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Found 18 hits Enz. Inhib. hit(s) with Target = 'Vasopressin V1a receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V1a receptor


(Mus musculus)
BDBM50077219
PNG
(CHEMBL3416884)
Show SMILES CN1CCC(CC1)n1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12
Show InChI InChI=1S/C27H30ClN3O2/c1-29-12-8-21(9-13-29)31-17-23(22-7-6-20(28)16-25(22)31)26(32)30-14-10-27(11-15-30)24-5-3-2-4-19(24)18-33-27/h2-7,16-17,21H,8-15,18H2,1H3
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11n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077221
PNG
(CHEMBL3416883)
Show SMILES CN1CCC[C@H]1Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12
Show InChI InChI=1/C27H30ClN3O2/c1-29-12-4-6-21(29)16-31-17-23(22-9-8-20(28)15-25(22)31)26(32)30-13-10-27(11-14-30)24-7-3-2-5-19(24)18-33-27/h2-3,5,7-9,15,17,21H,4,6,10-14,16,18H2,1H3/t21-/s2
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13n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077223
PNG
(CHEMBL3416881)
Show SMILES CN(C)C(=O)Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H26ClN3O3/c1-27(2)23(30)15-29-14-20(19-8-7-18(26)13-22(19)29)24(31)28-11-9-25(10-12-28)21-6-4-3-5-17(21)16-32-25/h3-8,13-14H,9-12,15-16H2,1-2H3
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14n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077217
PNG
(CHEMBL3416885)
Show SMILES CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H28ClN3O2/c1-27(2)13-14-29-16-21(20-8-7-19(26)15-23(20)29)24(30)28-11-9-25(10-12-28)22-6-4-3-5-18(22)17-31-25/h3-8,15-16H,9-14,17H2,1-2H3
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39n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077452
PNG
(CHEMBL3416868)
Show SMILES CN1CCN(CC1)C(=O)Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12
Show InChI InChI=1S/C28H31ClN4O3/c1-30-12-14-31(15-13-30)26(34)18-33-17-23(22-7-6-21(29)16-25(22)33)27(35)32-10-8-28(9-11-32)24-5-3-2-4-20(24)19-36-28/h2-7,16-17H,8-15,18-19H2,1H3
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41n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077222
PNG
(CHEMBL3416882)
Show SMILES Clc1ccc2c(cn(C[C@@H]3CCCN3)c2c1)C(=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1/C26H28ClN3O2/c27-19-7-8-21-22(16-30(24(21)14-19)15-20-5-3-11-28-20)25(31)29-12-9-26(10-13-29)23-6-2-1-4-18(23)17-32-26/h1-2,4,6-8,14,16,20,28H,3,5,9-13,15,17H2/t20-/s2
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125n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077310
PNG
(CHEMBL3416869)
Show SMILES CN(C)CCNC(=O)Cn1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12
Show InChI InChI=1S/C27H31ClN4O3/c1-30(2)14-11-29-25(33)17-32-16-22(21-8-7-20(28)15-24(21)32)26(34)31-12-9-27(10-13-31)23-6-4-3-5-19(23)18-35-27/h3-8,15-16H,9-14,17-18H2,1-2H3,(H,29,33)
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177n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077213
PNG
(CHEMBL3416860)
Show SMILES Cc1c(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C29H28N2O2/c1-21-27(24-12-6-8-14-26(24)31(21)19-22-9-3-2-4-10-22)28(32)30-17-15-29(16-18-30)25-13-7-5-11-23(25)20-33-29/h2-14H,15-20H2,1H3
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210n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077206
PNG
(CHEMBL3416861)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H19ClN2O2/c22-15-5-6-16-17(12-23-19(16)11-15)20(25)24-9-7-21(8-10-24)18-4-2-1-3-14(18)13-26-21/h1-6,11-12,23H,7-10,13H2
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1.01E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077309
PNG
(CHEMBL3416870)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC2(CC1)OCc1cccnc21
Show InChI InChI=1S/C20H18ClN3O2/c21-14-3-4-15-16(11-23-17(15)10-14)19(25)24-8-5-20(6-9-24)18-13(12-26-20)2-1-7-22-18/h1-4,7,10-11,23H,5-6,8-9,12H2
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1.02E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077226
PNG
(CHEMBL3416879)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H19ClN2O/c21-16-6-7-17-18(13-22-19(17)12-16)20(24)23-10-8-15(9-11-23)14-4-2-1-3-5-14/h1-7,12-13,15,22H,8-11H2
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1.49E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077224
PNG
(CHEMBL3416880)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1S/C19H17Cl2N3O/c20-13-5-6-14-15(12-22-17(14)11-13)19(25)24-9-7-23(8-10-24)18-4-2-1-3-16(18)21/h1-6,11-12,22H,7-10H2
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1.97E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077227
PNG
(CHEMBL3416878)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H19ClN4O2/c22-13-5-6-15-16(12-23-18(15)11-13)20(27)25-9-7-14(8-10-25)26-19-4-2-1-3-17(19)24-21(26)28/h1-6,11-12,14,23H,7-10H2,(H,24,28)
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2.40E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077274
PNG
(CHEMBL3416871)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC2(CC1)OCc1ccncc21
Show InChI InChI=1S/C20H18ClN3O2/c21-14-1-2-15-16(10-23-18(15)9-14)19(25)24-7-4-20(5-8-24)17-11-22-6-3-13(17)12-26-20/h1-3,6,9-11,23H,4-5,7-8,12H2
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2.98E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077249
PNG
(CHEMBL3416872)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC2(CC1)OCc1ncccc21
Show InChI InChI=1S/C20H18ClN3O2/c21-13-3-4-14-15(11-23-17(14)10-13)19(25)24-8-5-20(6-9-24)16-2-1-7-22-18(16)12-26-20/h1-4,7,10-11,23H,5-6,8-9,12H2
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4.82E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077228
PNG
(CHEMBL3416876)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC2(CC1)c1ccccc1CS2(=O)=O
Show InChI InChI=1S/C21H19ClN2O3S/c22-15-5-6-16-17(12-23-19(16)11-15)20(25)24-9-7-21(8-10-24)18-4-2-1-3-14(18)13-28(21,26)27/h1-6,11-12,23H,7-10,13H2
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5.89E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077248
PNG
(CHEMBL3416875)
Show SMILES Clc1ccc2c(c[nH]c2c1)C(=O)N1CCC2(CNc3ccccc23)CC1
Show InChI InChI=1S/C21H20ClN3O/c22-14-5-6-15-16(12-23-19(15)11-14)20(26)25-9-7-21(8-10-25)13-24-18-4-2-1-3-17(18)21/h1-6,11-12,23-24H,7-10,13H2
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5.89E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Mus musculus)
BDBM50077453
PNG
(CHEMBL3416867)
Show SMILES O=C(N1CCC2(CC1)OCc1ccccc21)c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H20N2O2/c24-20(17-13-22-19-8-4-2-6-16(17)19)23-11-9-21(10-12-23)18-7-3-1-5-15(18)14-25-21/h1-8,13,22H,9-12,14H2
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6.62E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-vasopressin from mouse vasopressin 1a receptor expressed in HEK293 cell membranes after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair