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Found 726 hits Enz. Inhib. hit(s) with Target = 'Zinc aminopeptidase' AND taxid = 186763   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339789
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-(4-methoxypheny...)
Show SMILES COc1ccc(C[C@@H](N)[C@H](O)C(=O)N[C@@H](CC(C)C)C(O)=O)cc1
Show InChI InChI=1S/C17H26N2O5/c1-10(2)8-14(17(22)23)19-16(21)15(20)13(18)9-11-4-6-12(24-3)7-5-11/h4-7,10,13-15,20H,8-9,18H2,1-3H3,(H,19,21)(H,22,23)/t13-,14+,15+/m1/s1
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43n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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190n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339790
PNG
((S)-2-((2S,3R)-3-amino-4-(4-(benzyloxy)phenyl)-2-h...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccc(OCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C23H30N2O5/c1-15(2)12-20(23(28)29)25-22(27)21(26)19(24)13-16-8-10-18(11-9-16)30-14-17-6-4-3-5-7-17/h3-11,15,19-21,26H,12-14,24H2,1-2H3,(H,25,27)(H,28,29)/t19-,20+,21+/m1/s1
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490n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339784
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamid...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-2-3-9-13(16(21)22)18-15(20)14(19)12(17)10-11-7-5-4-6-8-11/h4-8,12-14,19H,2-3,9-10,17H2,1H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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900n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339785
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamid...)
Show SMILES N[C@H](Cc1ccccc1)[C@H](O)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C24H31N3O6/c25-19(15-17-9-3-1-4-10-17)21(28)22(29)27-20(23(30)31)13-7-8-14-26-24(32)33-16-18-11-5-2-6-12-18/h1-6,9-12,19-21,28H,7-8,13-16,25H2,(H,26,32)(H,27,29)(H,30,31)/t19-,20+,21+/m1/s1
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1.45E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339791
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-(naphthalen-2-y...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C20H26N2O4/c1-12(2)9-17(20(25)26)22-19(24)18(23)16(21)11-13-7-8-14-5-3-4-6-15(14)10-13/h3-8,10,12,16-18,23H,9,11,21H2,1-2H3,(H,22,24)(H,25,26)/t16-,17+,18+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339792
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxyheptanamido)-4-met...)
Show SMILES CCCC[C@@H](N)[C@H](O)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C13H26N2O4/c1-4-5-6-9(14)11(16)12(17)15-10(13(18)19)7-8(2)3/h8-11,16H,4-7,14H2,1-3H3,(H,15,17)(H,18,19)/t9-,10+,11+/m1/s1
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5.30E+3n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339788
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamid...)
Show SMILES N[C@H](Cc1ccccc1)[C@H](O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H26N2O4/c26-21(15-17-7-3-1-4-8-17)23(28)24(29)27-22(25(30)31)16-18-11-13-20(14-12-18)19-9-5-2-6-10-19/h1-14,21-23,28H,15-16,26H2,(H,27,29)(H,30,31)/t21-,22+,23+/m1/s1
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>1.50E+4n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339786
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamid...)
Show SMILES N[C@H](Cc1ccccc1)[C@H](O)C(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C26H28N2O5/c27-22(15-18-7-3-1-4-8-18)24(29)25(30)28-23(26(31)32)16-19-11-13-21(14-12-19)33-17-20-9-5-2-6-10-20/h1-14,22-24,29H,15-17,27H2,(H,28,30)(H,31,32)/t22-,23+,24+/m1/s1
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>1.50E+4n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50339787
PNG
((S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamid...)
Show SMILES N[C@H](Cc1ccccc1)[C@H](O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C23H24N2O4/c24-19(13-15-6-2-1-3-7-15)21(26)22(27)25-20(23(28)29)14-16-10-11-17-8-4-5-9-18(17)12-16/h1-12,19-21,26H,13-14,24H2,(H,25,27)(H,28,29)/t19-,20+,21+/m1/s1
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>1.50E+4n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206554
PNG
(CHEMBL219777 | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1...)
Show SMILES ONC(=O)C(=C/c1ccccc1)\C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O3/c18-14-8-6-13(7-9-14)11-19-16(21)15(17(22)20-23)10-12-4-2-1-3-5-12/h1-10,23H,11H2,(H,19,21)(H,20,22)/b15-10-
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n/an/a 6n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206558
PNG
(CHEMBL375521 | N-hydroxy-N'-(4-phenyl-butyl)-2-[1-...)
Show SMILES ONC(=O)C(=C/c1ccccc1)\C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C20H22N2O3/c23-19(21-14-8-7-11-16-9-3-1-4-10-16)18(20(24)22-25)15-17-12-5-2-6-13-17/h1-6,9-10,12-13,15,25H,7-8,11,14H2,(H,21,23)(H,22,24)/b18-15-
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n/an/a 13n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206550
PNG
(2-benzyl-N-hydroxy-N'-(2-methyl-benzyl)-malonamide...)
Show SMILES Cc1ccccc1CNC(=O)C(Cc1ccccc1)C(=O)NO
Show InChI InChI=1S/C18H20N2O3/c1-13-7-5-6-10-15(13)12-19-17(21)16(18(22)20-23)11-14-8-3-2-4-9-14/h2-10,16,23H,11-12H2,1H3,(H,19,21)(H,20,22)
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n/an/a 41n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197503
PNG
(CHEMBL425291 | N-hydroxy-2-isobutyl-N'-(3-phenoxy-...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C20H24N2O4/c1-14(2)11-18(20(24)22-25)19(23)21-13-15-7-6-10-17(12-15)26-16-8-4-3-5-9-16/h3-10,12,14,18,25H,11,13H2,1-2H3,(H,21,23)(H,22,24)
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n/an/a 45n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197497
