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Found 447 hits Enz. Inhib. hit(s) with Target = 'Valosin containing protein, p97 subunit' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424917
PNG
(CHEMBL2311578)
Show SMILES Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3
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n/an/a 24n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424919
PNG
(CHEMBL2315422)
Show SMILES Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C26H27N5O3S2/c1-18-15-21(10-13-24(18)19-8-11-23(12-9-19)36(27,32)33)34-17-25-29-30-26(35-22-6-2-3-7-22)31(25)20-5-4-14-28-16-20/h4-5,8-16,22H,2-3,6-7,17H2,1H3,(H2,27,32,33)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040551
PNG
(CHEMBL3361184)
Show SMILES OC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccccc2)CC1
Show InChI InChI=1/C25H28N4O2/c30-24(31)21-13-11-19(12-14-21)17-27-25-28-22(20-9-5-2-6-10-20)15-23(29-25)26-16-18-7-3-1-4-8-18/h1-10,15,19,21H,11-14,16-17H2,(H,30,31)(H2,26,27,28,29)/t19-,21-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040550
PNG
(CHEMBL3361185)
Show SMILES OC(=O)[C@H]1CC[C@H](CNc2nc(Nc3ccccc3)cc(n2)-c2ccccc2)CC1
Show InChI InChI=1/C24H26N4O2/c29-23(30)19-13-11-17(12-14-19)16-25-24-27-21(18-7-3-1-4-8-18)15-22(28-24)26-20-9-5-2-6-10-20/h1-10,15,17,19H,11-14,16H2,(H,29,30)(H2,25,26,27,28)/t17-,19-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424939
PNG
(CHEMBL2315430)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C26H25N5O2S/c27-25(32)20-9-7-18(8-10-20)19-11-13-22(14-12-19)33-17-24-29-30-26(34-23-5-1-2-6-23)31(24)21-4-3-15-28-16-21/h3-4,7-16,23H,1-2,5-6,17H2,(H2,27,32)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424938
PNG
(CHEMBL2315431)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C27H27N5O2S/c1-28-26(33)21-10-8-19(9-11-21)20-12-14-23(15-13-20)34-18-25-30-31-27(35-24-6-2-3-7-24)32(25)22-5-4-16-29-17-22/h4-5,8-17,24H,2-3,6-7,18H2,1H3,(H,28,33)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424942
PNG
(CHEMBL2315427)
Show SMILES CONC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C27H27N5O3S/c1-34-31-26(33)21-10-8-19(9-11-21)20-12-14-23(15-13-20)35-18-25-29-30-27(36-24-6-2-3-7-24)32(25)22-5-4-16-28-17-22/h4-5,8-17,24H,2-3,6-7,18H2,1H3,(H,31,33)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040513
PNG
(CHEMBL3361210)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccccc2F)CC1
Show InChI InChI=1/C25H28FN5O/c26-21-9-5-4-8-20(21)22-14-23(28-15-17-6-2-1-3-7-17)31-25(30-22)29-16-18-10-12-19(13-11-18)24(27)32/h1-9,14,18-19H,10-13,15-16H2,(H2,27,32)(H2,28,29,30,31)/t18-,19-
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n/an/a 46n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424941
PNG
(CHEMBL2315428)
Show SMILES OCC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C27H26N4O3S/c32-17-25(33)21-9-7-19(8-10-21)20-11-13-23(14-12-20)34-18-26-29-30-27(35-24-5-1-2-6-24)31(26)22-4-3-15-28-16-22/h3-4,7-16,24,32H,1-2,5-6,17-18H2
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424916
PNG
(CHEMBL2315424)
Show SMILES CC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1C
Show InChI InChI=1S/C28H28N4O2S/c1-19-16-24(13-14-26(19)22-11-9-21(10-12-22)20(2)33)34-18-27-30-31-28(35-25-7-3-4-8-25)32(27)23-6-5-15-29-17-23/h5-6,9-17,25H,3-4,7-8,18H2,1-2H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424918
PNG
(CHEMBL2315423)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1C
Show InChI InChI=1S/C28H29N5O2S/c1-19-16-23(13-14-25(19)20-9-11-21(12-10-20)27(34)29-2)35-18-26-31-32-28(36-24-7-3-4-8-24)33(26)22-6-5-15-30-17-22/h5-6,9-17,24H,3-4,7-8,18H2,1-2H3,(H,29,34)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424920
PNG
(CHEMBL2315421)
Show SMILES CONC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1C
Show InChI InChI=1S/C28H29N5O3S/c1-19-16-23(13-14-25(19)20-9-11-21(12-10-20)27(34)32-35-2)36-18-26-30-31-28(37-24-7-3-4-8-24)33(26)22-6-5-15-29-17-22/h5-6,9-17,24H,3-4,7-8,18H2,1-2H3,(H,32,34)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040506
