
PNG
(CHEMBL536764)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C19H18N2O4S/c1-19(2,3)10-6-4-9(5-7-10)14(22)15-13(20)11-8-12(18(24)25)16(23)21-17(11)26-15/h4-8H,20H2,1-3H3,(H,21,23)(H,24,25)
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1.40E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411581
PNG
(CHEMBL537224)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H12N2O4S/c20-14-12-8-13(19(24)25)17(23)21-18(12)26-16(14)15(22)11-7-3-5-9-4-1-2-6-10(9)11/h1-8H,20H2,(H,21,23)(H,24,25)
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1.50E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411570
PNG
(CHEMBL537225)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)C1CCCCC1
Show InChI InChI=1S/C15H16N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h6-7H,1-5,16H2,(H,17,19)(H,20,21)
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2.00E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50326016
PNG
(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-6H,16H2,(H,17,19)(H,20,21)
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2.30E+3n/an/an/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50326016
PNG
(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-6H,16H2,(H,17,19)(H,20,21)
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2.80E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411572
PNG
(CHEMBL539345)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H9F3N2O4S/c17-16(18,19)7-3-1-6(2-4-7)11(22)12-10(20)8-5-9(15(24)25)13(23)21-14(8)26-12/h1-5H,20H2,(H,21,23)(H,24,25)
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3.60E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411573
PNG
(CHEMBL557989)
Show SMILES COc1ccccc1C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O5S/c1-23-10-5-3-2-4-7(10)12(19)13-11(17)8-6-9(16(21)22)14(20)18-15(8)24-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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5.30E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411575
PNG
(CHEMBL536763)
Show SMILES Cc1ccccc1C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O4S/c1-7-4-2-3-5-8(7)12(19)13-11(17)9-6-10(16(21)22)14(20)18-15(9)23-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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1.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411579
PNG
(CHEMBL539346)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C15H9ClN2O4S/c16-9-4-2-1-3-6(9)11(19)12-10(17)7-5-8(15(21)22)13(20)18-14(7)23-12/h1-5H,17H2,(H,18,20)(H,21,22)
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1.10E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411567
PNG
(CHEMBL537227)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1cccs1
Show InChI InChI=1S/C13H8N2O4S2/c14-8-5-4-6(13(18)19)11(17)15-12(5)21-10(8)9(16)7-2-1-3-20-7/h1-4H,14H2,(H,15,17)(H,18,19)
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2.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411566
PNG
(CHEMBL536995)
Show SMILES CC(C)(C)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C13H14N2O4S/c1-13(2,3)9(16)8-7(14)5-4-6(12(18)19)10(17)15-11(5)20-8/h4H,14H2,1-3H3,(H,15,17)(H,18,19)
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2.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411571
PNG
(CHEMBL537226)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccncc1
Show InChI InChI=1S/C14H9N3O4S/c15-9-7-5-8(14(20)21)12(19)17-13(7)22-11(9)10(18)6-1-3-16-4-2-6/h1-5H,15H2,(H,17,19)(H,20,21)
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3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411580
PNG
(CHEMBL557988)
Show SMILES COC(=O)c1cc2c(N)c(sc2[nH]c1=O)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C17H14N2O4S/c1-8-3-5-9(6-4-8)13(20)14-12(18)10-7-11(17(22)23-2)15(21)19-16(10)24-14/h3-7H,18H2,1-2H3,(H,19,21)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411562
PNG
(CHEMBL540118)
Show SMILES CC(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C10H8N2O4S/c1-3(13)7-6(11)4-2-5(10(15)16)8(14)12-9(4)17-7/h2H,11H2,1H3,(H,12,14)(H,15,16)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411576
PNG
(CHEMBL556784)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)N1CCCCC1
Show InChI InChI=1S/C14H15N3O4S/c15-9-7-6-8(14(20)21)11(18)16-12(7)22-10(9)13(19)17-4-2-1-3-5-17/h6H,1-5,15H2,(H,16,18)(H,20,21)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411564
PNG
(CHEMBL536997)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C16H9F3N2O4S/c17-16(18,19)9-4-2-1-3-6(9)11(22)12-10(20)7-5-8(15(24)25)13(23)21-14(7)26-12/h1-5H,20H2,(H,21,23)(H,24,25)
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3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411578
PNG
(CHEMBL539094)
Show SMILES COc1ccc(cc1)C(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C16H12N2O5S/c1-23-8-4-2-7(3-5-8)12(19)13-11(17)9-6-10(16(21)22)14(20)18-15(9)24-13/h2-6H,17H2,1H3,(H,18,20)(H,21,22)
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3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50411569
PNG
(CHEMBL538583)
Show SMILES NC(=O)c1sc2[nH]c(=O)c(cc2c1N)C(O)=O
Show InChI InChI=1S/C9H7N3O4S/c10-4-2-1-3(9(15)16)7(14)12-8(2)17-5(4)6(11)13/h1H,10H2,(H2,11,13)(H,12,14)(H,15,16)
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>3.00E+4n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of UCHL1


