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Found 24 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53421
PNG
(4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2...)
Show SMILES C1CCC(CC1)c1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)21-20(22-19)16-11-5-2-6-12-16/h2,5-8,11-15H,1,3-4,9-10H2
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n/an/a 600n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53469
PNG
(MLS001209351 | N-[1-(4-Bromo-phenyl)-ethylidene]-N...)
Show SMILES CC(N=Nc1cc(nc(C)n1)N1CCCCC1)c1ccc(Br)cc1
Show InChI InChI=1S/C18H22BrN5/c1-13(15-6-8-16(19)9-7-15)22-23-17-12-18(21-14(2)20-17)24-10-4-3-5-11-24/h6-9,12-13H,3-5,10-11H2,1-2H3
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n/an/a 1.60E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53467
PNG
(1,3-Dimethyl-5-nitro-6-[2-(4-propoxy-phenyl)-vinyl...)
Show SMILES CCCOc1ccc(\C=C\c2c([N+]([O-])=O)c(=O)n(C)c(=O)n2C)cc1
Show InChI InChI=1S/C17H19N3O5/c1-4-11-25-13-8-5-12(6-9-13)7-10-14-15(20(23)24)16(21)19(3)17(22)18(14)2/h5-10H,4,11H2,1-3H3/b10-7+
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n/an/a 1.70E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53470
PNG
(2-N,2-N,4-N,4-N-tetraethyl-6-N-(4-nitrophenyl)-1,3...)
Show SMILES CCN(CC)c1nc(Nc2ccc(cc2)[N+]([O-])=O)nc(n1)N(CC)CC
Show InChI InChI=1S/C17H25N7O2/c1-5-22(6-2)16-19-15(20-17(21-16)23(7-3)8-4)18-13-9-11-14(12-10-13)24(25)26/h9-12H,5-8H2,1-4H3,(H,18,19,20,21)
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n/an/a 1.80E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53443
PNG
(2-(3-chloro-4-methoxy-N-methylsulfonylanilino)-N-[...)
Show SMILES COc1ccc(cc1Cl)N(CC(=O)NCCSCc1cccc(Cl)c1)S(C)(=O)=O
Show InChI InChI=1S/C19H22Cl2N2O4S2/c1-27-18-7-6-16(11-17(18)21)23(29(2,25)26)12-19(24)22-8-9-28-13-14-4-3-5-15(20)10-14/h3-7,10-11H,8-9,12-13H2,1-2H3,(H,22,24)
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n/an/a 2.20E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53468
PNG
(2-[3-cyano-4-(2-methoxyphenyl)-6-phenyl-pyridin-2-...)
Show SMILES COc1ccccc1-c1cc(nc(SCC(O)=O)c1C#N)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-26-19-10-6-5-9-15(19)16-11-18(14-7-3-2-4-8-14)23-21(17(16)12-22)27-13-20(24)25/h2-11H,13H2,1H3,(H,24,25)
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n/an/a 2.30E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53416
PNG
((2S)-2-[[4-[(4-chlorophenyl)carbamoyl]-1H-imidazol...)
Show SMILES CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)c1[nH]cnc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN4O4/c1-24(2,3)33-23(32)18(13-15-7-5-4-6-8-15)29-22(31)20-19(26-14-27-20)21(30)28-17-11-9-16(25)10-12-17/h4-12,14,18H,13H2,1-3H3,(H,26,27)(H,28,30)(H,29,31)/t18-/m0/s1
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n/an/a 2.40E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53442
PNG
((7-chloranyl-3,5-dimethyl-1-benzofuran-2-yl)-(4-ox...)
Show SMILES Cc1c(oc2c(Cl)cc(C)cc12)C(=O)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C22H22ClNO3/c1-14-12-17-15(2)19(27-20(17)18(23)13-14)21(25)24-10-8-22(26,9-11-24)16-6-4-3-5-7-16/h3-7,12-13,26H,8-11H2,1-2H3
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n/an/a 2.50E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53441
PNG
(MLS001000876 | N-(1H-benzimidazol-2-yl)-3-chlorany...)
Show SMILES Clc1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10ClN3O/c15-10-5-3-4-9(8-10)13(19)18-14-16-11-6-1-2-7-12(11)17-14/h1-8H,(H2,16,17,18,19)
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n/an/a 2.50E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53413
PNG
((2S)-2-[[[4-[(4-methylanilino)-oxomethyl]-1H-imida...)
Show SMILES Cc1ccc(NC(=O)c2[nH]cnc2C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C27H39N5O6/c1-17-11-13-18(14-12-17)31-22(33)20-21(30-16-29-20)23(34)32-19(24(35)37-26(2,3)4)10-8-9-15-28-25(36)38-27(5,6)7/h11-14,16,19H,8-10,15H2,1-7H3,(H,28,36)(H,29,30)(H,31,33)(H,32,34)/t19-/m0/s1
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n/an/a 3.20E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53449
PNG
(4-(4-bromophenyl)-2-(o-toluoylamino)-3-thenoic aci...)
Show SMILES Cc1ccccc1C(=O)Nc1scc(c1C(O)=O)-c1ccc(Br)cc1
Show InChI InChI=1S/C19H14BrNO3S/c1-11-4-2-3-5-14(11)17(22)21-18-16(19(23)24)15(10-25-18)12-6-8-13(20)9-7-12/h2-10H,1H3,(H,21,22)(H,23,24)
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n/an/a 3.20E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53414
