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Found 63 hits Enz. Inhib. hit(s) with Target = 'beta-Glucuronidase (β-glucuronidase)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193719
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-fluoro...)
Show SMILES Fc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H24FN5OS/c32-25-9-3-6-12-28(25)35-31(39)37-36-30(38)20-15-13-19(14-16-20)29(23-17-33-26-10-4-1-7-21(23)26)24-18-34-27-11-5-2-8-22(24)27/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 100n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193733
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3,4-dich...)
Show SMILES Clc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1Cl
Show InChI InChI=1S/C31H23Cl2N5OS/c32-25-14-13-20(15-26(25)33)36-31(40)38-37-30(39)19-11-9-18(10-12-19)29(23-16-34-27-7-3-1-5-21(23)27)24-17-35-28-8-4-2-6-22(24)28/h1-17,29,34-35H,(H,37,39)(H2,36,38,40)
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n/an/a 120n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193734
PNG
(2-(4-(di(1H-indol-3-yl)methyl)benzoyl)-N-(4(triflu...)
Show SMILES FC(F)(F)c1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C32H24F3N5OS/c33-32(34,35)21-13-15-22(16-14-21)38-31(42)40-39-30(41)20-11-9-19(10-12-20)29(25-17-36-27-7-3-1-5-23(25)27)26-18-37-28-8-4-2-6-24(26)28/h1-18,29,36-37H,(H,39,41)(H2,38,40,42)
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n/an/a 200n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193720
PNG
(N-(2-Chlorophenyl)-2-(4-(di(1H-indol-3-yl)methyl)b...)
Show SMILES Clc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H24ClN5OS/c32-25-9-3-6-12-28(25)35-31(39)37-36-30(38)20-15-13-19(14-16-20)29(23-17-33-26-10-4-1-7-21(23)26)24-18-34-27-11-5-2-8-22(24)27/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 500n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019208
PNG
(CHEMBL137922)
Show SMILES COc1ccc(cc1OC)-c1nc(O)c2ccccc2n1
Show InChI InChI=1S/C16H14N2O3/c1-20-13-8-7-10(9-14(13)21-2)15-17-12-6-4-3-5-11(12)16(19)18-15/h3-9H,1-2H3,(H,17,18,19)
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n/an/a 600n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019283
PNG
(CHEMBL3289121)
Show SMILES CCOc1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2/c1-2-20-14-10-6-4-8-12(14)15-17-13-9-5-3-7-11(13)16(19)18-15/h3-10H,2H2,1H3,(H,17,18,19)
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n/an/a 700n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50028013
PNG
(CHEMBL3360798)
Show SMILES CCOC(OCC)(OCC)\C=C\C(=O)c1sc2sc(C(=O)\C=C\C(OCC)(OCC)OCC)c(-c3ccccc3)c2c1C
Show InChI InChI=1S/C33H42O8S2/c1-8-36-32(37-9-2,38-10-3)21-19-25(34)29-23(7)27-28(24-17-15-14-16-18-24)30(43-31(27)42-29)26(35)20-22-33(39-11-4,40-12-5)41-13-6/h14-22H,8-13H2,1-7H3/b21-19+,22-20+
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n/an/a 900n/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide substrate incubated for 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019166
PNG
(CHEMBL336718)
Show SMILES COc1ccc(cc1)-c1nc(O)c2ccccc2n1
Show InChI InChI=1S/C15H12N2O2/c1-19-11-8-6-10(7-9-11)14-16-13-5-3-2-4-12(13)15(18)17-14/h2-9H,1H3,(H,16,17,18)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019203
PNG
(2-(3'-Ethoxy-4'-hydroxyphenyl)quinazolin-4...)
