BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 363 hits Enz. Inhib. hit(s) with Target = 'Voltage-gated L-type calcium channel' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50336640
PNG
((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Show SMILES COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,13,15H,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.20n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50018796
PNG
(2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridi...)
Show SMILES COC([O-])=C1C(C(C(=[OH+])OC)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-6-5-7-12(8-11)19(22)23/h5-8,15,20H,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.20n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM79180
PNG
(2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methy...)
Show SMILES CCOC(=O)C1=C(COCCN)N=C(C)C(C1c1ccccc1Cl)C(=O)OC
Show InChI InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,16-17H,4,9-11,22H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
2n/an/an/an/an/an/an/an/a



Synaptic Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against rat L-type calcium channel


Bioorg Med Chem Lett 9: 2843-8 (1999)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042753
PNG
(2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihy...)
Show SMILES CCCCOC(=O)C1=C(C)N=C(C)C(C1c1ccccc1C(F)(F)F)C(=O)OC
Show InChI InChI=1S/C21H24F3NO4/c1-5-6-11-29-20(27)17-13(3)25-12(2)16(19(26)28-4)18(17)14-9-7-8-10-15(14)21(22,23)24/h7-10,16,18H,5-6,11H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
2.20n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079458
PNG
(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-1-yl-ethy...)
Show SMILES CCOC(=O)C1C(c2c(C)noc2CCc2cccc3ccccc23)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C29H32N2O5/c1-6-34-28(32)25-17(3)30-18(4)26(29(33)35-7-2)27(25)24-19(5)31-36-23(24)16-15-21-13-10-12-20-11-8-9-14-22(20)21/h8-14,25,27H,6-7,15-16H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
2.20n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042754
PNG
(2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihy...)
Show SMILES CCCCCCCCOC(=O)C1=C(C)N=C(C)C(C1c1ccccc1C(F)(F)F)C(=O)OC
Show InChI InChI=1S/C25H32F3NO4/c1-5-6-7-8-9-12-15-33-24(31)21-17(3)29-16(2)20(23(30)32-4)22(21)18-13-10-11-14-19(18)25(26,27)28/h10-11,13-14,20,22H,5-9,12,15H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
2.40n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50336640
PNG
((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Show SMILES COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,13,15H,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
3.5n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50453799
PNG
(NIGULDIPINE | Niguldipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
4.60n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Invitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determined


Citation and Details
More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072809
PNG
(4-[2-(4-Cyano-furazan-3-ylmethoxy)-phenyl]-2,6-dim...)
Show SMILES COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1ccccc1OCc1nonc1C#N
Show InChI InChI=1S/C21H20N4O6/c1-11-17(20(26)28-3)19(18(12(2)23-11)21(27)29-4)13-7-5-6-8-16(13)30-10-15-14(9-22)24-31-25-15/h5-8,17,19H,10H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
4.70n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053877
PNG
(Allyl-(9-allyl-2-{4-[2,2-bis-(4-fluoro-phenyl)-eth...)
Show SMILES Fc1ccc(cc1)C(CNC1CCN(CC1)c1nc(NCC=C)c2ncn(CC=C)c2n1)c1ccc(F)cc1
Show InChI InChI=1S/C30H33F2N7/c1-3-15-33-28-27-29(39(16-4-2)20-35-27)37-30(36-28)38-17-13-25(14-18-38)34-19-26(21-5-9-23(31)10-6-21)22-7-11-24(32)12-8-22/h3-12,20,25-26,34H,1-2,13-19H2,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
5n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079463
PNG
(4-{5-[2-(3-Bromo-phenyl)-ethyl]-3-phenyl-isoxazol-...)
Show SMILES CCOC(=O)C1C(c2c(CCc3cccc(Br)c3)onc2-c2ccccc2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C30H31BrN2O5/c1-5-36-29(34)24-18(3)32-19(4)25(30(35)37-6-2)27(24)26-23(16-15-20-11-10-14-22(31)17-20)38-33-28(26)21-12-8-7-9-13-21/h7-14,17,24,27H,5-6,15-16H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
5.60n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50029426
PNG
(CHEMBL24675 | [2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-...)
Show SMILES COc1ccc(cc1)C1Sc2ccccc2-n2c(CN(C)CCc3ccc(OC)c(OC)c3)ccc12
Show InChI InChI=1S/C30H32N2O3S/c1-31(18-17-21-9-16-27(34-3)28(19-21)35-4)20-23-12-15-26-30(22-10-13-24(33-2)14-11-22)36-29-8-6-5-7-25(29)32(23)26/h5-16,19,30H,17-18,20H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
8.30n/an/an/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channel


