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Compile Data Set for Download or QSAR

Found 1779 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent T-type calcium channel subunit alpha-1H'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium channel (Type T,L)


(MOUSE)
BDBM50022784
PNG
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Show SMILES CNCCC(Oc1ccccc1C)c1ccccc1
Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
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1.00E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




Neuropsychopharmacology 27: 699-711 (2002)


Article DOI: 10.1016/S0893-133X(02)00346-9
BindingDB Entry DOI: 10.7270/Q2GQ6W98
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)


Article DOI: 10.1016/0028-3908(96)84644-2
BindingDB Entry DOI: 10.7270/Q237777N
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM86694
PNG
(N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyform...)
Show SMILES ONC=Nc1ccc(N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
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>1.00E+4n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by PDSP Ki Database




J Pharmacol Exp Ther 314: 77-85 (2005)


Article DOI: 10.1124/jpet.105.083964
BindingDB Entry DOI: 10.7270/Q2MW2FQQ
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50035398
PNG
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Show SMILES CN1CCC[C@H]1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 270: 310-8 (1994)


BindingDB Entry DOI: 10.7270/Q2HH6HKJ
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
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Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)


Article DOI: 10.1016/0028-3908(96)84644-2
BindingDB Entry DOI: 10.7270/Q237777N
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM363976
PNG
(N-[(exo)-8-(tert-Butylcarbamoyl)methyl-8-azabicycl...)
Show SMILES CC(C)(C)NC(=O)CN1[C@H]2CC[C@@H]1C[C@@H](CNC(=O)c1coc3ccccc13)C2
Show InChI InChI=1S/C23H31N3O3/c1-23(2,3)25-21(27)13-26-16-8-9-17(26)11-15(10-16)12-24-22(28)19-14-29-20-7-5-4-6-18(19)20/h4-7,14-17H,8-13H2,1-3H3,(H,24,28)(H,25,27)/t15-,16-,17+
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n/an/a 3n/an/an/an/an/an/a



Toa Eiyo Ltd

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452243
PNG
(CHEMBL4205005)
Show SMILES CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1
Show InChI InChI=1S/C20H20F2N4O/c1-25(2)16-6-3-14(4-7-16)12-20(27)23-19-9-10-26(24-19)13-15-5-8-17(21)18(22)11-15/h3-11H,12-13H2,1-2H3,(H,23,24,27)
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n/an/a 3.40n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452233
PNG
(CHEMBL4203101)
Show SMILES CN1C(=O)C(C)(C)c2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C23H22F2N4O2/c1-23(2)16-10-14(5-7-19(16)28(3)22(23)31)12-21(30)26-20-8-9-29(27-20)13-15-4-6-17(24)18(25)11-15/h4-11H,12-13H2,1-3H3,(H,26,27,30)
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n/an/a 3.80n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50322938
PNG
(2-(3-chloro-4-fluorophenyl)-N-(3,5-difluorophenyl)...)
Show SMILES Fc1cc(F)cc(NC(=O)N2CCC3(CC2)C(N(C3=O)c2ccc(F)c(Cl)c2)c2ccccn2)c1
Show InChI InChI=1S/C25H20ClF3N4O2/c26-19-14-18(4-5-20(19)29)33-22(21-3-1-2-8-30-21)25(23(33)34)6-9-32(10-7-25)24(35)31-17-12-15(27)11-16(28)13-17/h1-5,8,11-14,22H,6-7,9-10H2,(H,31,35)
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratory

Curated by ChEMBL


Assay Description
Inhibition of human CaV3.2 expressed in HEK293 cells at -100 mV membrane potential by Ionworks HT assay