PNG
(CHEMBL3361216)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(NCc2ccccc2)nc(NC[C@H]2CC[C@@H](CC2)C(N)=O)n1
Show InChI InChI=1/C27H32N6O2/c1-18(34)31-23-13-11-21(12-14-23)24-15-25(29-16-19-5-3-2-4-6-19)33-27(32-24)30-17-20-7-9-22(10-8-20)26(28)35/h2-6,11-15,20,22H,7-10,16-17H2,1H3,(H2,28,35)(H,31,34)(H2,29,30,32,33)/t20-,22-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040557
PNG
(CHEMBL3361178)
Show SMILES Nc1ccc(cc1[N+]([O-])=O)-c1cc(nc(NC[C@H]2CC[C@@H](CC2)C(O)=O)n1)-c1ccccc1
Show InChI InChI=1/C24H25N5O4/c25-19-11-10-18(12-22(19)29(32)33)21-13-20(16-4-2-1-3-5-16)27-24(28-21)26-14-15-6-8-17(9-7-15)23(30)31/h1-5,10-13,15,17H,6-9,14,25H2,(H,30,31)(H,26,27,28)/t15-,17-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040499
PNG
(CHEMBL3361223)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2cc3ccccc3o2)CC1
Show InChI InChI=1/C27H29N5O2/c28-26(33)20-12-10-19(11-13-20)17-30-27-31-22(24-14-21-8-4-5-9-23(21)34-24)15-25(32-27)29-16-18-6-2-1-3-7-18/h1-9,14-15,19-20H,10-13,16-17H2,(H2,28,33)(H2,29,30,31,32)/t19-,20-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424937
PNG
(CHEMBL2315432)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C26H26N4O3S2/c1-35(31,32)24-14-10-20(11-15-24)19-8-12-22(13-9-19)33-18-25-28-29-26(34-23-6-2-3-7-23)30(25)21-5-4-16-27-17-21/h4-5,8-17,23H,2-3,6-7,18H2,1H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424936
PNG
(CHEMBL2315433)
Show SMILES CC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C27H26N4O2S/c1-19(32)20-8-10-21(11-9-20)22-12-14-24(15-13-22)33-18-26-29-30-27(34-25-6-2-3-7-25)31(26)23-5-4-16-28-17-23/h4-5,8-17,25H,2-3,6-7,18H2,1H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424915
PNG
(CHEMBL2315425)
Show SMILES Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1-c1ccc(C=O)cc1
Show InChI InChI=1S/C27H26N4O2S/c1-19-15-23(12-13-25(19)21-10-8-20(17-32)9-11-21)33-18-26-29-30-27(34-24-6-2-3-7-24)31(26)22-5-4-14-28-16-22/h4-5,8-17,24H,2-3,6-7,18H2,1H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312869
PNG
(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Show SMILES Oc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
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n/an/a 70n/an/an/an/an/an/a



Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424940
PNG
(CHEMBL2315429)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C25H25N5O3S2/c26-35(31,32)23-13-9-19(10-14-23)18-7-11-21(12-8-18)33-17-24-28-29-25(34-22-5-1-2-6-22)30(24)20-4-3-15-27-16-20/h3-4,7-16,22H,1-2,5-6,17H2,(H2,26,31,32)
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424921
PNG
(CHEMBL2315420)
Show SMILES Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H25N5OS/c1-19-15-23(12-13-25(19)21-10-8-20(16-28)9-11-21)33-18-26-30-31-27(34-24-6-2-3-7-24)32(26)22-5-4-14-29-17-22/h4-5,8-15,17,24H,2-3,6-7,18H2,1H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424884
PNG
(CHEMBL2315450)
Show SMILES Fc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1Cl
Show InChI InChI=1S/C19H18ClFN4OS/c20-16-8-7-14(10-17(16)21)26-12-18-23-24-19(27-15-5-1-2-6-15)25(18)13-4-3-9-22-11-13/h3-4,7-11,15H,1-2,5-6,12H2
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040498
PNG
(CHEMBL3361224)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccc3[nH]ncc3c2)CC1
Show InChI InChI=1/C26H29N7O/c27-25(34)19-8-6-18(7-9-19)15-29-26-31-23(20-10-11-22-21(12-20)16-30-33-22)13-24(32-26)28-14-17-4-2-1-3-5-17/h1-5,10-13,16,18-19H,6-9,14-15H2,(H2,27,34)(H,30,33)(H2,28,29,31,32)/t18-,19-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040497
PNG
(CHEMBL3361225)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2csc3ccccc23)CC1
Show InChI InChI=1/C27H29N5OS/c28-26(33)20-12-10-19(11-13-20)16-30-27-31-23(22-17-34-24-9-5-4-8-21(22)24)14-25(32-27)29-15-18-6-2-1-3-7-18/h1-9,14,17,19-20H,10-13,15-16H2,(H2,28,33)(H2,29,30,31,32)/t19-,20-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312870
PNG
(CHEMBL1080890 | N-aryl-4-aryl-1,3-thiazole-2-amine...)
