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Found 79 hits Enz. Inhib. hit(s) with Target = 'VEGFR-2 (KDR)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12340
PNG
(3-{[(E)-({4-amino-6-[(4-fluoro-2-methyl-1H-indol-5...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCCCO)ccc2[nH]1
Show InChI InChI=1S/C17H18FN5O3/c1-10-7-11-13(23-10)3-4-14(15(11)18)26-17-12(16(19)20-9-21-17)8-22-25-6-2-5-24/h3-4,7-9,23-24H,2,5-6H2,1H3,(H2,19,20,21)/b22-8+
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PubMed
n/an/a 11n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12336
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[...)
Show SMILES COCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C17H18FN5O3/c1-10-7-11-13(23-10)3-4-14(15(11)18)26-17-12(16(19)20-9-21-17)8-22-25-6-5-24-2/h3-4,7-9,23H,5-6H2,1-2H3,(H2,19,20,21)/b22-8+
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PubMed
n/an/a 24n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6878
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F
Show InChI InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
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PubMed
n/an/a 32n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12338
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-(...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3CN=O)ccc2[nH]1
Show InChI InChI=1S/C14H12FN5O2/c1-7-4-8-10(20-7)2-3-11(12(8)15)22-14-9(5-19-21)13(16)17-6-18-14/h2-4,6,20H,5H2,1H3,(H2,16,17,18)
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PubMed
n/an/a 33n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12334
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-{...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCCN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C20H23FN6O3/c1-13-10-14-16(26-13)2-3-17(18(14)21)30-20-15(19(22)23-12-24-20)11-25-29-9-6-27-4-7-28-8-5-27/h2-3,10-12,26H,4-9H2,1H3,(H2,22,23,24)/b25-11+
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n/an/a 39n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12324
PNG
(5-[(1E)-(ethoxyimino)methyl]-6-[(4-fluoro-2-methyl...)
Show SMILES CCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C16H16FN5O2/c1-3-23-21-7-11-15(18)19-8-20-16(11)24-13-5-4-12-10(14(13)17)6-9(2)22-12/h4-8,22H,3H2,1-2H3,(H2,18,19,20)/b21-7+
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n/an/a 42n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12325
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-(...)
Show SMILES CCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C17H18FN5O2/c1-3-6-24-22-8-12-16(19)20-9-21-17(12)25-14-5-4-13-11(15(14)18)7-10(2)23-13/h4-5,7-9,23H,3,6H2,1-2H3,(H2,19,20,21)/b22-8+
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n/an/a 43n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12339
PNG
(2-{[(E)-({4-amino-6-[(4-fluoro-2-methyl-1H-indol-5...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCCO)ccc2[nH]1
Show InChI InChI=1S/C16H16FN5O3/c1-9-6-10-12(22-9)2-3-13(14(10)17)25-16-11(7-21-24-5-4-23)15(18)19-8-20-16/h2-3,6-8,22-23H,4-5H2,1H3,(H2,18,19,20)/b21-7+
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n/an/a 44n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6870
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f ...)
Show SMILES Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
Show InChI InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19)
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n/an/a 51n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12327
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCC=C)ccc2[nH]1
Show InChI InChI=1S/C17H16FN5O2/c1-3-6-24-22-8-12-16(19)20-9-21-17(12)25-14-5-4-13-11(15(14)18)7-10(2)23-13/h3-5,7-9,23H,1,6H2,2H3,(H2,19,20,21)/b22-8+
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n/an/a 52n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12328
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCC#C)ccc2[nH]1
Show InChI InChI=1S/C17H14FN5O2/c1-3-6-24-22-8-12-16(19)20-9-21-17(12)25-14-5-4-13-11(15(14)18)7-10(2)23-13/h1,4-5,7-9,23H,6H2,2H3,(H2,19,20,21)/b22-8+
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n/an/a 52n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12337
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[...)
