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Compile Data Set for Download or QSAR

Found 57 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent calcium channel alpha2delta subunit' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305900
PNG
((+)-2-((1S,5S,6R)-6-(aminomethyl)bicyclo[3.2.0]hep...)
Show SMILES NC[C@@]1(CC(O)=O)C[C@@H]2CCC[C@H]12
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)4-7-2-1-3-8(7)10/h7-8H,1-6,11H2,(H,12,13)/t7-,8-,10-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305887
PNG
(3,4-trans-2-(1-(aminomethyl)-3,4-dimethylcyclopent...)
Show SMILES C[C@H]1CC(CN)(CC(O)=O)C[C@@H]1C
Show InChI InChI=1S/C10H19NO2/c1-7-3-10(6-11,4-8(7)2)5-9(12)13/h7-8H,3-6,11H2,1-2H3,(H,12,13)/t7-,8-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305894
PNG
((+/-)-2-((6S)-6-(aminomethyl)bicyclo[3.2.0]heptan-...)
Show SMILES NC[C@]1(CC(O)=O)CC2CCCC12
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)4-7-2-1-3-8(7)10/h7-8H,1-6,11H2,(H,12,13)/t7?,8?,10-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304703
PNG
(2-((3R)-1-(aminomethyl)-3-propylcyclopentyl)acetic...)
Show SMILES CCC[C@@H]1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C11H21NO2/c1-2-3-9-4-5-11(6-9,8-12)7-10(13)14/h9H,2-8,12H2,1H3,(H,13,14)/t9-,11?/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304707
PNG
(2-((1R,3R)-1-(aminomethyl)-3-methylcyclopentyl)ace...)
Show SMILES C[C@@H]1CC[C@](CN)(CC(O)=O)C1
Show InChI InChI=1S/C9H17NO2/c1-7-2-3-9(4-7,6-10)5-8(11)12/h7H,2-6,10H2,1H3,(H,11,12)/t7-,9-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305885
PNG
(CHEMBL595172 | cis-2-((1R,5S)-3-(aminomethyl)bicyc...)
Show SMILES NC[C@@]1(CC(O)=O)C[C@@H]2CC[C@@H]2C1
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)3-7-1-2-8(7)4-10/h7-8H,1-6,11H2,(H,12,13)/t7-,8+,10-
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n/an/a 38n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305899
PNG
((-)-2-((1R,5R,6S)-6-(aminomethyl)bicyclo[3.2.0]hep...)
Show SMILES NC[C@]1(CC(O)=O)C[C@H]2CCC[C@@H]12
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)4-7-2-1-3-8(7)10/h7-8H,1-6,11H2,(H,12,13)/t7-,8-,10-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304702
PNG
(2-((3R)-1-(aminomethyl)-3-ethylcyclopentyl)acetic ...)
Show SMILES CC[C@@H]1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C10H19NO2/c1-2-8-3-4-10(5-8,7-11)6-9(12)13/h8H,2-7,11H2,1H3,(H,12,13)/t8-,10?/m1/s1
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n/an/a 53n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304693
PNG
(2-(1-(aminomethyl)-3-ethylcyclopentyl)acetic acid ...)
Show SMILES CCC1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C10H19NO2/c1-2-8-3-4-10(5-8,7-11)6-9(12)13/h8H,2-7,11H2,1H3,(H,12,13)
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n/an/a 55n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304694
PNG
(2-(1-(aminomethyl)-3-propylcyclopentyl)acetic acid...)
Show SMILES CCCC1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C11H21NO2/c1-2-3-9-4-5-11(6-9,8-12)7-10(13)14/h9H,2-8,12H2,1H3,(H,13,14)
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n/an/a 69n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50080153
PNG
((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Show SMILES NCC1(CC(O)=O)CCCCC1
Show InChI InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
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n/an/a 70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304708
PNG
(2-((1S,3R)-1-(aminomethyl)-3-methylcyclopentyl)ace...)
Show SMILES C[C@@H]1CC[C@@](CN)(CC(O)=O)C1
Show InChI InChI=1S/C9H17NO2/c1-7-2-3-9(4-7,6-10)5-8(11)12/h7H,2-6,10H2,1H3,(H,11,12)/t7-,9+/m1/s1
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n/an/a 71n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50164279
PNG
((S)-3-(aminomethyl)-5-methylhexanoic acid | (S)-3-...)
Show SMILES CC(C)C[C@H](CN)CC(O)=O
Show InChI InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
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n/an/a 73n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50164279
PNG
((S)-3-(aminomethyl)-5-methylhexanoic acid | (S)-3-...)
Show SMILES CC(C)C[C@H](CN)CC(O)=O
Show InChI InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304692
PNG
(2-(1-(aminomethyl)-3-methylcyclopentyl)acetic acid...)