Show SMILES CCOc1cc(ccc1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O3/c1-2-21-14-9-10(7-8-13(14)19)15-17-12-6-4-3-5-11(12)16(20)18-15/h3-9,19H,2H2,1H3,(H,17,18,20)
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n/an/a 1.17E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019212
PNG
(CHEMBL3289116)
Show SMILES [O-][N+](=O)c1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H9N3O3/c18-14-9-5-1-3-7-11(9)15-13(16-14)10-6-2-4-8-12(10)17(19)20/h1-8H,(H,15,16,18)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019286
PNG
(CHEMBL3289123)
Show SMILES Clc1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H9ClN2O/c15-11-7-3-1-5-9(11)13-16-12-8-4-2-6-10(12)14(18)17-13/h1-8H,(H,16,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019285
PNG
(CHEMBL3289122)
Show SMILES COc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C15H12N2O3/c1-20-9-6-7-13(18)11(8-9)14-16-12-5-3-2-4-10(12)15(19)17-14/h2-8,18H,1H3,(H,16,17,19)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019288
PNG
(CHEMBL3289384)
Show SMILES CCOc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2/c1-2-20-12-9-7-11(8-10-12)15-17-14-6-4-3-5-13(14)16(19)18-15/h3-10H,2H2,1H3,(H,17,18,19)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019242
PNG
(2-(3',4'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Show SMILES Oc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H10N2O3/c17-11-6-5-8(7-12(11)18)13-15-10-4-2-1-3-9(10)14(19)16-13/h1-7,17-18H,(H,15,16,19)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092444
PNG
(CHEMBL3586121)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1O
Show InChI InChI=1S/C23H18N4O2/c1-13-11-18-19(12-14(13)2)25-21(24-18)15-7-9-16(10-8-15)22-26-27-23(29-22)17-5-3-4-6-20(17)28/h3-12,28H,1-2H3,(H,24,25)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193729
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3-fluoro...)
Show SMILES Fc1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C31H24FN5OS/c32-21-6-5-7-22(16-21)35-31(39)37-36-30(38)20-14-12-19(13-15-20)29(25-17-33-27-10-3-1-8-23(25)27)26-18-34-28-11-4-2-9-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019170
PNG
(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Show SMILES COc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C15H12N2O3/c1-20-13-7-6-9(8-12(13)18)14-16-11-5-3-2-4-10(11)15(19)17-14/h2-8,18H,1H3,(H,16,17,19)
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193721
PNG
(N-(2-Bromophenyl)-2-(4-(di(1H-indol-3-yl)methyl)be...)
Show SMILES Brc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C31H24BrN5OS/c32-25-9-3-6-12-28(25)35-31(39)37-36-30(38)20-15-13-19(14-16-20)29(23-17-33-26-10-4-1-7-21(23)26)24-18-34-27-11-5-2-8-22(24)27/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193723
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(4-fluoro...)
Show SMILES Fc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C31H24FN5OS/c32-21-13-15-22(16-14-21)35-31(39)37-36-30(38)20-11-9-19(10-12-20)29(25-17-33-27-7-3-1-5-23(25)27)26-18-34-28-8-4-2-6-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092351
PNG
(CHEMBL3586128)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(O)cc1
Show InChI InChI=1S/C26H25Cl2N3O/c1-32-26-13-12-19-22(20(26)11-7-3-6-10-18-8-4-2-5-9-18)15-30-31-25(19)14-21-23(27)16-29-17-24(21)28/h2,4-5,8-9,12-13,15-17H,3,6-7,10-11,14H2,1H3
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n/an/a 3.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019277
PNG
(2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-...)
Show SMILES Oc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H10N2O3/c17-8-5-6-12(18)10(7-8)13-15-11-4-2-1-3-9(11)14(19)16-13/h1-7,17-18H,(H,15,16,19)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092460
PNG
(CHEMBL3586119)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccn1
Show InChI InChI=1S/C22H17N5O/c1-13-11-18-19(12-14(13)2)25-20(24-18)15-6-8-16(9-7-15)21-26-27-22(28-21)17-5-3-4-10-23-17/h3-12H,1-2H3,(H,24,25)
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n/an/a 4.12E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019186
PNG
(CHEMBL1333995)
Show SMILES CN(C)c1ccc(cc1)-c1nc(O)c2ccccc2n1
Show InChI InChI=1S/C16H15N3O/c1-19(2)12-9-7-11(8-10-12)15-17-14-6-4-3-5-13(14)16(20)18-15/h3-10H,1-2H3,(H,17,18,20)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193731
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3-nitrop...)
Show SMILES [O-][N+](=O)c1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C31H24N6O3S/c38-30(35-36-31(41)34-21-6-5-7-22(16-21)37(39)40)20-14-12-19(13-15-20)29(25-17-32-27-10-3-1-8-23(25)27)26-18-33-28-11-4-2-9-24(26)28/h1-18,29,32-33H,(H,35,38)(H2,34,36,41)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193718
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(o-tolyl)...)
Show SMILES Cc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C32H27N5OS/c1-20-8-2-5-11-27(20)35-32(39)37-36-31(38)22-16-14-21(15-17-22)30(25-18-33-28-12-6-3-9-23(25)28)26-19-34-29-13-7-4-10-24(26)29/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,39)
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n/an/a 7.12E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092465
PNG
(CHEMBL3586113)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(O)c1
Show InChI InChI=1S/C23H18N4O2/c1-13-10-19-20(11-14(13)2)25-21(24-19)15-6-8-16(9-7-15)22-26-27-23(29-22)17-4-3-5-18(28)12-17/h3-12,28H,1-2H3,(H,24,25)
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n/an/a 8.14E+3n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193725
PNG
(N-(4-Chlorophenyl)-2-(4-(di(1H-indol-3-yl)methyl)b...)
