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Found 36 hits Enz. Inhib. hit(s) with Target = 'Von Hippel-Lindau disease tumor suppressor protein (VBC)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171824
PNG
(US9085572, 34)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-c2ccc(nc2)C#N)c1=O
Show InChI InChI=1S/C15H11N5O/c1-10-4-5-17-14(6-10)20-15(21)13(9-19-20)11-2-3-12(7-16)18-8-11/h2-6,8-9,19H,1H3
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n/an/a 180n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171821
PNG
(US9085572, 6)
Show SMILES O=c1c(c[nH]n1-c1ccccn1)-c1cccnc1
Show InChI InChI=1S/C13H10N4O/c18-13-11(10-4-3-6-14-8-10)9-16-17(13)12-5-1-2-7-15-12/h1-9,16H
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n/an/a 430n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171827
PNG
(US9085572, 46)
Show SMILES O=C(Cc1ccccc1)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H19N5O2/c28-21(12-16-5-2-1-3-6-16)25-13-17-8-10-24-20(11-17)27-22(29)19(15-26-27)18-7-4-9-23-14-18/h1-11,14-15,26H,12-13H2,(H,25,28)
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n/an/a 700n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171823
PNG
(US9085572, 26)
Show SMILES Cc1ncccc1-c1c[nH]n(-c2ccccn2)c1=O
Show InChI InChI=1S/C14H12N4O/c1-10-11(5-4-8-15-10)12-9-17-18(14(12)19)13-6-2-3-7-16-13/h2-9,17H,1H3
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n/an/a 760n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171822
PNG
(US9085572, 23)
Show SMILES OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H12N4O2/c19-9-10-3-4-13(16-6-10)18-14(20)12(8-17-18)11-2-1-5-15-7-11/h1-8,17,19H,9H2
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n/an/a 860n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171826
PNG
(US9085572, 43)
Show SMILES OCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H12N4O2/c19-9-10-3-5-16-13(6-10)18-14(20)12(8-17-18)11-2-1-4-15-7-11/h1-8,17,19H,9H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171829
PNG
(US9085572, 48)
Show SMILES O=C(NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O)c1ccccc1
Show InChI InChI=1S/C21H17N5O2/c27-20(16-5-2-1-3-6-16)24-12-15-8-10-23-19(11-15)26-21(28)18(14-25-26)17-7-4-9-22-13-17/h1-11,13-14,25H,12H2,(H,24,27)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171830
PNG
(US9085572, 50)
Show SMILES Clc1cnn(CCC(=O)NCc2ccnc(c2)-n2[nH]cc(-c3cccnc3)c2=O)c1
Show InChI InChI=1S/C20H18ClN7O2/c21-16-11-25-27(13-16)7-4-19(29)24-9-14-3-6-23-18(8-14)28-20(30)17(12-26-28)15-2-1-5-22-10-15/h1-3,5-6,8,10-13,26H,4,7,9H2,(H,24,29)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171828
PNG
(US9085572, 47)
Show SMILES CC(=O)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C16H15N5O2/c1-11(22)19-8-12-4-6-18-15(7-12)21-16(23)14(10-20-21)13-3-2-5-17-9-13/h2-7,9-10,20H,8H2,1H3,(H,19,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM171825
PNG
(US9085572, 35)
Show SMILES NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C14H13N5O/c15-7-10-3-5-17-13(6-10)19-14(20)12(9-18-19)11-2-1-4-16-8-11/h1-6,8-9,18H,7,15H2
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n/an/a 2.30E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...


US Patent US9085572 (2015)

More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446138
PNG
(CHEMBL3108881)
Show SMILES Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2cnco2)on1
Show InChI InChI=1S/C21H22N4O5/c1-13-6-17(30-24-13)8-20(27)25-11-16(26)7-18(25)21(28)23-9-14-2-4-15(5-3-14)19-10-22-12-29-19/h2-6,10,12,16,18,26H,7-9,11H2,1H3,(H,23,28)/t16-,18+/m1/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of 6xHis-tagged VHL (unknown origin) expressed in Escherichia coli BL21 cells by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099055
PNG
(CHEMBL3344088)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Show InChI InChI=1/C33H41N5O5S/c1-20-28(44-19-35-20)24-13-11-23(12-14-24)17-34-31(42)27-16-25(40)18-38(27)32(43)29(33(3,4)5)37-30(41)26(36-21(2)39)15-22-9-7-6-8-10-22/h6-14,19,25-27,29,40H,15-18H2,1-5H3,(H,34,42)(H,36,39)(H,37,41)/t25-,26+,27+,29-/s2
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n/an/an/a 291n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099056
PNG
(CHEMBL3344087)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Show InChI InChI=1/C30H43N5O5S/c1-17(2)12-23(33-19(4)36)27(38)34-26(30(5,6)7)29(40)35-15-22(37)13-24(35)28(39)31-14-20-8-10-21(11-9-20)25-18(3)32-16-41-25/h8-11,16-17,22-24,26,37H,12-15H2,1-7H3,(H,31,39)(H,33,36)(H,34,38)/t22-,23+,24+,26-/s2
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n/an/an/a 588n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099057
PNG
(CHEMBL3344086)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Show InChI InChI=1/C27H37N5O5S/c1-15-22(38-14-29-15)19-9-7-18(8-10-19)12-28-25(36)21-11-20(34)13-32(21)26(37)23(27(4,5)6)31-24(35)16(2)30-17(3)33/h7-10,14,16,20-21,23,34H,11-13H2,1-6H3,(H,28,36)(H,30,33)(H,31,35)/t16-,20+,21-,23+/s2
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n/an/an/a 943n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099058
PNG
(CHEMBL3344084)
Show SMILES CC(=O)N1CCCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C
Show InChI InChI=1/C24H30N4O4S/c1-15-22(33-14-26-15)18-8-6-17(7-9-18)12-25-23(31)21-11-19(30)13-28(21)24(32)20-5-3-4-10-27(20)16(2)29/h6-9,14,19-21,30H,3-5,10-13H2,1-2H3,(H,25,31)/t19-,20+,21+/s2
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n/an/an/a 384n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099059
PNG
(CHEMBL3344085)
Show SMILES CC(=O)N1C[C@H](O)C[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C
Show InChI InChI=1/C23H28N4O5S/c1-13-21(33-12-25-13)16-5-3-15(4-6-16)9-24-22(31)19-7-17(29)11-27(19)23(32)20-8-18(30)10-26(20)14(2)28/h3-6,12,17-20,29-30H,7-11H2,1-2H3,(H,24,31)/t17-,18-,19+,20+/s2
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n/an/an/a 1.10E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099060
PNG
(CHEMBL3344083)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C
Show InChI InChI=1/C23H28N4O4S/c1-14-21(32-13-25-14)17-7-5-16(6-8-17)11-24-22(30)20-10-18(29)12-27(20)23(31)19-4-3-9-26(19)15(2)28/h5-8,13,18-20,29H,3-4,9-12H2,1-2H3,(H,24,30)/t18-,19+,20+/s2
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n/an/an/a 714n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099061
PNG
(CHEMBL3344082)
Show SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)c1ccccc1
Show InChI InChI=1/C26H28N4O4S/c1-16-24(35-15-28-16)20-10-8-18(9-11-20)13-27-25(33)22-12-21(32)14-30(22)26(34)23(29-17(2)31)19-6-4-3-5-7-19/h3-11,15,21-23,32H,12-14H2,1-2H3,(H,27,33)(H,29,31)/t21-,22+,23+/s2
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n/an/an/a 826n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099062
PNG
(CHEMBL3344081)
Show SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Show InChI InChI=1/C24H32N4O4S/c1-14-20(33-13-26-14)17-8-6-16(7-9-17)11-25-22(31)19-10-18(30)12-28(19)23(32)21(24(3,4)5)27-15(2)29/h6-9,13,18-19,21,30H,10-12H2,1-5H3,(H,25,31)(H,27,29)/t18-,19+,21-/s2
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n/an/an/a 185n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099063
PNG
(CHEMBL3344080)
Show SMILES Cc1cc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(C)(C)C)ccc1-c1cncs1
Show InChI InChI=1/C22H29N3O3S/c1-14-7-15(5-6-17(14)19-11-23-13-29-19)10-24-21(28)18-8-16(26)12-25(18)20(27)9-22(2,3)4/h5-7,11,13,16,18,26H,8-10,12H2,1-4H3,(H,24,28)/t16-,18+/s2
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n/an/an/a 6.53E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099144
PNG
(CHEMBL3344079)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(C)(C)C)cc1
Show InChI InChI=1/C22H29N3O3S/c1-14-20(29-13-24-14)16-7-5-15(6-8-16)11-23-21(28)18-9-17(26)12-25(18)19(27)10-22(2,3)4/h5-8,13,17-18,26H,9-12H2,1-4H3,(H,23,28)/t17-,18+/s2
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n/an/an/a 3.27E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099145
PNG
(CHEMBL3344078)
Show SMILES CC(C)(C)CC(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1cncs1
Show InChI InChI=1/C21H27N3O3S/c1-21(2,3)9-19(26)24-12-16(25)8-17(24)20(27)23-10-14-4-6-15(7-5-14)18-11-22-13-28-18/h4-7,11,13,16-17,25H,8-10,12H2,1-3H3,(H,23,27)/t16-,17+/s2
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n/an/an/a 7.09E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099146
PNG
(CHEMBL3344077)
Show SMILES Cc1ncoc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(C)(C)C)cc1
Show InChI InChI=1/C22H29N3O4/c1-14-20(29-13-24-14)16-7-5-15(6-8-16)11-23-21(28)18-9-17(26)12-25(18)19(27)10-22(2,3)4/h5-8,13,17-18,26H,9-12H2,1-4H3,(H,23,28)/t17-,18+/s2
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n/an/an/a 1.02E+4n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099147
PNG
(CHEMBL3343404)
Show SMILES CC(C)(C)CC(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1cnco1
Show InChI InChI=1/C21H27N3O4/c1-21(2,3)9-19(26)24-12-16(25)8-17(24)20(27)23-10-14-4-6-15(7-5-14)18-11-22-13-28-18/h4-7,11,13,16-17,25H,8-10,12H2,1-3H3,(H,23,27)/t16-,17+/s2
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n/an/an/a 2.22E+4n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099054
PNG
(CHEMBL3344089)
Show SMILES CC(=O)N[C@H](C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C)C(C)(C)C
Show InChI InChI=1/C30H43N5O5S/c1-17-23(41-16-32-17)20-11-9-19(10-12-20)14-31-26(38)22-13-21(37)15-35(22)28(40)25(30(6,7)8)34-27(39)24(29(3,4)5)33-18(2)36/h9-12,16,21-22,24-25,37H,13-15H2,1-8H3,(H,31,38)(H,33,36)(H,34,39)/t21-,22+,24-,25-/s2
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n/an/an/a 9.52E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099053
PNG
(CHEMBL3344149)
Show SMILES CC(=O)N[C@H](C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C)c1ccccc1
Show InChI InChI=1/C32H39N5O5S/c1-19-27(43-18-34-19)23-13-11-21(12-14-23)16-33-29(40)25-15-24(39)17-37(25)31(42)28(32(3,4)5)36-30(41)26(35-20(2)38)22-9-7-6-8-10-22/h6-14,18,24-26,28,39H,15-17H2,1-5H3,(H,33,40)(H,35,38)(H,36,41)/t24-,25+,26+,28-/s2
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n/an/an/a 2.04E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50099052
PNG
(CHEMBL3344150)
Show SMILES CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C
Show InChI InChI=1/C34H41N5O5S/c1-20-29(45-19-36-20)23-12-10-22(11-13-23)16-35-31(42)28-15-26(41)18-39(28)33(44)30(34(3,4)5)37-32(43)27-14-24-8-6-7-9-25(24)17-38(27)21(2)40/h6-13,19,26-28,30,41H,14-18H2,1-5H3,(H,35,42)(H,37,43)/t26-,27+,28+,30-/s2
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n/an/an/a 2.32E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446139
PNG
(CHEMBL3108882)
Show SMILES Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)on1
Show InChI InChI=1S/C22H24N4O4S/c1-13-7-18(30-25-13)9-20(28)26-11-17(27)8-19(26)22(29)23-10-15-3-5-16(6-4-15)21-14(2)24-12-31-21/h3-7,12,17,19,27H,8-11H2,1-2H3,(H,23,29)/t17-,19+/m1/s1
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n/an/an/a 1.50E+3n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446138
PNG
(CHEMBL3108881)
Show SMILES Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2cnco2)on1
Show InChI InChI=1S/C21H22N4O5/c1-13-6-17(30-24-13)8-20(27)25-11-16(26)7-18(25)21(28)23-9-14-2-4-15(5-3-14)19-10-22-12-29-19/h2-6,10,12,16,18,26H,7-9,11H2,1H3,(H,23,28)/t16-,18+/m1/s1
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n/an/an/a 5.50E+3n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446137
PNG
(CHEMBL3108880)
Show SMILES CC(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C
Show InChI InChI=1S/C18H21N3O3S/c1-11-17(25-10-20-11)14-5-3-13(4-6-14)8-19-18(24)16-7-15(23)9-21(16)12(2)22/h3-6,10,15-16,23H,7-9H2,1-2H3,(H,19,24)/t15-,16+/m1/s1
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n/an/an/a 3.60E+4n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446136
PNG
(CHEMBL3108878)
Show SMILES CC(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1cnco1
Show InChI InChI=1S/C17H19N3O4/c1-11(21)20-9-14(22)6-15(20)17(23)19-7-12-2-4-13(5-3-12)16-8-18-10-24-16/h2-5,8,10,14-15,22H,6-7,9H2,1H3,(H,19,23)/t14-,15+/m1/s1
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n/an/an/a 1.50E+5n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446135
PNG
(CHEMBL3108879)
Show SMILES CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)Cc1cc(C)no1
Show InChI InChI=1S/C12H17N3O4/c1-7-3-9(19-14-7)5-11(17)15-6-8(16)4-10(15)12(18)13-2/h3,8,10,16H,4-6H2,1-2H3,(H,13,18)/t8-,10+/m1/s1
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n/an/an/a 2.40E+5n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446134
PNG
(CHEMBL3108877)
Show SMILES CNC(=O)[C@@H]1C[C@@H](O)CN1C(C)=O
Show InChI InChI=1S/C8H14N2O3/c1-5(11)10-4-6(12)3-7(10)8(13)9-2/h6-7,12H,3-4H2,1-2H3,(H,9,13)/t6-,7+/m1/s1
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n/an/an/a 4.90E+6n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446138
PNG
(CHEMBL3108881)
Show SMILES Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2cnco2)on1
Show InChI InChI=1S/C21H22N4O5/c1-13-6-17(30-24-13)8-20(27)25-11-16(26)7-18(25)21(28)23-9-14-2-4-15(5-3-14)19-10-22-12-29-19/h2-6,10,12,16,18,26H,7-9,11H2,1H3,(H,23,28)/t16-,18+/m1/s1
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n/an/an/a 5.30E+3n/an/an/an/an/a



Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Dow Street, Dundee, DD1 5EH, Scotland, U.K.

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446132
PNG
(CHEMBL3108874)
Show SMILES CC(C)NC(=O)Cc1cc(C)no1
Show InChI InChI=1S/C9H14N2O2/c1-6(2)10-9(12)5-8-4-7(3)11-13-8/h4,6H,5H2,1-3H3,(H,10,12)
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n/an/an/a 4.30E+6n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair
Von Hippel-Lindau disease tumor suppressor protein (VBC)


(Homo sapiens (Human))
BDBM50446133
PNG
(CHEMBL3108875)
Show SMILES CC(=O)NCc1ccc(cc1)-c1scnc1C
Show InChI InChI=1S/C13H14N2OS/c1-9-13(17-8-15-9)12-5-3-11(4-6-12)7-14-10(2)16/h3-6,8H,7H2,1-2H3,(H,14,16)
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n/an/an/a 2.70E+6n/an/an/an/an/a


TBA

Assay Description
Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysis


Citation and Details
More data for this
Ligand-Target Pair