Show SMILES CC1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C9H17NO2/c1-7-2-3-9(4-7,6-10)5-8(11)12/h7H,2-6,10H2,1H3,(H,11,12)
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n/an/a 82n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304701
PNG
(2-((3R)-1-(aminomethyl)-3-methylcyclopentyl)acetic...)
Show SMILES C[C@@H]1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C9H17NO2/c1-7-2-3-9(4-7,6-10)5-8(11)12/h7H,2-6,10H2,1H3,(H,11,12)/t7-,9?/m1/s1
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n/an/a 88n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50168499
PNG
((1-((1H-tetrazol-5-yl)methyl)cycloheptyl)methanami...)
Show SMILES NCC1(Cc2nnn[nH]2)CCCCCC1
Show InChI InChI=1S/C10H19N5/c11-8-10(5-3-1-2-4-6-10)7-9-12-14-15-13-9/h1-8,11H2,(H,12,13,14,15)
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n/an/a 100n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305886
PNG
(2-((3R,4S)-1-(aminomethyl)-3,4-dimethylcyclopentyl...)
Show SMILES C[C@H]1C[C@](CN)(CC(O)=O)C[C@H]1C
Show InChI InChI=1S/C10H19NO2/c1-7-3-10(6-11,4-8(7)2)5-9(12)13/h7-8H,3-6,11H2,1-2H3,(H,12,13)/t7-,8+,10+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50212317
PNG
((1-((1H-tetrazol-5-yl)methyl)cyclohexyl)methanamin...)
Show SMILES NCC1(Cc2nnn[nH]2)CCCCC1
Show InChI InChI=1S/C9H17N5/c10-7-9(4-2-1-3-5-9)6-8-11-13-14-12-8/h1-7,10H2,(H,11,12,13,14)
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n/an/a 108n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50080153
PNG
((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Show SMILES NCC1(CC(O)=O)CCCCC1
Show InChI InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
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n/an/a 140n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50171790
PNG
((S)-3-(aminomethyl)-4-(furan-2-yl)butanoic acid | ...)
Show SMILES NC[C@H](CC(O)=O)Cc1ccco1
Show InChI InChI=1S/C9H13NO3/c10-6-7(5-9(11)12)4-8-2-1-3-13-8/h1-3,7H,4-6,10H2,(H,11,12)/t7-/m0/s1
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n/an/a 178n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305884
PNG
(CHEMBL609569 | cis-2-((1R,5S)-3-(aminomethyl)bicyc...)
Show SMILES NC[C@]1(CC(O)=O)C[C@@H]2CC[C@@H]2C1
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)3-7-1-2-8(7)4-10/h7-8H,1-6,11H2,(H,12,13)/t7-,8+,10+
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n/an/a 332n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304691
PNG
(CHEMBL610734 | Gababutin)
Show SMILES NCC1(CC(O)=O)CCCC1
Show InChI InChI=1S/C8H15NO2/c9-6-8(5-7(10)11)3-1-2-4-8/h1-6,9H2,(H,10,11)
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n/an/a 420n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50171795
PNG
(3-(aminomethyl)-4-(furan-2-yl)butanoic acid | CHEM...)
Show SMILES NCC(CC(O)=O)Cc1ccco1
Show InChI InChI=1S/C9H13NO3/c10-6-7(5-9(11)12)4-8-2-1-3-13-8/h1-3,7H,4-6,10H2,(H,11,12)
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n/an/a 421n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50171794
PNG
(3-(aminomethyl)-4-(furan-3-yl)butanoic acid | CHEM...)
Show SMILES NCC(CC(O)=O)Cc1ccoc1
Show InChI InChI=1S/C9H13NO3/c10-5-8(4-9(11)12)3-7-1-2-13-6-7/h1-2,6,8H,3-5,10H2,(H,11,12)
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n/an/a 518n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305897
PNG
((+/-)-2-((7S)-7-(aminomethyl)bicyclo[4.2.0]octan-7...)
Show SMILES NC[C@]1(CC(O)=O)CC2CCCCC12
Show InChI InChI=1S/C11H19NO2/c12-7-11(6-10(13)14)5-8-3-1-2-4-9(8)11/h8-9H,1-7,12H2,(H,13,14)/t8?,9?,11-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304695
PNG
(2-(1-(aminomethyl)-3-butylcyclopentyl)acetic acid ...)
Show SMILES CCCCC1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C12H23NO2/c1-2-3-4-10-5-6-12(7-10,9-13)8-11(14)15/h10H,2-9,13H2,1H3,(H,14,15)
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n/an/a 690n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304705
PNG
(2-((3S)-1-(aminomethyl)-3-ethylcyclopentyl)acetic ...)
Show SMILES CC[C@H]1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C10H19NO2/c1-2-8-3-4-10(5-8,7-11)6-9(12)13/h8H,2-7,11H2,1H3,(H,12,13)/t8-,10?/m0/s1
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n/an/a 706n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305892
PNG
(2-((2R,3aR)-2-(aminomethyl)octahydro-1H-inden-2-yl...)
Show SMILES NC[C@]1(CC(O)=O)C[C@H]2CCCC[C@H]2C1
Show InChI InChI=1S/C12H21NO2/c13-8-12(7-11(14)15)5-9-3-1-2-4-10(9)6-12/h9-10H,1-8,13H2,(H,14,15)/t9-,10+,12-
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n/an/a 720n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304696
PNG
(2-(1-(aminomethyl)-3-isobutylcyclopentyl)acetic ac...)
Show SMILES CC(C)CC1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C12H23NO2/c1-9(2)5-10-3-4-12(6-10,8-13)7-11(14)15/h9-10H,3-8,13H2,1-2H3,(H,14,15)
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n/an/a 760n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50171796
PNG
(3-(aminomethyl)-4-(thiophen-3-yl)butanoic acid | C...)
Show SMILES NCC(CC(O)=O)Cc1ccsc1
Show InChI InChI=1S/C9H13NO2S/c10-5-8(4-9(11)12)3-7-1-2-13-6-7/h1-2,6,8H,3-5,10H2,(H,11,12)
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n/an/a 832n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304706
PNG
(2-((3S)-1-(aminomethyl)-3-propylcyclopentyl)acetic...)
Show SMILES CCC[C@H]1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C11H21NO2/c1-2-3-9-4-5-11(6-9,8-12)7-10(13)14/h9H,2-8,12H2,1H3,(H,13,14)/t9-,11?/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304704
PNG
(2-((3S)-1-(aminomethyl)-3-methylcyclopentyl)acetic...)
Show SMILES C[C@H]1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C9H17NO2/c1-7-2-3-9(4-7,6-10)5-8(11)12/h7H,2-6,10H2,1H3,(H,11,12)/t7-,9?/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50171792
PNG
((R)-3-(aminomethyl)-4-(furan-2-yl)butanoic acid | ...)
Show SMILES NC[C@@H](CC(O)=O)Cc1ccco1
Show InChI InChI=1S/C9H13NO3/c10-6-7(5-9(11)12)4-8-2-1-3-13-8/h1-3,7H,4-6,10H2,(H,11,12)/t7-/m1/s1
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n/an/a 1.46E+3n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50168498
PNG
((S)-2-((1H-tetrazol-5-yl)methyl)-4-methylpentan-1-...)
Show SMILES CC(C)C[C@H](CN)Cc1nnn[nH]1
Show InChI InChI=1S/C8H17N5/c1-6(2)3-7(5-9)4-8-10-12-13-11-8/h6-7H,3-5,9H2,1-2H3,(H,10,11,12,13)/t7-/m0/s1
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n/an/a 1.59E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50171789
PNG
(3-(aminomethyl)-4-(thiophen-2-yl)butanoic acid | C...)
Show SMILES NCC(CC(O)=O)Cc1cccs1
Show InChI InChI=1S/C9H13NO2S/c10-6-7(5-9(11)12)4-8-2-1-3-13-8/h1-3,7H,4-6,10H2,(H,11,12)
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n/an/a 2.14E+3n/an/an/an/an/an/a



PGRD Michigan Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50168502
PNG
((1-((1H-tetrazol-5-yl)methyl)cyclooctyl)methanamin...)
Show SMILES NCC1(Cc2nnn[nH]2)CCCCCCC1
Show InChI InChI=1S/C11H21N5/c12-9-11(8-10-13-15-16-14-10)6-4-2-1-3-5-7-11/h1-9,12H2,(H,13,14,15,16)
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n/an/a 2.36E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305890
PNG
(2-((2R,3aR)-2-(aminomethyl)octahydropentalen-2-yl)...)
Show SMILES NC[C@@]1(CC(O)=O)C[C@@H]2CCC[C@@H]2C1
Show InChI InChI=1S/C11H19NO2/c12-7-11(6-10(13)14)4-8-2-1-3-9(8)5-11/h8-9H,1-7,12H2,(H,13,14)/t8-,9+,11-
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n/an/a 2.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305895
PNG
((+/-)-2-((6R)-6-(aminomethyl)bicyclo[3.2.0]heptan-...)
Show SMILES NC[C@@]1(CC(O)=O)CC2CCCC12
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)4-7-2-1-3-8(7)10/h7-8H,1-6,11H2,(H,12,13)/t7?,8?,10-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305884
PNG
(CHEMBL609569 | cis-2-((1R,5S)-3-(aminomethyl)bicyc...)
