BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 677 hits Enz. Inhib. hit(s) with Target = 'Voltage-gated potassium channel subunit Kv1.5' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301472
PNG
(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-methyl-1H-ben...)
Show SMILES CC1=Nc2ccnn2C(C1c1nc2cc(F)ccc2n1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H16Cl2FN5/c1-11-19(21-27-16-10-13(24)4-6-17(16)28(21)2)20(29-18(26-11)7-8-25-29)12-3-5-14(22)15(23)9-12/h3-10,19-20H,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194360
PNG
((E)-thyl-1-methyl-6,7-dihydro-1H-indol-4(5H)-one O...)
Show SMILES CCc1c(CC)n(C)c2CCCC(=NOC(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C20H25N3O2/c1-4-15-17(5-2)23(3)18-13-9-12-16(19(15)18)22-25-20(24)21-14-10-7-6-8-11-14/h6-8,10-11H,4-5,9,12-13H2,1-3H3,(H,21,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50022107
PNG
(CHEMBL3298226)
Show SMILES COc1cccc2ccnc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C20H22N2O/c1-20(2,16-9-5-4-6-10-16)14-22-19-18-15(12-13-21-19)8-7-11-17(18)23-3/h4-13H,14H2,1-3H3,(H,21,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50022108
PNG
(CHEMBL3298228)
Show SMILES COc1cccc2nc(O)nc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C19H21N3O2/c1-19(2,13-8-5-4-6-9-13)12-20-17-16-14(21-18(23)22-17)10-7-11-15(16)24-3/h4-11H,12H2,1-3H3,(H2,20,21,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120918
PNG
(CHEMBL3356073)
Show SMILES COc1cccc2snc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C18H20N2OS/c1-18(2,13-8-5-4-6-9-13)12-19-17-16-14(21-3)10-7-11-15(16)22-20-17/h4-11H,12H2,1-3H3,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50022109
PNG
(CHEMBL3298224)
Show SMILES CCc1cccc2snc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C19H22N2S/c1-4-14-9-8-12-16-17(14)18(21-22-16)20-13-19(2,3)15-10-6-5-7-11-15/h5-12H,4,13H2,1-3H3,(H,20,21)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120913
PNG
(CHEMBL3622361)
Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)NC(=O)OCC(F)(F)F)c1ccccc1)=NS2(=O)=O
Show InChI InChI=1/C24H26F3N3O5S/c1-34-18-8-5-9-19-20(18)21(30-36(19,32)33)28-14-23(16-6-3-2-4-7-16)12-10-17(11-13-23)29-22(31)35-15-24(25,26)27/h2-9,17H,10-15H2,1H3,(H,28,30)(H,29,31)/t17-,23-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120899
PNG
(CHEMBL3622355)
Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)OC(=O)Nc1ccc(cc1)N(C)C)c1ccccc1)=NS2(=O)=O
Show InChI InChI=1/C30H34N4O5S/c1-34(2)23-14-12-22(13-15-23)32-29(35)39-24-16-18-30(19-17-24,21-8-5-4-6-9-21)20-31-28-27-25(38-3)10-7-11-26(27)40(36,37)33-28/h4-15,24H,16-20H2,1-3H3,(H,31,33)(H,32,35)/t24-,30-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50315563
PNG
(CHEMBL1088844 | {[(1S,2S,5R)-5-methyl-2-(propan-2-...)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1P(=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301473
PNG
(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-methyl-1H-ben...)