PNG
(2-benzyl-N-hydroxy-N'-(4-phenyl-butyl)-malonamide ...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C20H24N2O3/c23-19(21-14-8-7-11-16-9-3-1-4-10-16)18(20(24)22-25)15-17-12-5-2-6-13-17/h1-6,9-10,12-13,18,25H,7-8,11,14-15H2,(H,21,23)(H,22,24)
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n/an/a 46n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206556
PNG
(2-Benzyl-N-(4-fluoro-benzyl)-N'-hydroxy-malonamide...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H17FN2O3/c18-14-8-6-13(7-9-14)11-19-16(21)15(17(22)20-23)10-12-4-2-1-3-5-12/h1-9,15,23H,10-11H2,(H,19,21)(H,20,22)
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n/an/a 57n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206547
PNG
(CHEMBL374479 | N-hydroxy-2-isobutyl-N'-naphthalen-...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCc1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O3/c1-12(2)10-16(18(22)20-23)17(21)19-11-14-8-5-7-13-6-3-4-9-15(13)14/h3-9,12,16,23H,10-11H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a 91n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206543
PNG
(2-benzyl-N-hydroxy-N'-naphthalen-1-ylmethyl-malona...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCc1cccc2ccccc12
Show InChI InChI=1S/C21H20N2O3/c24-20(19(21(25)23-26)13-15-7-2-1-3-8-15)22-14-17-11-6-10-16-9-4-5-12-18(16)17/h1-12,19,26H,13-14H2,(H,22,24)(H,23,25)
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n/an/a 107n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206551
PNG
(CHEMBL376198 | N-hydroxy-2-isobutyl-N'-(1,2,3,4-te...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C16H22N2O3/c1-11(2)10-13(15(19)17-21)16(20)18-9-5-7-12-6-3-4-8-14(12)18/h3-4,6,8,11,13,21H,5,7,9-10H2,1-2H3,(H,17,19)
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n/an/a 109n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50062453
PNG
(2-Benzyl-N-hydroxy-N'-(3-phenyl-propyl)-malonamide...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C19H22N2O3/c22-18(20-13-7-12-15-8-3-1-4-9-15)17(19(23)21-24)14-16-10-5-2-6-11-16/h1-6,8-11,17,24H,7,12-14H2,(H,20,22)(H,21,23)
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n/an/a 125n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50062474
PNG
(2,N-Dibenzyl-N'-hydroxy-malonamide | 2N-dibenzyl-N...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H18N2O3/c20-16(18-12-14-9-5-2-6-10-14)15(17(21)19-22)11-13-7-3-1-4-8-13/h1-10,15,22H,11-12H2,(H,18,20)(H,19,21)
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n/an/a 125n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206552
PNG
(2-(3-phenoxybenzyl)-N1-(4-chlorobenzyl)-N3-hydroxy...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN2O4/c24-18-11-9-16(10-12-18)15-25-22(27)21(23(28)26-29)14-17-5-4-8-20(13-17)30-19-6-2-1-3-7-19/h1-13,21,29H,14-15H2,(H,25,27)(H,26,28)
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n/an/a 130n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197501
PNG
(2-(3-phenoxybenzyl)-N1-benzyl-N3-hydroxymalonamide...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H22N2O4/c26-22(24-16-17-8-3-1-4-9-17)21(23(27)25-28)15-18-10-7-13-20(14-18)29-19-11-5-2-6-12-19/h1-14,21,28H,15-16H2,(H,24,26)(H,25,27)
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n/an/a 164n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206546
PNG
(2-benzyl-N-(4-chloro-benzyl)-N'-hydroxy-malonamide...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C17H17ClN2O3/c18-14-8-6-13(7-9-14)11-19-16(21)15(17(22)20-23)10-12-4-2-1-3-5-12/h1-9,15,23H,10-11H2,(H,19,21)(H,20,22)
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n/an/a 170n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206557
PNG
(2-benzyl-3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-o...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H26N2O3/c25-21(23-27)20(16-18-9-5-2-6-10-18)22(26)24-13-11-19(12-14-24)15-17-7-3-1-4-8-17/h1-10,19-20,27H,11-16H2,(H,23,25)
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n/an/a 206n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197505
PNG
(2-(3-phenoxybenzyl)-N1-hydroxy-N3-(4-phenylbutyl)m...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C26H28N2O4/c29-25(27-17-8-7-12-20-10-3-1-4-11-20)24(26(30)28-31)19-21-13-9-16-23(18-21)32-22-14-5-2-6-15-22/h1-6,9-11,13-16,18,24,31H,7-8,12,17,19H2,(H,27,29)(H,28,30)
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n/an/a 225n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206566
PNG
(2-(3-phenoxybenzyl)-N1-(4-(trifluoromethyl)benzyl)...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N2O4/c25-24(26,27)18-11-9-16(10-12-18)15-28-22(30)21(23(31)29-32)14-17-5-4-8-20(13-17)33-19-6-2-1-3-7-19/h1-13,21,32H,14-15H2,(H,28,30)(H,29,31)
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n/an/a 231n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206564
PNG
(2-(3-phenoxybenzyl)-3-(4-benzylpiperidin-1-yl)-N-h...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H30N2O4/c31-27(29-33)26(20-23-10-7-13-25(19-23)34-24-11-5-2-6-12-24)28(32)30-16-14-22(15-17-30)18-21-8-3-1-4-9-21/h1-13,19,22,26,33H,14-18,20H2,(H,29,31)
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n/an/a 248n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206545
PNG
(2-benzyl-3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hyd...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C19H20N2O3/c22-18(20-24)17(12-14-6-2-1-3-7-14)19(23)21-11-10-15-8-4-5-9-16(15)13-21/h1-9,17,24H,10-13H2,(H,20,22)
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n/an/a 253n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 284n/an/an/an/an/an/a



