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Compile Data Set for Download or QSAR

Found 239 hits Enz. Inhib. hit(s) with Target = 'WD repeat-containing protein 5 (WDR5)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318541
PNG
(Ac-ARAEVHLRKS-NH2 | CHEMBL1086450)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C51H90N20O14/c1-25(2)20-35(47(83)67-33(14-11-19-60-51(56)57)44(80)66-31(12-8-9-17-52)45(81)70-37(23-72)40(53)76)68-48(84)36(21-30-22-58-24-61-30)69-49(85)39(26(3)4)71-46(82)34(15-16-38(74)75)65-42(78)28(6)63-43(79)32(13-10-18-59-50(54)55)64-41(77)27(5)62-29(7)73/h22,24-28,31-37,39,72H,8-21,23,52H2,1-7H3,(H2,53,76)(H,58,61)(H,62,73)(H,63,79)(H,64,77)(H,65,78)(H,66,80)(H,67,83)(H,68,84)(H,69,85)(H,70,81)(H,71,82)(H,74,75)(H4,54,55,59)(H4,56,57,60)/t27-,28-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318527
PNG
(Ac-ART-NH2 | CHEMBL1085865)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C15H29N7O5/c1-7(20-9(3)24)13(26)21-10(5-4-6-19-15(17)18)14(27)22-11(8(2)23)12(16)25/h7-8,10-11,23H,4-6H2,1-3H3,(H2,16,25)(H,20,24)(H,21,26)(H,22,27)(H4,17,18,19)/t7-,8+,10-,11-/m0/s1
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20n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318542
PNG
(CHEMBL1086451 | H2N-SARAEVHLRKS-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C52H93N21O15/c1-25(2)19-35(48(86)69-33(13-10-18-62-52(58)59)45(83)68-31(11-7-8-16-53)46(84)72-37(23-75)40(55)78)70-49(87)36(20-29-21-60-24-63-29)71-50(88)39(26(3)4)73-47(85)34(14-15-38(76)77)67-42(80)28(6)65-44(82)32(12-9-17-61-51(56)57)66-41(79)27(5)64-43(81)30(54)22-74/h21,24-28,30-37,39,74-75H,7-20,22-23,53-54H2,1-6H3,(H2,55,78)(H,60,63)(H,64,81)(H,65,82)(H,66,79)(H,67,80)(H,68,83)(H,69,86)(H,70,87)(H,71,88)(H,72,84)(H,73,85)(H,76,77)(H4,56,57,61)(H4,58,59,62)/t27-,28-,30-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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20n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318544
PNG
(Ac-ARAEVHL-NH2 | CHEMBL1086453)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(N)=O
Show InChI InChI=1S/C36H61N13O10/c1-17(2)13-25(29(37)53)47-34(58)26(14-22-15-40-16-42-22)48-35(59)28(18(3)4)49-33(57)24(10-11-27(51)52)46-31(55)20(6)44-32(56)23(9-8-12-41-36(38)39)45-30(54)19(5)43-21(7)50/h15-20,23-26,28H,8-14H2,1-7H3,(H2,37,53)(H,40,42)(H,43,50)(H,44,56)(H,45,54)(H,46,55)(H,47,58)(H,48,59)(H,49,57)(H,51,52)(H4,38,39,41)/t19-,20-,23-,24-,25-,26-,28-/m0/s1
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30n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318547
PNG
(Ac-ARAE-NH2 | CHEMBL1085604)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C19H34N8O7/c1-9(24-11(3)28)16(32)27-13(5-4-8-23-19(21)22)18(34)25-10(2)17(33)26-12(15(20)31)6-7-14(29)30/h9-10,12-13H,4-8H2,1-3H3,(H2,20,31)(H,24,28)(H,25,34)(H,26,33)(H,27,32)(H,29,30)(H4,21,22,23)/t9-,10-,12-,13-/m0/s1
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80n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318545
PNG
(Ac-ARAEVH-NH2 | CHEMBL1086454)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C30H50N12O9/c1-14(2)23(29(51)41-21(24(31)46)11-18-12-34-13-36-18)42-28(50)20(8-9-22(44)45)40-26(48)16(4)38-27(49)19(7-6-10-35-30(32)33)39-25(47)15(3)37-17(5)43/h12-16,19-21,23H,6-11H2,1-5H3,(H2,31,46)(H,34,36)(H,37,43)(H,38,49)(H,39,47)(H,40,48)(H,41,51)(H,42,50)(H,44,45)(H4,32,33,35)/t15-,16-,19-,20-,21-,23-/m0/s1
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90n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318548
PNG
(Ac-ARA-NH2 | CHEMBL1086455)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C14H27N7O4/c1-7(11(15)23)20-13(25)10(5-4-6-18-14(16)17)21-12(24)8(2)19-9(3)22/h7-8,10H,4-6H2,1-3H3,(H2,15,23)(H,19,22)(H,20,25)(H,21,24)(H4,16,17,18)/t7-,8-,10-/m0/s1
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120n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318521
PNG
(Ac-ARA-CONHMe | CHEMBL1084621)
Show SMILES CNC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O
Show InChI InChI=1S/C15H29N7O4/c1-8(12(24)18-4)21-14(26)11(6-5-7-19-15(16)17)22-13(25)9(2)20-10(3)23/h8-9,11H,5-7H2,1-4H3,(H,18,24)(H,20,23)(H,21,26)(H,22,25)(H4,16,17,19)/t8-,9-,11-/m0/s1
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150n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318546
PNG
(Ac-ARAEV-NH2 | CHEMBL1086531)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C24H43N9O8/c1-11(2)18(19(25)37)33-23(41)16(8-9-17(35)36)32-21(39)13(4)30-22(40)15(7-6-10-28-24(26)27)31-20(38)12(3)29-14(5)34/h11-13,15-16,18H,6-10H2,1-5H3,(H2,25,37)(H,29,34)(H,30,40)(H,31,38)(H,32,39)(H,33,41)(H,35,36)(H4,26,27,28)/t12-,13-,15-,16-,18-/m0/s1
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160n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318539
PNG
(Ac-GSARAEVHLRKS-NH2 | CHEMBL1086448)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C56H98N22O17/c1-27(2)20-37(51(92)74-35(14-11-19-65-56(61)62)48(89)73-33(12-8-9-17-57)49(90)77-39(24-79)44(58)85)75-52(93)38(21-32-22-63-26-67-32)76-54(95)43(28(3)4)78-50(91)36(15-16-42(83)84)72-46(87)29(5)68-47(88)34(13-10-18-64-55(59)60)71-45(86)30(6)69-53(94)40(25-80)70-41(82)23-66-31(7)81/h22,26-30,33-40,43,79-80H,8-21,23-25,57H2,1-7H3,(H2,58,85)(H,63,67)(H,66,81)(H,68,88)(H,69,94)(H,70,82)(H,71,86)(H,72,87)(H,73,89)(H,74,92)(H,75,93)(H,76,95)(H,77,90)(H,78,91)(H,83,84)(H4,59,60,64)(H4,61,62,65)/t29-,30-,33-,34-,35-,36-,37-,38-,39-,40-,43-/m0/s1
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160n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318540
PNG
(Ac-SARAEVHLRKS-NH2 | CHEMBL1086449)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C54H95N21O16/c1-26(2)20-36(49(88)71-34(14-11-19-63-54(59)60)46(85)70-32(12-8-9-17-55)47(86)74-38(23-76)42(56)81)72-50(89)37(21-31-22-61-25-64-31)73-52(91)41(27(3)4)75-48(87)35(15-16-40(79)80)69-44(83)28(5)65-45(84)33(13-10-18-62-53(57)58)68-43(82)29(6)66-51(90)39(24-77)67-30(7)78/h22,25-29,32-39,41,76-77H,8-21,23-24,55H2,1-7H3,(H2,56,81)(H,61,64)(H,65,84)(H,66,90)(H,67,78)(H,68,82)(H,69,83)(H,70,85)(H,71,88)(H,72,89)(H,73,91)(H,74,86)(H,75,87)(H,79,80)(H4,57,58,62)(H4,59,60,63)/t28-,29-,32-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
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200n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318523
PNG
(Ac-ARA-COOCH3 | CHEMBL1084623)
Show SMILES COC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O
Show InChI InChI=1S/C15H28N6O5/c1-8(19-10(3)22)12(23)21-11(6-5-7-18-15(16)17)13(24)20-9(2)14(25)26-4/h8-9,11H,5-7H2,1-4H3,(H,19,22)(H,20,24)(H,21,23)(H4,16,17,18)/t8-,9-,11-/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318537
PNG
(CHEMBL1086083 | CHO-ARA-NH2)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC=O)C(N)=O
Show InChI InChI=1S/C13H25N7O4/c1-7(10(14)22)19-12(24)9(4-3-5-17-13(15)16)20-11(23)8(2)18-6-21/h6-9H,3-5H2,1-2H3,(H2,14,22)(H,18,21)(H,19,24)(H,20,23)(H4,15,16,17)/t7-,8-,9-/m0/s1