Show SMILES COCC1=Nc2ccnn2C(C1c1nc2cc(F)ccc2n1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H18Cl2FN5O/c1-29-18-6-4-13(25)10-16(18)28-22(29)20-17(11-31-2)27-19-7-8-26-30(19)21(20)12-3-5-14(23)15(24)9-12/h3-10,20-21H,11H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120908
PNG
(CHEMBL3623054)
Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)n1cnnn1)c1ccccc1)=NS2(=O)=O
Show InChI InChI=1/C22H24N6O3S/c1-31-18-8-5-9-19-20(18)21(25-32(19,29)30)23-14-22(16-6-3-2-4-7-16)12-10-17(11-13-22)28-15-24-26-27-28/h2-9,15,17H,10-14H2,1H3,(H,23,25)/t17-,22-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Icagen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 channel mediated delayed rectifier potassium current by patch-clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120904
PNG
(CHEMBL3622346)
Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@H](O)CC1)c1ccccc1)=NS2(=O)=O
Show InChI InChI=1/C21H24N2O4S/c1-27-17-8-5-9-18-19(17)20(23-28(18,25)26)22-14-21(12-10-16(24)11-13-21)15-6-3-2-4-7-15/h2-9,16,24H,10-14H2,1H3,(H,22,23)/t16-,21-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120917
PNG
(CHEMBL3356074)
Show SMILES COc1cccc2C(=O)N=C(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C19H20N2O2/c1-19(2,13-8-5-4-6-9-13)12-20-17-16-14(18(22)21-17)10-7-11-15(16)23-3/h4-11H,12H2,1-3H3,(H,20,21,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194539
PNG
(4-(3-(2-fluorophenyl)propanamido)-N,N-diisopropyl-...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)CCc1ccccc1F)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H36FN3O2/c1-21(2)34(22(3)4)30(36)29(25-14-10-18-32-19-25)26(23-11-6-5-7-12-23)20-33-28(35)17-16-24-13-8-9-15-27(24)31/h5-15,18-19,21-22,26,29H,16-17,20H2,1-4H3,(H,33,35)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50430217
PNG
(CHEMBL2331989)
Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1C1CCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H20Cl2N6/c1-12-18(20-23-11-25-27(20)14-4-2-3-5-14)19(28-17(26-12)8-9-24-28)13-6-7-15(21)16(22)10-13/h6-11,14,18-19H,2-5H2,1H3/t18?,19-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50022110
PNG
(CHEMBL3298140)
Show SMILES COc1cccc2onc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C18H20N2O2/c1-18(2,13-8-5-4-6-9-13)12-19-17-16-14(21-3)10-7-11-15(16)22-20-17/h4-11H,12H2,1-3H3,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50022110
PNG
(CHEMBL3298140)
Show SMILES COc1cccc2onc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C18H20N2O2/c1-18(2,13-8-5-4-6-9-13)12-19-17-16-14(21-3)10-7-11-15(16)22-20-17/h4-11H,12H2,1-3H3,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50376745
PNG
(CHEMBL260684)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1CCCc2ccc(cc12)N(Cc1cccc(C)n1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C34H37N3O3S/c1-3-26-15-20-31(21-16-26)41(39,40)36-33-14-8-12-28-18-19-30(23-32(28)33)37(24-29-13-7-9-25(2)35-29)34(38)22-17-27-10-5-4-6-11-27/h4-7,9-11,13,15-16,18-21,23,33,36H,3,8,12,14,17,22,24H2,1-2H3/t33-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells assessed as blockade of ultra rapidly activating potassium current by volatge clamp t...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120907
PNG
(CHEMBL3623053)
Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)Nc1ncccn1)c1ccccc1)=NS2(=O)=O
Show InChI InChI=1/C25H27N5O3S/c1-33-20-9-5-10-21-22(20)23(30-34(21,31)32)28-17-25(18-7-3-2-4-8-18)13-11-19(12-14-25)29-24-26-15-6-16-27-24/h2-10,15-16,19H,11-14,17H2,1H3,(H,28,30)(H,26,27,29)/t19-,25-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301471
PNG
(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-propyl-1H-ben...)
