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Compile Data Set for Download or QSAR

Found 58 hits Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 1' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a 70n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065303
PNG
(3-[1-(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z...)
Show SMILES CCc1c(C)c(C)[nH]c1\C=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C17H18N2O/c1-4-12-10(2)11(3)18-16(12)9-14-13-7-5-6-8-15(13)19-17(14)20/h5-9,18H,4H2,1-3H3,(H,19,20)/b14-9-
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n/an/a 140n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a 180n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065292
PNG
((Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-met...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(C)cc23)[nH]1
Show InChI InChI=1S/C16H16N2O/c1-9-4-5-14-12(6-9)13(16(19)18-14)8-15-10(2)7-11(3)17-15/h4-8,17H,1-3H3,(H,18,19)/b13-8-
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n/an/a 300n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM17015
PNG
((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc[nH]1
Show InChI InChI=1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8,14H,(H,15,16)/b11-8-
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n/an/a 390n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM4882
PNG
((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 400n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM17747
PNG
((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
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n/an/a 800n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065288
PNG
(3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3cccc(C)c23)[nH]1
Show InChI InChI=1S/C16H16N2O/c1-9-5-4-6-13-15(9)12(16(19)18-13)8-14-10(2)7-11(3)17-14/h4-8,17H,1-3H3,(H,18,19)/b12-8-
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n/an/a 1.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM4810
PNG
((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
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n/an/a 1.04E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384721
PNG
(CHEMBL2037224)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1
Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14-
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n/an/a 1.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 1.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065312
PNG
((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c12
Show InChI InChI=1S/C20H20N2O2/c1-14-3-2-4-18-19(14)17(20(23)21-18)13-15-5-7-16(8-6-15)22-9-11-24-12-10-22/h2-8,13H,9-12H2,1H3,(H,21,23)/b17-13-
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n/an/a 2.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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n/an/a 2.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065273
PNG
(3-[1-(5-Methylsulfanyl-thiophen-2-yl)-meth-(Z)-yli...)
Show SMILES CSc1ccc(\C=C2/C(=O)Nc3ccccc23)s1
Show InChI InChI=1S/C14H11NOS2/c1-17-13-7-6-9(18-13)8-11-10-4-2-3-5-12(10)15-14(11)16/h2-8H,1H3,(H,15,16)/b11-8-
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n/an/a 2.34E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065290
PNG
((Z)-4-(4-((4-methyl-2-oxoindolin-3-ylidene)methyl)...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3ccc(cc3)N3CCN(CC3)C=O)c12
Show InChI InChI=1S/C21H21N3O2/c1-15-3-2-4-19-20(15)18(21(26)22-19)13-16-5-7-17(8-6-16)24-11-9-23(14-25)10-12-24/h2-8,13-14H,9-12H2,1H3,(H,22,26)/b18-13-
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n/an/a 2.50E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065280
PNG
(3-[1-(4-Morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C19H18N2O2/c22-19-17(16-3-1-2-4-18(16)20-19)13-14-5-7-15(8-6-14)21-9-11-23-12-10-21/h1-8,13H,9-12H2,(H,20,22)/b17-13-
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n/an/a 2.50E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065304
PNG
(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9-
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n/an/a 2.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065311
PNG
(3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C15H14N2O/c1-9-8-16-14(10(9)2)7-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-7-
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n/an/a 2.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065294
PNG
(3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihyd...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cccc(C)c23)cc1
Show InChI InChI=1S/C18H18N2O/c1-12-5-4-6-16-17(12)15(18(21)19-16)11-13-7-9-14(10-8-13)20(2)3/h4-11H,1-3H3,(H,19,21)/b15-11-
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n/an/a 3.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065314
PNG
(3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C19H18N2O/c22-19-17(16-5-1-2-6-18(16)20-19)13-14-7-9-15(10-8-14)21-11-3-4-12-21/h1-2,5-10,13H,3-4,11-12H2,(H,20,22)/b17-13-
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n/an/a 3.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065317
PNG
(5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-i...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1
