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Found 353 hits Enz. Inhib. hit(s) with Target = 'Uric Acid Transporter 1 (URAT1)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM26658
PNG
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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Article
PubMed
5.74E+3n/an/an/an/an/an/an/an/a



The Chinese University of Hong Kong

Curated by ChEMBL


Assay Description
Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165874
PNG
(US9067922, 213 | US9067922, 225)
Show SMILES Fc1ccc(Oc2cc(F)c(cc2Cl)S(=O)(=O)Nc2ncccn2)cc1C#N
Show InChI InChI=1S/C17H9ClF2N4O3S/c18-12-7-16(28(25,26)24-17-22-4-1-5-23-17)14(20)8-15(12)27-11-2-3-13(19)10(6-11)9-21/h1-8H,(H,22,23,24)
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US Patent
n/an/a 0n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165905
PNG
(US9067922, 247)
Show SMILES OCc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c20-17-8-15(3-1-12(17)11-25)28-18-5-4-16(7-13(18)9-22)29(26,27)24-19-6-2-14(21)10-23-19/h1-8,10,25H,11H2,(H,23,24)
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n/an/a 1n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165898
PNG
(US9067922, 239)
Show SMILES OCc1ncc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C17H12ClF2N3O4S/c18-13-5-12(8-21-15(13)9-24)27-11-2-3-16(14(20)6-11)28(25,26)23-17-4-1-10(19)7-22-17/h1-8,24H,9H2,(H,22,23)
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n/an/a 2n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165900
PNG
(US9067922, 241)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)c(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9Cl2FN4O3S/c20-16-6-13(7-17(21)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(22)10-25-19/h1-7,10H,(H,25,26)
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n/an/a 3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165745
PNG
(US9067922, 235 | US9067922, 79)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)
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n/an/a 7n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165896
PNG
(US9067922, 237)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H9ClF2N4O3S/c20-16-6-13(7-17(22)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(21)10-25-19/h1-7,10H,(H,25,26)
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n/an/a 8n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152051
PNG
(US8987473, 137)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3n[nH]c(=S)o3)ccc12
Show InChI InChI=1S/C18H14Cl2N4OS/c1-10-12-6-5-11(8-17-21-22-18(26)25-17)7-16(12)24(23-10)9-13-14(19)3-2-4-15(13)20/h2-7H,8-9H2,1H3,(H,22,26)
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n/an/a 10n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152041
PNG
(US8987473, 122)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C18H16Cl2N2O2/c1-11-13-7-5-12(6-8-18(23)24)9-17(13)22(21-11)10-14-15(19)3-2-4-16(14)20/h2-5,7,9H,6,8,10H2,1H3,(H,23,24)
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n/an/a 10n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165893
PNG
(US9067922, 232)
Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10Cl2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165667
PNG
(US9067922, 1)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-8-15(3-1-12(17)9-22)28-18-5-4-16(7-13(18)10-23)29(26,27)25-19-6-2-14(21)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165745
PNG
(US9067922, 235 | US9067922, 79)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152048
PNG
(US8987473, 134)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3nnn[nH]3)ccc12
Show InChI InChI=1S/C17H14Cl2N6/c1-10-12-6-5-11(8-17-20-23-24-21-17)7-16(12)25(22-10)9-13-14(18)3-2-4-15(13)19/h2-7H,8-9H2,1H3,(H,20,21,23,24)
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n/an/a 13n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165769
PNG
(US9067922, 104)
Show SMILES Fc1ccnc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)c1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-9-15(2-1-12(17)10-22)28-18-4-3-16(7-13(18)11-23)29(26,27)25-19-8-14(21)5-6-24-19/h1-9H,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152017
PNG
(US8987473, 82)
Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H15Cl2NO2/c1-11-9-21(10-14-15(19)3-2-4-16(14)20)17-7-12(8-18(22)23)5-6-13(11)17/h2-7,9H,8,10H2,1H3,(H,22,23)
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n/an/a 15n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152079
PNG
(US8987473, 183)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(ccc12)C(F)(F)C(O)=O
Show InChI InChI=1S/C17H12Cl2F2N2O2/c1-9-11-6-5-10(17(20,21)16(24)25)7-15(11)23(22-9)8-12-13(18)3-2-4-14(12)19/h2-7H,8H2,1H3,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152047
PNG
(US8987473, 133)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCCC(O)=O)ccc12