Show SMILES CCCn1c(nc2cc(F)ccc12)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1S/C23H20Cl2FN5/c1-3-10-30-19-7-5-15(26)12-18(19)29-23(30)21-13(2)28-20-8-9-27-31(20)22(21)14-4-6-16(24)17(25)11-14/h4-9,11-12,21-22H,3,10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50430216
PNG
(CHEMBL2331990)
Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1C1CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H18Cl2N6/c1-11-17(19-22-10-24-26(19)13-3-2-4-13)18(27-16(25-11)7-8-23-27)12-5-6-14(20)15(21)9-12/h5-10,13,17-18H,2-4H2,1H3/t17?,18-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50306906
PNG
(((R)-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)
Show SMILES CC1=Nc2ccnn2[C@@H](C1C(=O)N1CCC[C@H]1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3/t20-,22?,23+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells assessed as blockade of ultra rapidly activating potassium current by volatge clamp t...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120903
PNG
(CHEMBL3622360)
Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)NC(=O)OC(C)C)c1ccccc1)=NS2(=O)=O
Show InChI InChI=1/C25H31N3O5S/c1-17(2)33-24(29)27-19-12-14-25(15-13-19,18-8-5-4-6-9-18)16-26-23-22-20(32-3)10-7-11-21(22)34(30,31)28-23/h4-11,17,19H,12-16H2,1-3H3,(H,26,28)(H,27,29)/t19-,25-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120916
PNG
(CHEMBL3623052)
Show SMILES CCN(CC)S(=O)(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1
Show InChI InChI=1/C25H34N4O5S2/c1-4-29(5-2)36(32,33)27-20-14-16-25(17-15-20,19-10-7-6-8-11-19)18-26-24-23-21(34-3)12-9-13-22(23)35(30,31)28-24/h6-13,20,27H,4-5,14-18H2,1-3H3,(H,26,28)/t20-,25-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120901
PNG
(CHEMBL3622358)
Show SMILES CCOC(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1
Show InChI InChI=1/C24H29N3O5S/c1-3-32-23(28)26-18-12-14-24(15-13-18,17-8-5-4-6-9-17)16-25-22-21-19(31-2)10-7-11-20(21)33(29,30)27-22/h4-11,18H,3,12-16H2,1-2H3,(H,25,27)(H,26,28)/t18-,24-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 55n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301469
PNG
(6-(5-chloro-1-ethyl-1H-benzo[d]imidazol-2-yl)-7-(3...)
Show SMILES CCn1c(nc2cc(Cl)ccc12)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1S/C22H18Cl3N5/c1-3-29-18-7-5-14(23)11-17(18)28-22(29)20-12(2)27-19-8-9-26-30(19)21(20)13-4-6-15(24)16(25)10-13/h4-11,20-21H,3H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50211550
PNG
((3S,4R)-4-(N-butyl-4-ethylphenylsulfonamido)-3-hyd...)
Show SMILES CCCCN([C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1)S(=O)(=O)c1ccc(CC)cc1
Show InChI InChI=1S/C32H40N2O5S/c1-5-7-21-34(40(37,38)26-16-13-23(6-2)14-17-26)29-27-22-25(15-18-28(27)39-32(3,4)30(29)35)31(36)33-20-19-24-11-9-8-10-12-24/h8-18,22,29-30,35H,5-7,19-21H2,1-4H3,(H,33,36)/t29-,30+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50430219
PNG
(CHEMBL2331987)
Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1C1CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H22Cl2N6/c1-13-19(21-24-12-26-28(21)15-5-3-2-4-6-15)20(29-18(27-13)9-10-25-29)14-7-8-16(22)17(23)11-14/h7-12,15,19-20H,2-6H2,1H3/t19?,20-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50211535
PNG
(CHEMBL387993 | N-((3S,4R)-6-((S)-2-((2,6-dimethylp...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@H]1CNc1c(C)cccc1C
Show InChI InChI=1S/C33H41N3O5S/c1-6-23-12-15-26(16-13-23)42(39,40)35-30-27-19-24(14-17-28(27)41-33(4,5)31(30)37)32(38)36-18-8-11-25(36)20-34-29-21(2)9-7-10-22(29)3/h7,9-10,12-17,19,25,30-31,34-35,37H,6,8,11,18,20H2,1-5H3/t25-,30+,31-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells assessed as blockade of ultra rapidly activating potassium current by volatge clamp t...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50199068
PNG
(3-cyano-N-(2-hydroxyethyl)-6-methoxy-4-phenylisoqu...)