Bioorg Med Chem Lett 20: 4602-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.012
BindingDB Entry DOI: 10.7270/Q2NS0V34
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452301
PNG
(CHEMBL4204077)
Show SMILES CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(Cl)cc3)n2)cc1
Show InChI InChI=1S/C20H21ClN4O/c1-24(2)18-9-5-15(6-10-18)13-20(26)22-19-11-12-25(23-19)14-16-3-7-17(21)8-4-16/h3-12H,13-14H2,1-2H3,(H,22,23,26)
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n/an/a 4.10n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452289
PNG
(CHEMBL4215974)
Show SMILES CC1(COC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1
Show InChI InChI=1S/C22H21F2N3O2/c1-22(13-29-14-22)17-5-2-15(3-6-17)11-21(28)25-20-8-9-27(26-20)12-16-4-7-18(23)19(24)10-16/h2-10H,11-14H2,1H3,(H,25,26,28)
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n/an/a 4.30n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452236
PNG
(CHEMBL4204507)
Show SMILES CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)(F)F)cc3)n2)cc1
Show InChI InChI=1S/C21H21F3N4O2/c1-27(2)17-7-3-15(4-8-17)13-20(29)25-19-11-12-28(26-19)14-16-5-9-18(10-6-16)30-21(22,23)24/h3-12H,13-14H2,1-2H3,(H,25,26,29)
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n/an/a 5.10n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452256
PNG
(CHEMBL4212039)
Show SMILES Fc1ccc(Cn2ccc(NC(=O)Cc3ccc4cc[nH]c4c3)n2)cc1F
Show InChI InChI=1S/C20H16F2N4O/c21-16-4-2-14(9-17(16)22)12-26-8-6-19(25-26)24-20(27)11-13-1-3-15-5-7-23-18(15)10-13/h1-10,23H,11-12H2,(H,24,25,27)
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n/an/a 5.30n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452257
PNG
(CHEMBL4205399)
Show SMILES CC(C)c1ccc(CC(=O)Nc2ccn(CC3CCC(F)(F)CO3)n2)cc1
Show InChI InChI=1S/C20H25F2N3O2/c1-14(2)16-5-3-15(4-6-16)11-19(26)23-18-8-10-25(24-18)12-17-7-9-20(21,22)13-27-17/h3-6,8,10,14,17H,7,9,11-13H2,1-2H3,(H,23,24,26)
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n/an/a 5.5n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452294
PNG
(CHEMBL4207031)
Show SMILES CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1
Show InChI InChI=1S/C21H21F2N3O/c1-14(2)17-6-3-15(4-7-17)12-21(27)24-20-9-10-26(25-20)13-16-5-8-18(22)19(23)11-16/h3-11,14H,12-13H2,1-2H3,(H,24,25,27)
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n/an/a 6n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50200910
PNG
(CHEMBL3906825)
Show SMILES C[C@@H]1CN(Cc2ccccc2)c2nc(F)ccc2[C@H](C)N1C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H27FN4O/c1-18-16-29(17-21-11-7-4-8-12-21)24-22(13-14-23(26)28-24)19(2)30(18)25(31)27-15-20-9-5-3-6-10-20/h3-14,18-19H,15-17H2,1-2H3,(H,27,31)/t18-,19+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...


J Med Chem 59: 10661-10675 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01356
BindingDB Entry DOI: 10.7270/Q2RV0QN8
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452242
PNG
(CHEMBL4206509)
Show SMILES Fc1ccc(Cn2ccc(NC(=O)Cc3ccc(cc3)C3CC(F)(F)C3)n2)cc1F
Show InChI InChI=1S/C22H19F4N3O/c23-18-6-3-15(9-19(18)24)13-29-8-7-20(28-29)27-21(30)10-14-1-4-16(5-2-14)17-11-22(25,26)12-17/h1-9,17H,10-13H2,(H,27,28,30)
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n/an/a 6.10n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372453
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES Cn1ccc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C20H17F2N5O/c1-26-7-6-15-8-13(3-5-18(15)26)10-20(28)24-19-11-23-27(25-19)12-14-2-4-16(21)17(22)9-14/h2-9,11H,10,12H2,1H3,(H,24,25,28)
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n/an/a 6.40n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50451717
PNG
(CHEMBL4202587)
Show SMILES CC(C)OCc1ccccc1CNC(=O)c1c2CCC(C)(C)Cc2c(Cl)n1C
Show InChI InChI=1S/C23H31ClN2O2/c1-15(2)28-14-17-9-7-6-8-16(17)13-25-22(27)20-18-10-11-23(3,4)12-19(18)21(24)26(20)5/h6-9,15H,10-14H2,1-5H3,(H,25,27)
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n/an/a 6.60n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cav3.2 expressed in HEK293 cells assessed as reduction in CaCl2-induced intracellular calcium flux incubated for 20 m...