Show InChI InChI=1S/C19H18Cl2N2O2/c1-12-14-9-8-13(4-2-7-19(24)25)10-18(14)23(22-12)11-15-16(20)5-3-6-17(15)21/h3,5-6,8-10H,2,4,7,11H2,1H3,(H,24,25)
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n/an/a 16n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152080
PNG
(US8987473, 185)
Show SMILES Cc1nn(Cc2c(Cl)cccc2C2CC2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C21H21ClN2O2/c1-13-16-9-5-14(6-10-21(25)26)11-20(16)24(23-13)12-18-17(15-7-8-15)3-2-4-19(18)22/h2-5,9,11,15H,6-8,10,12H2,1H3,(H,25,26)
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n/an/a 17n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152026
PNG
(US8987473, 97)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C17H14Cl2N2O2/c1-10-12-6-5-11(8-17(22)23)7-16(12)21(20-10)9-13-14(18)3-2-4-15(13)19/h2-7H,8-9H2,1H3,(H,22,23)
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n/an/a 18n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152016
PNG
(US8987473, 80)
Show SMILES Cc1cccc(C)c1CN1CC(C)(C)c2ccc(CC(O)=O)cc12
Show InChI InChI=1S/C21H25NO2/c1-14-6-5-7-15(2)17(14)12-22-13-21(3,4)18-9-8-16(10-19(18)22)11-20(23)24/h5-10H,11-13H2,1-4H3,(H,23,24)
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n/an/a 18n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165744
PNG
(US9067922, 78)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-15-8-13(2-4-16(15)21)27-17-5-3-14(7-11(17)9-22)28(25,26)24-18-6-1-12(20)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 19n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM60431
PNG
(US9067922, 249)
Show SMILES Cc1cc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N
Show InChI InChI=1S/C20H15F2N3O3S/c1-12-7-16(8-13(2)17(12)10-23)28-15-4-5-19(18(22)9-15)29(26,27)25-20-6-3-14(21)11-24-20/h3-9,11H,1-2H3,(H,24,25)
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n/an/a 21n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152011
PNG
(US8987473, 64)
Show SMILES Cc1cn(Cc2c(C)cccc2C)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C20H21NO2/c1-13-5-4-6-14(2)18(13)12-21-11-15(3)17-8-7-16(9-19(17)21)10-20(22)23/h4-9,11H,10,12H2,1-3H3,(H,22,23)
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n/an/a 22n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152023
PNG
(US8987473, 89)
Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C19H17Cl2NO2/c1-12-10-22(11-15-16(20)3-2-4-17(15)21)18-9-13(5-7-14(12)18)6-8-19(23)24/h2-5,7,9-10H,6,8,11H2,1H3,(H,23,24)
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n/an/a 23n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152049
PNG
(US8987473, 135)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCc3nnn[nH]3)ccc12
Show InChI InChI=1S/C18H16Cl2N6/c1-11-13-7-5-12(6-8-18-21-24-25-22-18)9-17(13)26(23-11)10-14-15(19)3-2-4-16(14)20/h2-5,7,9H,6,8,10H2,1H3,(H,21,22,24,25)
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n/an/a 23n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165780
PNG
(US9067922, 115)
Show SMILES COc1cccc(C)c1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C20H16FN3O4S/c1-13-4-3-5-18(27-2)20(13)28-17-8-7-16(10-14(17)11-22)29(25,26)24-19-9-6-15(21)12-23-19/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 24n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152015
PNG
(US8987473, 78)
Show SMILES CC1CN(Cc2c(C)cccc2C)c2cc(CC(O)=O)ccc12
Show InChI InChI=1/C20H23NO2/c1-13-5-4-6-14(2)18(13)12-21-11-15(3)17-8-7-16(9-19(17)21)10-20(22)23/h4-9,15H,10-12H2,1-3H3,(H,22,23)
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n/an/a 24n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152054
PNG
(US8987473, 140)
Show SMILES CCc1nn(Cc2c(Cl)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H16Cl2N2O2/c1-2-16-12-7-6-11(9-18(23)24)8-17(12)22(21-16)10-13-14(19)4-3-5-15(13)20/h3-8H,2,9-10H2,1H3,(H,23,24)
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n/an/a 24n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165736
PNG
(US9067922, 70)
Show SMILES COc1ncc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C18H12ClFN4O4S/c1-27-18-15(19)7-13(10-23-18)28-16-4-3-14(6-11(16)8-21)29(25,26)24-17-5-2-12(20)9-22-17/h2-7,9-10H,1H3,(H,22,24)
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n/an/a 25n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152058
PNG
(US8987473, 145)
Show SMILES CCc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C19H18Cl2N2O2/c1-2-17-13-8-6-12(7-9-19(24)25)10-18(13)23(22-17)11-14-15(20)4-3-5-16(14)21/h3-6,8,10H,2,7,9,11H2,1H3,(H,24,25)
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n/an/a 26n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM50158460
PNG
((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...)
Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Show InChI InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
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n/an/a 26n/an/an/an/an/an/a