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3.20E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318543
PNG
(Ac-RAEVHLRKS-NH2 | CHEMBL1086452)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C48H85N19O13/c1-24(2)19-33(44(78)63-31(13-10-18-57-48(53)54)41(75)62-30(11-7-8-16-49)42(76)66-35(22-68)38(50)72)64-45(79)34(20-28-21-55-23-58-28)65-46(80)37(25(3)4)67-43(77)32(14-15-36(70)71)61-39(73)26(5)59-40(74)29(60-27(6)69)12-9-17-56-47(51)52/h21,23-26,29-35,37,68H,7-20,22,49H2,1-6H3,(H2,50,72)(H,55,58)(H,59,74)(H,60,69)(H,61,73)(H,62,75)(H,63,78)(H,64,79)(H,65,80)(H,66,76)(H,67,77)(H,70,71)(H4,51,52,56)(H4,53,54,57)/t26-,29-,30-,31-,32-,33-,34-,35-,37-/m0/s1
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6.30E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318522
PNG
(Ac-ARA-CONMe2 | CHEMBL1084622)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N(C)C
Show InChI InChI=1S/C16H31N7O4/c1-9(20-11(3)24)13(25)22-12(7-6-8-19-16(17)18)14(26)21-10(2)15(27)23(4)5/h9-10,12H,6-8H2,1-5H3,(H,20,24)(H,21,26)(H,22,25)(H4,17,18,19)/t9-,10-,12-/m0/s1
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PubMed
6.50E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318535
PNG
(CHEMBL1086456 | H2N-ARAEVHLRKS-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C49H88N20O13/c1-24(2)19-33(45(80)65-31(13-10-18-59-49(55)56)42(77)64-29(11-7-8-16-50)43(78)68-35(22-70)38(52)73)66-46(81)34(20-28-21-57-23-60-28)67-47(82)37(25(3)4)69-44(79)32(14-15-36(71)72)63-40(75)27(6)61-41(76)30(62-39(74)26(5)51)12-9-17-58-48(53)54/h21,23-27,29-35,37,70H,7-20,22,50-51H2,1-6H3,(H2,52,73)(H,57,60)(H,61,76)(H,62,74)(H,63,75)(H,64,77)(H,65,80)(H,66,81)(H,67,82)(H,68,78)(H,69,79)(H,71,72)(H4,53,54,58)(H4,55,56,59)/t26-,27-,29-,30-,31-,32-,33-,34-,35-,37-/m0/s1
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PubMed
7.30E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318529
PNG
(CHEMBL1082285 | H2N-ARTK(Me2)QTARKS-NH2)
Show SMILES CNCCCC[C@H](N(C)C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C48H92N20O14/c1-24(50)38(74)61-30(15-12-22-59-48(55)56)42(78)67-36(27(4)71)46(82)68(6)33(16-8-10-20-57-5)44(80)64-31(17-18-34(51)72)43(79)66-35(26(3)70)45(81)60-25(2)39(75)62-29(14-11-21-58-47(53)54)40(76)63-28(13-7-9-19-49)41(77)65-32(23-69)37(52)73/h24-33,35-36,57,69-71H,7-23,49-50H2,1-6H3,(H2,51,72)(H2,52,73)(H,60,81)(H,61,74)(H,62,75)(H,63,76)(H,64,80)(H,65,77)(H,66,79)(H,67,78)(H4,53,54,58)(H4,55,56,59)/t24-,25-,26+,27+,28-,29-,30-,31-,32-,33-,35-,36-/m0/s1
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PubMed
9.00E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318528
PNG
(CHEMBL1082284 | H2N-ARTK(Me)QTARKS-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)N(C)C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C47H90N20O14/c1-23(50)37(73)60-29(14-11-21-58-47(55)56)41(77)66-35(26(4)70)45(81)67(5)32(15-7-9-19-49)43(79)63-30(16-17-33(51)71)42(78)65-34(25(3)69)44(80)59-24(2)38(74)61-28(13-10-20-57-46(53)54)39(75)62-27(12-6-8-18-48)40(76)64-31(22-68)36(52)72/h23-32,34-35,68-70H,6-22,48-50H2,1-5H3,(H2,51,71)(H2,52,72)(H,59,80)(H,60,73)(H,61,74)(H,62,75)(H,63,79)(H,64,76)(H,65,78)(H,66,77)(H4,53,54,57)(H4,55,56,58)/t23-,24-,25+,26+,27-,28-,29-,30-,31-,32-,34-,35-/m0/s1
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PubMed
1.50E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318524
PNG