Bioorg Med Chem Lett 27: 5326-5331 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452323
PNG
(CHEMBL4214862)
Show SMILES Fc1ccc(Cn2ccc(NC(=O)Cc3ccc(nc3)N3CCC(F)(F)C3)n2)cc1F
Show InChI InChI=1S/C21H19F4N5O/c22-16-3-1-15(9-17(16)23)12-30-7-5-18(28-30)27-20(31)10-14-2-4-19(26-11-14)29-8-6-21(24,25)13-29/h1-5,7,9,11H,6,8,10,12-13H2,(H,27,28,31)
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n/an/a 6.70n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452258
PNG
(CHEMBL4208907)
Show SMILES Cc1cc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)ccc1OCC(F)(F)F
Show InChI InChI=1S/C21H18F3N5O2/c1-14-8-15(3-5-18(14)31-13-21(22,23)24)9-20(30)27-19-6-7-29(28-19)12-17-4-2-16(10-25)11-26-17/h2-8,11H,9,12-13H2,1H3,(H,27,28,30)
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n/an/a 7n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372463
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES Fc1ccc(Cn2ncc(NC(=O)Cc3ccc(nc3)N3CCC(F)(F)C3)n2)cc1F
Show InChI InChI=1S/C20H18F4N6O/c21-15-3-1-14(7-16(15)22)11-30-26-10-17(28-30)27-19(31)8-13-2-4-18(25-9-13)29-6-5-20(23,24)12-29/h1-4,7,9-10H,5-6,8,11-12H2,(H,27,28,31)
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n/an/a 7.30n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372533
PNG
(2-(1-Methyl-1H-indol-5-yl)-N-[2-(4-trifluoromethox...)
Show SMILES Cn1ccc2cc(CC(=O)Nc3cnn(Cc4ccc(OC(F)(F)F)cc4)n3)ccc12
Show InChI InChI=1S/C21H18F3N5O2/c1-28-9-8-16-10-15(4-7-18(16)28)11-20(30)26-19-12-25-29(27-19)13-14-2-5-17(6-3-14)31-21(22,23)24/h2-10,12H,11,13H2,1H3,(H,26,27,30)
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n/an/a 7.40n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452303
PNG
(CHEMBL4218608)
Show SMILES CC(C)(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)cc1
Show InChI InChI=1S/C22H23N5O/c1-22(2,3)18-7-4-16(5-8-18)12-21(28)25-20-10-11-27(26-20)15-19-9-6-17(13-23)14-24-19/h4-11,14H,12,15H2,1-3H3,(H,25,26,28)
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n/an/a 7.5n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452246
PNG
(CHEMBL4216687)
Show SMILES COc1c(F)cc(Cn2ccc(NC(=O)Cc3ccc(cc3)N(C)C)n2)cc1F
Show InChI InChI=1S/C21H22F2N4O2/c1-26(2)16-6-4-14(5-7-16)12-20(28)24-19-8-9-27(25-19)13-15-10-17(22)21(29-3)18(23)11-15/h4-11H,12-13H2,1-3H3,(H,24,25,28)
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n/an/a 7.80n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452238
PNG
(CHEMBL4207291)
Show SMILES CCc1cc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)ccc1OCC(F)(F)F
Show InChI InChI=1S/C22H20F3N5O2/c1-2-17-9-15(4-6-19(17)32-14-22(23,24)25)10-21(31)28-20-7-8-30(29-20)13-18-5-3-16(11-26)12-27-18/h3-9,12H,2,10,13-14H2,1H3,(H,28,29,31)
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n/an/a 7.80n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50192668
PNG
(CHEMBL1684950)
Show SMILES CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1
Show InChI InChI=1S/C20H23F3N2O2/c1-13(2)16-6-4-15(5-7-16)10-19(26)25-14(3)18-9-8-17(11-24-18)27-12-20(21,22)23/h4-9,11,13-14H,10,12H2,1-3H3,(H,25,26)/t14-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of human T-type calcium channel Cav3.2 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...


