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Found 53 hits Enz. Inhib. hit(s) with Target = 'beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)' AND taxid = 85962   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31965
PNG
(carbohydrazide derivative, 5h)
Show SMILES Oc1cc2ccccc2cc1C(=O)NN=Cc1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C18H12Br2N2O4/c19-13-6-11(16(24)15(20)17(13)25)8-21-22-18(26)12-5-9-3-1-2-4-10(9)7-14(12)23/h1-8,23-25H,(H,22,26)
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PubMed
n/an/a 860n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31930
PNG
(carbohydrazide derivative, 3m)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccc3ccccc3c2)c(O)c1Br
Show InChI InChI=1S/C18H12Br2N2O3/c19-14-8-13(16(23)15(20)17(14)24)9-21-22-18(25)12-6-5-10-3-1-2-4-11(10)7-12/h1-9,23-24H,(H,22,25)/b21-9+
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PubMed
n/an/a 1.42E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31927
PNG
(carbohydrazide derivative, 3j)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccc(Br)cc2)c(O)c1Br
Show InChI InChI=1S/C14H9Br3N2O3/c15-9-3-1-7(2-4-9)14(22)19-18-6-8-5-10(16)13(21)11(17)12(8)20/h1-6,20-21H,(H,19,22)/b18-6+
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n/an/a 1.50E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31934
PNG
(carbohydrazide derivative, 3q)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)N\N=C\c1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C18H18Br2N2O3/c1-18(2,3)12-6-4-10(5-7-12)17(25)22-21-9-11-8-13(19)16(24)14(20)15(11)23/h4-9,23-24H,1-3H3,(H,22,25)/b21-9+
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n/an/a 1.52E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31926
PNG
(carbohydrazide derivative, 3i)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccc(Cl)cc2)c(O)c1Br
Show InChI InChI=1S/C14H9Br2ClN2O3/c15-10-5-8(12(20)11(16)13(10)21)6-18-19-14(22)7-1-3-9(17)4-2-7/h1-6,20-21H,(H,19,22)/b18-6+
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n/an/a 1.52E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31964
PNG
(carbohydrazide derivative, 5g)
Show SMILES Oc1c(Br)cc(C=NNC(=O)c2ccc3ccccc3c2O)c(O)c1Br
Show InChI InChI=1S/C18H12Br2N2O4/c19-13-7-10(15(23)14(20)17(13)25)8-21-22-18(26)12-6-5-9-3-1-2-4-11(9)16(12)24/h1-8,23-25H,(H,22,26)
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n/an/a 1.97E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31928
PNG
(carbohydrazide derivative, 3k)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2cccc(Br)c2)c(O)c1Br
Show InChI InChI=1S/C14H9Br3N2O3/c15-9-3-1-2-7(4-9)14(22)19-18-6-8-5-10(16)13(21)11(17)12(8)20/h1-6,20-21H,(H,19,22)/b18-6+
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n/an/a 1.98E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31960
PNG
(carbohydrazide derivative, 5c)
Show SMILES Oc1c(Br)cc(C=NNC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(O)c1Br
Show InChI InChI=1S/C16H8Br2F6N2O3/c17-10-3-7(12(27)11(18)13(10)28)5-25-26-14(29)6-1-8(15(19,20)21)4-9(2-6)16(22,23)24/h1-5,27-28H,(H,26,29)
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n/an/a 2.13E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31967
PNG
(carbohydrazide derivative, 5j)
Show SMILES Oc1c(Br)cc(C=NNC(=O)c2ccc3cc(Br)ccc3c2)c(O)c1Br
Show InChI InChI=1S/C18H11Br3N2O3/c19-13-4-3-9-5-11(2-1-10(9)6-13)18(26)23-22-8-12-7-14(20)17(25)15(21)16(12)24/h1-8,24-25H,(H,23,26)
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n/an/a 3.55E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31963
PNG
(carbohydrazide derivative, 5f)
Show SMILES Oc1c(Br)cc(C=NNC(=O)c2ccc-3c(Cc4ccccc-34)c2)c(O)c1Br