(CHEMBL1082281 | H2N-ARTKQTARKS-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C46H88N20O14/c1-22(49)36(72)59-29(14-10-20-57-46(54)55)41(77)66-34(25(4)69)44(80)63-27(12-6-8-18-48)38(74)62-30(15-16-32(50)70)42(78)65-33(24(3)68)43(79)58-23(2)37(73)60-28(13-9-19-56-45(52)53)39(75)61-26(11-5-7-17-47)40(76)64-31(21-67)35(51)71/h22-31,33-34,67-69H,5-21,47-49H2,1-4H3,(H2,50,70)(H2,51,71)(H,58,79)(H,59,72)(H,60,73)(H,61,75)(H,62,74)(H,63,80)(H,64,76)(H,65,78)(H,66,77)(H4,52,53,56)(H4,54,55,57)/t22-,23-,24+,25+,26-,27-,28-,29-,30-,31-,33-,34-/m0/s1
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PubMed
1.51E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318530
PNG
(CHEMBL1082286 | H2N-ARTK(Me3)QTARKS-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C49H94N20O14/c1-25(51)39(75)61-31(16-13-22-59-49(56)57)43(79)67-37(28(4)72)47(83)69(7)34(17-9-11-23-68(5)6)45(81)64-32(18-19-35(52)73)44(80)66-36(27(3)71)46(82)60-26(2)40(76)62-30(15-12-21-58-48(54)55)41(77)63-29(14-8-10-20-50)42(78)65-33(24-70)38(53)74/h25-34,36-37,70-72H,8-24,50-51H2,1-7H3,(H2,52,73)(H2,53,74)(H,60,82)(H,61,75)(H,62,76)(H,63,77)(H,64,81)(H,65,78)(H,66,80)(H,67,79)(H4,54,55,58)(H4,56,57,59)/t25-,26-,27+,28+,29-,30-,31-,32-,33-,34-,36-,37-/m0/s1
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PubMed
1.56E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318549
PNG
(Ac-AR-NH2 | CHEMBL1085605)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C11H22N6O3/c1-6(16-7(2)18)10(20)17-8(9(12)19)4-3-5-15-11(13)14/h6,8H,3-5H2,1-2H3,(H2,12,19)(H,16,18)(H,17,20)(H4,13,14,15)/t6-,8-/m0/s1
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PubMed
2.70E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318526
PNG
(CHEMBL1085864 | H2N-ART-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(N)=O
Show InChI InChI=1S/C13H27N7O4/c1-6(14)11(23)19-8(4-3-5-18-13(16)17)12(24)20-9(7(2)21)10(15)22/h6-9,21H,3-5,14H2,1-2H3,(H2,15,22)(H,19,23)(H,20,24)(H4,16,17,18)/t6-,7+,8-,9-/m0/s1
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PubMed
2.73E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318538
PNG
(Ac-AR-(N-Me)A-NH2 | CHEMBL1084620)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(C)[C@@H](C)C(N)=O
Show InChI InChI=1S/C15H29N7O4/c1-8(20-10(3)23)13(25)21-11(6-5-7-19-15(17)18)14(26)22(4)9(2)12(16)24/h8-9,11H,5-7H2,1-4H3,(H2,16,24)(H,20,23)(H,21,25)(H4,17,18,19)/t8-,9-,11-/m0/s1
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PubMed
>5.00E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318536
PNG
(CHEMBL1085606 | H2N-ARA-NH2)
Show SMILES C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C12H25N7O3/c1-6(13)10(21)19-8(4-3-5-17-12(15)16)11(22)18-7(2)9(14)20/h6-8H,3-5,13H2,1-2H3,(H2,14,20)(H,18,22)(H,19,21)(H4,15,16,17)/t6-,7-,8-/m0/s1
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50164787
PNG
(CHEMBL3798088)
Show SMILES CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C
Show InChI InChI=1/C29H46N8O5/c1-5-20-24(39)36-22(19-12-7-6-8-13-19)26(41)32-16-10-9-15-29(4,37-23(38)18(2)3)27(42)35-21(25(40)34-20)14-11-17-33-28(30)31/h6-8,12-13,18,20-22H,5,9-11,14-17H2,1-4H3,(H,32,41)(H,34,40)(H,35,42)(H,36,39)(H,37,38)(H4,30,31,33)/t20-,21-,22+,29+/s2
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n/an/a 0.900n/an/an/an/an/an/a



Ontario Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of SUMO-His-tagged WDR5 (unknown origin) interaction with MLL1 assessed as displacement of fluorescence labelled Ac-ARA peptide substrate ...