J Med Chem 38: 4393-410 (1995)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079459
PNG
(4-[5-(2-Biphenyl-4-yl-ethyl)-3-methyl-isoxazol-4-y...)
Show SMILES CCOC(=O)C1C(c2c(C)noc2CCc2ccc(cc2)-c2ccccc2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C31H34N2O5/c1-6-36-30(34)27-19(3)32-20(4)28(31(35)37-7-2)29(27)26-21(5)33-38-25(26)18-15-22-13-16-24(17-14-22)23-11-9-8-10-12-23/h8-14,16-17,27,29H,6-7,15,18H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
8.70n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50453799
PNG
(NIGULDIPINE | Niguldipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
9n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.


J Med Chem 38: 3681-716 (1995)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50030617
PNG
(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Show SMILES Cc1nc(C)c(C(=O)NCCCN2CCC(CC2)(c2ccccc2)c2ccccc2)c(-c2ccc(cc2)[N+]([O-])=O)c1C(N)=O
Show InChI InChI=1S/C35H37N5O4/c1-24-30(33(36)41)32(26-14-16-29(17-15-26)40(43)44)31(25(2)38-24)34(42)37-20-9-21-39-22-18-35(19-23-39,27-10-5-3-6-11-27)28-12-7-4-8-13-28/h3-8,10-17H,9,18-23H2,1-2H3,(H2,36,41)(H,37,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
>10n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.


