BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase isozyme L5'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM50072959 (CHEMBL3410535) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Trieste Curated by ChEMBL					Assay Description Inhibition of GST-tagged UCHL5 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 mins b...				J Med Chem 58: 1691-704 (2015) Article DOI: 10.1021/jm501336h BindingDB Entry DOI: 10.7270/Q2J67JM0
Universit£ degli Studi di Trieste Curated by ChEMBL					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM65518 (5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM50242207 (CHEMBL455364 \| Mangiferin) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM50442907 (Acetyl Isogambogic Acid \| CHEMBL3039433) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.65E+4	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM50072960 (CHEMBL3410537) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Trieste Curated by ChEMBL					Assay Description Inhibition of GST-tagged UCHL5 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 mins b...				J Med Chem 58: 1691-704 (2015) Article DOI: 10.1021/jm501336h BindingDB Entry DOI: 10.7270/Q2J67JM0
Universit£ degli Studi di Trieste Curated by ChEMBL					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM205457 ((2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.66E+4	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM200235 (Rifampicin \| cid_5381226) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.28E+4	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM65524 ((-)-Aricine \| Heterophylline (VAN) \| Quinovatine) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.14E+5	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Homo sapiens (Human))	BDBM50069762 (CHEMBL3182437 \| ML323 \| US9802904, 87) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.14E+5	n/a	n/a	n/a	n/a	7.5	25
University of Delaware					Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...				ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD
University of Delaware					More data for this Ligand-Target Pair