J Med Chem 59: 8398-411 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00756
BindingDB Entry DOI: 10.7270/Q2J67JWK
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50192668
PNG
(CHEMBL1684950)
Show SMILES CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1
Show InChI InChI=1S/C20H23F3N2O2/c1-13(2)16-6-4-15(5-7-16)10-19(26)25-14(3)18-9-8-17(11-24-18)27-12-20(21,22)23/h4-9,11,13-14H,10,12H2,1-3H3,(H,25,26)/t14-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Inhibition of CaV 3.2 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assay


J Med Chem 59: 10661-10675 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01356
BindingDB Entry DOI: 10.7270/Q2RV0QN8
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452305
PNG
(CHEMBL4203847)
Show SMILES Cn1ncc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C20H17F2N5O/c1-26-18-5-3-13(8-15(18)11-23-26)10-20(28)24-19-6-7-27(25-19)12-14-2-4-16(21)17(22)9-14/h2-9,11H,10,12H2,1H3,(H,24,25,28)
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n/an/a 8.40n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372452
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C19H16F2N6O/c1-26-17-5-3-12(6-14(17)9-22-26)8-19(28)24-18-10-23-27(25-18)11-13-2-4-15(20)16(21)7-13/h2-7,9-10H,8,11H2,1H3,(H,24,25,28)
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n/an/a 8.60n/an/an/an/an/an/a



Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372629
PNG
(N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,...)
Show SMILES Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(OC(F)(F)F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C20H16F4N6O2/c1-29-16-4-2-12(6-14(16)9-25-29)8-19(31)27-18-10-26-30(28-18)11-13-3-5-17(15(21)7-13)32-20(22,23)24/h2-7,9-10H,8,11H2,1H3,(H,27,28,31)
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n/an/a 8.80n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50200787
PNG
(CHEMBL3906199)
Show SMILES C[C@@H]1CN(Cc2cccc(F)c2F)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1
Show InChI InChI=1S/C26H27F2N3O/c1-18-16-30(17-21-11-8-13-23(27)25(21)28)24-14-7-6-12-22(24)19(2)31(18)26(32)29-15-20-9-4-3-5-10-20/h3-14,18-19H,15-17H2,1-2H3,(H,29,32)/t18-,19+/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...