J Med Chem 38: 3681-716 (1995)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079464
PNG
(2,6-Dimethyl-4-[3-methyl-5-(2-naphthalen-2-yl-ethy...)
Show SMILES CCOC(=O)C1C(c2c(C)noc2CCc2ccc3ccccc3c2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C29H32N2O5/c1-6-34-28(32)25-17(3)30-18(4)26(29(33)35-7-2)27(25)24-19(5)31-36-23(24)15-13-20-12-14-21-10-8-9-11-22(21)16-20/h8-12,14,16,25,27H,6-7,13,15H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
11n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053873
PNG
(Allyl-(9-allyl-2-{4-[(2-methoxy-10,11-dihydro-5H-d...)
Show SMILES COc1ccc2C(CNC3CCN(CC3)c3nc(NCC=C)c4ncn(CC=C)c4n3)c3ccccc3CCc2c1
Show InChI InChI=1S/C33H39N7O/c1-4-16-34-31-30-32(40(17-5-2)22-36-30)38-33(37-31)39-18-14-25(15-19-39)35-21-29-27-9-7-6-8-23(27)10-11-24-20-26(41-3)12-13-28(24)29/h4-9,12-13,20,22,25,29,35H,1-2,10-11,14-19,21H2,3H3,(H,34,37,38)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
12n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042748
PNG
(2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihy...)
Show SMILES CCCCCCCCCCOC(=O)C1=C(C)N=C(C)C(C1c1ccccc1C(F)(F)F)C(=O)OC
Show InChI InChI=1S/C27H36F3NO4/c1-5-6-7-8-9-10-11-14-17-35-26(33)23-19(3)31-18(2)22(25(32)34-4)24(23)20-15-12-13-16-21(20)27(28,29)30/h12-13,15-16,22,24H,5-11,14,17H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
14n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042756
PNG
(2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihy...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C1=C(C)N=C(C)C(C1c1ccccc1C(F)(F)F)C(=O)OC
Show InChI InChI=1S/C31H44F3NO4/c1-5-6-7-8-9-10-11-12-13-14-15-18-21-39-30(37)27-23(3)35-22(2)26(29(36)38-4)28(27)24-19-16-17-20-25(24)31(32,33)34/h16-17,19-20,26,28H,5-15,18,21H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
16n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042758
PNG
(2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihy...)
Show SMILES CCCCCCCCCCCCOC(=O)C1=C(C)N=C(C)C(C1c1ccccc1C(F)(F)F)C(=O)OC
Show InChI InChI=1S/C29H40F3NO4/c1-5-6-7-8-9-10-11-12-13-16-19-37-28(35)25-21(3)33-20(2)24(27(34)36-4)26(25)22-17-14-15-18-23(22)29(30,31)32/h14-15,17-18,24,26H,5-13,16,19H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
17n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042752
PNG
(CHEMBL122740 | {12-[5-Methoxycarbonyl-2,6-dimethyl...)
Show SMILES COC(=O)C1C(C(C(=O)OCCCCCCCCCCCC[N+](C)(C)C)=C(C)N=C1C)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C32H48F3N2O4/c1-23-27(30(38)40-6)29(25-19-15-16-20-26(25)32(33,34)35)28(24(2)36-23)31(39)41-22-18-14-12-10-8-7-9-11-13-17-21-37(3,4)5/h15-16,19-20,27,29H,7-14,17-18,21-22H2,1-6H3/q+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
17n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042750
PNG
(CHEMBL410937 | {8-[5-Methoxycarbonyl-2,6-dimethyl-...)
Show SMILES COC(=O)C1C(C(C(=O)OCCCCCCCC[N+](C)(C)C)=C(C)N=C1C)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C28H40F3N2O4/c1-19-23(26(34)36-6)25(21-15-11-12-16-22(21)28(29,30)31)24(20(2)32-19)27(35)37-18-14-10-8-7-9-13-17-33(3,4)5/h11-12,15-16,23,25H,7-10,13-14,17-18H2,1-6H3/q+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
17n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072811
PNG
(2,6-Dimethyl-4-[2-(4-methyl-5-oxy-furazan-3-ylmeth...)
Show SMILES COC(=O)C1=C(C)[N-]C(C)=C(C1c1ccccc1OCc1no[n+]([O-])c1C)C(=[OH+])OC
Show InChI InChI=1S/C21H23N3O7/c1-11-17(20(25)28-4)19(18(12(2)22-11)21(26)29-5)14-8-6-7-9-16(14)30-10-15-13(3)24(27)31-23-15/h6-9,19H,10H2,1-5H3,(H,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
18n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072818
PNG
(4-[2-(4-Cyano-5-oxy-furazan-3-ylmethoxy)-phenyl]-2...)
Show SMILES COC(=O)C1=C(C)[N-]C(C)=C(C1c1ccccc1OCc1no[n+]([O-])c1C#N)C(=[OH+])OC
Show InChI InChI=1S/C21H20N4O7/c1-11-17(20(26)29-3)19(18(12(2)23-11)21(27)30-4)13-7-5-6-8-16(13)31-10-14-15(9-22)25(28)32-24-14/h5-8,19H,10H2,1-4H3,(H,23,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
21n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079462
PNG
(2,6-Dimethyl-4-(3-methyl-5-phenethyl-isoxazol-4-yl...)
Show SMILES CCOC(=O)C1C(c2c(C)noc2CCc2ccccc2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C25H30N2O5/c1-6-30-24(28)21-15(3)26-16(4)22(25(29)31-7-2)23(21)20-17(5)27-32-19(20)14-13-18-11-9-8-10-12-18/h8-12,21,23H,6-7,13-14H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
25n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50029415
PNG
((6-Chloro-4,4-diphenyl-4H-benzo[b]pyrrolo[1,2-d][1...)
Show SMILES CN(C)Cc1ccc2n1-c1cccc(Cl)c1SC2(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H23ClN2S/c1-28(2)18-21-16-17-24-26(19-10-5-3-6-11-19,20-12-7-4-8-13-20)30-25-22(27)14-9-15-23(25)29(21)24/h3-17H,18H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
26n/an/an/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channel


J Med Chem 38: 4393-410 (1995)