Show InChI InChI=1S/C21H14Br2N2O3/c22-17-9-14(19(26)18(23)20(17)27)10-24-25-21(28)12-5-6-16-13(8-12)7-11-3-1-2-4-15(11)16/h1-6,8-10,26-27H,7H2,(H,25,28)
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n/an/a 3.75E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31925
PNG
(carbohydrazide derivative, 3h)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccc(F)cc2)c(O)c1Br
Show InChI InChI=1S/C14H9Br2FN2O3/c15-10-5-8(12(20)11(16)13(10)21)6-18-19-14(22)7-1-3-9(17)4-2-7/h1-6,20-21H,(H,19,22)/b18-6+
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n/an/a 6.43E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31966
PNG
(carbohydrazide derivative, 5i)
Show SMILES Oc1ccc2cc(ccc2c1)C(=O)NN=Cc1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C18H12Br2N2O4/c19-14-7-12(16(24)15(20)17(14)25)8-21-22-18(26)11-2-1-10-6-13(23)4-3-9(10)5-11/h1-8,23-25H,(H,22,26)
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n/an/a 8.77E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31931
PNG
(carbohydrazide derivative, 3n)
Show SMILES COc1ccc(cc1)C(=O)N\N=C\c1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C15H12Br2N2O4/c1-23-10-4-2-8(3-5-10)15(22)19-18-7-9-6-11(16)14(21)12(17)13(9)20/h2-7,20-21H,1H3,(H,19,22)/b18-7+
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n/an/a 9.92E+3n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31961
PNG
(carbohydrazide derivative, 5d)
Show SMILES Oc1c(Br)cc(C=NNC(=O)c2ccc(Oc3ccccc3)cc2)c(O)c1Br
Show InChI InChI=1S/C20H14Br2N2O4/c21-16-10-13(18(25)17(22)19(16)26)11-23-24-20(27)12-6-8-15(9-7-12)28-14-4-2-1-3-5-14/h1-11,25-26H,(H,24,27)
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n/an/a 1.28E+4n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31917
PNG
(carbohydrazide derivative, 1)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2cccnc2)c(O)c1Br
Show InChI InChI=1S/C13H9Br2N3O3/c14-9-4-8(11(19)10(15)12(9)20)6-17-18-13(21)7-2-1-3-16-5-7/h1-6,19-20H,(H,18,21)/b17-6+
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n/an/a 3.98E+4n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31959
PNG
(carbohydrazide derivative, 5b)
Show SMILES Oc1ccc(cc1)-c1ccc(cc1)C(=O)NN=Cc1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C20H14Br2N2O4/c21-16-9-14(18(26)17(22)19(16)27)10-23-24-20(28)13-3-1-11(2-4-13)12-5-7-15(25)8-6-12/h1-10,25-27H,(H,24,28)
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n/an/a 4.27E+4n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31957
PNG
(1,3-thiazolidin-5-ylidene derivative, 4u)
Show SMILES COC(=O)c1cc(ccc1Cl)-c1ccc(\C=C2\S\C(=N\c3ccccc3)N(CCN3CCCC3)C2=O)o1
Show InChI InChI=1S/C28H26ClN3O4S/c1-35-27(34)22-17-19(9-11-23(22)29)24-12-10-21(36-24)18-25-26(33)32(16-15-31-13-5-6-14-31)28(37-25)30-20-7-3-2-4-8-20/h2-4,7-12,17-18H,5-6,13-16H2,1H3/b25-18+,30-28+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31951
PNG
(1,3-thiazolidin-5-ylidene derivative, 4o)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1cccc(OC)c1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C26H23ClN2O6S/c1-32-12-11-29-24(30)23(36-26(29)28-17-5-4-6-18(14-17)33-2)15-19-8-10-22(35-19)16-7-9-21(27)20(13-16)25(31)34-3/h4-10,13-15H,11-12H2,1-3H3/b23-15+,28-26+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31962
PNG
(carbohydrazide derivative, 5e)
Show SMILES Oc1c(Br)cc(C=NNC(=O)c2ccc(cc2)-c2ccccc2)c(O)c1Br
Show InChI InChI=1S/C20H14Br2N2O3/c21-16-10-15(18(25)17(22)19(16)26)11-23-24-20(27)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-11,25-26H,(H,24,27)
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31950
PNG