J Med Chem 59: 10661-10675 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01356
BindingDB Entry DOI: 10.7270/Q2RV0QN8
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372452
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C19H16F2N6O/c1-26-17-5-3-12(6-14(17)9-22-26)8-19(28)24-18-10-23-27(25-18)11-13-2-4-15(20)16(21)7-13/h2-7,9-10H,8,11H2,1H3,(H,24,25,28)
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n/an/a 9.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372465
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES CN1C(=O)C(C)(C)c2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C22H21F2N5O2/c1-22(2)15-8-13(5-7-18(15)28(3)21(22)31)10-20(30)26-19-11-25-29(27-19)12-14-4-6-16(23)17(24)9-14/h4-9,11H,10,12H2,1-3H3,(H,26,27,30)
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n/an/a 9.70n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372473
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES CCn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc12
Show InChI InChI=1S/C20H18F2N6O/c1-2-27-18-6-4-13(7-15(18)10-23-27)9-20(29)25-19-11-24-28(26-19)12-14-3-5-16(21)17(22)8-14/h3-8,10-11H,2,9,12H2,1H3,(H,25,26,29)
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IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372534
PNG
(2-(1-Methyl-1H-indazol-5-yl)-N-[2-(4-trifluorometh...)
Show SMILES Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(OC(F)(F)F)cc4)n3)ccc12
Show InChI InChI=1S/C20H17F3N6O2/c1-28-17-7-4-14(8-15(17)10-24-28)9-19(30)26-18-11-25-29(27-18)12-13-2-5-16(6-3-13)31-20(21,22)23/h2-8,10-11H,9,12H2,1H3,(H,26,27,30)
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n/an/a 9.90n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452229
PNG
(CHEMBL4209376)
Show SMILES CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)F)cc3)n2)cc1
Show InChI InChI=1S/C21H22F2N4O2/c1-26(2)17-7-3-15(4-8-17)13-20(28)24-19-11-12-27(25-19)14-16-5-9-18(10-6-16)29-21(22)23/h3-12,21H,13-14H2,1-2H3,(H,24,25,28)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452269
PNG
(CHEMBL4213335)
Show SMILES CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C)cc3)n2)cc1
Show InChI InChI=1S/C21H24N4O/c1-16-4-6-18(7-5-16)15-25-13-12-20(23-25)22-21(26)14-17-8-10-19(11-9-17)24(2)3/h4-13H,14-15H2,1-3H3,(H,22,23,26)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452225
PNG
(CHEMBL4203748)
Show SMILES CC1(C)OCC(O1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1
Show InChI InChI=1S/C23H23F2N3O3/c1-23(2)30-14-20(31-23)17-6-3-15(4-7-17)12-22(29)26-21-9-10-28(27-21)13-16-5-8-18(24)19(25)11-16/h3-11,20H,12-14H2,1-2H3,(H,26,27,29)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372536
PNG
(2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-...)
Show SMILES Fc1ccc(Cn2ncc(NC(=O)Cc3ccc(nc3)N3CCC(F)(F)C3)n2)cc1
Show InChI InChI=1S/C20H19F3N6O/c21-16-4-1-14(2-5-16)12-29-25-11-17(27-29)26-19(30)9-15-3-6-18(24-10-15)28-8-7-20(22,23)13-28/h1-6,10-11H,7-9,12-13H2,(H,26,27,30)
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IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM364007
PNG
(US9856250, 84)
Show SMILES CCC1=C(C2C=CC=CC2O1)C(=O)NC[C@H]1C[C@@H]2CC[C@H](C1)N2CC(=O)NC(C)(C)C
Show InChI InChI=1S/C25H37N3O3/c1-5-20-23(19-8-6-7-9-21(19)31-20)24(30)26-14-16-12-17-10-11-18(13-16)28(17)15-22(29)27-25(2,3)4/h6-9,16-19,21H,5,10-15H2,1-4H3,(H,26,30)(H,27,29)/t16-,17-,18+,19?,21?
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n/an/a 10n/an/an/an/an/an/a



Toa Eiyo Ltd

US Patent


Assay Description
The HEK293 cells having human Cav3.2 stably expressed therein were cultured at 37 C. in Alpha-MEM, to which 10% (v/v) fetal bovine serum (FBS), peni...


US Patent US9856250 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452306
PNG
(CHEMBL4211105)
Show SMILES Fc1ccc(Cn2ccc(NC(=O)Cc3ccc(OC4CC(F)(F)C4)cc3)n2)cc1F
Show InChI InChI=1S/C22H19F4N3O2/c23-18-6-3-15(9-19(18)24)13-29-8-7-20(28-29)27-21(30)10-14-1-4-16(5-2-14)31-17-11-22(25,26)12-17/h1-9,17H,10-13H2,(H,27,28,30)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372637
PNG
(2-(1,3-Dimethyl-1H-indazol-5-yl)-N-[2-(3-fluoro-4-...)
Show SMILES Cc1nn(C)c2ccc(CC(=O)Nc3cnn(Cc4ccc(OC(F)(F)F)c(F)c4)n3)cc12
Show InChI InChI=1S/C21H18F4N6O2/c1-12-15-7-13(3-5-17(15)30(2)28-12)9-20(32)27-19-10-26-31(29-19)11-14-4-6-18(16(22)8-14)33-21(23,24)25/h3-8,10H,9,11H2,1-2H3,(H,27,29,32)
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IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372477
PNG
(N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]...)
Show SMILES Cc1cc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc2[nH]1
Show InChI InChI=1S/C20H17F2N5O/c1-12-6-15-7-13(3-5-18(15)24-12)9-20(28)25-19-10-23-27(26-19)11-14-2-4-16(21)17(22)8-14/h2-8,10,24H,9,11H2,1H3,(H,25,26,28)
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n/an/a 11n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50200898
PNG
(CHEMBL3924174)
Show SMILES C[C@@H]1CN(Cc2ccccc2F)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1
Show InChI InChI=1S/C24H25FN4O/c1-17-15-28(16-19-8-3-5-11-22(19)25)23-12-6-4-10-21(23)18(2)29(17)24(30)27-20-9-7-13-26-14-20/h3-14,17-18H,15-16H2,1-2H3,(H,27,30)/t17-,18+/m1/s1
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Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...


J Med Chem 59: 10661-10675 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01356
BindingDB Entry DOI: 10.7270/Q2RV0QN8
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50452325
PNG
(CHEMBL4208950)
Show SMILES CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)cc3)n2)cc1
Show InChI InChI=1S/C20H21FN4O/c1-24(2)18-9-5-15(6-10-18)13-20(26)22-19-11-12-25(23-19)14-16-3-7-17(21)8-4-16/h3-12H,13-14H2,1-2H3,(H,22,23,26)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50451723
PNG
(CHEMBL4205453)
Show SMILES Cn1c(Cl)c2CC(C)(C)CCc2c1C(=O)NCc1ccccc1Cn1cccn1
Show InChI InChI=1S/C23H27ClN4O/c1-23(2)10-9-18-19(13-23)21(24)27(3)20(18)22(29)25-14-16-7-4-5-8-17(16)15-28-12-6-11-26-28/h4-8,11-12H,9-10,13-15H2,1-3H3,(H,25,29)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Cav3.2 expressed in HEK293 cells assessed as reduction in CaCl2-induced intracellular calcium flux incubated for 20 m...


Bioorg Med Chem Lett 27: 5326-5331 (2017)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM372496
PNG
(N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(...)
Show SMILES Cn1ccc2cc(CC(=O)Nc3cnn(Cc4ccc(F)cc4)n3)ccc12
Show InChI InChI=1S/C20H18FN5O/c1-25-9-8-16-10-15(4-7-18(16)25)11-20(27)23-19-12-22-26(24-19)13-14-2-5-17(21)6-3-14/h2-10,12H,11,13H2,1H3,(H,23,24,27)
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n/an/a 12n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS Ltd

US Patent


Assay Description
Stock solutions of test compounds are prepared to a concentration of 10 mM in DMSO. For the Cav3.2 assay, serial dilutions of the compounds are prepa...


US Patent US10246426 (2019)

More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))
BDBM50200904
PNG
(CHEMBL3936835)
Show SMILES C[C@@H]1CN(Cc2ccccc2)c2cc(F)ccc2[C@H](C)N1C(=O)Nc1cccnc1
Show InChI InChI=1S/C24H25FN4O/c1-17-15-28(16-19-7-4-3-5-8-19)23-13-20(25)10-11-22(23)18(2)29(17)24(30)27-21-9-6-12-26-14-21/h3-14,17-18H,15-16H2,1-2H3,(H,27,30)/t17-,18+/m1/s1
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Actelion Pharmaceuticals Ltd

Curated by ChEMBL


Assay Description
Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...


J Med Chem 59: 10661-10675 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01356
BindingDB Entry DOI: 10.7270/Q2RV0QN8
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Rattus norvegicus)
BDBM50452245
PNG
(ACT-709478 | Act-709478)
Show SMILES FC(F)(F)C1(CC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)cc1
Show InChI InChI=1S/C22H18F3N5O/c23-22(24,25)21(8-9-21)17-4-1-15(2-5-17)11-20(31)28-19-7-10-30(29-19)14-18-6-3-16(12-26)13-27-18/h1-7,10,13H,8-9,11,14H2,(H,28,29,31)
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Idorsia Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Cav3.2 in rat assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assa...


J Med Chem 60: 9769-9789 (2017)

More data for this
Ligand-Target Pair
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