More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072803
PNG
(2,6-Dimethyl-4-[2-(4-methyl-furazan-3-ylmethoxy)-p...)
Show SMILES COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1ccccc1OCc1nonc1C
Show InChI InChI=1S/C21H23N3O6/c1-11-15(24-30-23-11)10-29-16-9-7-6-8-14(16)19-17(20(25)27-4)12(2)22-13(3)18(19)21(26)28-5/h6-9,17,19H,10H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
27n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072814
PNG
(4-[2-(4-Cyano-2-oxy-furazan-3-ylmethoxy)-phenyl]-2...)
Show SMILES COC(=O)C1=C(C)[N-]C(C)=C(C1c1ccccc1OCc1c(no[n+]1[O-])C#N)C(=[OH+])OC
Show InChI InChI=1S/C21H20N4O7/c1-11-17(20(26)29-3)19(18(12(2)23-11)21(27)30-4)13-7-5-6-8-16(13)31-10-15-14(9-22)24-32-25(15)28/h5-8,19H,10H2,1-4H3,(H,23,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
30n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079460
PNG
(4-{5-[2-(3-Methoxy-phenyl)-ethyl]-3-phenyl-isoxazo...)
Show SMILES CCOC(=O)C1C(c2c(CCc3cccc(OC)c3)onc2-c2ccccc2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C31H34N2O6/c1-6-37-30(34)25-19(3)32-20(4)26(31(35)38-7-2)28(25)27-24(17-16-21-12-11-15-23(18-21)36-5)39-33-29(27)22-13-9-8-10-14-22/h8-15,18,25,28H,6-7,16-17H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
30n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50030621
PNG
(5-[3-(4,4-Diphenyl-piperidin-1-yl)-propylcarbamoyl...)
Show SMILES COC(=O)c1c(C)nc(C)c(C(=O)NCCCN2CCC(CC2)(c2ccccc2)c2ccccc2)c1-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C36H38N4O5/c1-25-31(33(32(26(2)38-25)35(42)45-3)27-12-10-17-30(24-27)40(43)44)34(41)37-20-11-21-39-22-18-36(19-23-39,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24H,11,18-23H2,1-3H3,(H,37,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
30n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.


J Med Chem 38: 3681-716 (1995)

More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072810
PNG
(2,6-Dimethyl-4-[2-(4-methyl-2-oxy-furazan-3-ylmeth...)
Show SMILES COC(=O)C1=C(C)[N-]C(C)=C(C1c1ccccc1OCc1c(C)no[n+]1[O-])C(=[OH+])OC
Show InChI InChI=1S/C21H23N3O7/c1-11-15(24(27)31-23-11)10-30-16-9-7-6-8-14(16)19-17(20(25)28-4)12(2)22-13(3)18(19)21(26)29-5/h6-9,19H,10H2,1-5H3,(H,22,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
32n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50029424
PNG
((3aR,4R)-4-(4-Methoxy-phenyl)-2,3,3a,4-tetrahydro-...)
Show SMILES COc1ccc(cc1)[C@H]1Sc2ccccc2N2[C@@H]1CCC2=O
Show InChI InChI=1S/C18H17NO2S/c1-21-13-8-6-12(7-9-13)18-15-10-11-17(20)19(15)14-4-2-3-5-16(14)22-18/h2-9,15,18H,10-11H2,1H3/t15-,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
35n/an/an/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channel


J Med Chem 38: 4393-410 (1995)

More data for this
Ligand-Target Pair
Cav1.3/Cav beta3/Cav alpha2delta complex


(Rattus norvegicus)
BDBM50072816
PNG
(2,6-Dimethyl-4-[2-(2-nitrooxy-ethoxy)-phenyl]-1,4-...)
Show SMILES COC([O-])=C1C(C(C(=[OH+])OC)=C(C)N=C1C)c1ccccc1OCCO[N+]([O-])=O
Show InChI InChI=1S/C19H22N2O8/c1-11-15(18(22)26-3)17(16(12(2)20-11)19(23)27-4)13-7-5-6-8-14(13)28-9-10-29-21(24)25/h5-8,17,22H,9-10H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
38n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Binding affinity for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
40n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle.


J Med Chem 38: 3681-716 (1995)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
45n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle.