(1,3-thiazolidin-5-ylidene derivative, 4n)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1OC)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C26H23ClN2O6S/c1-32-13-12-29-24(30)23(36-26(29)28-20-6-4-5-7-22(20)33-2)15-17-9-11-21(35-17)16-8-10-19(27)18(14-16)25(31)34-3/h4-11,14-15H,12-13H2,1-3H3/b23-15+,28-26+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31949
PNG
(1,3-thiazolidin-5-ylidene derivative, 4m)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1cccc(c1)C(F)(F)F)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C26H20ClF3N2O5S/c1-35-11-10-32-23(33)22(38-25(32)31-17-5-3-4-16(13-17)26(28,29)30)14-18-7-9-21(37-18)15-6-8-20(27)19(12-15)24(34)36-2/h3-9,12-14H,10-11H2,1-2H3/b22-14+,31-25+
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n/an/an/an/an/an/an/a8.025



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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31936
PNG
(1,3-thiazolidin-5-ylidene derivative, 2)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C24H19ClN2O5S/c1-31-12-11-27-22(28)21(33-24(27)26-16-5-3-2-4-6-16)14-17-8-10-20(32-17)15-7-9-19(25)18(13-15)23(29)30/h2-10,13-14H,11-12H2,1H3,(H,29,30)/b21-14+,26-24+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31937
PNG
(1,3-thiazolidin-5-ylidene derivative, 4a)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1)=C/c1ccc(o1)-c1cc(ccc1Cl)C(=O)OC
Show InChI InChI=1S/C25H21ClN2O5S/c1-31-13-12-28-23(29)22(34-25(28)27-17-6-4-3-5-7-17)15-18-9-11-21(33-18)19-14-16(24(30)32-2)8-10-20(19)26/h3-11,14-15H,12-13H2,1-2H3/b22-15+,27-25+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31958
PNG
(carbohydrazide derivative, 5a)
Show SMILES Oc1ccc(cc1)C(=O)NN=Cc1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C14H10Br2N2O4/c15-10-5-8(12(20)11(16)13(10)21)6-17-18-14(22)7-1-3-9(19)4-2-7/h1-6,19-21H,(H,18,22)
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31948
PNG
(1,3-thiazolidin-5-ylidene derivative, 4l)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1C(F)(F)F)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C26H20ClF3N2O5S/c1-35-12-11-32-23(33)22(38-25(32)31-20-6-4-3-5-18(20)26(28,29)30)14-16-8-10-21(37-16)15-7-9-19(27)17(13-15)24(34)36-2/h3-10,13-14H,11-12H2,1-2H3/b22-14+,31-25+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31969
PNG
(trimethoxyphenyl prop-2-enamide, 5l)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(OC)c1OC
Show InChI InChI=1S/C20H17F6NO4/c1-29-15-6-4-11(17(30-2)18(15)31-3)5-7-16(28)27-14-9-12(19(21,22)23)8-13(10-14)20(24,25)26/h4-10H,1-3H3,(H,27,28)/b7-5+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31968
PNG
(trimethoxybenzyl thiourea, 5k)
Show SMILES COc1cc(CNC(=S)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc(OC)c1OC
Show InChI InChI=1S/C19H18F6N2O3S/c1-28-14-4-10(5-15(29-2)16(14)30-3)9-26-17(31)27-13-7-11(18(20,21)22)6-12(8-13)19(23,24)25/h4-8H,9H2,1-3H3,(H2,26,27,31)
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31929
PNG
(carbohydrazide derivative, 3l)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2cccs2)c(O)c1Br
Show InChI InChI=1S/C12H8Br2N2O3S/c13-7-4-6(10(17)9(14)11(7)18)5-15-16-12(19)8-2-1-3-20-8/h1-5,17-18H,(H,16,19)/b15-5+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31918
PNG
(carbohydrazide derivative, 3a)
Show SMILES Oc1ccc(\C=N\NC(=O)c2cccnc2)c(O)c1
Show InChI InChI=1S/C13H11N3O3/c17-11-4-3-9(12(18)6-11)8-15-16-13(19)10-2-1-5-14-7-10/h1-8,17-18H,(H,16,19)/b15-8+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31932
PNG
(carbohydrazide derivative, 3o)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccncc2)c(O)c1Br
Show InChI InChI=1S/C13H9Br2N3O3/c14-9-5-8(11(19)10(15)12(9)20)6-17-18-13(21)7-1-3-16-4-2-7/h1-6,19-20H,(H,18,21)/b17-6+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31933
PNG
(carbohydrazide derivative, 3p)