J Med Chem 59: 2478-96 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318534
PNG
((7S,24S,27S,30S,33S,36S,39S,42S)-36-((1H-imidazol-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O
Show InChI InChI=1S/C91H136N24O24/c1-48(2)41-65(111-85(133)66(42-53-45-98-47-104-53)112-87(135)75(49(3)4)114-83(131)64(33-34-72(123)124)110-88(136)76(51(6)117)115-82(130)63(26-20-40-103-91(96)97)107-78(126)50(5)105-52(7)118)84(132)109-62(25-19-39-102-90(94)95)80(128)108-61(24-12-14-35-92)81(129)113-67(46-116)79(127)100-37-16-8-10-27-70(121)99-36-15-9-11-28-71(122)106-60(77(93)125)23-13-17-38-101-86(134)74-58(21-18-22-59(74)89(137)138)73-56-31-29-54(119)43-68(56)139-69-44-55(120)30-32-57(69)73/h18,21-22,29-32,43-45,47-51,60-67,75-76,116-117,119H,8-17,19-20,23-28,33-42,46,92H2,1-7H3,(H2,93,125)(H,98,104)(H,99,121)(H,100,127)(H,101,134)(H,105,118)(H,106,122)(H,107,126)(H,108,128)(H,109,132)(H,110,136)(H,111,133)(H,112,135)(H,113,129)(H,114,131)(H,115,130)(H,123,124)(H,137,138)(H4,94,95,102)(H4,96,97,103)/t50-,51+,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells after 24 hrs by optimized fluorescent polarization based saturation binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM200712
PNG
(US9233086, 10A)
Show SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccccc1)c1ccccc1
Show InChI InChI=1/C35H51N7O4/c1-5-34(6-2,41-29(43)24(3)4)31(45)39-27(20-15-23-38-33(36)37)30(44)42-35(21-13-14-22-35)32(46)40-28(25-16-9-7-10-17-25)26-18-11-8-12-19-26/h7-12,16-19,24,27-28H,5-6,13-15,20-23H2,1-4H3,(H,39,45)(H,40,46)(H,41,43)(H,42,44)(H4,36,37,38)/t27-/s2
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n/an/a 2.90n/an/an/an/an/an/a



Ontario Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) interaction with MLL1 assessed as displacement of 5-Lys-FAM peptide su...


