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Found 123 hits Enz. Inhib. hit(s) with Target = 'Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50118519
PNG
(CHEMBL3617050)
Show SMILES OC[C@H]1CON2[C@H]1C[C@]1(CN3C(=N)N[C@H]([C@@H]4N(COC(=O)NO)C(=N)N[C@]34C1(O)O)C2=O)OS(O)(=O)=O
Show InChI InChI=1/C16H24N8O12S/c17-11-19-8-9-15(20-12(18)22(9)5-34-13(27)21-30)16(28,29)14(4-23(11)15,36-37(31,32)33)1-7-6(2-25)3-35-24(7)10(8)26/h6-9,25,28-30H,1-5H2,(H2,17,19)(H2,18,20)(H,21,27)(H,31,32,33)/t6-,7-,8+,9-,14+,15-/s2
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n/an/a 6.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp method


J Med Chem 58: 7093-118 (2015)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50344821
PNG
(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Show SMILES NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO
Show InChI InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1
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n/an/a<30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated Na channel 1.2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329209
PNG
(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)
Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCCCC1
Show InChI InChI=1S/C24H24ClN3O/c25-22-10-8-18(9-11-22)20-14-21(16-26-15-20)24(29)27-17-19-6-2-3-7-23(19)28-12-4-1-5-13-28/h2-3,6-11,14-16H,1,4-5,12-13,17H2,(H,27,29)
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329205
PNG
(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)
Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCCCC1
Show InChI InChI=1S/C23H23ClN4O/c24-21-8-6-17(7-9-21)19-13-20(15-25-14-19)23(29)27-16-18-5-4-10-26-22(18)28-11-2-1-3-12-28/h4-10,13-15H,1-3,11-12,16H2,(H,27,29)
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n/an/a 70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50270707
PNG
(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C25H34N2O2/c1-25(2,3)20-11-9-19(10-12-20)22-13-14-23(29-22)24(28)27-17-15-26(16-18-27)21-7-5-4-6-8-21/h9-14,21H,4-8,15-18H2,1-3H3
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n/an/a 100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329211
PNG
(5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide ...)
Show SMILES Cc1ccccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H17ClN2O/c1-14-4-2-3-5-16(14)13-23-20(24)18-10-17(11-22-12-18)15-6-8-19(21)9-7-15/h2-12H,13H2,1H3,(H,23,24)
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n/an/a 110n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329208
PNG
(5-(4-chlorophenyl)-N-(2-morpholinobenzyl)nicotinam...)
Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1N1CCOCC1
Show InChI InChI=1S/C23H22ClN3O2/c24-21-7-5-17(6-8-21)19-13-20(15-25-14-19)23(28)26-16-18-3-1-2-4-22(18)27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,26,28)
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n/an/a 120n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50259542
PNG
(2-(3-Trifluoromethylphenyl)-4(5)-(3-trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(c1)-c1c[nH]c(n1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C17H10F6N2/c18-16(19,20)12-5-1-3-10(7-12)14-9-24-15(25-14)11-4-2-6-13(8-11)17(21,22)23/h1-9H,(H,24,25)
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n/an/a 200n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50118516
PNG
(CHEMBL3617053)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27)
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n/an/a 240n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 channel by patch clamp electrophysiology assay