Universit£ de Lille 2

Curated by ChEMBL


Assay Description
Inhibitory activity for Plasmodium falciparum Zinc aminopeptidase


Bioorg Med Chem Lett 13: 2659-62 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206555
PNG
(2-[1-Phenyl-meth-(Z)-ylidene]-malonic Acid Monoeth...)
Show SMILES ONC(=O)C(=C\c1ccccc1)\C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O3/c18-14-8-6-13(7-9-14)11-19-16(21)15(17(22)20-23)10-12-4-2-1-3-5-12/h1-10,23H,11H2,(H,19,21)(H,20,22)/b15-10+
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n/an/a 330n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197495
PNG
(2-(4-benzyl-piperidine-1-carbonyl)-4-methyl-pentan...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H28N2O3/c1-14(2)12-17(18(22)20-24)19(23)21-10-8-16(9-11-21)13-15-6-4-3-5-7-15/h3-7,14,16-17,24H,8-13H2,1-2H3,(H,20,22)
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n/an/a 406n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197494
PNG
(CHEMBL220253 | N-benzyl-N'-hydroxy-2-isobutyl-malo...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c1-10(2)8-12(14(18)16-19)13(17)15-9-11-6-4-3-5-7-11/h3-7,10,12,19H,8-9H2,1-2H3,(H,15,17)(H,16,18)
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n/an/a 495n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206565
PNG
(2-(3-phenoxybenzyl)-N1-hydroxy-N3-(3-phenylpropyl)...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C25H26N2O4/c28-24(26-16-8-12-19-9-3-1-4-10-19)23(25(29)27-30)18-20-11-7-15-22(17-20)31-21-13-5-2-6-14-21/h1-7,9-11,13-15,17,23,30H,8,12,16,18H2,(H,26,28)(H,27,29)
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n/an/a 527n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50062478
PNG
(CHEMBL116641 | N-Hydroxy-2-isobutyl-N'-(3-phenyl-p...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C16H24N2O3/c1-12(2)11-14(16(20)18-21)15(19)17-10-6-9-13-7-4-3-5-8-13/h3-5,7-8,12,14,21H,6,9-11H2,1-2H3,(H,17,19)(H,18,20)
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n/an/a 790n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50131276
PNG
(CHEMBL328470 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Show SMILES CC(C)CN(CCCN1CCN(CCCNc2ccnc3cc(Cl)ccc23)CC1)C(=O)CC(=O)NO
Show InChI InChI=1S/C26H39ClN6O3/c1-20(2)19-33(26(35)18-25(34)30-36)12-4-11-32-15-13-31(14-16-32)10-3-8-28-23-7-9-29-24-17-21(27)5-6-22(23)24/h5-7,9,17,20,36H,3-4,8,10-16,18-19H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 854n/an/an/an/an/an/a



Universit£ de Lille 2

Curated by ChEMBL


Assay Description
Inhibitory activity for Plasmodium falciparum Zinc aminopeptidase


Bioorg Med Chem Lett 13: 2659-62 (2003)

More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197502
PNG
(CHEMBL220010 | N-hydroxy-2-isobutyl-N'-phenethyl-m...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C15H22N2O3/c1-11(2)10-13(15(19)17-20)14(18)16-9-8-12-6-4-3-5-7-12/h3-7,11,13,20H,8-10H2,1-2H3,(H,16,18)(H,17,19)
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n/an/a 885n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197496
PNG
