BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Vitamin k epoxide reductase complex subunit 1 isoform 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vitamin K epoxide reductase complex subunit 1 (hVKORC1)


(Homo sapiens (Human))
BDBM50343352
PNG
(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Show SMILES CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O
Show InChI InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
1.80E+3n/an/an/an/an/an/an/an/a



Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon



Assay Description
Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K epoxide reductase complex subunit 1 (hVKORC1)


(Homo sapiens (Human))
BDBM50386849
PNG
(CHEMBL2048091)
Show SMILES Oc1c(-c2csc(Nc3ccc(cc3)S(O)(=O)=O)n2)c(=O)oc2ccccc12
Show InChI InChI=1S/C18H12N2O6S2/c21-16-12-3-1-2-4-14(12)26-17(22)15(16)13-9-27-18(20-13)19-10-5-7-11(8-6-10)28(23,24)25/h1-9,21H,(H,19,20)(H,23,24,25)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
4.48E+4n/an/an/an/an/an/an/an/a



University of Kragujevac

Curated by ChEMBL


Assay Description
Inhibition of VKORC1


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K epoxide reductase complex subunit 1 (hVKORC1)


(Homo sapiens (Human))
BDBM50386852
PNG
(CHEMBL2048084)
Show SMILES CCOC(=O)C(C(=O)OCC)=C(C)c1c(O)c2ccccc2oc1=O
Show InChI InChI=1S/C18H18O7/c1-4-23-16(20)14(17(21)24-5-2)10(3)13-15(19)11-8-6-7-9-12(11)25-18(13)22/h6-9,19H,4-5H2,1-3H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
6.89E+4n/an/an/an/an/an/an/an/a



University of Kragujevac

Curated by ChEMBL


Assay Description
Inhibition of VKORC1


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K epoxide reductase complex subunit 1 (hVKORC1)


(Homo sapiens (Human))
BDBM50386850
PNG
(CHEMBL2048092)
Show SMILES Cc1cccc(Nc2nc(cs2)-c2c(O)c3ccccc3oc2=O)c1
Show InChI InChI=1S/C19H14N2O3S/c1-11-5-4-6-12(9-11)20-19-21-14(10-25-19)16-17(22)13-7-2-3-8-15(13)24-18(16)23/h2-10,22H,1H3,(H,20,21)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
7.42E+4n/an/an/an/an/an/an/an/a



University of Kragujevac

Curated by ChEMBL


Assay Description
Inhibition of VKORC1


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K epoxide reductase complex subunit 1 (hVKORC1)


(Homo sapiens (Human))
BDBM50386851
PNG
(CHEMBL2048096)
Show SMILES Oc1c(-c2csc(Nc3cccc(c3)[N+]([O-])=O)n2)c(=O)oc2ccccc12
Show InChI InChI=1S/C18H11N3O5S/c22-16-12-6-1-2-7-14(12)26-17(23)15(16)13-9-27-18(20-13)19-10-4-3-5-11(8-10)21(24)25/h1-9,22H,(H,19,20)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
7.96E+4n/an/an/an/an/an/an/an/a



University of Kragujevac

Curated by ChEMBL


Assay Description
Inhibition of VKORC1


Citation and Details
More data for this
Ligand-Target Pair