J Med Chem 58: 7093-118 (2015)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50270679
PNG
(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C21H25ClN2O2/c22-17-8-6-16(7-9-17)19-10-11-20(26-19)21(25)24-14-12-23(13-15-24)18-4-2-1-3-5-18/h6-11,18H,1-5,12-15H2
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n/an/a 350n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330949
PNG
(CHEMBL1277877 | N-(3,5-Dimethylphenyl)-6-(4-ethoxy...)
Show SMILES CCOc1ccc(cc1)-c1cncc(n1)C(=O)Nc1cc(C)cc(C)c1
Show InChI InChI=1S/C21H21N3O2/c1-4-26-18-7-5-16(6-8-18)19-12-22-13-20(24-19)21(25)23-17-10-14(2)9-15(3)11-17/h5-13H,4H2,1-3H3,(H,23,25)
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n/an/a 360n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330948
PNG
(CHEMBL1277959 | N-(2-Methylbenzyl)-6-(4-ethoxyphen...)
Show SMILES CCOc1ccc(cc1)-c1cncc(n1)C(=O)NCc1ccccc1C
Show InChI InChI=1S/C21H21N3O2/c1-3-26-18-10-8-16(9-11-18)19-13-22-14-20(24-19)21(25)23-12-17-7-5-4-6-15(17)2/h4-11,13-14H,3,12H2,1-2H3,(H,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107034
PNG
(CHEMBL108347 | N-(4-Butoxy-benzoyl)-N'-(4-phenyl-b...)
Show SMILES CCCCOc1ccc(cc1)C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C22H29N3O2/c1-2-3-17-27-20-14-12-19(13-15-20)21(26)25-22(23)24-16-8-7-11-18-9-5-4-6-10-18/h4-6,9-10,12-15H,2-3,7-8,11,16-17H2,1H3,(H3,23,24,25,26)
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n/an/a 630n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329206
PNG
(5-(4-chlorophenyl)-N-((2-ethoxypyridin-3-yl)methyl...)
Show SMILES CCOc1ncccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClN3O2/c1-2-26-20-15(4-3-9-23-20)13-24-19(25)17-10-16(11-22-12-17)14-5-7-18(21)8-6-14/h3-12H,2,13H2,1H3,(H,24,25)
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n/an/a 670n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107029
PNG
(CHEMBL108727 | N-(4-Ethoxy-benzoyl)-N'-(4-phenyl-b...)
Show SMILES CCOc1ccc(cc1)C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C20H25N3O2/c1-2-25-18-13-11-17(12-14-18)19(24)23-20(21)22-15-7-6-10-16-8-4-3-5-9-16/h3-5,8-9,11-14H,2,6-7,10,15H2,1H3,(H3,21,22,23,24)
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CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107043
PNG
(CHEMBL321883 | N-(4-Methoxy-benzoyl)-N'-(4-phenyl-...)
Show SMILES COc1ccc(cc1)C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C19H23N3O2/c1-24-17-12-10-16(11-13-17)18(23)22-19(20)21-14-6-5-9-15-7-3-2-4-8-15/h2-4,7-8,10-13H,5-6,9,14H2,1H3,(H3,20,21,22,23)
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CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107032
PNG
(CHEMBL110572 | N-(Naphthalene-1-carbonyl)-N'-(4-ph...)
Show SMILES NC(NC(=O)c1cccc2ccccc12)=NCCCCc1ccccc1
Show InChI InChI=1S/C22H23N3O/c23-22(24-16-7-6-11-17-9-2-1-3-10-17)25-21(26)20-15-8-13-18-12-4-5-14-19(18)20/h1-5,8-10,12-15H,6-7,11,16H2,(H3,23,24,25,26)
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CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated Na channel 1.2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330938
PNG
(CHEMBL1277607 | N-(4-Chlorophenethyl)-6-(4-chlorop...)
Show SMILES Clc1ccc(CCNC(=O)c2cncc(n2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C19H15Cl2N3O/c20-15-5-1-13(2-6-15)9-10-23-19(25)18-12-22-11-17(24-18)14-3-7-16(21)8-4-14/h1-8,11-12H,9-10H2,(H,23,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330939
PNG
(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)
Show SMILES Cc1ccccc1CNC(=O)c1cncc(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H16N4O/c1-14-4-2-3-5-17(14)11-23-20(25)19-13-22-12-18(24-19)16-8-6-15(10-21)7-9-16/h2-9,12-13H,11H2,1H3,(H,23,25)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330935
PNG
(CHEMBL1277958 | N-(m-Tolyl)-6-(4-ethoxyphenyl)-pyr...)
Show SMILES CCOc1ccc(cc1)-c1cncc(n1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C20H19N3O2/c1-3-25-17-9-7-15(8-10-17)18-12-21-13-19(23-18)20(24)22-16-6-4-5-14(2)11-16/h4-13H,3H2,1-2H3,(H,22,24)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330934
PNG
(CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...)
Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCCC1
Show InChI InChI=1S/C21H20ClN5O/c22-17-7-5-15(6-8-17)18-13-23-14-19(26-18)21(28)25-12-16-4-3-9-24-20(16)27-10-1-2-11-27/h3-9,13-14H,1-2,10-12H2,(H,25,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50270649
PNG
(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N1CCNCC1
Show InChI InChI=1S/C15H15ClN2O2/c16-12-3-1-11(2-4-12)13-5-6-14(20-13)15(19)18-9-7-17-8-10-18/h1-6,17H,7-10H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp technique