Show SMILES CC(=O)N\N=C\c1cc(Br)c(O)c(Br)c1O
Show InChI InChI=1S/C9H8Br2N2O3/c1-4(14)13-12-3-5-2-6(10)9(16)7(11)8(5)15/h2-3,15-16H,1H3,(H,13,14)/b12-3+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31935
PNG
(carbohydrazide derivative, 3r)
Show SMILES Oc1ccc(CC(=O)N\N=C\c2cc(Br)c(O)c(Br)c2O)cc1
Show InChI InChI=1S/C15H12Br2N2O4/c16-11-6-9(14(22)13(17)15(11)23)7-18-19-12(21)5-8-1-3-10(20)4-2-8/h1-4,6-7,20,22-23H,5H2,(H,19,21)/b18-7+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31919
PNG
(carbohydrazide derivative, 3b)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2cccnc2)cc1Br
Show InChI InChI=1S/C13H9Br2N3O2/c14-10-4-8(5-11(15)12(10)19)6-17-18-13(20)9-2-1-3-16-7-9/h1-7,19H,(H,18,20)/b17-6+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31920
PNG
(carbohydrazide derivative, 3c)
Show SMILES Oc1ccc(\C=N\NC(=O)c2cccnc2)cc1
Show InChI InChI=1S/C13H11N3O2/c17-12-5-3-10(4-6-12)8-15-16-13(18)11-2-1-7-14-9-11/h1-9,17H,(H,16,18)/b15-8+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31921
PNG
(carbohydrazide derivative, 3d)
Show SMILES COc1c(Br)cc(\C=N\NC(=O)c2cccnc2)c(OC)c1Br
Show InChI InChI=1S/C15H13Br2N3O3/c1-22-13-10(6-11(16)14(23-2)12(13)17)8-19-20-15(21)9-4-3-5-18-7-9/h3-8H,1-2H3,(H,20,21)/b19-8+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31922
PNG
(carbohydrazide derivative, 3e)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccccc2)c(O)c1Br
Show InChI InChI=1S/C14H10Br2N2O3/c15-10-6-9(12(19)11(16)13(10)20)7-17-18-14(21)8-4-2-1-3-5-8/h1-7,19-20H,(H,18,21)/b17-7+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31923
PNG
(carbohydrazide derivative, 3f)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccco2)c(O)c1Br
Show InChI InChI=1S/C12H8Br2N2O4/c13-7-4-6(10(17)9(14)11(7)18)5-15-16-12(19)8-2-1-3-20-8/h1-5,17-18H,(H,16,19)/b15-5+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31924
PNG
(carbohydrazide derivative, 3g)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2cccc(F)c2)c(O)c1Br
Show InChI InChI=1S/C14H9Br2FN2O3/c15-10-5-8(12(20)11(16)13(10)21)6-18-19-14(22)7-2-1-3-9(17)4-7/h1-6,20-21H,(H,19,22)/b18-6+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31941
PNG
(1,3-thiazolidin-5-ylidene derivative, 4e)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccc(OC)cc1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C25H21ClN2O6S/c1-32-12-11-28-23(29)22(35-25(28)27-16-4-6-17(33-2)7-5-16)14-18-8-10-21(34-18)15-3-9-20(26)19(13-15)24(30)31/h3-10,13-14H,11-12H2,1-2H3,(H,30,31)/b22-14+,27-25+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31943
PNG
(1,3-thiazolidin-5-ylidene derivative, 4g)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1Br)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C25H20BrClN2O5S/c1-32-12-11-29-23(30)22(35-25(29)28-20-6-4-3-5-18(20)26)14-16-8-10-21(34-16)15-7-9-19(27)17(13-15)24(31)33-2/h3-10,13-14H,11-12H2,1-2H3/b22-14+,28-25+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31938
PNG
(1,3-thiazolidin-5-ylidene derivative, 4b)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1)=C/c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN2O3S/c1-28-14-13-26-22(27)21(30-23(26)25-18-5-3-2-4-6-18)15-19-11-12-20(29-19)16-7-9-17(24)10-8-16/h2-12,15H,13-14H2,1H3/b21-15+,25-23+
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Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31947
PNG
(1,3-thiazolidin-5-ylidene derivative, 4k)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccc(cc1)C(F)(F)F)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C26H20ClF3N2O5S/c1-35-12-11-32-23(33)22(38-25(32)31-17-6-4-16(5-7-17)26(28,29)30)14-18-8-10-21(37-18)15-3-9-20(27)19(13-15)24(34)36-2/h3-10,13-14H,11-12H2,1-2H3/b22-14+,31-25+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