University of Colorado Anschutz Medical Campus

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...


Citation and Details
More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165728
PNG
(US9067922, 62)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)cc(c3)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-14-5-12(9-22)6-16(8-14)28-18-3-2-17(7-13(18)10-23)29(26,27)25-19-4-1-15(21)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 27n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165737
PNG
(US9067922, 71)
Show SMILES COc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-18-9-14(3-5-16(18)20)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 27n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152020
PNG
(US8987473, 86)
Show SMILES Cc1cn(Cc2c(F)cccc2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H15ClFNO2/c1-11-9-21(10-14-15(19)3-2-4-16(14)20)17-7-12(8-18(22)23)5-6-13(11)17/h2-7,9H,8,10H2,1H3,(H,22,23)
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n/an/a 28n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165764
PNG
(US9067922, 99)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(F)c3)cc2F)nc1
Show InChI InChI=1S/C18H10F3N3O3S/c19-12-2-6-18(23-10-12)24-28(25,26)17-5-4-14(8-16(17)21)27-13-3-1-11(9-22)15(20)7-13/h1-8,10H,(H,23,24)
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n/an/a 29n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152013
PNG
(US8987473, 68)
Show SMILES Cc1cccc(C)c1Cn1cc(Cl)c2ccc(CC(O)=O)cc12
Show InChI InChI=1S/C19H18ClNO2/c1-12-4-3-5-13(2)16(12)10-21-11-17(20)15-7-6-14(8-18(15)21)9-19(22)23/h3-8,11H,9-10H2,1-2H3,(H,22,23)
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n/an/a 30n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152042
PNG
(US8987473, 124)
Show SMILES Cc1nn(Cc2csc3ccc(Cl)cc23)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C20H17ClN2O2S/c1-12-16-5-2-13(3-7-20(24)25)8-18(16)23(22-12)10-14-11-26-19-6-4-15(21)9-17(14)19/h2,4-6,8-9,11H,3,7,10H2,1H3,(H,24,25)
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n/an/a 31n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152050
PNG
(US8987473, 136)
Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3n[nH]c(=O)o3)ccc12
Show InChI InChI=1S/C18H14Cl2N4O2/c1-10-12-6-5-11(8-17-21-22-18(25)26-17)7-16(12)24(23-10)9-13-14(19)3-2-4-15(13)20/h2-7H,8-9H2,1H3,(H,22,25)
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n/an/a 34n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152056
PNG
(US8987473, 143)
Show SMILES CCc1nn(Cc2c(C)cccc2C)c2cc(ccc12)C(O)=O
Show InChI InChI=1S/C19H20N2O2/c1-4-17-15-9-8-14(19(22)23)10-18(15)21(20-17)11-16-12(2)6-5-7-13(16)3/h5-10H,4,11H2,1-3H3,(H,22,23)
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n/an/a 35n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM50158460
PNG
((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...)
Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Show InChI InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
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n/an/a 35n/an/an/an/an/an/a



