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Compile Data Set for Download or QSAR

Found 195 hits Enz. Inhib. hit(s) with Target = 'WD repeat-containing protein 5 (WDR5)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318541
PNG
(Ac-ARAEVHLRKS-NH2 | CHEMBL1086450)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C51H90N20O14/c1-25(2)20-35(47(83)67-33(14-11-19-60-51(56)57)44(80)66-31(12-8-9-17-52)45(81)70-37(23-72)40(53)76)68-48(84)36(21-30-22-58-24-61-30)69-49(85)39(26(3)4)71-46(82)34(15-16-38(74)75)65-42(78)28(6)63-43(79)32(13-10-18-59-50(54)55)64-41(77)27(5)62-29(7)73/h22,24-28,31-37,39,72H,8-21,23,52H2,1-7H3,(H2,53,76)(H,58,61)(H,62,73)(H,63,79)(H,64,77)(H,65,78)(H,66,80)(H,67,83)(H,68,84)(H,69,85)(H,70,81)(H,71,82)(H,74,75)(H4,54,55,59)(H4,56,57,60)/t27-,28-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318527
PNG
(Ac-ART-NH2 | CHEMBL1085865)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C15H29N7O5/c1-7(20-9(3)24)13(26)21-10(5-4-6-19-15(17)18)14(27)22-11(8(2)23)12(16)25/h7-8,10-11,23H,4-6H2,1-3H3,(H2,16,25)(H,20,24)(H,21,26)(H,22,27)(H4,17,18,19)/t7-,8+,10-,11-/m0/s1
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20n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318542
PNG
(CHEMBL1086451 | H2N-SARAEVHLRKS-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C52H93N21O15/c1-25(2)19-35(48(86)69-33(13-10-18-62-52(58)59)45(83)68-31(11-7-8-16-53)46(84)72-37(23-75)40(55)78)70-49(87)36(20-29-21-60-24-63-29)71-50(88)39(26(3)4)73-47(85)34(14-15-38(76)77)67-42(80)28(6)65-44(82)32(12-9-17-61-51(56)57)66-41(79)27(5)64-43(81)30(54)22-74/h21,24-28,30-37,39,74-75H,7-20,22-23,53-54H2,1-6H3,(H2,55,78)(H,60,63)(H,64,81)(H,65,82)(H,66,79)(H,67,80)(H,68,83)(H,69,86)(H,70,87)(H,71,88)(H,72,84)(H,73,85)(H,76,77)(H4,56,57,61)(H4,58,59,62)/t27-,28-,30-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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20n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318544
PNG
(Ac-ARAEVHL-NH2 | CHEMBL1086453)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(N)=O
Show InChI InChI=1S/C36H61N13O10/c1-17(2)13-25(29(37)53)47-34(58)26(14-22-15-40-16-42-22)48-35(59)28(18(3)4)49-33(57)24(10-11-27(51)52)46-31(55)20(6)44-32(56)23(9-8-12-41-36(38)39)45-30(54)19(5)43-21(7)50/h15-20,23-26,28H,8-14H2,1-7H3,(H2,37,53)(H,40,42)(H,43,50)(H,44,56)(H,45,54)(H,46,55)(H,47,58)(H,48,59)(H,49,57)(H,51,52)(H4,38,39,41)/t19-,20-,23-,24-,25-,26-,28-/m0/s1
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30n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318547
PNG
(Ac-ARAE-NH2 | CHEMBL1085604)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C19H34N8O7/c1-9(24-11(3)28)16(32)27-13(5-4-8-23-19(21)22)18(34)25-10(2)17(33)26-12(15(20)31)6-7-14(29)30/h9-10,12-13H,4-8H2,1-3H3,(H2,20,31)(H,24,28)(H,25,34)(H,26,33)(H,27,32)(H,29,30)(H4,21,22,23)/t9-,10-,12-,13-/m0/s1
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80n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318545
PNG
(Ac-ARAEVH-NH2 | CHEMBL1086454)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C30H50N12O9/c1-14(2)23(29(51)41-21(24(31)46)11-18-12-34-13-36-18)42-28(50)20(8-9-22(44)45)40-26(48)16(4)38-27(49)19(7-6-10-35-30(32)33)39-25(47)15(3)37-17(5)43/h12-16,19-21,23H,6-11H2,1-5H3,(H2,31,46)(H,34,36)(H,37,43)(H,38,49)(H,39,47)(H,40,48)(H,41,51)(H,42,50)(H,44,45)(H4,32,33,35)/t15-,16-,19-,20-,21-,23-/m0/s1