Show SMILES Nc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H12ClN3S/c16-11-3-1-10(2-4-11)14-9-20-15(19-14)18-13-7-5-12(17)6-8-13/h1-9H,17H2,(H,18,19)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040496
PNG
(CHEMBL3361226)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccc3[nH]ccc3c2)CC1
Show InChI InChI=1/C27H30N6O/c28-26(34)20-8-6-19(7-9-20)17-31-27-32-24(21-10-11-23-22(14-21)12-13-29-23)15-25(33-27)30-16-18-4-2-1-3-5-18/h1-5,10-15,19-20,29H,6-9,16-17H2,(H2,28,34)(H2,30,31,32,33)/t19-,20-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040512
PNG
(CHEMBL3361211)
Show SMILES CC(=O)c1cccc(c1)-c1cc(NCc2ccccc2)nc(NC[C@H]2CC[C@@H](CC2)C(N)=O)n1
Show InChI InChI=1/C27H31N5O2/c1-18(33)22-8-5-9-23(14-22)24-15-25(29-16-19-6-3-2-4-7-19)32-27(31-24)30-17-20-10-12-21(13-11-20)26(28)34/h2-9,14-15,20-21H,10-13,16-17H2,1H3,(H2,28,34)(H2,29,30,31,32)/t20-,21-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424883
PNG
(CHEMBL2315451)
Show SMILES N#Cc1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C26H23N5OS/c27-16-19-7-9-20(10-8-19)21-11-13-23(14-12-21)32-18-25-29-30-26(33-24-5-1-2-6-24)31(25)22-4-3-15-28-17-22/h3-4,7-15,17,24H,1-2,5-6,18H2
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040505
PNG
(CHEMBL3361217)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccc(CO)cc2)CC1
Show InChI InChI=1/C26H31N5O2/c27-25(33)22-12-6-19(7-13-22)16-29-26-30-23(21-10-8-20(17-32)9-11-21)14-24(31-26)28-15-18-4-2-1-3-5-18/h1-5,8-11,14,19,22,32H,6-7,12-13,15-17H2,(H2,27,33)(H2,28,29,30,31)/t19-,22-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424882
PNG
(CHEMBL2315452)
Show SMILES Clc1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1Cl
Show InChI InChI=1S/C19H18Cl2N4OS/c20-16-8-7-14(10-17(16)21)26-12-18-23-24-19(27-15-5-1-2-6-15)25(18)13-4-3-9-22-11-13/h3-4,7-11,15H,1-2,5-6,12H2
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312883
PNG
(4-(5-phenyloxazol-2-ylamino)phenol | CHEMBL1076570)
Show SMILES Oc1ccc(Nc2ncc(o2)-c2ccccc2)cc1
Show InChI InChI=1S/C15H12N2O2/c18-13-8-6-12(7-9-13)17-15-16-10-14(19-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424881
PNG
(CHEMBL2315453)
Show SMILES Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1Br
Show InChI InChI=1S/C20H21BrN4OS/c1-14-11-16(8-9-18(14)21)26-13-19-23-24-20(27-17-6-2-3-7-17)25(19)15-5-4-10-22-12-15/h4-5,8-12,17H,2-3,6-7,13H2,1H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040504
PNG
(CHEMBL3361218)
Show SMILES CC(=O)c1ccc(cc1)-c1cc(NCc2ccccc2)nc(NC[C@H]2CC[C@@H](CC2)C(N)=O)n1
Show InChI InChI=1/C27H31N5O2/c1-18(33)21-11-13-22(14-12-21)24-15-25(29-16-19-5-3-2-4-6-19)32-27(31-24)30-17-20-7-9-23(10-8-20)26(28)34/h2-6,11-15,20,23H,7-10,16-17H2,1H3,(H2,28,34)(H2,29,30,31,32)/t20-,23-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040503
PNG
(CHEMBL3361219)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1/C25H28ClN5O/c26-21-12-10-19(11-13-21)22-14-23(28-15-17-4-2-1-3-5-17)31-25(30-22)29-16-18-6-8-20(9-7-18)24(27)32/h1-5,10-14,18,20H,6-9,15-16H2,(H2,27,32)(H2,28,29,30,31)/t18-,20-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040511
PNG
(CHEMBL3361212)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2cccc(O)c2)CC1
Show InChI InChI=1/C25H29N5O2/c26-24(32)19-11-9-18(10-12-19)16-28-25-29-22(20-7-4-8-21(31)13-20)14-23(30-25)27-15-17-5-2-1-3-6-17/h1-8,13-14,18-19,31H,9-12,15-16H2,(H2,26,32)(H2,27,28,29,30)/t18-,19-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040495
PNG
(CHEMBL3361227)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2cccnc2)CC1
Show InChI InChI=1/C24H28N6O/c25-23(31)19-10-8-18(9-11-19)15-28-24-29-21(20-7-4-12-26-16-20)13-22(30-24)27-14-17-5-2-1-3-6-17/h1-7,12-13,16,18-19H,8-11,14-15H2,(H2,25,31)(H2,27,28,29,30)/t18-,19-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312866
PNG
(4-(4-(thiophen-2-yl)thiazol-2-ylamino)phenol | CHE...)
Show SMILES Oc1ccc(Nc2nc(cs2)-c2cccs2)cc1
Show InChI InChI=1S/C13H10N2OS2/c16-10-5-3-9(4-6-10)14-13-15-11(8-18-13)12-2-1-7-17-12/h1-8,16H,(H,14,15)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040558
PNG
(CHEMBL3361177)
Show SMILES Nc1ccc(cc1)-c1cc(nc(NC[C@H]2CC[C@@H](CC2)C(O)=O)n1)-c1ccccc1
Show InChI InChI=1/C24H26N4O2/c25-20-12-10-18(11-13-20)22-14-21(17-4-2-1-3-5-17)27-24(28-22)26-15-16-6-8-19(9-7-16)23(29)30/h1-5,10-14,16,19H,6-9,15,25H2,(H,29,30)(H,26,27,28)/t16-,19-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424935
PNG
(CHEMBL2315434)
Show SMILES O=Cc1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C26H24N4O2S/c31-17-19-7-9-20(10-8-19)21-11-13-23(14-12-21)32-18-25-28-29-26(33-24-5-1-2-6-24)30(25)22-4-3-15-27-16-22/h3-4,7-17,24H,1-2,5-6,18H2
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040569
PNG
(CHEMBL3360670)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc(nc(NC[C@H]2CC[C@@H](CC2)C(O)=O)n1)-c1ccccc1
Show InChI InChI=1/C25H27N3O4S/c1-33(31,32)21-9-5-8-20(14-21)23-15-22(18-6-3-2-4-7-18)27-25(28-23)26-16-17-10-12-19(13-11-17)24(29)30/h2-9,14-15,17,19H,10-13,16H2,1H3,(H,29,30)(H,26,27,28)/t17-,19-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312884
PNG
(4-(5-(2-methoxyphenyl)oxazol-2-ylamino)phenol | CH...)
Show SMILES COc1ccccc1-c1cnc(Nc2ccc(O)cc2)o1
Show InChI InChI=1S/C16H14N2O3/c1-20-14-5-3-2-4-13(14)15-10-17-16(21-15)18-11-6-8-12(19)9-7-11/h2-10,19H,1H3,(H,17,18)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312867
PNG
(3-(2-(4-hydroxyphenylamino)thiazol-4-yl)phenol | C...)