PNG
((2S)-4-methyl-2-[[4-(m-tolylcarbamoyl)-1H-imidazol...)
Show SMILES CC(C)C[C@H](NC(=O)c1nc[nH]c1C(=O)Nc1cccc(C)c1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C25H28N4O4/c1-16(2)12-20(25(32)33-14-18-9-5-4-6-10-18)29-24(31)22-21(26-15-27-22)23(30)28-19-11-7-8-17(3)13-19/h4-11,13,15-16,20H,12,14H2,1-3H3,(H,26,27)(H,28,30)(H,29,31)/t20-/m0/s1
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n/an/a 3.30E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53445
PNG
(2-(4-hydroxy-3-nitro-benzylidene)-3-keto-5-(2-meth...)
Show SMILES CCOC(=O)C1=C(C)N=c2s\c(=C/c3ccc(O)c(c3)[N+]([O-])=O)c(=O)n2C1c1ccccc1OC
Show InChI InChI=1S/C24H21N3O7S/c1-4-34-23(30)20-13(2)25-24-26(21(20)15-7-5-6-8-18(15)33-3)22(29)19(35-24)12-14-9-10-17(28)16(11-14)27(31)32/h5-12,21,28H,4H2,1-3H3/b19-12-
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n/an/a 4.00E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53482
PNG
(1-Butyl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-ca...)
Show SMILES CCCCn1c2ccccc2c(O)c(C(=O)NCc2ccccc2Cl)c1=O
Show InChI InChI=1S/C21H21ClN2O3/c1-2-3-12-24-17-11-7-5-9-15(17)19(25)18(21(24)27)20(26)23-13-14-8-4-6-10-16(14)22/h4-11,25H,2-3,12-13H2,1H3,(H,23,26)
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n/an/a 4.10E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53447
PNG
(4,4'-[1,4-phenylenebis(oxy)]diphenol | 4-[4-(4...)
Show SMILES Oc1ccc(Oc2ccc(Oc3ccc(O)cc3)cc2)cc1
Show InChI InChI=1S/C18H14O4/c19-13-1-5-15(6-2-13)21-17-9-11-18(12-10-17)22-16-7-3-14(20)4-8-16/h1-12,19-20H
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n/an/a 4.70E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53422
PNG
(2,4-Dicyclohexyl-6-methoxy-quinazoline | 2,4-dicyc...)
Show SMILES COc1ccc2nc(nc(C3CCCCC3)c2c1)C1CCCCC1
Show InChI InChI=1S/C21H28N2O/c1-24-17-12-13-19-18(14-17)20(15-8-4-2-5-9-15)23-21(22-19)16-10-6-3-7-11-16/h12-16H,2-11H2,1H3
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n/an/a 4.70E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53419
PNG
((2S)-2-[[4-[(4-methoxyphenyl)carbamoyl]-1H-imidazo...)
Show SMILES COc1ccc(NC(=O)c2[nH]cnc2C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C22H30N4O5/c1-13(2)11-16(21(29)31-22(3,4)5)26-20(28)18-17(23-12-24-18)19(27)25-14-7-9-15(30-6)10-8-14/h7-10,12-13,16H,11H2,1-6H3,(H,23,24)(H,25,27)(H,26,28)/t16-/m0/s1
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n/an/a 4.80E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53415
PNG
((2S)-2-[[4-(m-tolylcarbamoyl)-1H-imidazole-5-carbo...)
Show SMILES Cc1cccc(NC(=O)c2nc[nH]c2C(=O)N[C@@H](Cc2ccccc2)C(=O)OC(C)(C)C)c1
Show InChI InChI=1S/C25H28N4O4/c1-16-9-8-12-18(13-16)28-22(30)20-21(27-15-26-20)23(31)29-19(24(32)33-25(2,3)4)14-17-10-6-5-7-11-17/h5-13,15,19H,14H2,1-4H3,(H,26,27)(H,28,30)(H,29,31)/t19-/m0/s1
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n/an/a 5.20E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53454
PNG
((2E)-2-[(2Z)-2-(3-methoxy-4-oxidanylidene-cyclohex...)
Show SMILES COc1ccc(cc1)-n1c(C=Cc2ccc(O)c(OC)c2)nc2ccccc2c1=O
Show InChI InChI=1S/C24H20N2O4/c1-29-18-11-9-17(10-12-18)26-23(25-20-6-4-3-5-19(20)24(26)28)14-8-16-7-13-21(27)22(15-16)30-2/h3-15,27H,1-2H3
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n/an/a 5.20E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53418
PNG
((2S)-2-[[[4-[(4-chloroanilino)-oxomethyl]-1H-imida...)
Show SMILES CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)c1nc[nH]c1C(=O)Nc1ccc(Cl)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H36ClN5O6/c1-25(2,3)37-23(35)18(9-7-8-14-28-24(36)38-26(4,5)6)32-22(34)20-19(29-15-30-20)21(33)31-17-12-10-16(27)11-13-17/h10-13,15,18H,7-9,14H2,1-6H3,(H,28,36)(H,29,30)(H,31,33)(H,32,34)/t18-/m0/s1
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n/an/a 5.80E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM24778
PNG
(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Show SMILES CC1=CC(=O)c2ccccc2C1=O
Show InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
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n/an/a 7.10E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53471
PNG
((3-Ethyl-5-hydroxy-5-phenyl-4,5-dihydro-pyrazol-1-...)
Show SMILES CCC1=NN(C(=O)c2ccccc2O)C(O)(C1)c1ccccc1
Show InChI InChI=1S/C18H18N2O3/c1-2-14-12-18(23,13-8-4-3-5-9-13)20(19-14)17(22)15-10-6-7-11-16(15)21/h3-11,21,23H,2,12H2,1H3
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UniChem