J Med Chem 59: 2478-96 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318525
PNG
(Ac-ARTKQTARKS-NH2 | CHEMBL1082282)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C48H90N20O15/c1-23(59-27(5)72)38(75)62-31(15-11-21-58-48(55)56)43(80)68-36(26(4)71)46(83)65-29(13-7-9-19-50)40(77)64-32(16-17-34(51)73)44(81)67-35(25(3)70)45(82)60-24(2)39(76)61-30(14-10-20-57-47(53)54)41(78)63-28(12-6-8-18-49)42(79)66-33(22-69)37(52)74/h23-26,28-33,35-36,69-71H,6-22,49-50H2,1-5H3,(H2,51,73)(H2,52,74)(H,59,72)(H,60,82)(H,61,76)(H,62,75)(H,63,78)(H,64,77)(H,65,83)(H,66,79)(H,67,81)(H,68,80)(H4,53,54,57)(H4,55,56,58)/t23-,24-,25+,26+,28-,29-,30-,31-,32-,33-,35-,36-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318533
PNG
((7S,24S,27S,30S,33S,36S,39S,42S)-36-((1H-imidazol-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O
Show InChI InChI=1S/C90H134N24O23/c1-48(2)41-65(111-85(132)66(42-53-45-97-47-103-53)112-87(134)75(49(3)4)114-83(130)64(33-34-72(121)122)108-78(125)51(6)105-80(127)62(25-19-39-101-89(93)94)107-77(124)50(5)104-52(7)116)84(131)110-63(26-20-40-102-90(95)96)81(128)109-61(24-12-14-35-91)82(129)113-67(46-115)79(126)99-37-16-8-10-27-70(119)98-36-15-9-11-28-71(120)106-60(76(92)123)23-13-17-38-100-86(133)74-58(21-18-22-59(74)88(135)136)73-56-31-29-54(117)43-68(56)137-69-44-55(118)30-32-57(69)73/h18,21-22,29-32,43-45,47-51,60-67,75,115,117H,8-17,19-20,23-28,33-42,46,91H2,1-7H3,(H2,92,123)(H,97,103)(H,98,119)(H,99,126)(H,100,133)(H,104,116)(H,105,127)(H,106,120)(H,107,124)(H,108,125)(H,109,128)(H,110,131)(H,111,132)(H,112,134)(H,113,129)(H,114,130)(H,121,122)(H,135,136)(H4,93,94,101)(H4,95,96,102)/t50-,51-,60-,61-,62-,63-,64-,65-,66-,67-,75-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells after 24 hrs by optimized fluorescent polarization based saturation binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318541
PNG
(Ac-ARAEVHLRKS-NH2 | CHEMBL1086450)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C51H90N20O14/c1-25(2)20-35(47(83)67-33(14-11-19-60-51(56)57)44(80)66-31(12-8-9-17-52)45(81)70-37(23-72)40(53)76)68-48(84)36(21-30-22-58-24-61-30)69-49(85)39(26(3)4)71-46(82)34(15-16-38(74)75)65-42(78)28(6)63-43(79)32(13-10-18-59-50(54)55)64-41(77)27(5)62-29(7)73/h22,24-28,31-37,39,72H,8-21,23,52H2,1-7H3,(H2,53,76)(H,58,61)(H,62,73)(H,63,79)(H,64,77)(H,65,78)(H,66,80)(H,67,83)(H,68,84)(H,69,85)(H,70,81)(H,71,82)(H,74,75)(H4,54,55,59)(H4,56,57,60)/t27-,28-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318527
PNG
(Ac-ART-NH2 | CHEMBL1085865)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C15H29N7O5/c1-7(20-9(3)24)13(26)21-10(5-4-6-19-15(17)18)14(27)22-11(8(2)23)12(16)25/h7-8,10-11,23H,4-6H2,1-3H3,(H2,16,25)(H,20,24)(H,21,26)(H,22,27)(H4,17,18,19)/t7-,8+,10-,11-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318542
PNG
(CHEMBL1086451 | H2N-SARAEVHLRKS-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C52H93N21O15/c1-25(2)19-35(48(86)69-33(13-10-18-62-52(58)59)45(83)68-31(11-7-8-16-53)46(84)72-37(23-75)40(55)78)70-49(87)36(20-29-21-60-24-63-29)71-50(88)39(26(3)4)73-47(85)34(14-15-38(76)77)67-42(80)28(6)65-44(82)32(12-9-17-61-51(56)57)66-41(79)27(5)64-43(81)30(54)22-74/h21,24-28,30-37,39,74-75H,7-20,22-23,53-54H2,1-6H3,(H2,55,78)(H,60,63)(H,64,81)(H,65,82)(H,66,79)(H,67,80)(H,68,83)(H,69,86)(H,70,87)(H,71,88)(H,72,84)(H,73,85)(H,76,77)(H4,56,57,61)(H4,58,59,62)/t27-,28-,30-,31-,32-,33-,34-,35-,36-,37-,39-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (human))
BDBM200659
PNG
(US9233086, 3B)
Show SMILES CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1/C15H29N7O4/c1-4-10(12(16)24)21-14(26)11(6-5-7-19-15(17)18)22-13(25)8(2)20-9(3)23/h8,10-11H,4-7H2,1-3H3,(H2,16,24)(H,20,23)(H,21,26)(H,22,25)(H4,17,18,19)/t8-,10-,11-/s2
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n/an/a<100n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...