Show SMILES Clc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C31H24ClN5OS/c32-21-13-15-22(16-14-21)35-31(39)37-36-30(38)20-11-9-19(10-12-20)29(25-17-33-27-7-3-1-5-23(25)27)26-18-34-28-8-4-2-6-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 8.50E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193735
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(2-methox...)
Show SMILES COc1ccccc1NC(=S)NNC(=O)c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C32H27N5O2S/c1-39-29-13-7-6-12-28(29)35-32(40)37-36-31(38)21-16-14-20(15-17-21)30(24-18-33-26-10-4-2-8-22(24)26)25-19-34-27-11-5-3-9-23(25)27/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,40)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019284
PNG
(CHEMBL1526444)
Show SMILES Oc1ccccc1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H10N2O2/c17-12-8-4-2-6-10(12)13-15-11-7-3-1-5-9(11)14(18)16-13/h1-8,17H,(H,15,16,18)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092464
PNG
(CHEMBL3586114)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C23H17N5O3/c1-13-10-19-20(11-14(13)2)25-21(24-19)15-6-8-16(9-7-15)22-26-27-23(31-22)17-4-3-5-18(12-17)28(29)30/h3-12H,1-2H3,(H,24,25)
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n/an/a 1.11E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193726
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(4-methox...)
Show SMILES COc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C32H27N5O2S/c1-39-23-16-14-22(15-17-23)35-32(40)37-36-31(38)21-12-10-20(11-13-21)30(26-18-33-28-8-4-2-6-24(26)28)27-19-34-29-9-5-3-7-25(27)29/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,40)
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n/an/a 1.16E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193727
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(4-nitrop...)
Show SMILES [O-][N+](=O)c1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C31H24N6O3S/c38-30(35-36-31(41)34-21-13-15-22(16-14-21)37(39)40)20-11-9-19(10-12-20)29(25-17-32-27-7-3-1-5-23(25)27)26-18-33-28-8-4-2-6-24(26)28/h1-18,29,32-33H,(H,35,38)(H2,34,36,41)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092461
PNG
(CHEMBL3586118)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H17FN4O/c1-13-11-19-20(12-14(13)2)26-21(25-19)15-3-5-16(6-4-15)22-27-28-23(29-22)17-7-9-18(24)10-8-17/h3-12H,1-2H3,(H,25,26)
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n/an/a 1.31E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193728
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(m-tolyl)...)
Show SMILES Cc1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C32H27N5OS/c1-20-7-6-8-23(17-20)35-32(39)37-36-31(38)22-15-13-21(14-16-22)30(26-18-33-28-11-4-2-9-24(26)28)27-19-34-29-12-5-3-10-25(27)29/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,39)
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n/an/a 1.47E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193722
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(p-tolyl)...)
Show SMILES Cc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C32H27N5OS/c1-20-10-16-23(17-11-20)35-32(39)37-36-31(38)22-14-12-21(13-15-22)30(26-18-33-28-8-4-2-6-24(26)28)27-19-34-29-9-5-3-7-25(27)29/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,39)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092463
PNG
(CHEMBL3586115)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C23H17ClN4O/c1-13-11-19-20(12-14(13)2)26-21(25-19)15-7-9-16(10-8-15)22-27-28-23(29-22)17-5-3-4-6-18(17)24/h3-12H,1-2H3,(H,25,26)
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n/an/a 1.51E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092459
PNG
(CHEMBL3586120)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(F)c1
Show InChI InChI=1S/C23H17FN4O/c1-13-10-19-20(11-14(13)2)26-21(25-19)15-6-8-16(9-7-15)22-27-28-23(29-22)17-4-3-5-18(24)12-17/h3-12H,1-2H3,(H,25,26)
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n/an/a 1.61E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092462
PNG
(CHEMBL3586116)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccccc1F
Show InChI InChI=1S/C23H17FN4O/c1-13-11-19-20(12-14(13)2)26-21(25-19)15-7-9-16(10-8-15)22-27-28-23(29-22)17-5-3-4-6-18(17)24/h3-12H,1-2H3,(H,25,26)
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n/an/a 1.92E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019164
PNG
(CHEMBL1164165)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H9N3O3/c18-14-11-3-1-2-4-12(11)15-13(16-14)9-5-7-10(8-6-9)17(19)20/h1-8H,(H,15,16,18)
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n/an/a 2.01E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092349
PNG
(CHEMBL3586129)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccnc1
Show InChI InChI=1S/C20H17Cl2F2N3O2/c21-15-9-25-10-16(22)13(15)7-17-12-5-6-18(29-20(23)24)19(14(12)8-26-27-17)28-11-3-1-2-4-11/h5-6,8-11,20H,1-4,7H2
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n/an/a 2.01E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193730
PNG
(N-(3-Bromophenyl)-2-(4-(di(1H-indol-3-yl)methyl)be...)