Show SMILES COCCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C18H20FN5O3/c1-11-8-12-14(24-11)4-5-15(16(12)19)27-18-13(17(20)21-10-22-18)9-23-26-7-3-6-25-2/h4-5,8-10,24H,3,6-7H2,1-2H3,(H2,20,21,22)/b23-9+
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n/an/a 62n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6417
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H20ClN5O/c20-15-4-3-5-16(9-15)24-19-13-22-12-18(25-19)14-8-17(11-21-10-14)23-6-1-2-7-26/h3-5,8-13,23,26H,1-2,6-7H2,(H,24,25)
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n/an/a 63n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6421
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cncn3)c2)c1
Show InChI InChI=1S/C20H19ClN8/c21-16-3-1-4-17(8-16)27-20-12-23-11-19(28-20)15-7-18(10-22-9-15)25-5-2-6-29-14-24-13-26-29/h1,3-4,7-14,25H,2,5-6H2,(H,27,28)
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n/an/a 67n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6419
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-6-1-7-20(11-19)29-23-16-27-15-22(30-23)18-10-21(14-26-13-18)28-9-3-5-17-4-2-8-25-12-17/h1-2,4,6-8,10-16,28H,3,5,9H2,(H,29,30)
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n/an/a 76n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6391
PNG
((3-Chloro-phenyl)-{6-[5-(3-pyridin-4-yl-propylamin...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)c1
Show InChI InChI=1S/C23H21ClN6/c24-19-4-1-5-20(12-19)29-23-16-27-15-22(30-23)18-11-21(14-26-13-18)28-8-2-3-17-6-9-25-10-7-17/h1,4-7,9-16,28H,2-3,8H2,(H,29,30)
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n/an/a 76n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 84n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 1886-900 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6416
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 84n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12331
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-{...)
Show SMILES CNCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C17H19FN6O2/c1-10-7-11-13(24-10)3-4-14(15(11)18)26-17-12(16(19)21-9-22-17)8-23-25-6-5-20-2/h3-4,7-9,20,24H,5-6H2,1-2H3,(H2,19,21,22)/b23-8+
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n/an/a 93n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6420
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCn3cccn3)c2)c1
Show InChI InChI=1S/C21H20ClN7/c22-17-4-1-5-18(11-17)27-21-15-24-14-20(28-21)16-10-19(13-23-12-16)25-6-2-8-29-9-3-7-26-29/h1,3-5,7,9-15,25H,2,6,8H2,(H,27,28)
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n/an/a 94n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12335
PNG
(5-[(1E)-{[3-(dimethylamino)propoxy]imino}methyl]-6...)
Show SMILES CN(C)CCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C19H23FN6O2/c1-12-9-13-15(25-12)5-6-16(17(13)20)28-19-14(18(21)22-11-23-19)10-24-27-8-4-7-26(2)3/h5-6,9-11,25H,4,7-8H2,1-3H3,(H2,21,22,23)/b24-10+
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n/an/a 101n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6418
PNG
(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)
Show SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H21ClN6/c1-26(2)7-6-23-17-8-14(10-21-11-17)18-12-22-13-19(25-18)24-16-5-3-4-15(20)9-16/h3-5,8-13,23H,6-7H2,1-2H3,(H,24,25)
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n/an/a 105n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12326
PNG
(5-[(1E)-(butoxyimino)methyl]-6-[(4-fluoro-2-methyl...)
Show SMILES CCCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C18H20FN5O2/c1-3-4-7-25-23-9-13-17(20)21-10-22-18(13)26-15-6-5-14-12(16(15)19)8-11(2)24-14/h5-6,8-10,24H,3-4,7H2,1-2H3,(H2,20,21,22)/b23-9+
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n/an/a 115n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12322
PNG
(6-[(4-fluoro-1H-indol-5-yl)oxy]-5-[(1E)-(methoxyim...)
Show SMILES CO\N=C\c1c(N)ncnc1Oc1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C14H12FN5O2/c1-21-20-6-9-13(16)18-7-19-14(9)22-11-3-2-10-8(12(11)15)4-5-17-10/h2-7,17H,1H3,(H2,16,18,19)/b20-6+
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n/an/a 117n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12323
PNG
(6-[(6-fluoro-1H-indol-5-yl)oxy]-5-[(1E)-(methoxyim...)
Show SMILES CO\N=C\c1c(N)ncnc1Oc1cc2cc[nH]c2cc1F
Show InChI InChI=1S/C14H12FN5O2/c1-21-20-6-9-13(16)18-7-19-14(9)22-12-4-8-2-3-17-11(8)5-10(12)15/h2-7,17H,1H3,(H2,16,18,19)/b20-6+
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n/an/a 121n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6408
PNG
((3-Chlorophenyl)-(6-{5-[3-(4-methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CCCNc2cncc(c2)-c2cncc(Nc3cccc(Cl)c3)n2)CC1
Show InChI InChI=1S/C23H28ClN7/c1-30-8-10-31(11-9-30)7-3-6-27-21-12-18(14-25-15-21)22-16-26-17-23(29-22)28-20-5-2-4-19(24)13-20/h2,4-5,12-17,27H,3,6-11H2,1H3,(H,28,29)
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n/an/a 123n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6866
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 130n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6398
PNG
(N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]...)