Show SMILES COc1ccc2c(nc(C#N)c(-c3ccccc3)c2c1)C(=O)NCCO
Show InChI InChI=1S/C20H17N3O3/c1-26-14-7-8-15-16(11-14)18(13-5-3-2-4-6-13)17(12-21)23-19(15)20(25)22-9-10-24/h2-8,11,24H,9-10H2,1H3,(H,22,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.5 channel expressed in CHO cell membrane by HT clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120914
PNG
(CHEMBL3622362)
Show SMILES CCS(=O)(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1
Show InChI InChI=1/C23H29N3O5S2/c1-3-32(27,28)25-18-12-14-23(15-13-18,17-8-5-4-6-9-17)16-24-22-21-19(31-2)10-7-11-20(21)33(29,30)26-22/h4-11,18,25H,3,12-16H2,1-2H3,(H,24,26)/t18-,23-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301456
PNG
(7-(3,4-dichlorophenyl)-6-(4-fluoro-1-methyl-1H-ben...)
Show SMILES CC1=Nc2ccnn2C(C1c1nc2c(F)cccc2n1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H16Cl2FN5/c1-11-18(21-27-19-15(24)4-3-5-16(19)28(21)2)20(29-17(26-11)8-9-25-29)12-6-7-13(22)14(23)10-12/h3-10,18,20H,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120909
PNG
(CHEMBL3622348)
Show SMILES CCNC(=O)O[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1
Show InChI InChI=1/C24H29N3O5S/c1-3-25-23(28)32-18-12-14-24(15-13-18,17-8-5-4-6-9-17)16-26-22-21-19(31-2)10-7-11-20(21)33(29,30)27-22/h4-11,18H,3,12-16H2,1-2H3,(H,25,28)(H,26,27)/t18-,24-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194358
PNG
((E)--2-methyl-6,7-dihydro-1H-indol-4(5H)-one O-phe...)
Show SMILES CCc1c(C)[nH]c2CCCC(=NOC(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C18H21N3O2/c1-3-14-12(2)19-15-10-7-11-16(17(14)15)21-23-18(22)20-13-8-5-4-6-9-13/h4-6,8-9,19H,3,7,10-11H2,1-2H3,(H,20,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301459
PNG
(6-(5-chloro-1-methyl-1H-benzo[d]imidazol-2-yl)-7-(...)
Show SMILES CC1=Nc2ccnn2C(C1c1nc2cc(Cl)ccc2n1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H16Cl3N5/c1-11-19(21-27-16-10-13(22)4-6-17(16)28(21)2)20(29-18(26-11)7-8-25-29)12-3-5-14(23)15(24)9-12/h3-10,19-20H,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 68n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50198247
PNG
(2-(3,4-dimethylphenyl)-3-(4-methoxyphenethyl)-2-me...)