(CHEMBL220176 | N-(4-chloro-benzyl)-N'-hydroxy-2-is...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C14H19ClN2O3/c1-9(2)7-12(14(19)17-20)13(18)16-8-10-3-5-11(15)6-4-10/h3-6,9,12,20H,7-8H2,1-2H3,(H,16,18)(H,17,19)
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n/an/a 904n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206553
PNG
(2-(3-phenoxybenzyl)-3-(3,4-dihydroisoquinolin-2(1H...)
Show SMILES ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C25H24N2O4/c28-24(26-30)23(25(29)27-14-13-19-8-4-5-9-20(19)17-27)16-18-7-6-12-22(15-18)31-21-10-2-1-3-11-21/h1-12,15,23,30H,13-14,16-17H2,(H,26,28)
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n/an/a 966n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM53946
PNG
(4-[(N'E)-N'-(6-ketocyclohexa-2,4-dien-1-ylidene)hy...)
Show SMILES Cc1[nH]n(-c2ccccc2)c(=O)c1N=Nc1ccccc1O
Show InChI InChI=1S/C16H14N4O2/c1-11-15(18-17-13-9-5-6-10-14(13)21)16(22)20(19-11)12-7-3-2-4-8-12/h2-10,19,21H,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50536
PNG
(MLS000685727 | N-[(5Z)-5-(5-bromanyl-2-oxidanylide...)
Show SMILES Brc1ccc2NC(=O)\C(=C3/SC(=S)N(NS(=O)(=O)c4ccccc4)C3=O)c2c1
Show InChI InChI=1S/C17H10BrN3O4S3/c18-9-6-7-12-11(8-9)13(15(22)19-12)14-16(23)21(17(26)27-14)20-28(24,25)10-4-2-1-3-5-10/h1-8,20H,(H,19,22)/b14-13-
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n/an/a 1.00E+3n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM53869
PNG
((4-{[(2-[(2,6-dimethylphenoxy)methyl]-4-oxo-3(4H)-...)
Show SMILES Cc1cccc(C)c1OCc1nc2ccccc2c(=O)n1N=Cc1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C26H23N3O5/c1-17-6-5-7-18(2)25(17)34-15-23-28-22-9-4-3-8-21(22)26(32)29(23)27-14-19-10-12-20(13-11-19)33-16-24(30)31/h3-14H,15-16H2,1-2H3,(H,30,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206544
PNG
(2-benzyl-N-hydroxy-N'-phenethyl-malonamide | 2-ben...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H20N2O3/c21-17(19-12-11-14-7-3-1-4-8-14)16(18(22)20-23)13-15-9-5-2-6-10-15/h1-10,16,23H,11-13H2,(H,19,21)(H,20,22)
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n/an/a 1.01E+3n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50197498
PNG
(CHEMBL220311 | N-hydroxy-2-isobutyl-N'-(4-phenyl-b...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C17H26N2O3/c1-13(2)12-15(17(21)19-22)16(20)18-11-7-6-10-14-8-4-3-5-9-14/h3-5,8-9,13,15,22H,6-7,10-12H2,1-2H3,(H,18,20)(H,19,21)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206548
PNG
(2-benzyl-N-biphenyl-3-ylmethyl-N'-hydroxy-malonami...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NCc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H22N2O3/c26-22(21(23(27)25-28)15-17-8-3-1-4-9-17)24-16-18-10-7-13-20(14-18)19-11-5-2-6-12-19/h1-14,21,28H,15-16H2,(H,24,26)(H,25,27)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50131273
PNG
(CHEMBL430903 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Show SMILES CC(C)CC(C(=O)NO)C(=O)N(CCCN1CCN(CCCNc2ccnc3cc(Cl)ccc23)CC1)CC(C)C
Show InChI InChI=1S/C30H47ClN6O3/c1-22(2)19-26(29(38)34-40)30(39)37(21-23(3)4)14-6-13-36-17-15-35(16-18-36)12-5-10-32-27-9-11-33-28-20-24(31)7-8-25(27)28/h7-9,11,20,22-23,26,40H,5-6,10,12-19,21H2,1-4H3,(H,32,33)(H,34,38)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Universit£ de Lille 2