Show SMILES CN(C)CCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C20H23ClN6/c1-27(2)8-4-7-24-18-9-15(11-22-12-18)19-13-23-14-20(26-19)25-17-6-3-5-16(21)10-17/h3,5-6,9-14,24H,4,7-8H2,1-2H3,(H,25,26)
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n/an/a 135n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12320
PNG
(5-[(1E)-(methoxyimino)methyl]-6-[(2-methyl-1H-indo...)
Show SMILES CO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1
Show InChI InChI=1S/C15H15N5O2/c1-9-5-10-6-11(3-4-13(10)20-9)22-15-12(7-19-21-2)14(16)17-8-18-15/h3-8,20H,1-2H3,(H2,16,17,18)/b19-7+
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n/an/a 146n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6388
PNG
(3-[(5-{6-[(3-fluorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cncc(c1)-c1cncc(Nc2cccc(F)c2)n1
Show InChI InChI=1S/C18H18FN5O/c19-14-3-1-4-15(8-14)23-18-12-21-11-17(24-18)13-7-16(10-20-9-13)22-5-2-6-25/h1,3-4,7-12,22,25H,2,5-6H2,(H,23,24)
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n/an/a 168n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6409
PNG
(N-(3-chlorophenyl)-6-(5-{[3-(morpholin-4-yl)propyl...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCOCC3)c2)c1
Show InChI InChI=1S/C22H25ClN6O/c23-18-3-1-4-19(12-18)27-22-16-25-15-21(28-22)17-11-20(14-24-13-17)26-5-2-6-29-7-9-30-10-8-29/h1,3-4,11-16,26H,2,5-10H2,(H,27,28)
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n/an/a 180n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12332
PNG
(5-[(1E)-{[2-(dimethylamino)ethoxy]imino}methyl]-6-...)
Show SMILES CN(C)CCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F
Show InChI InChI=1S/C18H21FN6O2/c1-11-8-12-14(24-11)4-5-15(16(12)19)27-18-13(17(20)21-10-22-18)9-23-26-7-6-25(2)3/h4-5,8-10,24H,6-7H2,1-3H3,(H2,20,21,22)/b23-9+
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n/an/a 187n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6393
PNG
((3,4-Dichloro-phenyl)-{6-[5-(3-pyridin-4-yl-propyl...)
Show SMILES Clc1ccc(Nc2cncc(n2)-c2cncc(NCCCc3ccncc3)c2)cc1Cl
Show InChI InChI=1S/C23H20Cl2N6/c24-20-4-3-18(11-21(20)25)30-23-15-28-14-22(31-23)17-10-19(13-27-12-17)29-7-1-2-16-5-8-26-9-6-16/h3-6,8-15,29H,1-2,7H2,(H,30,31)
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n/an/a 189n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12330
PNG
(5-[(1E)-[(benzyloxy)imino]methyl]-6-[(4-fluoro-2-m...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C21H18FN5O2/c1-13-9-15-17(27-13)7-8-18(19(15)22)29-21-16(20(23)24-12-25-21)10-26-28-11-14-5-3-2-4-6-14/h2-10,12,27H,11H2,1H3,(H2,23,24,25)/b26-10+
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n/an/a 201n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12333
PNG
(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-{...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCCN3CCCC3)ccc2[nH]1
Show InChI InChI=1S/C20H23FN6O2/c1-13-10-14-16(26-13)4-5-17(18(14)21)29-20-15(19(22)23-12-24-20)11-25-28-9-8-27-6-2-3-7-27/h4-5,10-12,26H,2-3,6-9H2,1H3,(H2,22,23,24)/b25-11+
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n/an/a 214n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6407
PNG
(N-(3-Chlorophenyl)-6-[5-[[3-(1-piperazinyl)propyl]...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCNCC3)c2)c1
Show InChI InChI=1S/C22H26ClN7/c23-18-3-1-4-19(12-18)28-22-16-26-15-21(29-22)17-11-20(14-25-13-17)27-5-2-8-30-9-6-24-7-10-30/h1,3-4,11-16,24,27H,2,5-10H2,(H,28,29)
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n/an/a 236n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6423
PNG
(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-6-fl...)