J Med Chem 38: 3681-716 (1995)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053900
PNG
(Allyl-(9-allyl-2-{4-[(10,11-dihydro-5H-dibenzo[a,d...)
Show SMILES C=CCNc1nc(nc2n(CC=C)cnc12)N1CCC(CC1)NCC1Cc2ccccc2Cc2ccccc12
Show InChI InChI=1S/C32H37N7/c1-3-15-33-30-29-31(39(16-4-2)22-35-29)37-32(36-30)38-17-13-27(14-18-38)34-21-26-20-24-10-6-5-9-23(24)19-25-11-7-8-12-28(25)26/h3-12,22,26-27,34H,1-2,13-21H2,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
46n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079465
PNG
(4-[5-(2-Biphenyl-2-yl-ethyl)-3-methyl-isoxazol-4-y...)
Show SMILES CCOC(=O)C1C(c2c(C)noc2CCc2ccccc2-c2ccccc2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C31H34N2O5/c1-6-36-30(34)27-19(3)32-20(4)28(31(35)37-7-2)29(27)26-21(5)33-38-25(26)18-17-23-15-11-12-16-24(23)22-13-9-8-10-14-22/h8-16,27,29H,6-7,17-18H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
46n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053872
PNG
(Allyl-(2-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohe...)
Show SMILES CCCn1cnc2c(NCC=C)nc(nc12)N1CCC(CC1)NCC1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C32H39N7/c1-3-17-33-30-29-31(39(18-4-2)22-35-29)37-32(36-30)38-19-15-25(16-20-38)34-21-28-26-11-7-5-9-23(26)13-14-24-10-6-8-12-27(24)28/h3,5-12,22,25,28,34H,1,4,13-21H2,2H3,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
48n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50029417
PNG
(CHEMBL277363 | [4-(4-Methoxy-phenyl)-4H-benzo[b]py...)
Show SMILES COc1ccc(cc1)C1Sc2ccccc2-n2c(CN(C)C)ccc12
Show InChI InChI=1S/C21H22N2OS/c1-22(2)14-16-10-13-19-21(15-8-11-17(24-3)12-9-15)25-20-7-5-4-6-18(20)23(16)19/h4-13,21H,14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
53n/an/an/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Calcium antagonistic activity by measuring [3H]-nitrendipine displacement from rat heart L-type [Ca2+] channel


J Med Chem 38: 4393-410 (1995)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50079461
PNG
(2,6-Dimethyl-4-(5-phenethyl-3-phenyl-isoxazol-4-yl...)
Show SMILES CCOC(=O)C1C(c2c(CCc3ccccc3)onc2-c2ccccc2)C(C(=O)OCC)=C(C)N=C1C
Show InChI InChI=1S/C30H32N2O5/c1-5-35-29(33)24-19(3)31-20(4)25(30(34)36-6-2)27(24)26-23(18-17-21-13-9-7-10-14-21)37-32-28(26)22-15-11-8-12-16-22/h7-16,24,27H,5-6,17-18H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
55n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-PN200-110 binding from calcium channels of rat cardiac membranes.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM81939
PNG
(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Show SMILES COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Show InChI InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
58n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053892
PNG
(Allyl-(9-allyl-2-{4-[(6,7,8,9-tetrahydro-5H-benzoc...)
Show SMILES C=CCNc1nc(nc2n(CC=C)cnc12)N1CCC(CC1)NCC1CCCCc2ccccc12
Show InChI InChI=1S/C28H37N7/c1-3-15-29-26-25-27(35(16-4-2)20-31-25)33-28(32-26)34-17-13-23(14-18-34)30-19-22-11-6-5-9-21-10-7-8-12-24(21)22/h3-4,7-8,10,12,20,22-23,30H,1-2,5-6,9,11,13-19H2,(H,29,32,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
62n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053880
PNG
(Allyl-(9-allyl-6-{4-[(10,11-dihydro-5H-dibenzo[a,d...)
Show SMILES C=CCNc1nc(N2CCC(CC2)NCC2c3ccccc3CCc3ccccc23)c2ncn(CC=C)c2n1
Show InChI InChI=1S/C32H37N7/c1-3-17-33-32-36-30(29-31(37-32)39(18-4-2)22-35-29)38-19-15-25(16-20-38)34-21-28-26-11-7-5-9-23(26)13-14-24-10-6-8-12-27(24)28/h3-12,22,25,28,34H,1-2,13-21H2,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
62n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042751
PNG
(CHEMBL125814 | {16-[5-Methoxycarbonyl-2,6-dimethyl...)
Show SMILES COC(=O)C1C(C(C(=O)OCCCCCCCCCCCCCCCC[N+](C)(C)C)=C(C)N=C1C)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C36H56F3N2O4/c1-27-31(34(42)44-6)33(29-23-19-20-24-30(29)36(37,38)39)32(28(2)40-27)35(43)45-26-22-18-16-14-12-10-8-7-9-11-13-15-17-21-25-41(3,4)5/h19-20,23-24,31,33H,7-18,21-22,25-26H2,1-6H3/q+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
64n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053891
PNG
((9-Allyl-2-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclo...)
Show SMILES CCCNc1nc(nc2n(CC=C)cnc12)N1CCC(CC1)NCC1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C32H39N7/c1-3-17-33-30-29-31(39(18-4-2)22-35-29)37-32(36-30)38-19-15-25(16-20-38)34-21-28-26-11-7-5-9-23(26)13-14-24-10-6-8-12-27(24)28/h4-12,22,25,28,34H,2-3,13-21H2,1H3,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
84n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50042747
PNG
(2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihy...)
Show SMILES CCCCCCCCCCCCCCCCCCOC(=O)C1=C(C)N=C(C)C(C1c1ccccc1C(F)(F)F)C(=O)OC
Show InChI InChI=1S/C35H52F3NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-43-34(41)31-27(3)39-26(2)30(33(40)42-4)32(31)28-23-20-21-24-29(28)35(36,37)38/h20-21,23-24,30,32H,5-19,22,25H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
87n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Inhibition of [3H](+)-PN200-110 binding to L-type calcium channel 1,4-DHP binding site of rat ventricular myocytes