Show SMILES Brc1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C31H24BrN5OS/c32-21-6-5-7-22(16-21)35-31(39)37-36-30(38)20-14-12-19(13-15-20)29(25-17-33-27-10-3-1-8-23(25)27)26-18-34-28-11-4-2-9-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 2.14E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019165
PNG
(2-(4'-Hydroxyphenyl)quinazolin-4(3H)-one (2) |...)
Show SMILES Oc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H10N2O2/c17-10-7-5-9(6-8-10)13-15-12-4-2-1-3-11(12)14(18)16-13/h1-8,17H,(H,15,16,18)
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n/an/a 2.22E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


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More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193732
PNG
(2-(4-(Di(1H-indol-3-yl)methyl)benzoyl)-N-(3-methox...)
Show SMILES COc1cccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C32H27N5O2S/c1-39-23-8-6-7-22(17-23)35-32(40)37-36-31(38)21-15-13-20(14-16-21)30(26-18-33-28-11-4-2-9-24(26)28)27-19-34-29-12-5-3-10-25(27)29/h2-19,30,33-34H,1H3,(H,36,38)(H2,35,37,40)
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n/an/a 2.81E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


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More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092433
PNG
(CHEMBL3586123)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H17N5O3/c1-13-11-19-20(12-14(13)2)25-21(24-19)15-3-5-16(6-4-15)22-26-27-23(31-22)17-7-9-18(10-8-17)28(29)30/h3-12H,1-2H3,(H,24,25)
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n/an/a 3.01E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019279
PNG
(CHEMBL3289120)
Show SMILES COc1cccc(c1O)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C15H12N2O3/c1-20-12-8-4-6-10(13(12)18)14-16-11-7-3-2-5-9(11)15(19)17-14/h2-8,18H,1H3,(H,16,17,19)
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n/an/a 3.09E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092352
PNG
(CHEMBL3586126)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H17ClN4O/c1-13-10-19-20(11-14(13)2)26-21(25-19)15-6-8-16(9-7-15)22-27-28-23(29-22)17-4-3-5-18(24)12-17/h3-12H,1-2H3,(H,25,26)
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n/an/a 3.11E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50092354
PNG
(CHEMBL3586124)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)-c1nnc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19Cl2N3O2/c1-26-19-6-12-9-24-25-18(7-15-16(21)10-23-11-17(15)22)14(12)8-20(19)27-13-4-2-3-5-13/h6,8-11,13H,2-5,7H2,1H3
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n/an/a 3.21E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM193724
PNG
(N-(4-Bromophenyl)-2-(4-(di(1H-indol-3-yl)methyl)be...)
Show SMILES Brc1ccc(NC(=S)NNC(=O)c2ccc(cc2)C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C31H24BrN5OS/c32-21-13-15-22(16-14-21)35-31(39)37-36-30(38)20-11-9-19(10-12-20)29(25-17-33-27-7-3-1-5-23(25)27)26-18-34-28-8-4-2-6-24(26)28/h1-18,29,33-34H,(H,36,38)(H2,35,37,39)
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n/an/a 3.32E+4n/an/an/an/an/an/a



Universiti Teknologi MARA



Assay Description
β-Glucuronidase activity was determined by measuring the absorbance at 405 nm of p-nitrophenol formed from the substrate by the spectrophotometr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50019171
PNG
(CHEMBL3289113)
Show SMILES Clc1cccc(Cl)c1-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H8Cl2N2O/c15-9-5-3-6-10(16)12(9)13-17-11-7-2-1-4-8(11)14(19)18-13/h1-7H,(H,17,18,19)
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n/an/a 3.77E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))
BDBM50321122
PNG
(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)
Show SMILES Clc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C14H9ClN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8H,(H,16,17,18)
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n/an/a 3.98E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...


Citation and Details
More data for this
Ligand-Target Pair
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