University of Colorado Anschutz Medical Campus

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in human MDCK cells


Citation and Details
More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165864
PNG
(US9067922, 203)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(c3)C3CC3)c(c2)C#N)nc1
Show InChI InChI=1S/C22H15FN4O3S/c23-17-4-8-22(26-13-17)27-31(28,29)19-6-7-21(16(9-19)12-25)30-18-5-3-15(11-24)20(10-18)14-1-2-14/h3-10,13-14H,1-2H2,(H,26,27)
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n/an/a 37n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165863
PNG
(US9067922, 202)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cncc(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C17H10ClFN4O3S/c18-12-6-14(10-21-8-12)26-16-3-2-15(5-11(16)7-20)27(24,25)23-17-4-1-13(19)9-22-17/h1-6,8-10H,(H,22,23)
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n/an/a 37n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165797
PNG
(US9067922, 132)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1F
Show InChI InChI=1S/C19H13F2N3O4S/c1-27-18-5-3-14(9-16(18)21)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(20)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 38n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165727
PNG
(US9067922, 61)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1C#N
Show InChI InChI=1S/C20H13FN4O3S/c1-13-8-17(4-2-14(13)10-22)28-19-6-5-18(9-15(19)11-23)29(26,27)25-20-7-3-16(21)12-24-20/h2-9,12H,1H3,(H,24,25)
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n/an/a 39n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165809
PNG
(US9067922, 144)
Show SMILES COc1cc(F)c(F)cc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H12F3N3O4S/c1-28-17-7-14(21)15(22)8-18(17)29-16-4-3-13(6-11(16)9-23)30(26,27)25-19-5-2-12(20)10-24-19/h2-8,10H,1H3,(H,24,25)
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n/an/a 40n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152027
PNG
(US8987473, 99)
Show SMILES Cc1nn(Cc2cccc(Cl)c2Cl)c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C17H14Cl2N2O2/c1-10-13-6-5-11(8-16(22)23)7-15(13)21(20-10)9-12-3-2-4-14(18)17(12)19/h2-7H,8-9H2,1H3,(H,22,23)
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n/an/a 41n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152040
PNG
(US8987473, 121)
Show SMILES Cc1nn(Cc2c(C)cccc2C)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C20H22N2O2/c1-13-5-4-6-14(2)18(13)12-22-19-11-16(8-10-20(23)24)7-9-17(19)15(3)21-22/h4-7,9,11H,8,10,12H2,1-3H3,(H,23,24)
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n/an/a 41n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM152057
PNG
(US8987473, 144)
Show SMILES CCc1nn(Cc2c(Cl)cccc2Cl)c2cc(ccc12)C(O)=O
Show InChI InChI=1S/C17H14Cl2N2O2/c1-2-15-11-7-6-10(17(22)23)8-16(11)21(20-15)9-12-13(18)4-3-5-14(12)19/h3-8H,2,9H2,1H3,(H,22,23)
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n/an/a 42n/an/an/an/an/an/a



Sato Pharmaceutical Co., Ltd.

US Patent


Assay Description
It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result...


US Patent US8987473 (2015)

More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM50342286
PNG
((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-methoxyben...)
Show SMILES CCc1oc2ccc(OC)cc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Show InChI InChI=1S/C18H14Br2O4/c1-3-14-16(11-8-10(23-2)4-5-15(11)24-14)17(21)9-6-12(19)18(22)13(20)7-9/h4-8,22H,3H2,1-2H3
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Article
PubMed
n/an/a 42n/an/an/an/an/an/a



University of Colorado Anschutz Medical Campus

Curated by ChEMBL


Assay Description
Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...


Citation and Details
More data for this
Ligand-Target Pair
Uric Acid Transporter 1 (URAT1)


(Homo sapiens (Human))
BDBM165743
PNG
(US9067922, 77)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(F)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10F3N3O3S/c19-12-1-6-18(23-10-12)24-28(25,26)14-3-5-17(11(7-14)9-22)27-13-2-4-15(20)16(21)8-13/h1-8,10H,(H,23,24)
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n/an/a 43n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...


US Patent US9067922 (2015)

More data for this
Ligand-Target Pair
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