Curated by ChEMBL


Assay Description
Inhibitory activity for Plasmodium falciparum Zinc aminopeptidase


Bioorg Med Chem Lett 13: 2659-62 (2003)

More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM53650
PNG
(1-Phenylmethanesulfonyl-piperidine-4-carboxylic ac...)
Show SMILES Fc1cccc(CNC(=O)C2CCN(CC2)S(=O)(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C20H23FN2O3S/c21-19-8-4-7-17(13-19)14-22-20(24)18-9-11-23(12-10-18)27(25,26)15-16-5-2-1-3-6-16/h1-8,13,18H,9-12,14-15H2,(H,22,24)
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n/an/a 1.71E+3n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206561
PNG
(2-benzyl-3-(4-benzyl-piperazin-1-yl)-N-hydroxy-3-o...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H25N3O3/c25-20(22-27)19(15-17-7-3-1-4-8-17)21(26)24-13-11-23(12-14-24)16-18-9-5-2-6-10-18/h1-10,19,27H,11-16H2,(H,22,25)
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n/an/a 1.76E+3n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM50206559
PNG
(2-benzyl-N-hydroxy-N'-indan-2-yl-malonamide | 2-be...)
Show SMILES ONC(=O)C(Cc1ccccc1)C(=O)NC1Cc2ccccc2C1
Show InChI InChI=1S/C19H20N2O3/c22-18(20-16-11-14-8-4-5-9-15(14)12-16)17(19(23)21-24)10-13-6-2-1-3-7-13/h1-9,16-17,24H,10-12H2,(H,20,22)(H,21,23)
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n/an/a 1.93E+3n/an/an/an/an/an/a



Inserm

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Zinc aminopeptidase


(Plasmodium falciparum (isolate FcB1 / Columbia))
BDBM53702
PNG
(1-[(5-bromo-2-thienyl)sulfonyl]-N-piperonyl-isonip...)
Show SMILES Brc1ccc(s1)S(=O)(=O)N1CCC(CC1)C(=O)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C18H19BrN2O5S2/c19-16-3-4-17(27-16)28(23,24)21-7-5-13(6-8-21)18(22)20-10-12-1-2-14-15(9-12)26-11-25-14/h1-4,9,13H,5-8,10-11H2,(H,20,22)
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n/an/a 2.11E+3n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...


Citation and Details
More data for this
Ligand-Target Pair
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