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90n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318548
PNG
(Ac-ARA-NH2 | CHEMBL1086455)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C14H27N7O4/c1-7(11(15)23)20-13(25)10(5-4-6-18-14(16)17)21-12(24)8(2)19-9(3)22/h7-8,10H,4-6H2,1-3H3,(H2,15,23)(H,19,22)(H,20,25)(H,21,24)(H4,16,17,18)/t7-,8-,10-/m0/s1
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120n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318521
PNG
(Ac-ARA-CONHMe | CHEMBL1084621)
Show SMILES CNC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O
Show InChI InChI=1S/C15H29N7O4/c1-8(12(24)18-4)21-14(26)11(6-5-7-19-15(16)17)22-13(25)9(2)20-10(3)23/h8-9,11H,5-7H2,1-4H3,(H,18,24)(H,20,23)(H,21,26)(H,22,25)(H4,16,17,19)/t8-,9-,11-/m0/s1
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150n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318539
PNG
(Ac-GSARAEVHLRKS-NH2 | CHEMBL1086448)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C56H98N22O17/c1-27(2)20-37(51(92)74-35(14-11-19-65-56(61)62)48(89)73-33(12-8-9-17-57)49(90)77-39(24-79)44(58)85)75-52(93)38(21-32-22-63-26-67-32)76-54(95)43(28(3)4)78-50(91)36(15-16-42(83)84)72-46(87)29(5)68-47(88)34(13-10-18-64-55(59)60)71-45(86)30(6)69-53(94)40(25-80)70-41(82)23-66-31(7)81/h22,26-30,33-40,43,79-80H,8-21,23-25,57H2,1-7H3,(H2,58,85)(H,63,67)(H,66,81)(H,68,88)(H,69,94)(H,70,82)(H,71,86)(H,72,87)(H,73,89)(H,74,92)(H,75,93)(H,76,95)(H,77,90)(H,78,91)(H,83,84)(H4,59,60,64)(H4,61,62,65)/t29-,30-,33-,34-,35-,36-,37-,38-,39-,40-,43-/m0/s1
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160n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318546
PNG
(Ac-ARAEV-NH2 | CHEMBL1086531)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C24H43N9O8/c1-11(2)18(19(25)37)33-23(41)16(8-9-17(35)36)32-21(39)13(4)30-22(40)15(7-6-10-28-24(26)27)31-20(38)12(3)29-14(5)34/h11-13,15-16,18H,6-10H2,1-5H3,(H2,25,37)(H,29,34)(H,30,40)(H,31,38)(H,32,39)(H,33,41)(H,35,36)(H4,26,27,28)/t12-,13-,15-,16-,18-/m0/s1
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160n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318540
PNG
(Ac-SARAEVHLRKS-NH2 | CHEMBL1086449)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C54H95N21O16/c1-26(2)20-36(49(88)71-34(14-11-19-63-54(59)60)46(85)70-32(12-8-9-17-55)47(86)74-38(23-76)42(56)81)72-50(89)37(21-31-22-61-25-64-31)73-52(91)41(27(3)4)75-48(87)35(15-16-40(79)80)69-44(83)28(5)65-45(84)33(13-10-18-62-53(57)58)68-43(82)29(6)66-51(90)39(24-77)67-30(7)78/h22,25-29,32-39,41,76-77H,8-21,23-24,55H2,1-7H3,(H2,56,81)(H,61,64)(H,65,84)(H,66,90)(H,67,78)(H,68,82)(H,69,83)(H,70,85)(H,71,88)(H,72,89)(H,73,91)(H,74,86)(H,75,87)(H,79,80)(H4,57,58,62)(H4,59,60,63)/t28-,29-,32-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
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200n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318523
PNG
(Ac-ARA-COOCH3 | CHEMBL1084623)
Show SMILES COC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O
Show InChI InChI=1S/C15H28N6O5/c1-8(19-10(3)22)12(23)21-11(6-5-7-18-15(16)17)13(24)20-9(2)14(25)26-4/h8-9,11H,5-7H2,1-4H3,(H,19,22)(H,20,24)(H,21,23)(H4,16,17,18)/t8-,9-,11-/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318537
PNG
(CHEMBL1086083 | CHO-ARA-NH2)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC=O)C(N)=O