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n/an/a 7.20E+4n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53448
PNG
(1-methyl-1-[4-(4-methylphenyl)-6-phenyl-2-pyrimidi...)
Show SMILES CN(N)c1nc(cc(n1)-c1ccc(C)cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-13-8-10-15(11-9-13)17-12-16(14-6-4-3-5-7-14)20-18(21-17)22(2)19/h3-12H,19H2,1-2H3
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PubMed
n/an/a 1.13E+5n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3)


(Mus musculus (Mouse))
BDBM53420
PNG
((4S,5S,6R)-1-benzyl-2-keto-6-methyl-4-phenethyl-he...)
Show SMILES COC(=O)[C@H]1[C@H](CCc2ccccc2)NC(=O)N(Cc2ccccc2)[C@@H]1C
Show InChI InChI=1S/C22H26N2O3/c1-16-20(21(25)27-2)19(14-13-17-9-5-3-6-10-17)23-22(26)24(16)15-18-11-7-4-8-12-18/h3-12,16,19-20H,13-15H2,1-2H3,(H,23,26)/t16-,19+,20-/m1/s1
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PubMed
n/an/a 1.16E+5n/an/an/an/a7.625



Brigham and Women's Hospital



Assay Description
Inhibition activity and selectivity for UCH-L1 and UCH-L3.


Chem Biol 10: 837-46 (2003)

More data for this
Ligand-Target Pair