Show SMILES COc1ccc(CCN2C(=O)CSC2(C)c2ccc(C)c(C)c2)cc1
Show InChI InChI=1S/C21H25NO2S/c1-15-5-8-18(13-16(15)2)21(3)22(20(23)14-25-21)12-11-17-6-9-19(24-4)10-7-17/h5-10,13H,11-12,14H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50306891
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50258540
PNG
(CHEMBL468514 | N-((7R,8R)-7-hydroxy-8-(4-pentylphe...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)CCc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C29H34N2O5S/c1-3-4-5-7-20-10-15-25(16-11-20)37(34,35)31-28-26-19-23(14-12-21(26)13-17-27(28)32)30-29(33)22-8-6-9-24(18-22)36-2/h6,8-12,14-16,18-19,27-28,31-32H,3-5,7,13,17H2,1-2H3,(H,30,33)/t27-,28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Icagen Inc

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by patch-clamp electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254809
PNG
((R)-(7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)
Show SMILES CC1=Nc2ccnn2[C@@H](C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-12-10-30(11-13-31)18-5-3-17(27)4-6-18)23(32-21(29-15)8-9-28-32)16-2-7-19(25)20(26)14-16/h2-9,14,22-23H,10-13H2,1H3/t22?,23-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254617
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)
Show SMILES CCCN(CCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1S/C20H24Cl2N4O/c1-4-10-25(11-5-2)20(27)18-13(3)24-17-8-9-23-26(17)19(18)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,4-5,10-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254617
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)
Show SMILES CCCN(CCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1S/C20H24Cl2N4O/c1-4-10-25(11-5-2)20(27)18-13(3)24-17-8-9-23-26(17)19(18)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,4-5,10-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50385935
PNG
(CHEMBL2042152)
Show SMILES COCC1=Nc2ccnn2[C@@H](C1C(=O)N1CCC[C@H]1c1cc(C)no1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H23Cl2N5O3/c1-13-10-19(33-28-13)18-4-3-9-29(18)23(31)21-17(12-32-2)27-20-7-8-26-30(20)22(21)14-5-6-15(24)16(25)11-14/h5-8,10-11,18,21-22H,3-4,9,12H2,1-2H3/t18-,21?,22+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 ion channel expressed in mouse L929 cells by whole cell patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301457
PNG
(6-(7-chloro-1-methyl-1H-benzo[d]imidazol-2-yl)-7-(...)
Show SMILES CC1=Nc2ccnn2C(C1c1nc2cccc(Cl)c2n1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H16Cl3N5/c1-11-18(21-27-16-5-3-4-14(23)20(16)28(21)2)19(29-17(26-11)8-9-25-29)12-6-7-13(22)15(24)10-12/h3-10,18-19H,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 71n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50385942
PNG
(CHEMBL2042162)
Show SMILES Cc1cc(on1)[C@@H]1CCCN1C(=O)C1[C@@H](c2cc3ccccc3n2C)n2nc(cc2N=C1C)C(F)(F)F
Show InChI InChI=1S/C26H25F3N6O2/c1-14-11-20(37-32-14)18-9-6-10-34(18)25(36)23-15(2)30-22-13-21(26(27,28)29)31-35(22)24(23)19-12-16-7-4-5-8-17(16)33(19)3/h4-5,7-8,11-13,18,23-24H,6,9-10H2,1-3H3/t18-,23?,24+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 72n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 ion channel expressed in mouse L929 cells by whole cell patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50022111
PNG
(CHEMBL3298227)
Show SMILES COc1cccc2nc(Cl)nc(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C19H20ClN3O/c1-19(2,13-8-5-4-6-9-13)12-21-17-16-14(22-18(20)23-17)10-7-11-15(16)24-3/h4-11H,12H2,1-3H3,(H,21,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 73n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50430227
PNG
(CHEMBL2332455)
Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1-c1ccccc1F)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H15Cl2FN6/c1-12-19(21-25-11-27-29(21)17-5-3-2-4-16(17)24)20(30-18(28-12)8-9-26-30)13-6-7-14(22)15(23)10-13/h2-11,19-20H,1H3/t19?,20-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50301452
PNG
(7-(3,4-dichlorophenyl)-5-methyl-6-(1-methyl-1H-ben...)
Show SMILES CC1=Nc2ccnn2C(C1c1nc2ccccc2n1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H17Cl2N5/c1-12-19(21-26-16-5-3-4-6-17(16)27(21)2)20(28-18(25-12)9-10-24-28)13-7-8-14(22)15(23)11-13/h3-11,19-20H,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 677 total )  |  Next  |  Last  >>
Jump to: