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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Voltage-gated sodium channel Nav1.5 cardiac isoform' AND taxid = 9615   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel Nav1.5 cardiac isoform


(Canis lupus familiaris)
BDBM50173335
PNG
(CHEBI:87690 | CVT-303 | RANOLAZINE | RS-43285-003 ...)
Show SMILES COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1
Show InChI InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
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DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.90E+3n/an/an/an/an/an/a



Gilead Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of canine ventricular myocytes Nav 1.5 assessed as reduction in ATX-2 induced late channel current by manual single-patch clamp assay


Bioorg Med Chem Lett 26: 3202-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.101
BindingDB Entry DOI: 10.7270/Q21R6SDP
More data for this
Ligand-Target Pair