Show InChI InChI=1S/C13H25N7O4/c1-7(10(14)22)19-12(24)9(4-3-5-17-13(15)16)20-11(23)8(2)18-6-21/h6-9H,3-5H2,1-2H3,(H2,14,22)(H,18,21)(H,19,24)(H,20,23)(H4,15,16,17)/t7-,8-,9-/m0/s1
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3.20E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318543
PNG
(Ac-RAEVHLRKS-NH2 | CHEMBL1086452)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C48H85N19O13/c1-24(2)19-33(44(78)63-31(13-10-18-57-48(53)54)41(75)62-30(11-7-8-16-49)42(76)66-35(22-68)38(50)72)64-45(79)34(20-28-21-55-23-58-28)65-46(80)37(25(3)4)67-43(77)32(14-15-36(70)71)61-39(73)26(5)59-40(74)29(60-27(6)69)12-9-17-56-47(51)52/h21,23-26,29-35,37,68H,7-20,22,49H2,1-6H3,(H2,50,72)(H,55,58)(H,59,74)(H,60,69)(H,61,73)(H,62,75)(H,63,78)(H,64,79)(H,65,80)(H,66,76)(H,67,77)(H,70,71)(H4,51,52,56)(H4,53,54,57)/t26-,29-,30-,31-,32-,33-,34-,35-,37-/m0/s1
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6.30E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318522
PNG
(Ac-ARA-CONMe2 | CHEMBL1084622)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N(C)C
Show InChI InChI=1S/C16H31N7O4/c1-9(20-11(3)24)13(25)22-12(7-6-8-19-16(17)18)14(26)21-10(2)15(27)23(4)5/h9-10,12H,6-8H2,1-5H3,(H,20,24)(H,21,26)(H,22,25)(H4,17,18,19)/t9-,10-,12-/m0/s1
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PubMed
6.50E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318535
PNG
(CHEMBL1086456 | H2N-ARAEVHLRKS-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C49H88N20O13/c1-24(2)19-33(45(80)65-31(13-10-18-59-49(55)56)42(77)64-29(11-7-8-16-50)43(78)68-35(22-70)38(52)73)66-46(81)34(20-28-21-57-23-60-28)67-47(82)37(25(3)4)69-44(79)32(14-15-36(71)72)63-40(75)27(6)61-41(76)30(62-39(74)26(5)51)12-9-17-58-48(53)54/h21,23-27,29-35,37,70H,7-20,22,50-51H2,1-6H3,(H2,52,73)(H,57,60)(H,61,76)(H,62,74)(H,63,75)(H,64,77)(H,65,80)(H,66,81)(H,67,82)(H,68,78)(H,69,79)(H,71,72)(H4,53,54,58)(H4,55,56,59)/t26-,27-,29-,30-,31-,32-,33-,34-,35-,37-/m0/s1
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PubMed
7.30E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318529
PNG
(CHEMBL1082285 | H2N-ARTK(Me2)QTARKS-NH2)
Show SMILES CNCCCC[C@H](N(C)C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C48H92N20O14/c1-24(50)38(74)61-30(15-12-22-59-48(55)56)42(78)67-36(27(4)71)46(82)68(6)33(16-8-10-20-57-5)44(80)64-31(17-18-34(51)72)43(79)66-35(26(3)70)45(81)60-25(2)39(75)62-29(14-11-21-58-47(53)54)40(76)63-28(13-7-9-19-49)41(77)65-32(23-69)37(52)73/h24-33,35-36,57,69-71H,7-23,49-50H2,1-6H3,(H2,51,72)(H2,52,73)(H,60,81)(H,61,74)(H,62,75)(H,63,76)(H,64,80)(H,65,77)(H,66,79)(H,67,78)(H4,53,54,58)(H4,55,56,59)/t24-,25-,26+,27+,28-,29-,30-,31-,32-,33-,35-,36-/m0/s1
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PubMed
9.00E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318528
PNG
(CHEMBL1082284 | H2N-ARTK(Me)QTARKS-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)N(C)C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C47H90N20O14/c1-23(50)37(73)60-29(14-11-21-58-47(55)56)41(77)66-35(26(4)70)45(81)67(5)32(15-7-9-19-49)43(79)63-30(16-17-33(51)71)42(78)65-34(25(3)69)44(80)59-24(2)38(74)61-28(13-10-20-57-46(53)54)39(75)62-27(12-6-8-18-48)40(76)64-31(22-68)36(52)72/h23-32,34-35,68-70H,6-22,48-50H2,1-5H3,(H2,51,71)(H2,52,72)(H,59,80)(H,60,73)(H,61,74)(H,62,75)(H,63,79)(H,64,76)(H,65,78)(H,66,77)(H4,53,54,57)(H4,55,56,58)/t23-,24-,25+,26+,27-,28-,29-,30-,31-,32-,34-,35-/m0/s1