Show SMILES Oc1ccc(Nc2nc(cs2)-c2cccc(O)c2)cc1
Show InChI InChI=1S/C15H12N2O2S/c18-12-6-4-11(5-7-12)16-15-17-14(9-20-15)10-2-1-3-13(19)8-10/h1-9,18-19H,(H,16,17)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040547
PNG
(CHEMBL3361188)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccccc2)CC1
Show InChI InChI=1/C25H29N5O/c26-24(31)21-13-11-19(12-14-21)17-28-25-29-22(20-9-5-2-6-10-20)15-23(30-25)27-16-18-7-3-1-4-8-18/h1-10,15,19,21H,11-14,16-17H2,(H2,26,31)(H2,27,28,29,30)/t19-,21-
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n/an/a 127n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312864
PNG
(4-(5-(4-morpholinophenyl)oxazol-2-ylamino)phenol |...)
Show SMILES Oc1ccc(Nc2ncc(o2)-c2ccc(cc2)N2CCOCC2)cc1
Show InChI InChI=1S/C19H19N3O3/c23-17-7-3-15(4-8-17)21-19-20-13-18(25-19)14-1-5-16(6-2-14)22-9-11-24-12-10-22/h1-8,13,23H,9-12H2,(H,20,21)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040545
PNG
(CHEMBL3361190)
Show SMILES CS(=O)(=O)NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2ccccc2)CC1
Show InChI InChI=1/C26H31N5O3S/c1-35(33,34)31-25(32)22-14-12-20(13-15-22)18-28-26-29-23(21-10-6-3-7-11-21)16-24(30-26)27-17-19-8-4-2-5-9-19/h2-11,16,20,22H,12-15,17-18H2,1H3,(H,31,32)(H2,27,28,29,30)/t20-,22-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424880
PNG
(CHEMBL2315454)
Show SMILES Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc(C)c1Cl
Show InChI InChI=1S/C21H23ClN4OS/c1-14-10-17(11-15(2)20(14)22)27-13-19-24-25-21(28-18-7-3-4-8-18)26(19)16-6-5-9-23-12-16/h5-6,9-12,18H,3-4,7-8,13H2,1-2H3
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040510
PNG
(CHEMBL3361213)
Show SMILES NC(=O)[C@H]1CC[C@H](CNc2nc(NCc3ccccc3)cc(n2)-c2cccc(CO)c2)CC1
Show InChI InChI=1/C26H31N5O2/c27-25(33)21-11-9-19(10-12-21)16-29-26-30-23(22-8-4-7-20(13-22)17-32)14-24(31-26)28-15-18-5-2-1-3-6-18/h1-8,13-14,19,21,32H,9-12,15-17H2,(H2,27,33)(H2,28,29,30,31)/t19-,21-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50424890
PNG
(CHEMBL2315444)
Show SMILES Clc1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Show InChI InChI=1S/C19H19ClN4OS/c20-14-7-9-16(10-8-14)25-13-18-22-23-19(26-17-5-1-2-6-17)24(18)15-4-3-11-21-12-15/h3-4,7-12,17H,1-2,5-6,13H2
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TBA

Assay Description
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir ...


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312885
PNG
(4-(5-(3-chlorophenyl)oxazol-2-ylamino)phenol | CHE...)
Show SMILES Oc1ccc(Nc2ncc(o2)-c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C15H11ClN2O2/c16-11-3-1-2-10(8-11)14-9-17-15(20-14)18-12-4-6-13(19)7-5-12/h1-9,19H,(H,17,18)
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Myriad Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Citation and Details
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50040697
PNG
(CHEMBL3360663)
Show SMILES OC(=O)[C@H]1CC[C@H](CNc2nc(cc(n2)-c2ccccc2F)-c2ccccc2)CC1
Show InChI InChI=1/C24H24FN3O2/c25-20-9-5-4-8-19(20)22-14-21(17-6-2-1-3-7-17)27-24(28-22)26-15-16-10-12-18(13-11-16)23(29)30/h1-9,14,16,18H,10-13,15H2,(H,29,30)(H,26,27,28)/t16-,18-
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP for...


Citation and Details
More data for this
Ligand-Target Pair
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