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50017659
PNG
(2-(Dimethylamino)ethyl p-(butylamino)benzoate | 2-...)
Show SMILES CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Show InChI InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107031
PNG
(CHEMBL108728 | N-(4-Methyl-benzoyl)-N'-(4-phenyl-b...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-15-10-12-17(13-11-15)18(23)22-19(20)21-14-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,10-13H,5-6,9,14H2,1H3,(H3,20,21,22,23)
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n/an/a 1.14E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107030
PNG
(CHEMBL106459 | N-(2-Methyl-benzoyl)-N'-(4-phenyl-b...)
Show SMILES Cc1ccccc1C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-15-9-5-6-13-17(15)18(23)22-19(20)21-14-8-7-12-16-10-3-2-4-11-16/h2-6,9-11,13H,7-8,12,14H2,1H3,(H3,20,21,22,23)
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n/an/a 1.20E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330942
PNG
(CHEMBL1278224 | N-(2-methylbenzyl)-6-(4-(trifluoro...)
Show SMILES Cc1ccccc1CNC(=O)c1cncc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H16F3N3O2/c1-13-4-2-3-5-15(13)10-25-19(27)18-12-24-11-17(26-18)14-6-8-16(9-7-14)28-20(21,22)23/h2-9,11-12H,10H2,1H3,(H,25,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329210
PNG
(CHEMBL1269883 | N-(2-chlorobenzyl)-5-(4-chlorophen...)
Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C19H14Cl2N2O/c20-17-7-5-13(6-8-17)15-9-16(11-22-10-15)19(24)23-12-14-3-1-2-4-18(14)21/h1-11H,12H2,(H,23,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50066068
PNG
(CHEMBL28853 | N-Acenaphthen-5-yl-N'-(4-methoxy-nap...)
Show SMILES COc1ccc(N=C(N)Nc2ccc3CCc4cccc2c34)c2ccccc12
Show InChI InChI=1S/C24H21N3O/c1-28-22-14-13-20(17-6-2-3-7-18(17)22)26-24(25)27-21-12-11-16-10-9-15-5-4-8-19(21)23(15)16/h2-8,11-14H,9-10H2,1H3,(H3,25,26,27)
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n/an/a 1.31E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channel


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107046
PNG
(CHEMBL110164 | N-(4-Phenyl-butyl)-N'-(3,4,5-trimet...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)NC(N)=NCCCCc1ccccc1
Show InChI InChI=1S/C21H27N3O4/c1-26-17-13-16(14-18(27-2)19(17)28-3)20(25)24-21(22)23-12-8-7-11-15-9-5-4-6-10-15/h4-6,9-10,13-14H,7-8,11-12H2,1-3H3,(H3,22,23,24,25)
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n/an/a 1.39E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50259490
PNG
(2-Phenyl-4(5)-(4-trifluoromethylphenyl)imidazole |...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1c[nH]c(n1)-c1ccccc1
Show InChI InChI=1S/C16H11F3N2/c17-16(18,19)13-8-6-11(7-9-13)14-10-20-15(21-14)12-4-2-1-3-5-12/h1-10H,(H,20,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50259388
PNG
(2-(4-Chlorophenyl)-4(5)-phenylimidazole | CHEMBL50...)
Show SMILES Clc1ccc(cc1)-c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C15H11ClN2/c16-13-8-6-12(7-9-13)15-17-10-14(18-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107039
PNG
(CHEMBL109012 | N-(2,3-Dichloro-benzoyl)-N'-(4-phen...)
Show SMILES NC(NC(=O)c1cccc(Cl)c1Cl)=NCCCCc1ccccc1
Show InChI InChI=1S/C18H19Cl2N3O/c19-15-11-6-10-14(16(15)20)17(24)23-18(21)22-12-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10-11H,4-5,9,12H2,(H3,21,22,23,24)
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n/an/a 1.48E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330932
PNG
(CHEMBL1276882 | N-((2-Morpholin-4-yl-pyridin-3-yl)...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCOCC1
Show InChI InChI=1S/C22H20F3N5O3/c23-22(24,25)33-17-5-3-15(4-6-17)18-13-26-14-19(29-18)21(31)28-12-16-2-1-7-27-20(16)30-8-10-32-11-9-30/h1-7,13-14H,8-12H2,(H,28,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329204
PNG
(5-(4-chlorophenyl)-N-((2-morpholinopyridin-3-yl)me...)
Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1cccnc1N1CCOCC1
Show InChI InChI=1S/C22H21ClN4O2/c23-20-5-3-16(4-6-20)18-12-19(14-24-13-18)22(28)26-15-17-2-1-7-25-21(17)27-8-10-29-11-9-27/h1-7,12-14H,8-11,15H2,(H,26,28)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330944
PNG
(CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...)
Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C20H16N4O/c1-13-7-14(2)9-17(8-13)23-20(25)19-12-22-11-18(24-19)16-5-3-15(10-21)4-6-16/h3-9,11-12H,1-2H3,(H,23,25)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107045
PNG
(CHEMBL421032 | N-[2-(5-Methoxy-1H-indol-3-yl)-ethy...)
Show SMILES COc1ccc2[nH]cc(CCN=C(N)NC(=O)c3ccc(C)cc3)c2c1
Show InChI InChI=1S/C20H22N4O2/c1-13-3-5-14(6-4-13)19(25)24-20(21)22-10-9-15-12-23-18-8-7-16(26-2)11-17(15)18/h3-8,11-12,23H,9-10H2,1-2H3,(H3,21,22,24,25)
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n/an/a 1.76E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50329212
PNG
(CHEMBL1271417 | N-benzyl-5-(4-chlorophenyl)nicotin...)
Show SMILES Clc1ccc(cc1)-c1cncc(c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H15ClN2O/c20-18-8-6-15(7-9-18)16-10-17(13-21-12-16)19(23)22-11-14-4-2-1-3-5-14/h1-10,12-13H,11H2,(H,22,23)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107020
PNG
(CHEMBL105782 | N-(4-Methyl-benzoyl)-N'-(3,4,5-trim...)
Show SMILES COc1cc(cc(OC)c1OC)N=C(N)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H21N3O4/c1-11-5-7-12(8-6-11)17(22)21-18(19)20-13-9-14(23-2)16(25-4)15(10-13)24-3/h5-10H,1-4H3,(H3,19,20,21,22)
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n/an/a 1.92E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107050
PNG
(CHEMBL107394 | N-(4-Isopropyl-phenyl)-N'-(4-methyl...)
Show SMILES CC(C)c1ccc(cc1)N=C(N)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H21N3O/c1-12(2)14-8-10-16(11-9-14)20-18(19)21-17(22)15-6-4-13(3)5-7-15/h4-12H,1-3H3,(H3,19,20,21,22)
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n/an/a 1.95E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107035
PNG
(CHEMBL320332 | N-[2-(4-Chloro-phenyl)-ethyl]-N'-(4...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H18ClN3O/c1-12-2-6-14(7-3-12)16(22)21-17(19)20-11-10-13-4-8-15(18)9-5-13/h2-9H,10-11H2,1H3,(H3,19,20,21,22)
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n/an/a 1.97E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107025
PNG
(CHEMBL106351 | N-(4-Isopropoxy-phenyl)-N'-(4-methy...)
Show SMILES CC(C)Oc1ccc(cc1)N=C(N)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H21N3O2/c1-12(2)23-16-10-8-15(9-11-16)20-18(19)21-17(22)14-6-4-13(3)5-7-14/h4-12H,1-3H3,(H3,19,20,21,22)
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n/an/a 2.02E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50285278
PNG
(CHEMBL307395 | N,N'-Di-acenaphthen-5-yl-guanidine)
Show SMILES NC(Nc1ccc2CCc3cccc1c23)=Nc1ccc2CCc3cccc1c23
Show InChI InChI=1S/C25H21N3/c26-25(27-21-13-11-17-9-7-15-3-1-5-19(21)23(15)17)28-22-14-12-18-10-8-16-4-2-6-20(22)24(16)18/h1-6,11-14H,7-10H2,(H3,26,27,28)
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n/an/a 2.03E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channel


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107037
PNG
(CHEMBL106610 | N-(4-Methyl-benzoyl)-N'-(5-phenyl-p...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCCCCc1ccccc1
Show InChI InChI=1S/C20H25N3O/c1-16-11-13-18(14-12-16)19(24)23-20(21)22-15-7-3-6-10-17-8-4-2-5-9-17/h2,4-5,8-9,11-14H,3,6-7,10,15H2,1H3,(H3,21,22,23,24)
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n/an/a 2.11E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM30705
PNG
(CHEMBL744 | MLS000069369 | RILUZOLE | SMR000058231...)
Show SMILES Nc1nc2ccc(OC(F)(F)F)cc2s1
Show InChI InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channel


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50330945
PNG
(CHEMBL1278223 | N-(m-Tolyl)-6-(4-trifluoromethoxyp...)
Show SMILES Cc1cccc(NC(=O)c2cncc(n2)-c2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C19H14F3N3O2/c1-12-3-2-4-14(9-12)24-18(26)17-11-23-10-16(25-17)13-5-7-15(8-6-13)27-19(20,21)22/h2-11H,1H3,(H,24,26)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NaV1.2 by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107051
PNG
(CHEMBL108627 | N-(4-Methyl-benzoyl)-N'-naphthalen-...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCc1cccc2ccccc12
Show InChI InChI=1S/C20H19N3O/c1-14-9-11-16(12-10-14)19(24)23-20(21)22-13-17-7-4-6-15-5-2-3-8-18(15)17/h2-12H,13H2,1H3,(H3,21,22,23,24)
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n/an/a 2.38E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50259541
PNG
(2-(4-Nitrophenyl)-4(5)-(3-trifluoromethylphenyl)-i...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1nc(c[nH]1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H10F3N3O2/c17-16(18,19)12-3-1-2-11(8-12)14-9-20-15(21-14)10-4-6-13(7-5-10)22(23)24/h1-9H,(H,20,21)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Università degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology method


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50066430
PNG
(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Show SMILES CN1CCN(CC1)c1ncc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl
Show InChI InChI=1S/C15H16Cl3N5/c1-22-2-4-23(5-3-22)15-20-8-11(14(19)21-15)10-6-9(16)7-12(17)13(10)18/h6-8H,2-5H2,1H3,(H2,19,20,21)
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n/an/a 2.55E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channel


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.2 (Nav1.2)


(Homo sapiens (Human))
BDBM50107044
PNG
(CHEMBL107354 | N-(4-Methyl-benzoyl)-N'-phenethyl-g...)
Show SMILES Cc1ccc(cc1)C(=O)NC(N)=NCCc1ccccc1
Show InChI InChI=1S/C17H19N3O/c1-13-7-9-15(10-8-13)16(21)20-17(18)19-12-11-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H3,18,19,20,21)
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n/an/a 2.66E+3n/an/an/an/an/an/a



CeNeS Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of sodium channel blockade in CHO cells expressing neuronal mammalian type IIA (CNaIIA) sodium channel


Bioorg Med Chem Lett 11: 3151-5 (2001)

More data for this
Ligand-Target Pair
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