Show InChI InChI=1S/C13H9ClN2O/c14-8-3-4-12-10(6-8)11(13(17)16-12)7-9-2-1-5-15-9/h1-7,15H,(H,16,17)/b11-7-
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n/an/a 3.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384720
PNG
(CHEMBL2037220)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4cc(c[nH]4)C(O)=O)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H29F3N6O4/c1-41-7-9-42(10-8-41)26-13-19(11-21(14-26)33(34,35)36)30(43)39-23-4-2-3-22(15-23)38-24-5-6-27-28(31(44)40-29(27)17-24)16-25-12-20(18-37-25)32(45)46/h2-6,11-18,37-38H,7-10H2,1H3,(H,39,43)(H,40,44)(H,45,46)/b28-16-
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n/an/a 3.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065295
PNG
(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)
Show SMILES CCc1ccc(\C=C2/C(=O)Nc3ccccc23)s1
Show InChI InChI=1S/C15H13NOS/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9-
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n/an/a 3.40E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 3.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065277
PNG
(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17ClN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a 4.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065307
PNG
(5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H22ClNO2/c1-11(2)15-7-13(8-16(12(3)4)20(15)24)9-18-17-10-14(22)5-6-19(17)23-21(18)25/h5-12,24H,1-4H3,(H,23,25)/b18-9-
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n/an/a 4.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384727
PNG
(CHEMBL2037226)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
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n/an/a 4.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065276
PNG
(3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C20H20N2O/c23-20-18(17-6-2-3-7-19(17)21-20)14-15-8-10-16(11-9-15)22-12-4-1-5-13-22/h2-3,6-11,14H,1,4-5,12-13H2,(H,21,23)/b18-14-
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n/an/a 4.50E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065298
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H15FN2O/c1-20(2)13-6-3-11(4-7-13)9-15-14-8-5-12(18)10-16(14)19-17(15)21/h3-10H,1-2H3,(H,19,21)/b15-9-
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n/an/a 4.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065297
PNG
(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Show SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
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n/an/a 5.20E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065289
PNG
(3-{4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-yliden...)
Show SMILES COC(=O)CCc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-11-12(7-8-17(21)23-2)10-19-16(11)9-14-13-5-3-4-6-15(13)20-18(14)22/h3-6,9-10,19H,7-8H2,1-2H3,(H,20,22)/b14-9-
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n/an/a 6.30E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065284
PNG
(3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-...)
Show SMILES Clc1cn[nH]c1C=C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C12H8ClN3O/c13-9-6-14-16-11(9)5-8-7-3-1-2-4-10(7)15-12(8)17/h1-6H,(H,14,16)(H,15,17)
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n/an/a 7.41E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065296
PNG
(3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C16H13NO2/c1-19-12-8-6-11(7-9-12)10-14-13-4-2-3-5-15(13)17-16(14)18/h2-10H,1H3,(H,17,18)/b14-10-
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n/an/a 7.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065275
PNG
(3-(3,5-di-tert-butyl-4-hydroxybenzylidene)indolin-...)
Show SMILES CC(C)(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(c1O)C(C)(C)C
Show InChI InChI=1S/C23H27NO2/c1-22(2,3)17-12-14(13-18(20(17)25)23(4,5)6)11-16-15-9-7-8-10-19(15)24-21(16)26/h7-13,25H,1-6H3,(H,24,26)/b16-11-
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n/an/a 8.40E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065271
PNG
(3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H23NO2/c1-12(2)16-9-14(10-17(13(3)4)20(16)23)11-18-15-7-5-6-8-19(15)22-21(18)24/h5-13,23H,1-4H3,(H,22,24)/b18-11-
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n/an/a 8.50E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50384725
PNG
(CHEMBL2037209)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14-
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FLT1 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065310
PNG
(5-Bromo-3-(4-morpholin-4-yl-benzylidene)-1,3-dihyd...)
Show SMILES Brc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H17BrN2O2/c20-14-3-6-18-16(12-14)17(19(23)21-18)11-13-1-4-15(5-2-13)22-7-9-24-10-8-22/h1-6,11-12H,7-10H2,(H,21,23)/b17-11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065272
PNG
(3-[1-(3-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)
Show SMILES Brc1ccsc1\C=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C13H8BrNOS/c14-10-5-6-17-12(10)7-9-8-3-1-2-4-11(8)15-13(9)16/h1-7H,(H,15,16)/b9-7-
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n/an/a 1.54E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065300
PNG
(3-[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1...)