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PubMed
1.50E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318524
PNG
(CHEMBL1082281 | H2N-ARTKQTARKS-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C46H88N20O14/c1-22(49)36(72)59-29(14-10-20-57-46(54)55)41(77)66-34(25(4)69)44(80)63-27(12-6-8-18-48)38(74)62-30(15-16-32(50)70)42(78)65-33(24(3)68)43(79)58-23(2)37(73)60-28(13-9-19-56-45(52)53)39(75)61-26(11-5-7-17-47)40(76)64-31(21-67)35(51)71/h22-31,33-34,67-69H,5-21,47-49H2,1-4H3,(H2,50,70)(H2,51,71)(H,58,79)(H,59,72)(H,60,73)(H,61,75)(H,62,74)(H,63,80)(H,64,76)(H,65,78)(H,66,77)(H4,52,53,56)(H4,54,55,57)/t22-,23-,24+,25+,26-,27-,28-,29-,30-,31-,33-,34-/m0/s1
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PubMed
1.51E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318530
PNG
(CHEMBL1082286 | H2N-ARTK(Me3)QTARKS-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C49H94N20O14/c1-25(51)39(75)61-31(16-13-22-59-49(56)57)43(79)67-37(28(4)72)47(83)69(7)34(17-9-11-23-68(5)6)45(81)64-32(18-19-35(52)73)44(80)66-36(27(3)71)46(82)60-26(2)40(76)62-30(15-12-21-58-48(54)55)41(77)63-29(14-8-10-20-50)42(78)65-33(24-70)38(53)74/h25-34,36-37,70-72H,8-24,50-51H2,1-7H3,(H2,52,73)(H2,53,74)(H,60,82)(H,61,75)(H,62,76)(H,63,77)(H,64,81)(H,65,78)(H,66,80)(H,67,79)(H4,54,55,58)(H4,56,57,59)/t25-,26-,27+,28+,29-,30-,31-,32-,33-,34-,36-,37-/m0/s1
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PubMed
1.56E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318549
PNG
(Ac-AR-NH2 | CHEMBL1085605)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C11H22N6O3/c1-6(16-7(2)18)10(20)17-8(9(12)19)4-3-5-15-11(13)14/h6,8H,3-5H2,1-2H3,(H2,12,19)(H,16,18)(H,17,20)(H4,13,14,15)/t6-,8-/m0/s1
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PubMed
2.70E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318526
PNG
(CHEMBL1085864 | H2N-ART-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(N)=O
Show InChI InChI=1S/C13H27N7O4/c1-6(14)11(23)19-8(4-3-5-18-13(16)17)12(24)20-9(7(2)21)10(15)22/h6-9,21H,3-5,14H2,1-2H3,(H2,15,22)(H,19,23)(H,20,24)(H4,16,17,18)/t6-,7+,8-,9-/m0/s1
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PubMed
2.73E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318538
PNG
(Ac-AR-(N-Me)A-NH2 | CHEMBL1084620)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(C)[C@@H](C)C(N)=O
Show InChI InChI=1S/C15H29N7O4/c1-8(20-10(3)23)13(25)21-11(6-5-7-19-15(17)18)14(26)22(4)9(2)12(16)24/h8-9,11H,5-7H2,1-4H3,(H2,16,24)(H,20,23)(H,21,25)(H4,17,18,19)/t8-,9-,11-/m0/s1
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PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318536
PNG
(CHEMBL1085606 | H2N-ARA-NH2)
Show SMILES C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C12H25N7O3/c1-6(13)10(21)19-8(4-3-5-17-12(15)16)11(22)18-7(2)9(14)20/h6-8H,3-5,13H2,1-2H3,(H2,14,20)(H,18,22)(H,19,21)(H4,15,16,17)/t6-,7-,8-/m0/s1
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318534
PNG
((7S,24S,27S,30S,33S,36S,39S,42S)-36-((1H-imidazol-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O
Show InChI InChI=1S/C91H136N24O24/c1-48(2)41-65(111-85(133)66(42-53-45-98-47-104-53)112-87(135)75(49(3)4)114-83(131)64(33-34-72(123)124)110-88(136)76(51(6)117)115-82(130)63(26-20-40-103-91(96)97)107-78(126)50(5)105-52(7)118)84(132)109-62(25-19-39-102-90(94)95)80(128)108-61(24-12-14-35-92)81(129)113-67(46-116)79(127)100-37-16-8-10-27-70(121)99-36-15-9-11-28-71(122)106-60(77(93)125)23-13-17-38-101-86(134)74-58(21-18-22-59(74)89(137)138)73-56-31-29-54(119)43-68(56)139-69-44-55(120)30-32-57(69)73/h18,21-22,29-32,43-45,47-51,60-67,75-76,116-117,119H,8-17,19-20,23-28,33-42,46,92H2,1-7H3,(H2,93,125)(H,98,104)(H,99,121)(H,100,127)(H,101,134)(H,105,118)(H,106,122)(H,107,126)(H,108,128)(H,109,132)(H,110,136)(H,111,133)(H,112,135)(H,113,129)(H,114,131)(H,115,130)(H,123,124)(H,137,138)(H4,94,95,102)(H4,96,97,103)/t50-,51+,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells after 24 hrs by optimized fluorescent polarization based saturation binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318525
PNG
(Ac-ARTKQTARKS-NH2 | CHEMBL1082282)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C48H90N20O15/c1-23(59-27(5)72)38(75)62-31(15-11-21-58-48(55)56)43(80)68-36(26(4)71)46(83)65-29(13-7-9-19-50)40(77)64-32(16-17-34(51)73)44(81)67-35(25(3)70)45(82)60-24(2)39(76)61-30(14-10-20-57-47(53)54)41(78)63-28(12-6-8-18-49)42(79)66-33(22-69)37(52)74/h23-26,28-33,35-36,69-71H,6-22,49-50H2,1-5H3,(H2,51,73)(H2,52,74)(H,59,72)(H,60,82)(H,61,76)(H,62,75)(H,63,78)(H,64,77)(H,65,83)(H,66,79)(H,67,81)(H,68,80)(H4,53,54,57)(H4,55,56,58)/t23-,24-,25+,26+,28-,29-,30-,31-,32-,33-,35-,36-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318533
PNG
((7S,24S,27S,30S,33S,36S,39S,42S)-36-((1H-imidazol-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O
Show InChI InChI=1S/C90H134N24O23/c1-48(2)41-65(111-85(132)66(42-53-45-97-47-103-53)112-87(134)75(49(3)4)114-83(130)64(33-34-72(121)122)108-78(125)51(6)105-80(127)62(25-19-39-101-89(93)94)107-77(124)50(5)104-52(7)116)84(131)110-63(26-20-40-102-90(95)96)81(128)109-61(24-12-14-35-91)82(129)113-67(46-115)79(126)99-37-16-8-10-27-70(119)98-36-15-9-11-28-71(120)106-60(76(92)123)23-13-17-38-100-86(133)74-58(21-18-22-59(74)88(135)136)73-56-31-29-54(117)43-68(56)137-69-44-55(118)30-32-57(69)73/h18,21-22,29-32,43-45,47-51,60-67,75,115,117H,8-17,19-20,23-28,33-42,46,91H2,1-7H3,(H2,92,123)(H,97,103)(H,98,119)(H,99,126)(H,100,133)(H,104,116)(H,105,127)(H,106,120)(H,107,124)(H,108,125)(H,109,128)(H,110,131)(H,111,132)(H,112,134)(H,113,129)(H,114,130)(H,121,122)(H,135,136)(H4,93,94,101)(H4,95,96,102)/t50-,51-,60-,61-,62-,63-,64-,65-,66-,67-,75-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells after 24 hrs by optimized fluorescent polarization based saturation binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318541
PNG
(Ac-ARAEVHLRKS-NH2 | CHEMBL1086450)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C51H90N20O14/c1-25(2)20-35(47(83)67-33(14-11-19-60-51(56)57)44(80)66-31(12-8-9-17-52)45(81)70-37(23-72)40(53)76)68-48(84)36(21-30-22-58-24-61-30)69-49(85)39(26(3)4)71-46(82)34(15-16-38(74)75)65-42(78)28(6)63-43(79)32(13-10-18-59-50(54)55)64-41(77)27(5)62-29(7)73/h22,24-28,31-37,39,72H,8-21,23,52H2,1-7H3,(H2,53,76)(H,58,61)(H,62,73)(H,63,79)(H,64,77)(H,65,78)(H,66,80)(H,67,83)(H,68,84)(H,69,85)(H,70,81)(H,71,82)(H,74,75)(H4,54,55,59)(H4,56,57,60)/t27-,28-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318527
PNG
(Ac-ART-NH2 | CHEMBL1085865)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C15H29N7O5/c1-7(20-9(3)24)13(26)21-10(5-4-6-19-15(17)18)14(27)22-11(8(2)23)12(16)25/h7-8,10-11,23H,4-6H2,1-3H3,(H2,16,25)(H,20,24)(H,21,26)(H,22,27)(H4,17,18,19)/t7-,8+,10-,11-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318542
PNG
(CHEMBL1086451 | H2N-SARAEVHLRKS-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C52H93N21O15/c1-25(2)19-35(48(86)69-33(13-10-18-62-52(58)59)45(83)68-31(11-7-8-16-53)46(84)72-37(23-75)40(55)78)70-49(87)36(20-29-21-60-24-63-29)71-50(88)39(26(3)4)73-47(85)34(14-15-38(76)77)67-42(80)28(6)65-44(82)32(12-9-17-61-51(56)57)66-41(79)27(5)64-43(81)30(54)22-74/h21,24-28,30-37,39,74-75H,7-20,22-23,53-54H2,1-6H3,(H2,55,78)(H,60,63)(H,64,81)(H,65,82)(H,66,79)(H,67,80)(H,68,83)(H,69,86)(H,70,87)(H,71,88)(H,72,84)(H,73,85)(H,76,77)(H4,56,57,61)(H4,58,59,62)/t27-,28-,30-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200659
PNG
(US9233086, 3B)
Show SMILES CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C15H29N7O4/c1-4-10(12(16)24)21-14(26)11(6-5-7-19-15(17)18)22-13(25)8(2)20-9(3)23/h8,10-11H,4-7H2,1-3H3,(H2,16,24)(H,20,23)(H,21,26)(H,22,25)(H4,17,18,19)/t8-,10-,11-/s2
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n/an/a<100n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318544
PNG
(Ac-ARAEVHL-NH2 | CHEMBL1086453)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(N)=O
Show InChI InChI=1S/C36H61N13O10/c1-17(2)13-25(29(37)53)47-34(58)26(14-22-15-40-16-42-22)48-35(59)28(18(3)4)49-33(57)24(10-11-27(51)52)46-31(55)20(6)44-32(56)23(9-8-12-41-36(38)39)45-30(54)19(5)43-21(7)50/h15-20,23-26,28H,8-14H2,1-7H3,(H2,37,53)(H,40,42)(H,43,50)(H,44,56)(H,45,54)(H,46,55)(H,47,58)(H,48,59)(H,49,57)(H,51,52)(H4,38,39,41)/t19-,20-,23-,24-,25-,26-,28-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318547
PNG
(Ac-ARAE-NH2 | CHEMBL1085604)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C19H34N8O7/c1-9(24-11(3)28)16(32)27-13(5-4-8-23-19(21)22)18(34)25-10(2)17(33)26-12(15(20)31)6-7-14(29)30/h9-10,12-13H,4-8H2,1-3H3,(H2,20,31)(H,24,28)(H,25,34)(H,26,33)(H,27,32)(H,29,30)(H4,21,22,23)/t9-,10-,12-,13-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318545
PNG
(Ac-ARAEVH-NH2 | CHEMBL1086454)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C30H50N12O9/c1-14(2)23(29(51)41-21(24(31)46)11-18-12-34-13-36-18)42-28(50)20(8-9-22(44)45)40-26(48)16(4)38-27(49)19(7-6-10-35-30(32)33)39-25(47)15(3)37-17(5)43/h12-16,19-21,23H,6-11H2,1-5H3,(H2,31,46)(H,34,36)(H,37,43)(H,38,49)(H,39,47)(H,40,48)(H,41,51)(H,42,50)(H,44,45)(H4,32,33,35)/t15-,16-,19-,20-,21-,23-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318548
PNG
(Ac-ARA-NH2 | CHEMBL1086455)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C14H27N7O4/c1-7(11(15)23)20-13(25)10(5-4-6-18-14(16)17)21-12(24)8(2)19-9(3)22/h7-8,10H,4-6H2,1-3H3,(H2,15,23)(H,19,22)(H,20,25)(H,21,24)(H4,16,17,18)/t7-,8-,10-/m0/s1
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n/an/a 540n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318521
PNG
(Ac-ARA-CONHMe | CHEMBL1084621)
Show SMILES CNC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O
Show InChI InChI=1S/C15H29N7O4/c1-8(12(24)18-4)21-14(26)11(6-5-7-19-15(16)17)22-13(25)9(2)20-10(3)23/h8-9,11H,5-7H2,1-4H3,(H,18,24)(H,20,23)(H,21,26)(H,22,25)(H4,16,17,19)/t8-,9-,11-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318539
PNG
(Ac-GSARAEVHLRKS-NH2 | CHEMBL1086448)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C56H98N22O17/c1-27(2)20-37(51(92)74-35(14-11-19-65-56(61)62)48(89)73-33(12-8-9-17-57)49(90)77-39(24-79)44(58)85)75-52(93)38(21-32-22-63-26-67-32)76-54(95)43(28(3)4)78-50(91)36(15-16-42(83)84)72-46(87)29(5)68-47(88)34(13-10-18-64-55(59)60)71-45(86)30(6)69-53(94)40(25-80)70-41(82)23-66-31(7)81/h22,26-30,33-40,43,79-80H,8-21,23-25,57H2,1-7H3,(H2,58,85)(H,63,67)(H,66,81)(H,68,88)(H,69,94)(H,70,82)(H,71,86)(H,72,87)(H,73,89)(H,74,92)(H,75,93)(H,76,95)(H,77,90)(H,78,91)(H,83,84)(H4,59,60,64)(H4,61,62,65)/t29-,30-,33-,34-,35-,36-,37-,38-,39-,40-,43-/m0/s1
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n/an/a 750n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318546
PNG
(Ac-ARAEV-NH2 | CHEMBL1086531)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C24H43N9O8/c1-11(2)18(19(25)37)33-23(41)16(8-9-17(35)36)32-21(39)13(4)30-22(40)15(7-6-10-28-24(26)27)31-20(38)12(3)29-14(5)34/h11-13,15-16,18H,6-10H2,1-5H3,(H2,25,37)(H,29,34)(H,30,40)(H,31,38)(H,32,39)(H,33,41)(H,35,36)(H4,26,27,28)/t12-,13-,15-,16-,18-/m0/s1
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n/an/a 750n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318531
PNG
((7S,19S,22S,25S,28S,31S,34S,37S)-31-((1H-imidazol-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O
Show InChI InChI=1S/C89H129N27O27/c1-43(2)31-60(113-83(137)61(32-48-35-96-42-104-48)114-86(140)73(44(3)4)116-81(135)59(25-26-70(126)127)110-76(130)45(5)105-78(132)57(19-13-29-98-88(92)93)109-75(129)46(6)106-84(138)63(41-118)108-68(124)38-100-47(7)119)82(136)112-58(20-14-30-99-89(94)95)79(133)111-56(18-8-10-27-90)80(134)115-62(40-117)77(131)103-37-67(123)101-36-66(122)102-39-69(125)107-55(74(91)128)17-9-11-28-97-85(139)72-53(15-12-16-54(72)87(141)142)71-51-23-21-49(120)33-64(51)143-65-34-50(121)22-24-52(65)71/h12,15-16,21-24,33-35,42-46,55-63,73,117-118,120H,8-11,13-14,17-20,25-32,36-41,90H2,1-7H3,(H2,91,128)(H,96,104)(H,97,139)(H,100,119)(H,101,123)(H,102,122)(H,103,131)(H,105,132)(H,106,138)(H,107,125)(H,108,124)(H,109,129)(H,110,130)(H,111,133)(H,112,136)(H,113,137)(H,114,140)(H,115,134)(H,116,135)(H,126,127)(H,141,142)(H4,92,93,98)(H4,94,95,99)/t45-,46-,55-,56-,57-,58-,59-,60-,61-,62-,63-,73-/m0/s1
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n/an/a 860n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells after 24 hrs by optimized fluorescent polarization based saturation binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318532
PNG
((7S,24S,27S,30S,33S,36S,39S,42S)-36-((1H-imidazol-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O
Show InChI InChI=1S/C95H142N26O26/c1-50(2)41-67(118-89(141)68(42-55-45-102-49-109-55)119-92(144)79(51(3)4)121-87(139)66(33-34-76(130)131)115-82(134)52(5)110-84(136)64(25-19-39-106-94(98)99)114-81(133)53(6)111-90(142)70(48-123)113-75(129)46-108-54(7)124)88(140)117-65(26-20-40-107-95(100)101)85(137)116-63(24-12-14-35-96)86(138)120-69(47-122)83(135)104-37-16-8-10-27-73(127)103-36-15-9-11-28-74(128)112-62(80(97)132)23-13-17-38-105-91(143)78-60(21-18-22-61(78)93(145)146)77-58-31-29-56(125)43-71(58)147-72-44-57(126)30-32-59(72)77/h18,21-22,29-32,43-45,49-53,62-70,79,122-123,125H,8-17,19-20,23-28,33-42,46-48,96H2,1-7H3,(H2,97,132)(H,102,109)(H,103,127)(H,104,135)(H,105,143)(H,108,124)(H,110,136)(H,111,142)(H,112,128)(H,113,129)(H,114,133)(H,115,134)(H,116,137)(H,117,140)(H,118,141)(H,119,144)(H,120,138)(H,121,139)(H,130,131)(H,145,146)(H4,98,99,106)(H4,100,101,107)/t52-,53-,62-,63-,64-,65-,66-,67-,68-,69-,70-,79-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells after 24 hrs by optimized fluorescent polarization based saturation binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200642
PNG
(US9233086, 1B)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1/C15H29N7O4/c1-4-10(21-9(3)23)13(25)22-11(6-5-7-19-15(17)18)14(26)20-8(2)12(16)24/h8,10-11H,4-7H2,1-3H3,(H2,16,24)(H,20,26)(H,21,23)(H,22,25)(H4,17,18,19)/t8-,10-,11-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200643
PNG
(US9233086, 1C)
Show SMILES CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1/C16H31N7O4/c1-8(2)12(22-10(4)24)15(27)23-11(6-5-7-20-16(18)19)14(26)21-9(3)13(17)25/h8-9,11-12H,5-7H2,1-4H3,(H2,17,25)(H,21,26)(H,22,24)(H,23,27)(H4,18,19,20)/t9-,11-,12-/s2
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n/an/a<1.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200651
PNG
(US9233086, 2A)
Show SMILES CCCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1/C14H26N4O4/c1-5-6-7-11(14(22)17-8(2)12(15)20)18-13(21)9(3)16-10(4)19/h8-9,11H,5-7H2,1-4H3,(H2,15,20)(H,16,19)(H,17,22)(H,18,21)/t8-,9-,11-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200652
PNG
(US9233086, 2B)
Show SMILES C[C@H](NC(=O)[C@H](CCCN)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C13H25N5O4/c1-7(11(15)20)17-13(22)10(5-4-6-14)18-12(21)8(2)16-9(3)19/h7-8,10H,4-6,14H2,1-3H3,(H2,15,20)(H,16,19)(H,17,22)(H,18,21)/t7-,8-,10-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200653
PNG
(US9233086, 2C)
Show SMILES C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C14H27N5O4/c1-8(12(16)21)18-14(23)11(6-4-5-7-15)19-13(22)9(2)17-10(3)20/h8-9,11H,4-7,15H2,1-3H3,(H2,16,21)(H,17,20)(H,18,23)(H,19,22)/t8-,9-,11-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200654
PNG
(US9233086, 2D)
Show SMILES C[C@H](NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C14H26N6O5/c1-7(11(15)22)19-13(24)10(5-4-6-17-14(16)25)20-12(23)8(2)18-9(3)21/h7-8,10H,4-6H2,1-3H3,(H2,15,22)(H,18,21)(H,19,24)(H,20,23)(H3,16,17,25)/t7-,8-,10-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200658
PNG
(US9233086, 3A)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
Show InChI InChI=1/C13H25N7O4/c1-7(19-8(2)21)11(23)20-9(4-3-5-17-13(15)16)12(24)18-6-10(14)22/h7,9H,3-6H2,1-2H3,(H2,14,22)(H,18,24)(H,19,21)(H,20,23)(H4,15,16,17)/t7-,9-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200660
PNG
(US9233086, 3C)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C16H31N7O4/c1-8(2)12(13(17)25)23-15(27)11(6-5-7-20-16(18)19)22-14(26)9(3)21-10(4)24/h8-9,11-12H,5-7H2,1-4H3,(H2,17,25)(H,21,24)(H,22,26)(H,23,27)(H4,18,19,20)/t9-,11-,12-/s2
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200661
PNG
(US9233086, 3D)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(N)=O
Show InChI InChI=1/C14H27N7O4S/c1-7(19-8(2)22)12(24)20-9(4-3-5-18-14(16)17)13(25)21-10(6-26)11(15)23/h7,9-10,26H,3-6H2,1-2H3,(H2,15,23)(H,19,22)(H,20,24)(H,21,25)(H4,16,17,18)/t7-,9-,10-/s2
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n/an/a<1.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200666
PNG
(US9233086, 3I)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C15H29N7O5/c1-7(20-9(3)24)13(26)21-10(5-4-6-19-15(17)18)14(27)22-11(8(2)23)12(16)25/h7-8,10-11,23H,4-6H2,1-3H3,(H2,16,25)(H,20,24)(H,21,26)(H,22,27)(H4,17,18,19)/t7-,8+,10-,11-/s2
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n/an/a<1.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
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