Show SMILES OCCCNc1cnc(F)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H17ClFN5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)
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n/an/a 251n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6412
PNG
(N-(3-Chlorophenyl)-6-[5-[[4-(4-pyridinyl)butyl]ami...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCCc3ccncc3)c2)c1
Show InChI InChI=1S/C24H23ClN6/c25-20-5-3-6-21(13-20)30-24-17-28-16-23(31-24)19-12-22(15-27-14-19)29-9-2-1-4-18-7-10-26-11-8-18/h3,5-8,10-17,29H,1-2,4,9H2,(H,30,31)
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n/an/a 266n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6397
PNG
(2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H16ClN5O/c18-13-2-1-3-14(7-13)22-17-11-20-10-16(23-17)12-6-15(9-19-8-12)21-4-5-24/h1-3,6-11,21,24H,4-5H2,(H,22,23)
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n/an/a 275n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12318
PNG
(6-(1H-indol-5-yloxy)-5-[(1E)-(methoxyimino)methyl]...)
Show SMILES CO\N=C\c1c(N)ncnc1Oc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C14H13N5O2/c1-20-19-7-11-13(15)17-8-18-14(11)21-10-2-3-12-9(6-10)4-5-16-12/h2-8,16H,1H3,(H2,15,17,18)/b19-7+
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n/an/a 276n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6402
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES COCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H16ClN5O2/c1-26-11-18(25)23-15-5-12(7-20-8-15)16-9-21-10-17(24-16)22-14-4-2-3-13(19)6-14/h2-10H,11H2,1H3,(H,22,24)(H,23,25)
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n/an/a 303n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6401
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES OCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H14ClN5O2/c18-12-2-1-3-13(5-12)21-16-9-20-8-15(23-16)11-4-14(7-19-6-11)22-17(25)10-24/h1-9,24H,10H2,(H,21,23)(H,22,25)
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n/an/a 346n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6411
PNG
(N-(3-Chlorophenyl)-6-[5-[[(tetrahydro-2H-pyran-4-y...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCC3CCOCC3)c2)c1
Show InChI InChI=1S/C21H22ClN5O/c22-17-2-1-3-18(9-17)26-21-14-24-13-20(27-21)16-8-19(12-23-11-16)25-10-15-4-6-28-7-5-15/h1-3,8-9,11-15,25H,4-7,10H2,(H,26,27)
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n/an/a 391n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6410
PNG
((3-Chlorophenyl)-{6-[5-(3-piperidin-1-yl-propylami...)
Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H27ClN6/c24-19-6-4-7-20(13-19)28-23-17-26-16-22(29-23)18-12-21(15-25-14-18)27-8-5-11-30-9-2-1-3-10-30/h4,6-7,12-17,27H,1-3,5,8-11H2,(H,28,29)
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n/an/a 399n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM12329
PNG
(5-[(1E)-[(cyclohexylmethoxy)imino]methyl]-6-[(4-fl...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCC3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C21H24FN5O2/c1-13-9-15-17(27-13)7-8-18(19(15)22)29-21-16(20(23)24-12-25-21)10-26-28-11-14-5-3-2-4-6-14/h7-10,12,14,27H,2-6,11H2,1H3,(H2,23,24,25)/b26-10+
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n/an/a 413n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


Bioorg Med Chem Lett 16: 6063-6 (2006)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6431
PNG
(3-[(6-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyraz...)
Show SMILES OCCCNc1cncc(n1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-12-3-1-4-13(7-12)22-17-11-20-9-15(24-17)14-8-19-10-16(23-14)21-5-2-6-25/h1,3-4,7-11,25H,2,5-6H2,(H,21,23)(H,22,24)
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n/an/a 497n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 1886-900 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6433
PNG
(3-[(4-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OCCCNc1cc(ccn1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(10-14)23-18-12-20-11-16(24-18)13-5-7-22-17(9-13)21-6-2-8-25/h1,3-5,7,9-12,25H,2,6,8H2,(H,21,22)(H,23,24)
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n/an/a 500n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 1886-900 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6867
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Show SMILES Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F
Show InChI InChI=1S/C16H14F2N6O3S/c1-8-2-7-11(17)12(13(8)18)14(25)24-15(19)22-16(23-24)21-9-3-5-10(6-4-9)28(20,26)27/h2-7H,1H3,(H2,20,26,27)(H3,19,21,22,23)
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n/an/a 510n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6415
PNG
(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)
Show SMILES OC(=O)CCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c20-14-3-1-4-15(8-14)24-18-12-22-11-17(25-18)13-7-16(10-21-9-13)23-6-2-5-19(26)27/h1,3-4,7-12,23H,2,5-6H2,(H,24,25)(H,26,27)
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n/an/a 568n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6403
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES COCCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H18ClN5O2/c1-27-6-5-19(26)24-16-7-13(9-21-10-16)17-11-22-12-18(25-17)23-15-4-2-3-14(20)8-15/h2-4,7-12H,5-6H2,1H3,(H,23,25)(H,24,26)
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n/an/a 593n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)

More data for this
Ligand-Target Pair
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