Show SMILES Cn1cccc1\C=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-16-8-4-5-10(16)9-12-11-6-2-3-7-13(11)15-14(12)17/h2-9H,1H3,(H,15,17)/b12-9-
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n/an/a 2.04E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065315
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1
Show InChI InChI=1S/C18H18N2O/c1-19(2)14-10-8-13(9-11-14)12-16-15-6-4-5-7-17(15)20(3)18(16)21/h4-12H,1-3H3/b16-12-
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n/an/a 2.26E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM17016
PNG
((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3ccc[nH]3)c12
Show InChI InChI=1S/C14H12N2O/c1-9-4-2-6-12-13(9)11(14(17)16-12)8-10-5-3-7-15-10/h2-8,15H,1H3,(H,16,17)/b11-8-
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n/an/a 3.10E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065291
PNG
(3-(5-Ethyl-furan-2-ylmethylene)-1,3-dihydro-indol-...)
Show SMILES CCc1ccc(\C=C2\C(=O)Nc3ccccc23)o1
Show InChI InChI=1S/C15H13NO2/c1-2-10-7-8-11(18-10)9-13-12-5-3-4-6-14(12)16-15(13)17/h3-9H,2H2,1H3,(H,16,17)/b13-9+
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n/an/a 4.12E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065285
PNG
(3-[1-(3-Bromo-5-tert-butyl-4-methoxy-phenyl)-meth-...)
Show SMILES COc1c(Br)cc(\C=C2/C(=O)Nc3ccccc23)cc1C(C)(C)C
Show InChI InChI=1S/C20H20BrNO2/c1-20(2,3)15-10-12(11-16(21)18(15)24-4)9-14-13-7-5-6-8-17(13)22-19(14)23/h5-11H,1-4H3,(H,22,23)/b14-9-
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n/an/a 4.66E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065299
PNG
(4-[4-(5-Bromo-2-oxo-1,2-dihydro-indol-3-ylidenemet...)
Show SMILES Brc1ccc2NC(=O)\C(=C/c3ccc(cc3)N3CCN(CC3)C=O)c2c1
Show InChI InChI=1S/C20H18BrN3O2/c21-15-3-6-19-17(12-15)18(20(26)22-19)11-14-1-4-16(5-2-14)24-9-7-23(13-25)8-10-24/h1-6,11-13H,7-10H2,(H,22,26)/b18-11-
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n/an/a>5.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065309
PNG
(3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol...)
Show SMILES Cc1ccc(\C=C2\C(=O)Nc3ccccc23)o1
Show InChI InChI=1S/C14H11NO2/c1-9-6-7-10(17-9)8-12-11-4-2-3-5-13(11)15-14(12)16/h2-8H,1H3,(H,15,16)/b12-8+
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n/an/a 7.36E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065286
PNG
(3-[1-(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z...)
Show SMILES CCc1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H18N2O/c1-4-12-10(2)16(18-11(12)3)9-14-13-7-5-6-8-15(13)19-17(14)20/h5-9,18H,4H2,1-3H3,(H,19,20)/b14-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065318
PNG
(3-[1-(3-tert-Butyl-4-methoxy-phenyl)-meth-(Z)-ylid...)
Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1C(C)(C)C
Show InChI InChI=1S/C20H21NO2/c1-20(2,3)16-12-13(9-10-18(16)23-4)11-15-14-7-5-6-8-17(14)21-19(15)22/h5-12H,1-4H3,(H,21,22)/b15-11-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065274
PNG
(4-Methyl-3-(5-methylsulfanyl-thiophen-2-ylmethylen...)
Show SMILES CSc1ccc(\C=C2/C(=O)Nc3cccc(C)c23)s1
Show InChI InChI=1S/C15H13NOS2/c1-9-4-3-5-12-14(9)11(15(17)16-12)8-10-6-7-13(18-2)19-10/h3-8H,1-2H3,(H,16,17)/b11-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065278
PNG
(3-(3-tert-Butyl-4-methoxy-benzylidene)-5-chloro-1,...)
Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccc(Cl)cc23)cc1C(C)(C)C
Show InChI InChI=1S/C20H20ClNO2/c1-20(2,3)16-10-12(5-8-18(16)24-4)9-15-14-11-13(21)6-7-17(14)22-19(15)23/h5-11H,1-4H3,(H,22,23)/b15-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065279
PNG
(3-[1-(4-Chloro-1-methyl-1H-pyrazol-3-yl)-meth-(Z)-...)
Show SMILES Cn1cc(Cl)c(\C=C2/C(=O)Nc3ccccc23)n1
Show InChI InChI=1S/C13H10ClN3O/c1-17-7-10(14)12(16-17)6-9-8-4-2-3-5-11(8)15-13(9)18/h2-7H,1H3,(H,15,18)/b9-6-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


Citation and Details
More data for this
Ligand-Target Pair
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