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More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31944
PNG
(1,3-thiazolidin-5-ylidene derivative, 4h)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1cccc(Br)c1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C25H20BrClN2O5S/c1-32-11-10-29-23(30)22(35-25(29)28-17-5-3-4-16(26)13-17)14-18-7-9-21(34-18)15-6-8-20(27)19(12-15)24(31)33-2/h3-9,12-14H,10-11H2,1-2H3/b22-14+,28-25+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31945
PNG
(1,3-thiazolidin-5-ylidene derivative, 4i)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccc2ccccc2c1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C29H23ClN2O5S/c1-35-14-13-32-27(33)26(38-29(32)31-21-9-7-18-5-3-4-6-19(18)15-21)17-22-10-12-25(37-22)20-8-11-24(30)23(16-20)28(34)36-2/h3-12,15-17H,13-14H2,1-2H3/b26-17+,31-29+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31946
PNG
(1,3-thiazolidin-5-ylidene derivative, 4j)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccc2ccccc2c1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C28H21ClN2O5S/c1-35-13-12-31-26(32)25(37-28(31)30-20-8-6-17-4-2-3-5-18(17)14-20)16-21-9-11-24(36-21)19-7-10-23(29)22(15-19)27(33)34/h2-11,14-16H,12-13H2,1H3,(H,33,34)/b25-16+,30-28+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31942
PNG
(1,3-thiazolidin-5-ylidene derivative, 4f)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccc(Br)cc1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C25H20BrClN2O5S/c1-32-12-11-29-23(30)22(35-25(29)28-17-6-4-16(26)5-7-17)14-18-8-10-21(34-18)15-3-9-20(27)19(13-15)24(31)33-2/h3-10,13-14H,11-12H2,1-2H3/b22-14+,28-25+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31939
PNG
(1,3-thiazolidin-5-ylidene derivative, 4c)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccccc1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C25H21ClN2O5S/c1-31-13-12-28-23(29)22(34-25(28)27-17-6-4-3-5-7-17)15-18-9-11-21(33-18)16-8-10-20(26)19(14-16)24(30)32-2/h3-11,14-15H,12-13H2,1-2H3/b22-15+,27-25+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31940
PNG
(1,3-thiazolidin-5-ylidene derivative, 4d)
Show SMILES COCCN1C(=O)\C(S\C1=N\c1ccc(OC)cc1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C26H23ClN2O6S/c1-32-13-12-29-24(30)23(36-26(29)28-17-5-7-18(33-2)8-6-17)15-19-9-11-22(35-19)16-4-10-21(27)20(14-16)25(31)34-3/h4-11,14-15H,12-13H2,1-3H3/b23-15+,28-26+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31956
PNG
(1,3-thiazolidin-5-ylidene derivative, 4t)
Show SMILES CCN(CC)CCN1C(=O)\C(S\C1=N\c1ccccc1)=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OC
Show InChI InChI=1S/C28H28ClN3O4S/c1-4-31(5-2)15-16-32-26(33)25(37-28(32)30-20-9-7-6-8-10-20)18-21-12-14-24(36-21)19-11-13-23(29)22(17-19)27(34)35-3/h6-14,17-18H,4-5,15-16H2,1-3H3/b25-18+,30-28+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)


(Helicobacter pylori (Campylobacter pylori))
BDBM31955
PNG
(1,3-thiazolidin-5-ylidene derivative, 4s)
Show SMILES COC(=O)c1cc(ccc1Cl)-c1ccc(\C=C2\S\C(=N\c3ccccc3)N(CCCN(C)C)C2=O)o1
Show InChI InChI=1S/C27H26ClN3O4S/c1-30(2)14-7-15-31-25(32)24(36-27(31)29-19-8-5-4-6-9-19)17-20-11-13-23(35-20)18-10-12-22(28)21(16-18)26(33)34-3/h4-6,8-13,16-17H,7,14-15H2,1-3H3/b24-17+,29-27+
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n/an/an/an/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The enzymatic inhibition assay of HpFabZ was monitored by the spectrophotometric method. The activity of HpFabZ was measured by detection of the decr...


Citation and Details
More data for this
Ligand-Target Pair
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