J Med Chem 36: 3743-5 (1994)

More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053885
PNG
(Allyl-(9-allyl-2-{4-[(8-chloro-11-methyl-10,10-dio...)
Show SMILES CN1c2ccccc2C(CNC2CCN(CC2)c2nc(NCC=C)c3ncn(CC=C)c3n2)c2ccc(Cl)cc2S1(=O)=O
Show InChI InChI=1S/C31H35ClN8O2S/c1-4-14-33-29-28-30(40(15-5-2)20-35-28)37-31(36-29)39-16-12-22(13-17-39)34-19-25-23-8-6-7-9-26(23)38(3)43(41,42)27-18-21(32)10-11-24(25)27/h4-11,18,20,22,25,34H,1-2,12-17,19H2,3H3,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
87n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053888
PNG
(CHEMBL85156 | N,N'-Diallyl-6-{4-[2,2-bis-(4-fluoro...)
Show SMILES Fc1ccc(cc1)C(CNC1CCN(CC1)c1nc(NCC=C)nc(NCC=C)n1)c1ccc(F)cc1
Show InChI InChI=1S/C28H33F2N7/c1-3-15-31-26-34-27(32-16-4-2)36-28(35-26)37-17-13-24(14-18-37)33-19-25(20-5-9-22(29)10-6-20)21-7-11-23(30)12-8-21/h3-12,24-25,33H,1-2,13-19H2,(H2,31,32,34,35,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
89n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053871
PNG
(Allyl-(9-allyl-6-{4-[(5H-dibenzo[a,d]cyclohepten-5...)
Show SMILES C=CCNc1nc(N2CCC(CC2)NCC2c3ccccc3C=Cc3ccccc23)c2ncn(CC=C)c2n1
Show InChI InChI=1S/C32H35N7/c1-3-17-33-32-36-30(29-31(37-32)39(18-4-2)22-35-29)38-19-15-25(16-20-38)34-21-28-26-11-7-5-9-23(26)13-14-24-10-6-8-12-27(24)28/h3-14,22,25,28,34H,1-2,15-21H2,(H,33,36,37)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
90n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated L-type calcium channel


(Rattus norvegicus)
BDBM50053896
PNG
(Allyl-(9-allyl-6-{4-[(6,11-dihydro-dibenzo[b,e]oxe...)
Show SMILES C=CCNc1nc(N2CCC(CC2)NCC2c3ccccc3COc3ccccc23)c2ncn(CC=C)c2n1
Show InChI InChI=1S/C31H35N7O/c1-3-15-32-31-35-29(28-30(36-31)38(16-4-2)21-34-28)37-17-13-23(14-18-37)33-19-26-24-10-6-5-9-22(24)20-39-27-12-8-7-11-25(26)27/h3-12,21,23,26,33H,1-2,13-20H2,(H,32,35,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
93n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 363 total )  |  Next  |  Last  >>
Jump to: