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Found 54 hits Enz. Inhib. hit(s) with Target = 'brd4 bd1 (aa 42-168)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM321350
PNG
(3-(6-isobutyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)...)
Show SMILES CC(C)Cn1cc(-c2cccc(c2)C(=O)N(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H23N3O2/c1-13(2)11-23-12-17(16-8-9-21-18(16)20(23)25)14-6-5-7-15(10-14)19(24)22(3)4/h5-10,12-13,21H,11H2,1-4H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.00E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM321362
PNG
(6-(2-furylmethyl)-4-phenyl-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES O=c1n(Cc2ccco2)cc(-c2ccccc2)c2cc[nH]c12
Show InChI InChI=1S/C18H14N2O2/c21-18-17-15(8-9-19-17)16(13-5-2-1-3-6-13)12-20(18)11-14-7-4-10-22-14/h1-10,12,19H,11H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.40E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM321347
PNG
(3-[6-(2-cyclohexylethyl)-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CCC2CCCCC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C24H29N3O2/c1-26(2)23(28)19-10-6-9-18(15-19)21-16-27(14-12-17-7-4-3-5-8-17)24(29)22-20(21)11-13-25-22/h6,9-11,13,15-17,25H,3-5,7-8,12,14H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM321345
PNG
(3-[6-(cyclohexylmethyl)-7-oxo-1H-pyrrolo[2,3-c]pyr...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CC2CCCCC2)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C23H27N3O2/c1-25(2)22(27)18-10-6-9-17(13-18)20-15-26(14-16-7-4-3-5-8-16)23(28)21-19(20)11-12-24-21/h6,9-13,15-16,24H,3-5,7-8,14H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
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