US Patent US9233086 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184787
PNG
(CHEMBL3823308)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccncc1
Show InChI InChI=1S/C24H24ClFN4O/c1-16-20(26)5-4-19(23(16)25)24(31)28-21-15-18(17-7-9-27-10-8-17)3-6-22(21)30-13-11-29(2)12-14-30/h3-10,15H,11-14H2,1-2H3,(H,28,31)
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n/an/a 104n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184956
PNG
(CHEMBL3822521)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C25H24ClFN4O3/c1-16-21(27)9-8-20(24(16)26)25(32)28-22-15-18(17-3-6-19(7-4-17)31(33)34)5-10-23(22)30-13-11-29(2)12-14-30/h3-10,15H,11-14H2,1-2H3,(H,28,32)
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n/an/a 127n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184789
PNG
(CHEMBL3822691)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(c(F)c(C)c1Cl)[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C19H19ClFN5O5/c1-11-17(20)13(10-16(18(11)21)26(30)31)19(27)22-14-9-12(25(28)29)3-4-15(14)24-7-5-23(2)6-8-24/h3-4,9-10H,5-8H2,1-2H3,(H,22,27)
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n/an/a 130n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318544
PNG
(Ac-ARAEVHL-NH2 | CHEMBL1086453)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(N)=O
Show InChI InChI=1S/C36H61N13O10/c1-17(2)13-25(29(37)53)47-34(58)26(14-22-15-40-16-42-22)48-35(59)28(18(3)4)49-33(57)24(10-11-27(51)52)46-31(55)20(6)44-32(56)23(9-8-12-41-36(38)39)45-30(54)19(5)43-21(7)50/h15-20,23-26,28H,8-14H2,1-7H3,(H2,37,53)(H,40,42)(H,43,50)(H,44,56)(H,45,54)(H,46,55)(H,47,58)(H,48,59)(H,49,57)(H,51,52)(H4,38,39,41)/t19-,20-,23-,24-,25-,26-,28-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184951
PNG
(CHEMBL3823328)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24ClFN4O/c1-17-22(28)9-8-21(25(17)27)26(33)30-23-15-20(19-5-3-18(16-29)4-6-19)7-10-24(23)32-13-11-31(2)12-14-32/h3-10,15H,11-14H2,1-2H3,(H,30,33)
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n/an/a 199n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184957
PNG
(CHEMBL3822596)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccc(N)cc1
Show InChI InChI=1S/C25H26ClFN4O/c1-16-21(27)9-8-20(24(16)26)25(32)29-22-15-18(17-3-6-19(28)7-4-17)5-10-23(22)31-13-11-30(2)12-14-31/h3-10,15H,11-14,28H2,1-2H3,(H,29,32)
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n/an/a 206n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184958
PNG
(CHEMBL3823310)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(c(F)c(C)c1Cl)[N+]([O-])=O)-c1ccccc1
Show InChI InChI=1S/C25H24ClFN4O3/c1-16-23(26)19(15-22(24(16)27)31(33)34)25(32)28-20-14-18(17-6-4-3-5-7-17)8-9-21(20)30-12-10-29(2)11-13-30/h3-9,14-15H,10-13H2,1-2H3,(H,28,32)
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n/an/a 207n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50428271
PNG
(CHEMBL2337032)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)[N+]([O-])=O
Show InChI InChI=1S/C19H20ClFN4O3/c1-12-15(21)5-4-14(18(12)20)19(26)22-16-11-13(25(27)28)3-6-17(16)24-9-7-23(2)8-10-24/h3-6,11H,7-10H2,1-2H3,(H,22,26)
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n/an/a 339n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184954
PNG
(CHEMBL3822660)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccc(F)cc1
Show InChI InChI=1S/C25H24ClF2N3O/c1-16-21(28)9-8-20(24(16)26)25(32)29-22-15-18(17-3-6-19(27)7-4-17)5-10-23(22)31-13-11-30(2)12-14-31/h3-10,15H,11-14H2,1-2H3,(H,29,32)
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n/an/a 393n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318547
PNG
(Ac-ARAE-NH2 | CHEMBL1085604)
Show SMILES C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C19H34N8O7/c1-9(24-11(3)28)16(32)27-13(5-4-8-23-19(21)22)18(34)25-10(2)17(33)26-12(15(20)31)6-7-14(29)30/h9-10,12-13H,4-8H2,1-3H3,(H2,20,31)(H,24,28)(H,25,34)(H,26,33)(H,27,32)(H,29,30)(H4,21,22,23)/t9-,10-,12-,13-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318545
PNG
(Ac-ARAEVH-NH2 | CHEMBL1086454)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C30H50N12O9/c1-14(2)23(29(51)41-21(24(31)46)11-18-12-34-13-36-18)42-28(50)20(8-9-22(44)45)40-26(48)16(4)38-27(49)19(7-6-10-35-30(32)33)39-25(47)15(3)37-17(5)43/h12-16,19-21,23H,6-11H2,1-5H3,(H2,31,46)(H,34,36)(H,37,43)(H,38,49)(H,39,47)(H,40,48)(H,41,51)(H,42,50)(H,44,45)(H4,32,33,35)/t15-,16-,19-,20-,21-,23-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184952
PNG
(CHEMBL3823476)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccccc1
Show InChI InChI=1S/C25H25ClFN3O/c1-17-21(27)10-9-20(24(17)26)25(31)28-22-16-19(18-6-4-3-5-7-18)8-11-23(22)30-14-12-29(2)13-15-30/h3-11,16H,12-15H2,1-2H3,(H,28,31)
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n/an/a 466n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318548
PNG
(Ac-ARA-NH2 | CHEMBL1086455)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C14H27N7O4/c1-7(11(15)23)20-13(25)10(5-4-6-18-14(16)17)21-12(24)8(2)19-9(3)22/h7-8,10H,4-6H2,1-3H3,(H2,15,23)(H,19,22)(H,20,25)(H,21,24)(H4,16,17,18)/t7-,8-,10-/m0/s1
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n/an/a 540n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184950
PNG
(CHEMBL3823415)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H25ClFN3O3/c1-16-21(28)9-8-20(24(16)27)25(32)29-22-15-19(17-3-5-18(6-4-17)26(33)34)7-10-23(22)31-13-11-30(2)12-14-31/h3-10,15H,11-14H2,1-2H3,(H,29,32)(H,33,34)
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n/an/a 661n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318521
PNG
(Ac-ARA-CONHMe | CHEMBL1084621)
Show SMILES CNC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O
Show InChI InChI=1S/C15H29N7O4/c1-8(12(24)18-4)21-14(26)11(6-5-7-19-15(16)17)22-13(25)9(2)20-10(3)23/h8-9,11H,5-7H2,1-4H3,(H,18,24)(H,20,23)(H,21,26)(H,22,25)(H4,16,17,19)/t8-,9-,11-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50184955
PNG
(CHEMBL3824206)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1Cl)-c1cncnc1
Show InChI InChI=1S/C23H23ClFN5O/c1-15-19(25)5-4-18(22(15)24)23(31)28-20-11-16(17-12-26-14-27-13-17)3-6-21(20)30-9-7-29(2)8-10-30/h3-6,11-14H,7-10H2,1-2H3,(H,28,31)
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n/an/a 733n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...


Eur J Med Chem 118: 1-8 (2016)

More data for this
Ligand-Target Pair
WD repeat-containing protein 5 (WDR5)


(Homo sapiens (Human))
BDBM50318546
PNG
(Ac-ARAEV-NH2 | CHEMBL1086531)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)C(N)=O
Show InChI InChI=1S/C24H43N9O8/c1-11(2)18(19(25)37)33-23(41)16(8-9-17(35)36)32-21(39)13(4)30-22(40)15(7-6-10-28-24(26)27)31-20(38)12(3)29-14(5)34/h11-13,15-16,18H,6-10H2,1-5H3,(H2,25,37)(H,29,34)(H,30,40)(H,31,38)(H,32,39)(H,33,41)(H,35,36)(H4,26,27,28)/t12-,13-,15-,16-,18-/m0/s1
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n/an/a 750n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Binding affinity to WDR5 expressed in pLysS cells by optimized fluorescent polarization based competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
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