Show SMILES NC[C@]1(CC(O)=O)C[C@@H]2CC[C@@H]2C1
Show InChI InChI=1S/C10H17NO2/c11-6-10(5-9(12)13)3-7-1-2-8(7)4-10/h7-8H,1-6,11H2,(H,12,13)/t7-,8+,10+
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n/an/a 2.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305898
PNG
((+/-)-2-((7R)-7-(aminomethyl)bicyclo[4.2.0]octan-7...)
Show SMILES NC[C@@]1(CC(O)=O)CC2CCCCC12
Show InChI InChI=1S/C11H19NO2/c12-7-11(6-10(13)14)5-8-3-1-2-4-9(8)11/h8-9H,1-7,12H2,(H,13,14)/t8?,9?,11-/m0/s1
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n/an/a 3.09E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304690
PNG
(2-(1-(aminomethyl)-3,3-dimethylcyclopentyl)acetic ...)
Show SMILES CC1(C)CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C10H19NO2/c1-9(2)3-4-10(6-9,7-11)5-8(12)13/h3-7,11H2,1-2H3,(H,12,13)
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n/an/a 3.18E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304698
PNG
(2-(1-(aminomethyl)-3-phenylcyclopentyl)acetic acid...)
Show SMILES NCC1(CC(O)=O)CCC(C1)c1ccccc1
Show InChI InChI=1S/C14H19NO2/c15-10-14(9-13(16)17)7-6-12(8-14)11-4-2-1-3-5-11/h1-5,12H,6-10,15H2,(H,16,17)
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n/an/a 5.06E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304700
PNG
(2-(1-(aminomethyl)-3-phenethylcyclopentyl)acetic a...)
Show SMILES NCC1(CC(O)=O)CCC(CCc2ccccc2)C1
Show InChI InChI=1S/C16H23NO2/c17-12-16(11-15(18)19)9-8-14(10-16)7-6-13-4-2-1-3-5-13/h1-5,14H,6-12,17H2,(H,18,19)
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n/an/a 6.23E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305896
PNG
((+/-)-2-((1S)-1-(aminomethyl)octahydropentalen-1-y...)
Show SMILES NC[C@]1(CC(O)=O)CCC2CCCC12
Show InChI InChI=1S/C11H19NO2/c12-7-11(6-10(13)14)5-4-8-2-1-3-9(8)11/h8-9H,1-7,12H2,(H,13,14)/t8?,9?,11-/m1/s1
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n/an/a 7.18E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304699
PNG
(2-(1-(aminomethyl)-3-benzylcyclopentyl)acetic acid...)
Show SMILES NCC1(CC(O)=O)CCC(Cc2ccccc2)C1
Show InChI InChI=1S/C15H21NO2/c16-11-15(10-14(17)18)7-6-13(9-15)8-12-4-2-1-3-5-12/h1-5,13H,6-11,16H2,(H,17,18)
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n/an/a 9.28E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305888
PNG
((+/-)-2-(2-(aminomethyl)octahydropentalen-2-yl)ace...)
Show SMILES NCC1(CC(O)=O)CC2CCCC2C1
Show InChI InChI=1S/C11H19NO2/c12-7-11(6-10(13)14)4-8-2-1-3-9(8)5-11/h8-9H,1-7,12H2,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50305891
PNG
(2-((2S,3aR)-2-(aminomethyl)octahydropentalen-2-yl)...)
Show SMILES NC[C@]1(CC(O)=O)C[C@@H]2CCC[C@@H]2C1
Show InChI InChI=1S/C11H19NO2/c12-7-11(6-10(13)14)4-8-2-1-3-9(8)5-11/h8-9H,1-7,12H2,(H,13,14)/t8-,9+,11+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50168504
PNG
((1-((1-methyl-1H-tetrazol-5-yl)methyl)cyclohexyl)m...)
Show SMILES Cn1nnnc1CC1(CN)CCCCC1
Show InChI InChI=1S/C10H19N5/c1-15-9(12-13-14-15)7-10(8-11)5-3-2-4-6-10/h2-8,11H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane


Citation and Details
More data for this
Ligand-Target Pair
Voltage-dependent calcium channel alpha2delta subunit


(Sus scrofa)
BDBM50304697
PNG
(2-(1-(aminomethyl)-3-tert-butylcyclopentyl)acetic ...)
Show SMILES CC(C)(C)C1CCC(CN)(CC(O)=O)C1
Show InChI InChI=1S/C12H23NO2/c1-11(2,3)9-4-5-12(6-9,8-13)7-10(14)15/h9H,4-8,13H2,1-3H3,(H,14,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]gabapentin from calcium channel alpha2delta in pig cerebral cortex membrane after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
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