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50326012
PNG
(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-12-7-11(18)3-5-15(12)22(17(16)24)8-10-2-4-13(19)14(20)6-10/h2-7H,8H2,1H3
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n/an/a 810n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50326013
PNG
(3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-13-7-11(18)2-5-15(13)22(17(16)24)8-10-6-12(19)3-4-14(10)20/h2-7H,8H2,1H3
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n/an/a 880n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50326014
PNG
(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(I)cc12
Show InChI InChI=1S/C17H11Cl2IN2O3/c1-9(23)25-21-16-12-7-11(20)3-5-15(12)22(17(16)24)8-10-2-4-13(18)14(19)6-10/h2-7H,8H2,1H3
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n/an/a 940n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50437695
PNG
(CHEMBL1923233)
Show SMILES CCC[C@H](NC(=O)C(=C\c1cccc(Br)n1)\C#N)c1ccccc1
Show InChI InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Tokyo University of Agriculture

Curated by ChEMBL


Assay Description
Inhibition of UCH-L1 in human Z138 cells after 1 hr by immunoblotting analysis


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50437693
PNG
(VIALININ A)
Show SMILES Oc1ccc(cc1)-c1c(O)c(O)c(-c2ccc(O)cc2)c(OC(=O)Cc2ccccc2)c1OC(=O)Cc1ccccc1
Show InChI InChI=1S/C34H26O8/c35-25-15-11-23(12-16-25)29-31(39)32(40)30(24-13-17-26(36)18-14-24)34(42-28(38)20-22-9-5-2-6-10-22)33(29)41-27(37)19-21-7-3-1-4-8-21/h1-18,35-36,39-40H,19-20H2
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n/an/a 2.23E+4n/an/an/an/an/an/a



Tokyo University of Agriculture

Curated by ChEMBL


Assay Description
Inhibition of human UCH-L1 using Ub-AMC as substrate after 60 mins by fluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM53421
PNG
(4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2...)
Show SMILES C1CCC(CC1)c1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)21-20(22-19)16-11-5-2-6-12-16/h2,5-8,11-15H,1,3-4,9-10H2
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n/an/a 7.50E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM50326015
PNG
(5-(4-butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-t...)
Show SMILES CCCCc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H25N3S/c1-4-5-6-16-7-9-18(10-8-16)20-22-23-21(25)24(20)19-13-11-17(12-14-19)15(2)3/h7-15H,4-6H2,1-3H3,(H,23,25)
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n/an/a 1.26E+5n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1


(Homo sapiens)
BDBM24778
PNG
(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Show SMILES CC1=CC(=O)c2ccccc2C1=O
Show InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
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n/an/a 2.90E+5n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL1 in human H1299 cells


Citation and Details
More data for this
Ligand-Target Pair