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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Uncharacterized protein' AND taxid = 9615   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor subtype 3


(Canis lupus familiaris)
BDBM50091414
PNG
(CHEMBL3582336)
Show SMILES CCn1cc(cn1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cn1)c1nn(C)c(=O)o1
Show InChI InChI=1/C27H24FN9O2/c1-3-37-14-15(11-31-37)27(25-35-36(2)26(38)39-25)23-18(17-6-4-5-7-19(17)32-23)10-21(34-27)24-30-13-22(33-24)20-9-8-16(28)12-29-20/h4-9,11-14,21,32,34H,3,10H2,1-2H3,(H,30,33)/t21-,27-/s2
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UniChem

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PubMed
n/an/a 2.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dog SSTR3


Citation and Details
More data for this
Ligand-Target Pair
Uncharacterized protein


(Canis familiaris)
BDBM50360601
PNG
(CHEMBL1933349)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)/t19-/m0/s1
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PDB
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Article
PubMed
n/an/a 105n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at dog GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Uncharacterized protein


(Canis familiaris)
BDBM50334481
PNG
(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Show SMILES OC(=O)CCNC(=O)c1ccc(Cn2nc(cc2-c2ccc(OC(F)(F)F)cc2)-c2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C27H20Cl2F3N3O4/c28-20-11-19(12-21(29)13-20)23-14-24(17-5-7-22(8-6-17)39-27(30,31)32)35(34-23)15-16-1-3-18(4-2-16)26(38)33-10-9-25(36)37/h1-8,11-14H,9-10,15H2,(H,33,38)(H,36,37)
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n/an/a 400n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at dog GCGR assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Uncharacterized protein


(Canis lupus familiaris)
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/s2
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n/an/an/an/a 6.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at canine GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)

More data for this
Ligand-Target Pair